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  • 1
    Electronic Resource
    Electronic Resource
    Evaluation of Mode II Interlaminar Fracture Toughness of Composite Laminates under Impact Loading (1997)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 141-143 (Sept. 1997), p. 477-500 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/44/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.141-143.477.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Structure of the exocrine pancreas of flounder (Paralichthys olivaceus): immunological localization of zymogen granules in the digestive tract using anti-trypsinogen antibody (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 46 (1995), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Most fish have a diffuse exocrine pancreas located around the internal organs, but its exact structure is not well understood. In this study, we developed a method for analysing zymogen granules using anti-fish trypsinogen, and the structure of the flounder pancreas was examined by localizing pancreatic exocrine cells. Anionic trypsinogen was purified from eel pancreas by chromatography using DE-52-cellulose and Superose 12 columns. Rabbit antiserum (anti-eel trypsinogen antibody: anti-eTrg) was raised against purified trypsinogen. Immunoblotting analysis demonstrated that anti-eTrg recognized two isoforms of eel trypsinogens and trypsins. This antibody also reacted with flounder trypsin. Zymogen granules containing trypsinogen were visualized within pancreatic glandular cells of the flounder Paralichthys olivaceus by immunohistochemistry using anti-eTrg. The flounder exocrine pancreas was reconstructed from observations of serial sections of digestive tract. The exocrine pancreas cells were localized along the hepatic portal vein and the veins running to the portal vein from the intestine, stomach, pyloric appendage and spleen, forming a highly branched tissue. Interlobular ducts from pancreatic acini formed a pancreatic duct covered with smooth muscle at the point where it met (but did not join) the bile duct. The pancreatic duct opened into the intestinal lumen at the basal portion of the third pyloric appendage in parallel with the bile duct.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1995.tb05970.x
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  • 3
    Electronic Resource
    Electronic Resource
    Suppression of allergic reaction by λ-carrageenan: Toll-like receptor 4/MyD88-dependent and -independent modulation of immunity (2003)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 33 (2003), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Recognition of foreign substances by innate immunity through pattern recognition receptors (PRRs) regulates acquired immunity such as allergic reaction. Because PRRs recognize heterogeneous ligands, daily food intake can potentially regulate immune allergic reaction.Objective Elucidation of the effect of λ-carrageenan on allergic reactions was aimed.Method IFN-γ and IL-4 was measured in in vitro T cell-stimulated culture. Cytokine production from macrophages in response to λ-carrageenan was measured as indicator for innate immunity activation. Mice were immunized with OVA in alum to induce specific IgE, and then histamine release was induced by systemic injection of OVA.Results Activation of innate immunity by λ-carrageenan is dependent on Toll-like receptor-4 (TLR4) and MyD88, in which induction of pro-inflammatory cytokines such as TNF-α and IL-6 was largely impaired in macrophages from TLR4- and MyD88-deficient mice. Footpad oedema, a model for in vivo inflammatory reactions, was significantly reduced in these mice. Similar to recent evidence showing a preference for the stimulation of Th1 via TLR/MyD88 signalling, λ-carrageenan showed enhanced IFN-γ and decreased IL-4 in stimulated T cell cultures. Interestingly, increased IFN-γ production was still seen in TLR4- and MyD88-deficient splenocytes. Oral administration of λ-carrageenan to immunized mice successfully decreased OVA-specific IgE, and λ-carrageenan was also effective in previously immunized mice. Further, serum histamine release upon systemic challenge of OVA was significantly inhibited. Neither OVA-specific IgG1/IgG2a nor cytokine secretion from in vitro cultures were altered, suggesting the involvement of multiple PRRs as demonstrated by TLR4/MyD88-independent IFN-γ up-regulation. The simultaneous feeding of OVA with lipopolysaccharide abrogated oral tolerance, but λ-carrageenan was not only devoid of such an effect but was also found to promote oral tolerance in the absence of TLR4.Conclusion λ-Carrageenan was suggested to be a useful dietary supplement to ameliorate allergic reactions while maintaining oral tolerance-dependent intestinal homeostasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2003.01575.x
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  • 4
    Electronic Resource
    Electronic Resource
    Error-free 2.5 Gbit/s operation of a semi-insulating buried heterostructure side-injection light-controlled bistable laser diode (1997)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 70 (1997), S. 2946-2948 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We demonstrate optical response from a side-injection light-controlled bistable laser diode buried with semi-insulating InP using hydride vapor phase epitaxy. The buried surface around both the 〈110〉 and 〈−110〉 oriented mesas is flat. The bistable operation is obtained by applying control voltage to the saturable absorption region. After optimization of the device parameters, we obtained error-free operation at a bit rate as high as 2.5 Gbit/s. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.118752
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  • 5
    Electronic Resource
    Electronic Resource
    Growth of vertical-cavity surface-emitting laser structures on GaAs (311)B substrates by metalorganic chemical vapor deposition (1997)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 70 (1997), S. 3395-3397 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Vertical-cavity surface-emitting laser (VCSEL) structures have been grown on GaAs (311)B substrates by metalorganic chemical vapor deposition. C-doped GaAs and AlAs layers with smooth surface morphology and a hole concentration of 1018 cm−3 were obtained by optimizing the growth conditions; these conditions contributed to high-quality p-type distributed Bragg reflectors (DBRs). The devices on the (311)B substrates exhibited a threshold current of 9.6 mA, voltage of 2.1 V, and maximum power of 4.1 mW at a 20 μm φ size; these characteristics are similar to those obtained on (100) substrates. The polarization was aligned to [2¯33¯]. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.119182
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  • 6
    Electronic Resource
    Electronic Resource
    Functional Characterization of CD8+ Antigen-Specific Cytotoxic T Lymphocytes after Enrichment Based on Cytokine Secretion: Comparison with the MHC-Tetramer Technology (2000)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 52 (2000), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cell therapy with antigen-specific T cells holds promise for various diseases including cancer and viral infections. The powerful enrichment procedure based on major histocompatibility complex (MHC)-tetramers, however, is of limited applicability so far. Therefore, the recently developed cell surface affinity matrix technology that allows direct identification and enrichment of life antigen-specific T cells based on cytokine secretion was evaluated in this respect. To this end, CD8+ T cells directed against the HLA-A*0201-restricted melanoma-associated peptide Melan-A (aa26–35) were generated by combining stimulation of peptide-pulsed autologous dendritic cells (DC) with antigen-independent expansion with anti-CD3/anti-CD28 monoclonal antibodies (MoAb). Antigen-specific cytotoxic T lympocyte (CTL) were detected based on stimulation-induced interferon (IFN)-γ and interleukin (IL)-4 secretion and enriched 〉 100-fold using the cell surface affinity matrix technology. The resulting IFN-γ- and IL-4-secreting CTL lines contained 〉 80% and 〉 70% cytokine positive T cells, respectively. They exhibited a cytotoxic activity against Melan-A expressing target cells that was significantly higher as compared to nonpurified CTL. Direct staining of enriched CTL with HLA-A2-Melan-A-tetramers revealed a high correlation between the results obtained from the cell surface affinity matrix technology and those obtained from tetrameric complexes. Altogether, our study demonstrates that cytokine-driven enrichment based on the cell surface affinity matrix technology enables selective isolation of functionally active antigen-specific CTL that may be used for an adoptive T cell transfer in immunotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.2000.00810.x
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  • 7
    Electronic Resource
    Electronic Resource
    Post-release adaptation processes of hatchery-reared honmasu salmon parr (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 56 (2000), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Hatchery-reared honmasu salmon Oncorhynchus rhodurus × masou parr released into the Yanagisawa River, Tochigi Prefecture on 24 June 1996 increased significantly in length and weight by November, while siblings retained in hatchery tanks did not. Plasma growth hormone (GH) levels of the released parr increased from 1 day after the release until 23 August, while the GH levels of the wild parr in the river did not increase. The released parr started to consume various natural prey organisms within a day after release. However, stomach fullness of the released parr was considerably lower than that of the wild parr during the first week following release. Trypsin activity in the released parr increased after 23 August, 2 months post-release. The results demonstrate that the released parr adapt to the natural river environment within weeks. Endocrine control by GH and exocrine pancreas activity appear to play important roles in the post-release adaptation processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.2000.tb02092.x
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  • 8
    Electronic Resource
    Electronic Resource
    Stimulation of Bone Formation by Recombinant Fibroblast Growth Factor-2 in Callotasis Bone Lengthening of Rabbits (1999)
    Springer
    Calcified tissue international 64 (1999), S. 542-546 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Fibroblast growth factor — Bone lengthening — Bone formation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Bone lengthening by callotasis is one of the most useful methods not only for the treatment of short extremities but also for extensive bone defects; however, the procedure takes a long time especially for the consolidation of the distracted callus. In this study, effects of a single local injection of recombinant human fibroblast growth factor-2 (FGF-2 or basic FGF) on callotasis bone lengthening were examined in rabbits. Ten days after the osteotomy at the middle of the tibia and the installment of an external fixator, the osteotomized site was distracted at a rate of 1.4 mm/day for 7 days, resulting in 9.8 mm lengthening. On the final day of distraction, 200 μg of FGF-2 in 150 μl of saline solution or vehicle alone was injected into the center of the distracted callus. Injection of FGF-2 increased bone formation at the distracted callus radiologically and histologically. A significant effect on bone mineral content (BMC) at the callus was observed as early as 2 weeks, and FGF-2 increased the BMC about twofold at 5 weeks after a normal remodeling process. We conclude that the callotasis method in combination with FGF-2 injection at the consolidation step could be clinically beneficial to shorten the bone lengthening period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900646
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  • 9
    Electronic Resource
    Electronic Resource
    Microperforate hymen at 27 years of age diagnosed with withdrawal bleeding and hysterofiberscopy (2000)
    Springer
    Archives of gynecology and obstetrics 264 (2000), S. 49-50 
    Details
    ISSN: 1432-0711
    Keywords: Key words Microperforate hymen ; Hysterofiberoscopy ; Withdrawal bleeding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Microperforate hymen is a congenital obstructive vaginal membrane with a tiny opening. It is usually detected long before menarche because of recurring vulvovaginitis and urinary tract infection. We report a case of microperforate hymen in a 27-year-old women presenting oligomenorrhea, in whom the location of the tiny opening on the hymenal membrane was detected by withdrawal bleeding without anesthesia, and definitively diagnosed preoperatively by using hysterofiberscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004040000072
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  • 10
    Electronic Resource
    Electronic Resource
    Local application of basic fibroblast growth factor into the bone increases bone mass at the applied site in rabbits (1996)
    Springer
    Archives of orthopaedic and trauma surgery 115 (1996), S. 344-346 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of basic fibroblast growth factor (bFGF) applied locally into the bone under physiological conditions was investigated. An aqueous solution containing Oμg (vehicle), 100 μg or 400 μg recombinant human bFGF was percutaneously applied through a needle into the right ilium in rabbit, and the ilia were harvested 4 weeks after the application. Compared with vehicle-treated animals, bone mineral density measured by dual-energy X-ray increased in the 400 μg bFGF group. The width of trabeculae in the bFGF-treated groups was greater than in the vehicle group. These results showed that bFGF applied locally into the bone under physiological conditions affected bone formation, and suggested that such an application might have potential for increasing bone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00420329
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