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  • 1
    Electronic Resource
    Electronic Resource
    Solution properties of ionomers. 2. Simple salt effect (1989)
    s.l. : American Chemical Society
    Macromolecules 22 (1989), S. 754-757 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00192a040
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  • 2
    Electronic Resource
    Electronic Resource
    No diabetes-associated mutations in the coding region of the hepatocyte nuclear factor-4γ gene (HNF4G) in Japanese patients with MODY (2000)
    Springer
    Diabetologia 43 (2000), S. 1064-1069 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Maturity-onset diabetes of the young ; MODY ; transcription factor ; nuclear receptor ; HNF-4γ ; diabetes mellitus ; insulin ; genetics ; mutation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Mutations in the transcription factor hepatocyte nuclear factor (HNF)-4α are the cause of one form of maturity-onset diabetes of the young, MODY1. The HNF-4γ is structurally related to HNF-4α and is expressed together with HNF-4α in pancreatic islets. We therefore tested the hypothesis that genetic variation in the HNF-4γ gene (HNF4G) is associated with MODY in Japanese subjects. Methods. We screened the protein coding region of HNF4G (exons 3–11) for mutations in 57 unrelated Japanese subjects with MODY by amplifying each exon and adjacent intron region using the polymerase chain reaction (PCR) and specific primers and then directly sequencing the PCR products. The frequency of each variant was compared between patients with MODY and a group of non-diabetic subjects. Results. We found ten sequence variants, two of these were located in exons: exon 6, a silent substitution in codon 144, c.432A/G and exon 7, a G-to-A substitution in codon 190 (c.570G/A) resulting in a conservative Met-to-Ile substitution (M/I190) in the putative ligand-binding region of HNF-4γ protein. The remaining eight variants were located in introns. There was no significant difference in the frequency of these polymorphisms between subjects with MODY and non-diabetic control subjects. Conclusion/interpretation. Genetic variation in the coding region of HNF4G is unlikely to be a major cause of MODY in Japanese people. [Diabetologia (2000) 43: 1064–1069]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051491
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  • 3
    Electronic Resource
    Electronic Resource
    Elevation of Nitric Oxide Metabolites in the Cerebrospinal Fluid of Patients with Moyamoya Disease (2000)
    Springer
    Acta neurochirurgica 142 (2000), S. 1275-1280 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Collateral circulation; intracranial-extracranial bypass surgery; moyamoya disease; nitric oxide.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Background. To investigate whether nitric oxide (NO) contributes to formation of abnormal collateral circulation in patients with moyamoya disease.  Methods. Cerebrospinal fluid (CSF) samples were obtained from the subarachnoid space of the Sylvian fissure during combined bypass surgery for moyamoya disease and kept frozen until NO metabolites, nitrate and nitrite, were measured using a Griess method.  Results. Compared with control CSF obtained from 18 patients with hemifacial spasm, unruptured aneurysm, etc., concentrations of NO metabolites in 26 CSF samples of 18 patients with moyamoya disease were significantly higher (mean±SE; 17.6±1.2 vs. 10.5±1.0 μM, p〈0.01). In eight patients, the CSF samples from both the first and second operation could be obtained. NO metabolite concentrations (20.5±2.3 μM) in CSF obtained from the first surgery decreased to 15.7±1.8 μM (p〈0.01) in CSF obtained from the second, contralateral procedure. The cases of moyamoya disease with greater development of moyamoya vessels at angiographic stage 3 and 4 tended to show higher concentrations of NO metabolites than cases at earlier or later stages with a few moyamoya vessels.  Interpretation. Nitric oxide concentrations in CSF are chronically elevated in moyamoya disease, probably reflecting development of abnormal collateral circulation. i.e. moyamoya vessels. Vascular bypass surgery can reduce abnormal collateral circulation with reduced production of nitric oxide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010070025
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  • 4
    Electronic Resource
    Electronic Resource
    Alterations of monoamine metabolites and of tryptophan in the basal cisternal CSF of patients after subarachnoid haemorrhage (1987)
    Springer
    Acta neurochirurgica 87 (1987), S. 58-62 
    Details
    ISSN: 0942-0940
    Keywords: Homovanillic acid (HVA ; 5-hydroxyindoleacetic acid (5-HIAA) ; Tryptophan (TRP) ; subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and tryptophan (TRP) were measured in the CSF obtained from the basal cistern of 20 patients, who had undergone surgical obliteration of bleeding aneurysms within 3 days after subarachnoid haemorrhage (SAH). The concentrations of these substances, which were assayed by high performance liquid chromatography (HPLC), were the highest on days 3 or 4, and thereafter showed a gradual decrease with an increase in time. The cisternal CSF in patients who had severe pre-operative clinical grades of SAH or vasospasm contained relatively higher concentrations of HVA, 5-HIAA and TRP than those contained in patients who did not. It is proposed that SAH stimulates the release of monoamines from the brain with the resultant extracellular accumulation of their metabolites and their diffusion into CSF during the acute stage. This stimulatory effect of SAH on the brain monoamine system may be consistent with those previously reported in cases of cerebral haemorrhage or infarction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02076018
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  • 5
    Electronic Resource
    Electronic Resource
    Reduction of the source size of gas-puff z-pinch plasmas using an inductive pulsed power system (2000)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 71 (2000), S. 4438-4444 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A small scale inductive pulsed power (IPP) generator with copper wire fuses as an opening switch has been applied to an argon gas-puff z-pinch plasma which can be used as a point source for x-ray lithography. The IPP generator with fuses supplies a driving current of 60 kA in 400 ns to the z-pinch plasma. Without fuses, the generator serves as a conventional fast bank (FB) system which supplies z-pinch current of 60 kA in 4.5 μs. Characteristics of the z-pinch implosions in IPP and FB systems are investigated and compared. The result obtained shows that the intensity of soft x rays emitted from hot spots in both systems is decreased gradually with longer delay time, which is the time difference between energizing a gas-puff actuator and a primary current trigger. Dual axis pinhole imagery shows that the hot spot size is 0.8 mm in diameter in both systems. However, the average radial displacement of hot spots is 0.9 mm in the FB system and it is reduced to 0.4 mm in the IPP system. Optical framing camera images have confirmed that the radial distribution of hot spots is due to kink instability. The framing images also show that the imploding plasma in the FB system which has a pinch size of 2.2 mm in diameter can be further compressed to 1.3 mm. The IPP system can suppress the kink instability of pinch plasma and increases plasma column uniformity along the z axis. This suggests that the IPP system can improve the stability of the pinched plasma so as to minimize the end-on source size for x-ray lithography applications. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1322576
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  • 6
    Electronic Resource
    Electronic Resource
    Bolometric measurements in JT-60 (1988)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 59 (1988), S. 1866-1868 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Radiation losses from the main plasma of the JAERI Tokamak-60 (JT-60) were measured by a 15-channel bolometer array and those from divertor chambers in the ion and electron drift sides were each measured by two bolometers. The bolometric detector consisting of three layers (5-μm-thick gold absorber, 7-μm-thick polyimide foil, and 0.1-μm-thick gold resistor grid) was developed for this measurement. In typical diverted discharges with NB heating, the ratios of power radiated from the main and divertor chambers to the absorbed power were approximately 10% and 20%, respectively. Intense poloidal asymmetries of radiated power localized near the X point outside the torus were observed in diverted discharges. The profiles of the radiated power were reconstructed by an Abel inversion with an asymmetric term. On the other hand, a poloidally asymmetric radiation band localized near the inner wall, "marfe,'' was observed for dense plasmas in limiter discharges with neutral beam heating.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1140090
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  • 7
    Electronic Resource
    Electronic Resource
    6-GeV synchrotron radiation project : International conference on synchrotron radiation instrumentation (1989)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 60 (1989), S. 1719-1721 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: This paper outlines the status of a 6-GeV synchrotron radiation designed at RIKEN. This facility consists of a main storage ring, a booster synchrotron, a 1.5-GeV preinjector linac, positron injection linacs, and others. The electronan GeV. The storage ring has a circumference of 1069.2 m and 7-m-long straight sections for insertion devices. The lattice of the main ring is a Chasman–Green-type one and has 36 periodicity. The low emittance (εx=8.2 nm rad) and large dynamic aperture are expected even with field errors and misalignments of magnetic elements. Three years of a preconstruction research and development period and 5 years of construction period are scheduled.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1140937
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  • 8
    Electronic Resource
    Electronic Resource
    Urinary sediment podocalyxin in children with IgA nephropathy and Henoch Schoenlein purpura nephritis (2002)
    Melbourne, Australia : Blackwell Science Pty
    Nephrology 7 (2002), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1797.7.s.35.x
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  • 9
    Electronic Resource
    Electronic Resource
    Urinary sediment podocalyxin in children with IgA nephropathy and Henoch Schoenlein purpura nephritis (2002)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 7 (2002), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1797.2002.tb00545.x
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  • 10
    Electronic Resource
    Electronic Resource
    Significance of urinary binucleated podocytes in IgA nephropathy (2001)
    Melbourne, Australia : Blackwell Science Pty
    Nephrology 6 (2001), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: We have reported clinico-pathological significance of podocytes excreted in urine in previous papers. During these studies we found the presence of binucleated podocytes in urine. The aim of the present study was to look for the significance of urinary binucleated podocytes in IgA nephropathy.Patients and methods: 123 patients aged 2–25-year-old with various renal diseases were studied: UTI, five cases; nephrotic syndrome, 30 cases; MGN, three cases; MPGN, six cases; Alport syndrome, five cases; lupus nephritis, seven cases; HSPN, 12 cases; IgA GN, 50 cases. A total of 1225 urine samples from these diseases were examined. As a control, 203 urine samples from 100 normal healthy children were examined.Usual IF using monoclonal antibody to podocalyxin was used to detect urinary podocytes and binucleated podocytes.The presence of urinary binucleated podocytes were confirmed by immunoelectron microscopic examination and confocal immunofluorescent examination.Pathological changes were scored into six items: acute intracapillary, chronic intracapillary, acute extracapillary, chronic extracapillary, acute tubulo-interstitial and chronic tubulo-interstitial lesions.Results:〈list style="custom"〉1Urinary binucleated podocytes were found in various renal disases.2In IgA GN, patients with u-binucleated podocytes had significantly higher level of proteinuria.2The number of u-binucleated podocytes paralleled that of u-mononucleated podocytes.4. Patients with u-binucleated podocytes had significantly more acute lesions histologically.Conclusion: Urinary binucleated podocytes were found in IgA GN with acute glomerular lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1797.2001.00011.x
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