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  • 1995-1999  (8)
  • 1999  (8)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 141 (1999), S. 219-220 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 41 (1999), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A phase I study of escalating doses of humanized bispecific antibody (bsAb) MDX-H210 with granulocyte-colony-stimulating factor (G-CSF) was conducted in patients with metastatic breast cancer that overexpressed HER2/neu. The main objectives of the study were to define the maximal tolerated dose (MTD) of MDX-H210 when combined with G-CSF, to measure the pharmacokinetics of MDX-H210 when administered with G-CSF, and to determine the toxicity, biological effects and possible therapeutic effect of MDX-H210 with G-CSF. MDX-H210 is a F(ab)′ × F(ab)′ humanized bispecific murine antibody that binds to both HER2/neu and the FcγR1 receptor (CD64), and was administered intravenously weekly for three doses followed by a 2-week break and then three more weekly doses. A total of 23 patients were treated, and doses were escalated from 1 mg/m2 to 40 mg/m2 with no MTD reached. The toxicity of the bsAb + G-CSF combination was modest, with no dose-limiting toxicity noted: 19 patients had fevers, 7 patients had diarrhea, and 3 patients had allergic reactions that did not limit therapy. The β-elimination half-life varied from 4 h to 8 h at doses up to 20 mg/m2. Significant release of cytokines interleukin-6, G-CSF, and tumor necrosis factor α was observed after administration of bsAb. Circulating monocytes disappeared within 1 h of bsAb infusion, which correlated with binding of bsAb, noted by flow-cytometric analysis. Significant levels of human anti-(bispecific antibody) were measured in the plasma of most patients by the third infusion. No objective clinical responses were seen in this group of heavily pre-treated patients.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Czechoslovak journal of physics 49 (1999), S. 823-832 
    ISSN: 1572-9486
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The photoluminescence (PL) spectra of n- and p-type Al x Ga1−x As (x 〉 0.42) grown by metalorganic vapor phase epitaxy (MOVPE) and liquid phase epitaxy show typically a broad PL band (BB) centered about 300 meV below the near band-gap PL lines. In the MOVPE grown samples the BB is composed out of four lines. The BB intensity increases with the doping level and dominates the spectrum at concentrations 〉 1017 cm−3. The temperature dependence of the BB intensity shows two distinct maxima at ≍ 19 K and ≍ 80 K. Hydrogenation of MOVPE grown samples at 170°C reveal an effective passivation of the shallow acceptors and the centers associated with the BB line. On the contrary hydrogenation at temperatures 〉 250°C leads to an increase in the BB intensity which is related with the evaporation of As from the surface and the generation of VAs in the layers at these temperatures. Our results suggest that the BB is related with isoelectronic centers formed when VAs and CAs or SiAs associate to form next nearest neighbor ion pairs. The PL is then due to a recombination of excitons in analogy to the case of (Zn,O) isoelectronic complexes in GaP.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 18 (1999), S. 97-98 
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1572-8943
    Keywords: cellulose ; infrared spectroscopy ; in situ analysis ; thermal behaviour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The part I of this work discusses the potentialities and limits of the in situ spectroscopic analysis of cellulose by Diffuse Reflectance Infrared Fourier Transform in an environment device. In this paper, we describe: the in situ evolutions of cellulose from 25 to 270°C under N2 or air; the evolution of a partially thermolyzed cellulose residue during thermal treatment from 25 to 450°C and finally the oxidation in air of a cellulose char at 300°C. We observe a limited evolution of the cellulose below 270°C. Only some carbonyle groups issued from rearrangement of cellulose chains are formed. The thermal treatment of the thermolyzed residue leads to a progressive aromatization of the solid between 270 and 450°C. The oxidation in air induces the formation of oxygenated groups (carbonyles, carboxylic acids, lactones) and proceeds by reaction on both aliphatic and aromatic sites. Some dehydration of carboxylic groups to anhydrides are observed.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The coarsening behavior of γ′ precipitates with a uniform size distribution and with a bimodal size distribution in a mechanically alloyed ODS Ni-base superalloy were investigated to clarify the effect of elastic interaction energy on the coarsening behavior of γ′ precipitates. The coarsening rate decreased with increasing size of γ′ precipitates with a uniform size distribution, contrary to the classical LSW theory, and the coarsening behavior of γ′ precipitates with a bimodal size distribution exhibited Ostwald ripening in which the larger precipitates grow at the expense of smaller precipitates. The driving force for coarsening of γ′ precipitates was analyzed based on the two-particle model, considering the effect of elastic interaction energy in addition to the effect of interfacial energy. The contribution of elastic interaction energy on the total energy was found to increase with increasing size of precipitates, and the decelerated coarsening of γ′ precipitates was attributed to the decrease in the driving force for coarsening with increasing size of precipitates.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 71 (1999), S. 994-994 
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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