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  • Articles: DFG German National Licenses  (9)
  • 2005-2009  (3)
  • 1995-1999  (6)
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  • Articles: DFG German National Licenses  (9)
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  • 1
    Electronic Resource
    Electronic Resource
    ErbB-2, a c-erbB-2-coded protein, is expressed in metastatic cells of adenocarcinoma of endometrium, cervix and ovaries (1995)
    Suite 500, 5th Floor, 238 Main Street, Cambridge Massachusetts 02142, USA : Blackwell Science Inc.
    International journal of gynecological cancer 5 (1995), S. 0 
    Details
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ten cases of gynecologic malignancies, including three endometrial, two ovarian and four cervical carcinomas, were studied for the expression of a 185 kDa protein (ErbB-2), coded by a proto-oncogene, c-erbB-2, in primary lesions as well as in metastatic lesions. Positive immunoreactivity was observed in all primary adenocarcinomas but not from squamous cell carcinomas. Many adenocarcinoma cells in distant metastatic sites or in tertiary lymph nodes were strongly stained for ErbB-2. These metastatic cells also showed an expression of proliferating cell nuclear antigen (PCNA). Detection of ErbB-2 mRNA by a reverse-transcription polymerase chain reaction showed that the transcription occurred exclusively in adenocarcinomas. To our knowledge, this is the first report demonstrating ErbB-2 expression in distant metastatic lesions of gynecologic cancers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1438.1995.05060411.x
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  • 2
    Electronic Resource
    Electronic Resource
    General session V
Moderated by Yashihiko Maehara: Reduction of Ischemia-Reperfusion Injury to Skin Flaps by Monoclonal Antibody to Leukocyte Endothelial Adhesion Molecule-1 (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim:  Ischemia-reperfusion (I-R) injury continues to be a problem for successful free tissue transfer and replantation after prolonged periods of ischemia. It has been shown that leukocytes and vascular endothelial cells release a variety of inflammatory mediators during reperfusion after ischemia. The leukocyte endothelial adhesion molecule-1 (LECAM-1) is a ligand on the endothelium for some of the adhesion receptors on leukocytes. The purpose of this study was to evaluate the blockage of leukocyte-endothelial adhesion by a monoclonal antibody (MAb) to LECAM-1 in skin flaps to prevent I-R injury in rats.Methods:  Male SD rats (225–250 g) were used. A skin flap (45 × 30 mm) supplied by the superficial epigastric A&V including the femoral vessels was isolated unilaterally. The femoral vessels were cross-clamped the epigastric vessels for 9 hours of ischemia. Animals in treated group received MAb to LECAM −1 i.v. 15 minutes prior to reperfusion; those in the control group received normal saline. Skin flap viability was assessed by tracing the outline of viable and nonviable areas. Data were collected for the following 7 days. These data were corroborated with histological evidence on comparable areas of the flap.Results:  Tracing analysis revealed average flap survival area of about 90% in treated group and about 20% in control group (p 〈 0.05). Histopathologically, few inflammatory changes could be observed in treated group, while marked damage was observed in control group.Conclusions:  From this study, we concluded that treating skin flaps with Mab to LECAM -1 was effective for I-R injury after 9 hours of warm ischemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130116s.x
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  • 3
    Electronic Resource
    Electronic Resource
    Histamine-2 receptor expression in gastric mucosa before and after Helicobacter pylori cure (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Helicobacter pylori infection prevents the occurrence of the tolerance phenomenon of Histamine-2 (H2) receptor antagonists. Gastro-esophageal reflux disease develops in some cases with the restoration of acid secretion after H. pylori eradication therapy.Aim : To clarify the mechanisms of H2 receptor restoration after the eradication of H. pylori on parietal cells.Methods:  We enrolled 80 consecutive asymptomatic male patients with H. pylori infection, having chronic gastritis with or without the presence of peptic ulcers. Biopsy specimens from the greater curvatures at the mid-corpus of the stomach were obtained endoscopically from all subjects before and 12 weeks after the eradication of H. pylori. Degrees of gastric atrophy were evaluated by serum pepsinogen levels. The amounts of mRNA expression of H2 receptor were evaluated in each subject's gastric mucosa by real time reverse transcriptase-polymerase chain reaction (RT-PCR).Results : H2 receptor mRNA expression levels significantly correlated with serum pepsinogens I and II ratios. The expression level of H2 receptor mRNA was lower in subjects with hypergastrinemia. The median expression level of H2 receptor after H. pylori eradication was threefold greater than prior to treatment. In addition, its restoration became more pronounced in subjects with severe gastric atrophy. However, a comparatively low restoration of H2 receptor mRNA was found in subjects with hypergastrinemia.Conclusions : H2 receptor mRNA levels decrease with the progression of gastric atrophy induced by H. pylori infection, and are restored after H. pylori eradication. Such expression levels of H2 receptor may explain a part of the tolerance phenomenon to H2 receptor antagonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02481.x
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison of hemostatic effects by route of H2 receptor antagonist administration following endoscopic mucosal resection in patients with neoplastic gastric lesions (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : To date, there has not been an in-depth investigation to identify differences in the effects of bleeding prevention among different routes of administration of H2 receptor antagonists to treat gastric ulcers following endoscopic mucosal resection (EMR).Aim : To prospectively compare the frequency of bleeding following EMR between patients treated with intravenous(IV) famotidine and those with oral famotidine.Methods : Fifty-three patients with neoplastic gastric lesions (33 carcinoma and 20 adenoma) treated by EMR were included. Subjects underwent EMR with circumferential mucosal incision assisted by submucosal injection of sodium hyaluronate (EMRSH), followed by IV or oral (PO) administration of famotidine at a dosage of 40 mg/day for 2 days. Patients with odd ID numbers were assigned to IV therapy (30 cases) while even numbers were given PO therapy (23 cases). Frequencies and endoscopic findings of bleeding during the first 2 days after EMR were examined.Results : Frequency of bleeding within 2 days after EMR was 3 and 4% in IV and PO patients, respectively, showing no significant difference. No significant difference was seen in the endoscopic findings of bleeding and therapy, either, with respective IV and PO findings at 23 and 26%.Conclusions : No significant difference was observed in frequency of bleeding within 2 days after gastric EMR between IV and oral administrations of famotidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02483.x
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  • 5
    Electronic Resource
    Electronic Resource
    Comparison of ranitidine and lansoprazole in short-term low-dose triple therapy for Helicobacter pylori infection (1997)
    Oxford UK : Blackwell Science Ltd.
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To evaluate the efficacy and safety of two 1-week low-dose triple-therapy drug regimens involving antisecretory drugs for Helicobacter pylori infection, 99␣patients with H. pylori infection were treated with either lansoprazole or ranitidine used together with clarithromycin and metronidazole.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:The drug combination and administration periods in the proton pump inhibitor group were lansoprazole 30 mg o.m., clarithromycin 200 mg b.d. and metronidazole 250 mg b.d., all given for 7 days (LCM group). The ranitidine group received ranitidine 150 mg b.d., clarithromycin 200 mg b.d. and metronidazole 250 mg b.d. also for 7 days (RCM group). The presence or absence of H. pylori was determined from gastric biopsy specimens taken from both the antrum and the body, by smear, culture and tissue section (Giemsa stain). Cure was defined as failure to find evidence of H. pylori infection 4 weeks after antimicrobial therapy had ended.〈section xml:id="abs1-3"〉〈title type="main"〉Results:The cure of H. pylori infection was 88% in the LCM group (44 of 50; 95% confidence interval (CI) = 79–97%) and 92% in the RCM group (45 of 49; 95% CI = 84–99%). The incidence of adverse events was 16% and 18% for the two groups, respectively.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions:No significant differences in cure rate and safety profiles were noted between the two regimens, suggesting that moderate acid inhibition using an H2-blocker is sufficient to achieve optimal H. pylori eradication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1997.00186.x
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  • 6
    Electronic Resource
    Electronic Resource
    Clonal expansion of γδ-T lymphocytes in an HTLV-I carrier, associated with chronic neutropenia and rheumatoid arthritis (1999)
    Springer
    Annals of hematology 78 (1999), S. 101-104 
    Details
    ISSN: 1432-0584
    Keywords: Key words LGL ; γδ-T lymphocyte ; Neutropenia ; HTLV-I ; Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report on an HTLV-I carrier showing clonal proliferation of γδ-T lymphocytes associated with chronic neutropenia and rheumatoid arthritis (RA). A 75-year-old Japanese woman had a 20-year history of RA and was found to have neutropenia and lymphocytosis by routine examinations. Her white cell count was 5,800/μl with 89% lymphocytes. The proliferating γδ-lymphocytes did not show the typical morphology of large granular lymphocytes (LGL) and were positive for CD3, TCRδ1, and HLA-DR but negative for CD4, CD8, and δTCS1. Clonally rearranged TCRγ-chain (Jγ) and TCRβ-chain (Cβ1) genes were detected by Southern blot analysis. Clonality of these proliferating γδ-T cells was confirmed by CDR3 size analysis for the TCRδ-chain. Anti-HTLV-I antibody was positive and the pX region of HTLV-I proviral DNA was detected by PCR analysis, but clonal integration of HTLV-I proviral DNA was not detected by Southern blotting analysis. The patient's clinical course has been stable, except for infrequent infectious episodes. The association of HTLV-I/II infection with T-LGL leukemia has been reported by several groups, although most cases exhibit TCRαβ+ type T cells. Analysis of the junctional sequence of TCR on T-LGL leukemia cells may clarify the role of HTLV-I/II infection in clonal T-cell proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050483
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  • 7
    Electronic Resource
    Electronic Resource
    Endoscopic ultrasound and intraductal ultrasound in the diagnosis of small pancreatic tumors (1998)
    Springer
    Abdominal imaging 23 (1998), S. 380-386 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Endoscopic ultrasound—Intraductal ultrasound—Pancreas—Small tumors—Characterization.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: The purpose of this study was to assess the diagnostic value of endoscopic ultrasound (EUS) and intraductal ultrasound (IDUS) in the detection of small pancreatic tumors. Methods: EUS was performed in 166 patients with verified pancreatic disease. IDUS was performed in 46 patients. A microprobe was introduced into the main pancreatic duct through the papilla of Vater using the duodenoscope. Results: EUS was valuable in the detection of small pancreatic tumors. Ductal adenocarcinomas smaller than 1 cm were demonstrated as a hypoechoic mass with a central irregular hyperechoic area. EUS and IDUS were useful in the characterization of intraductal paillary tumors (ductectatic mucinous tumors). EUS demonstrated nodular excrescences, and IDUS depicted papillary proliferation of the duct epithelium, which are characteristic of carcinomas and adenomas but not of hyperplasia. Internal architecture of cystic neoplasms was clearly depicted by EUS, and differentiation of serous and mucinous tumors was readily achieved. A tumor as small as a 5-mm islet cell was demonstrated on EUS because islet cell tumors are very hypoechoic. Conclusion: EUS and IDUS are relatively noninvasive procedures and are useful in the detection of small tumors and differentiation of pancreatic diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900365
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  • 8
    Electronic Resource
    Electronic Resource
    A new adhesion process of glass to metal using the redox reaction (1996)
    Springer
    Journal of materials science 31 (1996), S. 4891-4898 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A new adhesion process of glass to metal was developed based on the redox reaction without oxidation of the metal surface. PbO-based glasses were strongly adhered to nickel metal at low temperature (400–500 °C) in a low-oxygen atmosphere (〈 0.1 p.p.m.). The interfaces between glasses and metal were analysed by SEM-EDS. It was found that the reaction layer and lead metal were formed by the redox reaction at the interface. In the case of the adhesion of PbO-based glasses containing CuO to nickel, the main reduced product in the glass was Cu2O, and lead was not detected. The redox reaction was simulated by a thermodynamic equilibrium theory; the results agreed with the analysis by SEM-EDS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00355877
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  • 9
    Electronic Resource
    Electronic Resource
    Studies of the positive muon behavior in solid H2 and D2 (1997)
    Springer
    Hyperfine interactions 106 (1997), S. 39-44 
    Details
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using a pulsed muon beam, we have investigated the microscopic μ+ behavior in solid H2 and D2 down to 0.6 K by the μ+SR method. From the studies of μ+ spin relaxation phenomena in solid para‐ H2 and ortho‐ D2, we have found that μ+ forms three distinct microscopic states; H2μ+( D2μ+)(20\sim25\%), muonium (15\sim20\%) and μ+(\sim60\%). In H2μ+, the μ+ spin is depolarized in solid para‐ H2 and a local magnetic field Bloc=1\sim2 G is deduced from LF‐μ+SR measurements. The magnitude of Bloc is inconsistent with the magnetic dipolar field (\sim25 G) expected from the magnetic moments of two protons in the H2μ+ molecule and suggests that the H2μ+ molecule might be in the rotationally excited state. From LF‐μ+SR measurements, muonium and μ+ have been found to diffuse in solid o‐ D_2. The diffusion rate of muonium is two order of magnitude larger than that of μ+.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1012604900148
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