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  • 1
    Electronic Resource
    Electronic Resource
    A Model for Anharmonic Vibrational Excitation of 〈111〉-Bond-Interstitial Impurities in Si and Ge Crystals (1993)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 143-147 (Oct. 1993), p. 1391-1396 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/00/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.143-147.1391.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Senile dementia of Alzheimer type characterized by laminar neuronal loss exclusively in the hippocampus, parahippocampus and medial occipitotemporal cortex (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 575-580 
    Details
    ISSN: 1432-0533
    Keywords: Senile dementia of Alzheimer's type ; Alzheimer's disease ; Pick's disease ; Laminar neuronal loss ; Limbic system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven cases of senile dementia of Alzheimer type (SDAT) with unusual clinico-pathological findings are reported. The patients showed neuronal loss in laminar pattern, with gliosis exclusively confined to the CA1 of the hippocampus, the area of the hippocampal gyrus (entorhinal cortex) and medial occipitotemporal cortex. This change was more pronounced in the oral region. The subcortical white matter showed more pronounced fibrillary gliosis than loss of myelin. Both Alzheimer's neurofibrillary tangles and senile plaques were less marked than those usually seen in SDAT. The mental disturbance started after the age of 65 in all patients. The main clinical feature was marked character change in addition to disturbance of cognitive function. Cranial computed tomography showed marked dilatation of the oral portion of the inferior horn of the lateral ventricle in the early stage. It was apparent that although the cases in this group could be incorporated within in the spectrum of SDAT, they could also be considered to represent a variant of SDAT. This group could contribute to an understanding of the clinico-pathological spectrum of SDAT as well as indicating ways of managing such patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307623
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  • 3
    Electronic Resource
    Electronic Resource
    Curly fibers are tau-positive strands in the pre- and post-synaptic neurites, consisting of paired helical filaments: observations by the freeze-etch and replica method (1990)
    Springer
    Acta neuropathologica 81 (1990), S. 111-115 
    Details
    ISSN: 1432-0533
    Keywords: Curly fibers ; Anti-tau antibody ; Immunoelectron microscopy ; Rapid-freeze and deep-etch method ; Neuritic paired helical filaments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ultrastructure of the curly fibers was examined by the transmission and immunoelectron microscopy as well as by the rapid-freeze, deep-etch and replica method. The curly fibers consisted mainly of paired helical filaments (PHF) in the neuropils, both pre- and post-synaptic. On the deep-etch replicas, PHF in the neurites had similar dimensions to those of Alzheimer's neurofibrillary tangles in the nerve cell somata, having the width of 28 to 36 nm. The two component filaments, 14 to 18 nm in width, were twisted left-handedly with about 70- to 90-nm intervals. There were also cross-bridging fibrils of about 6 nm in diameter connecting the neighboring PHF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334498
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  • 4
    Electronic Resource
    Electronic Resource
    Corticobasal degeneration: a disease with widespread appearance of abnormal tau and neurofibrillary tangles, and its relation to progressive supranuclear palsy (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 113-121 
    Details
    ISSN: 1432-0533
    Keywords: Key words: Corticobasal degeneration ; Progressive ; supranuclear palsy ; Neurofibrillary tangles ; Abnormal tau
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The neuropathological findings, including immunohistochemistry and electron microscopy, of two patients with clinical findings consistent with corticobasal degeneration (CBD) are reported. Both patients showed degeneration of the precentral cortex, the substantia nigra, the pallidum, and the thalamus. Many ballooned neurons were seen in the cerebral cortex, and argentophilic, skein-like inclusions suggesting neurofibrillary tangles (NFTs) were found in the brain stem and precentral cortex in patient 1. In contrast, patient 2 clearly showed NFTs in the brain stem and dentate nucleus which were indistinguishable from those seen in progressive supranuclear palsy (PSP), while only a few ballooned neurons were found in the cerebral cortex. Gallyas silver stain showed many argentophilic inclusions suggesting NFTs in the brain stem, subcortical nuclei, and cerebral cortex in both patients. Immunohistochemistry for tau showed tau-positive neurons in the cerebral cortex, brain stem, subcortical nuclei and spinal cord, and tau-positive glial cells were seen in the cerebral cortex, white matter and subcortical nuclei, and thread-like structures were seen in the cerebral cortex and white matter. Electron microscopy of the brain stem showed NFTs consisting of paired helical filaments in patient 1, and paired helical filaments and straight tubules in patient 2. Immunoelectron microscopy revealed parallel tau-positive filaments in the cerebral cortex in patent 1. From the two patients, the widespread appearance of abnormal tau and NFTs is one of the essential pathological features in CBD, and it also appears that CBD and PSP have some common underlying pathological processes. Patient 2 is closer to PSP than patient 1 and suggests CBD would link to PSP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294503
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  • 5
    Electronic Resource
    Electronic Resource
    An α-fetoprotein producing pancreatic cystadenocarcinoma (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 377-380 
    Details
    ISSN: 1432-1440
    Keywords: Mucinous cystadenocarcinoma ; Pancreas ; α-Fetoprotein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An autopsy case of an 83-year-old Japanese woman with pancreatic cancer with significantly elevated serum α-fetoprotein levels is reported. The pancreatic tumor was a mucinous cystadeno-carcinoma with multiple metastasis to the liver. The immunohistochemistry for α-fetoprotein revealed positive reactivity in the cytoplasm of cancer cells in the primary and liver metastatic lesions. The current case is the first reported in which mucinous cystadenocarcinoma of the pancreas produced α-fetoprotein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252831
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  • 6
    Electronic Resource
    Electronic Resource
    Nucleolar organizer region score and Ki-67 labelling index in high-grade gliomas and metastatic brain tumours (1991)
    Springer
    Acta neurochirurgica 109 (1991), S. 37-41 
    Details
    ISSN: 0942-0940
    Keywords: Glioma ; metastatic brain tumour ; Ki-67 ; nucleolar organizer regions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sixteen cases of malignant brain tumours comprising 6 anaplastic astrocytomas, 3 glioblastoma multiforme, 1 medulloblastoma and 6 metastatic brain tumours were investigated independently by a silver colloid method for nucleolar organizer regions (NORs) and an immunohistochemistry using a monoclonal antibody against a nuclear antigen, Ki-67, in proliferating cells. The correlation between the mean number of NORs and the percentage of Ki-67 labelled cells (Ki-67 labelling index) was examined. In addition, four normal brain tissue samples without neoplastic cells were stained for NOR. The mean number of NORs in these malignant brain tumours was significantly greater than that in normal astrocytes (p〈0.001). Moreover, both the mean number of NORs and the Ki-67 labelling index in metastatic brain tumours were significantly greater than those in high-grade gliomas (p〈0.001). The Ki-67 labelling index and the mean number of NORs in malignant brain tumours including metastatic brain tumours were found to be linearly related (r=0.86). These results suggest that the proliferative potential of malignant brain tumours could be evaluated by NOR score as well as Ki-67 labelling index and that such indices provide clear discrimination between high-grade gliomas and metastatic brain tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405695
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  • 7
    Electronic Resource
    Electronic Resource
    Pituitary granuloma and chronic inflammation of hypophysis: Clinical and immunohistochemical studies (1993)
    Springer
    Acta neurochirurgica 121 (1993), S. 152-158 
    Details
    ISSN: 0942-0940
    Keywords: Pituitary granuloma ; giant cell granuloma ; chronic inflammation of hypophysis ; diabetes insipidus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We describe five patients with chronic inflammation of the hypophysis including three pituitary granulomas of unknown aetiology. In contrast to the previously reported cases, the involvement of neurohypophysis or hypothalamus was a distinct clinical feature in these patients. Impairment of anterior pituitary function was less prominent, while polyuria and polydipsia occurred in all cases. Enlargement of the sella turcica was absent in three and slight in two cases. CT scan and MR images demonstrated a contrast-enhanced sellar mass in all patients; abnormally thickened pituitary stalk and infundibulum with contrast-enhancement was observed in four. The fibrous tissues were removed by the transsphenoidal approach in four patients, and by the subfrontal approach in one case. In all patients, the endocrinological dysfunction was prolonged. No increase in the size of the remaining pituitary mass was demonstrated on repeated MR images in any of the patients. On histological examination, granulomatous formation was present in three samples, and multinucleated Langhans' giant cells were seen in one. The epithelioid cells and multinucleated giant cells constituting the granulomas were positive for anti-macrophage antibody. No firm laboratory or histological evidence was obtained supporting the presence of systemic disease leading to granulomas. In the other two cases, the pituitary lesions were composed of chronic inflammation tissue, and serum antipituitary antibodies were present in a patient with concurrent Hashimoto's thyroiditis. Our experiences with chronic inflammation of the hypophysis indicate that these patients are best managed by histological confirmation of the lesion followed by adequate hormonal replacement. Based on our findings and those reported in the literature, we propose that patients with granulomatous hypophysitis or chronic inflammation of the hypophysis be managed as follows: When an underlying disease is detected, the patient should begin to receive conservative treatment for the causative disease plus hormonal replacement therapy, as necessary. However, when visual disturbance is progressive and uncontrollable by conservative means, surgical decompression of the chiasma is required. If the pathogenesis of the pituitary lesion cannot be identified, surgical exploration is essential for a precise pathological diagnosis. When a granulomatous or chronic inflammatory process is evident intra-operatively, partial removal or biopsy are recommended. Radical resection of fibrous and adhesive tissue with infundibular impairment will lead not only to exacerbation of the pre-existing anterior- and/or posterior pituitary dysfunction, but also to grave hypothalamic injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01809268
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  • 8
    Electronic Resource
    Electronic Resource
    Grain Refinement and Mechanical Properties of Magnesium Alloy by Hydrogenation Treatment (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 558-559 (Oct. 2007), p. 757-762 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/17/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.558-559.757.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    Improvement of the Fatigue Characteristic of AZ31 Magnesium Alloy by Microstructures Control (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 558-559 (Oct. 2007), p. 781-786 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: High-strain conditions as a means of microstructure control have recently been investigated to improve theductility and enhance the strength of magnesium alloys. The level of superplastic deformation and the fatigueproperties of the wrought materials have also been studied. In comparison, only a small number of suchreports are available on cast materials. As a part of the search for applications of magnesium alloys,comparisons of structural changes and mechanical properties should be made between wrought and castmaterials.In the present study, the grain refinement of cast and extruded materials made from commerciallyavailable AZ31 magnesium alloy was conducted using a multi-axial alternative forging method. Therelationships between the structural changes and working processes and the relationships between changes inthe mechanical properties as well as grain sizes and fatigue properties are discussed. Both the cast and theextruded materials tended to exhibit uniform crystalline structures with an increasing number of workingcycles. Dynamic recrystallization was observed during both working and static recrystallization during bothreheating and holding. When an equivalent strain of 0.6 was applied, the localized formation of ultra-finegrains of 0.5 μm was observed. The tensile strength and yield stress had maximum values in the initial stageof the multi-axial alternative forging. Although ductility improved with higher numbers of working cycles,the strength decreased. This can be explained by the dynamic and static recrystallization processes and worksoftening
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/17/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.558-559.781.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    Biaxial Tensile Deformation Behavior and Microstructural Evolutions of Superplasticity in AZ31 Magnesium Alloy (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 551-552 (July 2007), p. 225-230 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Magnesium alloys show promise in meeting the demand for materials of lighter weight andhigher rigidity. Mg alloys are hard to process and normally require grain refining for improvedformability and mechanical properties. To process these fine-grained Mg alloys effectively, it isimportant to relate their load stress and mechanical properties to changes in their microstructures.Using a biaxial tensile machine and cruciform specimens, to evaluate the mechanical properties,microstructure, and plasticity, in a high temperature biaxial stress state, used of AZ31 Mg alloy sheet.With biaxial deformation, grain boundary slide occurred more frequently than with uniaxialdeformation, causing grain boundary separation and formation of micro-voids between the grains. Inthe vicinity of the cracks and at the locations of grain boundary separation, although deformationtemperature at higher than the recrystallization temperature, fine grains (about 2 )m) showing induplex grain structures were formed locally. The formation of duplex grain structures as a result oflocal formation of fine grains during the deformation process is a major issue to be solved from theviewpoint of plasticity processing
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/16/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.551-552.225.pdf
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