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  • 1
    Electronic Resource
    Electronic Resource
    Aspartic acid at position 57 of DQβ chain does not protect against Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects (1989)
    Springer
    Diabetologia 32 (1989), S. 762-764 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 (insulin-dependent) diabetes mellitus ; HLA-DR ; HLA-DQ ; polymerase chain reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary HLA DQβ chain, in particular amino acid at position 57, has been reported to contribute to susceptibility and resistance to Type 1 (insulin-dependent) diabetes mellitus in Caucasians. Resistance has been proposed to be conferred by aspartic acid at this position. To ascertain the association of HLA DQβ and DRβ genes with Type 1 diabetes in Japanese subjects, ten Japanese Type 1 diabetic patients were investigated at DNA level. Genomic DNA was amplified by polymerase chain reaction, and dot blot analysis was carried out using the amplified DNA with allele specific oligonucleotide probes. All patients had aspartic acid at position 57 of at least one of their two DQβ chains, and there was no significant difference of amino acids at the same position of DRβ chain in patients compared to control subjects. These data indicate that the protective role of aspartic acid at position 57 of DQβ chain is less significant in Japanese compared with Caucasian subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274539
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  • 2
    Electronic Resource
    Electronic Resource
    Changes in microflora of a puffer fish Fugu niphobles, with different water temperatures (1989)
    Springer
    Marine biology 101 (1989), S. 299-304 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Grass puffer Fugu niphobles, captured in November 1986 at Shimoda, Japan, and then reared at different temperatures ranging from 10 to 29°C, was examined for microflora changes in the skin, gill and intestines. At 10°C, the skin and gill were colonized mainly by Pseudomonas, Flavobacterium and Moraxella, while at 29°C Vibrio and Flavobacterium appeared abundantly. The intestinal microflora, consisting of Vibrio, Pseudomonas and Flavobacterium, revealed little temperature dependence, although the intrageneric composition of Vibrio changed conspicuously depending on the change of water temperature. Vibrio group 1, tentatively identified as V. alginolyticus, was detected in all tissues examined at 20 and 29°C. This, along with the fact that V. alginolyticus produces tetrodotoxin, suggests that the tetrodotoxin contained in puffer is, at least partly, accounted for by this bacterial species inhabiting intestines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428125
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  • 3
    Electronic Resource
    Electronic Resource
    Tetrodotoxin-producing bacteria from the blue-ringed octopus Octopus maculosus (1989)
    Springer
    Marine biology 100 (1989), S. 327-332 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Several live specimens of the blue-ringed octopus Octopus maculosus were collected from the Philippines in November 1985, and from Japan in February 1986, and the distribution of toxicity, along with toxin composition, in the posterior salivary gland and other soft parts were examined. Tetrodotoxin (TTX: 1400 mouse units g-1) was detected in the posterior salivary gland of a Japanese specimen, while not only the salivary gland but other soft parts were toxic in the Philippine specimens. The Philippine specimens contained TTX and anhydrotetrodotoxin, the Japanese specimen TTX, 4-epitetrodotoxin, and an unknown toxin. The posterior salivary gland, intestine and other parts were excised from the Philippine specimens and examined for bacterial flora. Twenty-two dominant strains were isolated and cultured in a 2xORI medium (Ocean Research Institute, Simidu and Tsukamoto 1985) at 20°C for 20 to 48 h. Cells were harvested by centrifugation, and disrupted by ultrasonication. The toxins were partially purified from the cell lyzate by ultrafiltration and Bio-Gel P-2 column-chromatography. Instrumental analyses disclosed that 16 of the 22 strains produced TTX and/or related substances. Six strains which clearly exhibited TTX productivity were identified as Alteromonas (2 strains), Bacillus (2), Pseudomonas (1) and Vibrio (1), based on biochemical and biological characteristics. Of these, one strain each of Bacillus and Pseudomonas produced TTX at a level detectable by the mouse assay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391147
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  • 4
    Electronic Resource
    Electronic Resource
    Occurrence of tetrodotoxin in the starfishes Astropecten polyacanthus and A. scoparius in the Seto Inland Sea (1985)
    Springer
    Marine biology 90 (1985), S. 61-64 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Two starfishes, “togemomijigai” Astropecten polyacanthus and “momijigai” A. scoparius were collected from the Seto Inland Sea in October 1983 through November 1984, and assayed for toxicity by the standard method for tetrodotoxin (TTX). Most of the 54 A. polyacanthus specimens assayed were toxic, with the highest toxicity score being 520 mouse units (MU) g-1. All seven A. scoparius were toxic, with the highest score being 46 MU g-1. The toxin from A. polyacanthus was purified by a method which consisted mainly of activated charcoal treatment, and chromatography on CM-Sephadex C-25 and Bio-Rex 70 columns. The purified starfish toxin showed a specific toxicity of 4 700 MU mg-1, a value which was almost comparable to that of authentic TTX. From the thin-layer chromatographic and electrophoretic behavior, along with 1H-NMR spectrum, A. polyacanthus toxin was identified as TTX.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428215
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  • 5
    Electronic Resource
    Electronic Resource
    Vibrio alginolyticus, a tetrodotoxin-producing bacterium, in the intestines of the fish Fugu vermicularis vermicularis (1987)
    Springer
    Marine biology 94 (1987), S. 625-630 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract To clarify the mechanism of toxification in animals contaminated with tetrodotoxin, the intestinal contents of the puffer Fugu vermicularis vermicularis were examined for bacterial flora in 1985. Twenty-six out of 33 strains belonged to the genus Vibrio. These bacteria were classified into Groups I to VII, based on biological and biochemical characters. High performance liquid chromatography and gas chromatography-mass spectrometry, together with mouse bioassay for toxicity, clearly demonstrated that Group I produced tetrodotoxin and anhydrotetrodotoxin under cultivation with a medium composed of Phytone peptone (BBL) and NaCl. Some other groups also produced this toxin and/or related substances to some extent. Strains of Group I were all identified as Vibrio alginolyticus. Two strains among four produced a detectable amount of tetrodotoxin and/or anhydrotetrodotoxin, as measured by all instrumental analyses applied. Our findings suggest that some strains of V. alginolyticus are closely related to the toxification of the puffer, and probably of other species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431409
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  • 6
    Electronic Resource
    Electronic Resource
    Measurement of bunch lengthening in TERAS : International conference on synchrotron radiation instrumentation (SRI−88) (1989)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 60 (1989), S. 1748-1751 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The bunch length was measured by using a highly sensitive streak camera with a time resolution of 2 ps. It was found that fine structures appeared in the electron bunch shape and that the shapes of electron bunches were described by a Gaussian distribution on the average. The dependence of bunch length on beam current was measured for an electron beam of 607 MeV. The bunch length was well represented by a power function of beam current with an exponent of 0.197 at currents lower than 35 mA or 0.30 at high currents. The experimental results suggest that the longitudinal coupled-bunch beam instability takes place at low beam currents and the turbulent instability dominates at high currents. It was also found from the three-dimensional bunch shape measurements that the bunch shape tended to blow up at high currents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1140945
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  • 7
    Electronic Resource
    Electronic Resource
    Use of the laryngeal tube after failed insertion of a laryngeal mask airway (2005)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 60 (2005), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.2005.04312.x
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  • 8
    Electronic Resource
    Electronic Resource
    Inhibitory effects of rabbit antisera on mitogenic activity of Actinobacillus actinomycetemcomitans lipopolysaccharide (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 24 (1989), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Lipopolysaccharides (LPSs) were isolated from Actinobacillus actinomycetemcomitans strains ATCC 29523 (serotype a), Y4 (b), and NCTC 9710 (c) by the hot phenol-water procedure. Y4 lipid A was obtained by the hydrolysis of Y4 LPS in 1 % acetic acid. All the LPS preparations and Y4 lipid A were mitogenic for C3H/HeN mouse spleen cells, but not for C3H/HeJ mouse spleen cells. Immuno-globulin preparations partially purified by ammonium sulfate precipitation at 33% saturation from rabbit antisera against Y4 whole cells inhibited the mitogenic response of C3H/HeN mouse spleen cells to LPSs from all the strains of A. actinomycetemcomitans and Y4 lipid A. Anti-Y4 LPS immunoglobulin preparation inhibited the mitogenic acuvity of Y4 LPS and Y4 lipid A. Furthermore, anti-Y4 whole cell Fab fragments inhibited the mitogenic activity of both Y4 LPS and Y4 lipid A. These results suggest that antibodies against A. actinomycetemcomitans LPS may modify immune responses of lymphocytes to this organism at periodontal sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1989.tb02001.x
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  • 9
    Electronic Resource
    Electronic Resource
    Influence of Newly Developed Resin and MMA Resin on Mouse Fibroblasts Cellular Viability (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 309-311 (May 2006), p. 817-820 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The aim of this study is evaluate to the cellular viability of elution from the newlydeveloped resin and Osteobond® in vitro. The basis of the newly developed resin are methacryloyloxyethyl methyl succinate and 1,6-Hexanediol dimethacrylate. The basis of Osteobond is methyl methacrylate. The concentrations of basis in each elution were determined by high-performance liquid chromatography (HPLC). Cellular viabilities of L-929 mouse fibroblasts were evaluated by direct cells counting, and then, each IC50 value was calculated. Moreover, patterns of cell death were analyzed using annexin V/propidium iodide staining with thephase-contrast microscope and flow cytometry. The concentration of Osteobond elution was 2.16 mM of MMA, and the newly developed resin elution was 1.02 mM of TA and 1.87 x 10-2 mM of HX. Until 72 hours of incubation, treatment with each elution impaired the viability of L-929 cells in a dose-dependent manner. IC50 value of Osteobond was 6.48 x 10-4 mM of MMA. However, IC50 of the newly developed resin was not calculated. Treatment with Osteobond elution showedmore necrotic cells than with the newly developed resin elution. In conclusion, the results demonstrated much more excellent cellular viability of the newly developed resin than that of MMA resin. Thus, it is suggested that the newly developed resin will be more useful as an implantation material for dentistry and orthopaedics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/51/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.309-311.817.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    Distribution of tetrodotoxin in various organs of the starfish Astropecten polyacanthus (1987)
    Springer
    Marine biology 96 (1987), S. 385-390 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Tissues of various organs of the starfish Astropecten polyacanthus collected in the Hiroshima Prefecture from April 1985 to June 1986 were analyzed for lethal potency by the assay method for tetrodotoxin. The ovary showed the highest potency (47 to 1 450 MU g-1), followed by the digestive organs (〈10 to 960 MU g-1) and the exoskeleton including spines and tube-feet (〈10 to 170 MU g-1). The pyloric caecum and testis were less toxic. Overall toxicity was remarkably higher in females (2 060±382 MU, mean±SE) than in males (1 106±214 MU).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412522
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