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  • 2005-2009  (18)
  • 1995-1999  (5)
  • 1990-1994  (3)
  • 1
    Digitale Medien
    Digitale Medien
    A Web-enabled product definition and customization system for product conceptualization (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Expert systems 22 (2005), S. 0 
    Details
    ISSN: 1468-0394
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Informatik
    Notizen: Abstract: Owing to rapidly changing customer needs and much shorter product life cycles, for developing a successful product it is imperative to employ more efficient and flexible approaches for product conceptualization. To meet this demand, a Web-enabled product definition and customization system (PDCS) is proposed, from a design-knowledge-handling viewpoint, in this paper. It comprises two phases, namely product definition based on the laddering technique and a novel design knowledge hierarchy, and product customization based on an integrated methodology of conjoint analysis and Kohonen association techniques. Basically, this system is a method of conducting design decision-making via customer involvement, i.e. a strategy for transforming customer preference into a specific product concept. A case study on wood golf club design is used to illustrate and validate the proposed Web-enabled PDCS.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1468-0394.2005.00315.x
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  • 2
    Digitale Medien
    Digitale Medien
    A Prototype Recombinant Vaccine Against Respiratory Syncytial Virus and Parainfluenza Virus Type 3 (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 813-818 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] We have produced a genetically-engineered chimeric protein composed of the external domains of the respiratory syncytial virus (RSV) fusion (F) protein and the parainfluenza virus type 3 (PIV-3) hemagglutinin-neuraminidase (HN) protein in insect cells using the baculovirus expression system. The ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/nbt0894-813
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  • 3
    Digitale Medien
    Digitale Medien
    Biological and Biomechanical Behavior of Titanium Implants with Fluoridated Hydroxyapatite Coatings (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 361-363 (Nov. 2007), p. 1087-1090 
    Details
    ISSN: 1013-9826
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Notizen: For dental/orthopedic implants to achieve better bone apposition and bone-implantbonding, various approaches to improve titanium surfaces have been developed. Recently, afluoridated hydroxyapatite (FHA) coating on titanium (Ti) implants was made by sol–gel methodand shown to be a possible applicative bone implant. The purpose of the current study was toevaluate biological responses and biomechanical bonding strength of FHA coated Ti implants ascompared with that of the conventional Ti alloys and hydroxyapatite (HA) coated Ti implants. Invitro assays were made using human osteoblast-like cell (MG63) culture on different implants withcell attachment, morphology and differentiation evaluations. The implant plates were alsoimplanted into the proximal metaphysis of New Zealand White rabbit tibiae. After 8 and 16 weeksimplantation, mechanical and histological assessments were performed to evaluate biomechanicaland biological behavior in vivo. The results showed that the cell adhesion and cell growth rate onthe FHA and HA surface was higher than that on cp Ti surface (p〈0.01), and insignificantdifference was observed between two coated groups. Mechanical test demonstrated that the FHAimplants had a higher interface shear strength than the both controls at 8 and 16 wks, with nosignificant difference with HA-Ti. Histologically, the coated implants revealed a significantlygreater percentage of bone-implant contact when compared with the uncoated implants. Resultsdemonstrated that the new FHA surface improved cell adhesion and proliferation. The coatingexhibited a bioactive mechanical and histological behavior at bone-implant interface, suggestingthat a useful approach by combined coating processes could optimize implant surfaces for bonedeposition and early implant fixation
    Materialart: Digitale Medien
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.1087.pdf
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  • 4
    Digitale Medien
    Digitale Medien
    Functional Behaviour of Human Periodontal Ligament Cells around Various Dental Implants (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 361-363 (Nov. 2007), p. 837-840 
    Details
    ISSN: 1013-9826
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Notizen: In the present investigation, four titanium (Ti) surfaces of dental implants were comparedthrough in vitro systems. The surface roughness of Ti was measured by TR240 mobile surfaceroughmeter. The Ti implants were seeded with human periodontal ligament cells (hPLDCs) andmaintained for a period of 0-7 days. The adhesion, proliferation, and differentiation of hPLDCswere observed by using Cell morphology, cell counting and Osteocalcin (OC) immunofluorescentstaining. Results suggest that surface roughness of titanium favors hPDLCs behavior and improvescell adhesion, proliferation, and differentiation
    Materialart: Digitale Medien
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.837.pdf
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  • 5
    Digitale Medien
    Digitale Medien
    Pressureless Sintering the Al〈sub〉2〈/sub〉O〈sub〉3〈/sub〉/SiC Nanocomposites in Deoxidized Atmosphere (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 280-283 (Feb. 2007), p. 1093-1096 
    Details
    ISSN: 1013-9826
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Notizen: Many significant improvements have been shown in mechanical properties of ceramic nanocomposites with ceramic matrix being dispersed with second sub-micro sized (or nano-sized) phase. This study designed and fabricated Al2O3/SiC nanocomposites with a raw material used for 85% alumina as matrix andSiC grits in submicro-scale as dispersion phase via a controlled pressureless sintering in air. With coarse SiC powder as bed powder, both C and SiC powder making deoxidized atmosphere, 85Al2O3/SiC nanocomposites with different SiC contents were densified by pressureless sintering at low temperature. Fracture surface investigation indicated that dense nanocomposites with small grain size were produced. General material properties and microstructure were measured and characterized. The results showed that composites sintered in deoxidized atmosphere had better mechanical properties than those sintered in flowing argon
    Materialart: Digitale Medien
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.280-283.1093.pdf
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  • 6
    Digitale Medien
    Digitale Medien
    Processing of Calcium Phosphate Porous Materials by 'Self-Setting' (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 280-283 (Feb. 2007), p. 1563-1566 
    Details
    ISSN: 1013-9826
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Notizen: Macroporous biomaterials based on a-tricalcium phosphate (a-TCP) bone cement with porous structures suitable for implantation purposes were prepared in the present work. According to the reversible swelling/deswelling behavior of gelatin at a single temperature or pH, a “self-setting” method that uses gelatin granules as pore formers was developed to process the porous microstructure. By mixing gelatin powder and bone cement powder (BCP), and adding water (1% solution of NaH2PO4×HO) to form pastes which set within 15 to 30 min, this setted cement was then immerged in deionized water of temperature 25°C or 32°C for hydration. During the hydration, the pH of deionized water after cement pastes were introduced at 32°C changed from 8.6 to 7.2 which caused by the transformation of a-TCP to hydroxyapatite (HA). Meanwhile, gelatin particles will swell by water uptake to form large size spheres in cementmatrix. This swelling behavior is sensitive to the variation of pH value. After hydration for 4 day, a body containing gelatin gel spheres was obtained. Then heating the deionized water to temperature 50°C, gelatin spheres in cement matrix were solved and porous microstructure composed of larger pore sizes corresponding approximately to the average size ofthe swelling gelatin granules was obtained. The porous bodies by this technique were found to have tractable and interconnected porosity in the range of 60~84%, with typical pore sizes ranging from 100~300 microns. This new processing technique can be used in the manufacture of unsintered biomaterials
    Materialart: Digitale Medien
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.280-283.1563.pdf
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  • 7
    Digitale Medien
    Digitale Medien
    Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts (1999)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 401 (1999), S. 670-677 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Id proteins may control cell differentiation by interfering with DNA binding of transcription factors. Here we show that targeted disruption of the dominant negative helix–loop–helix proteins Id1 and Id3 in mice results in premature withdrawal of neuroblasts from the cell cycle and ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/44334
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  • 8
    Digitale Medien
    Digitale Medien
    In vitro Investigation of Mesenchymal Stem Cells with Nanophase PLGA/HA Composite (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 1153-1156 
    Details
    ISSN: 1013-9826
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Notizen: Bone grafts have been used to fill bone defects caused by disease or trauma. The amount ofautografts is limited and allogenic bone grafts may transmit diseases and cause immune responses.Numerous materials have been proposed and used as scaffolds for bone tissue reconstruction. In thisstudy, we tested nanophase PLGA/HA composite with mesenchymal stem cells in vitro to examineits biological response and cellular activity. The nanophase composite was compared toconventional polystyrene on cytocompatibility by cell attachment, proliferation, alkalinephosphotase activity test and scanning electron microscopy (SEM) analysis. The resultsdemonstrated that human mesenchymal cells showed more cell attachment and higher cellproliferation rate when growing on nanophase PLGA/HA composite than those growing onpolystyrene alone. And the composite also promoted MSC cells differentiate to osteoblast cells ascompared with control. It was suggested that the combination of bone marrow mesenchymal cellswith artificial materials or differentiation factors may enhance bone formation and regeneration,nanophase PLGA/HA composite might therefore be a promising scaffold material for bone tissuesubstitute in clinical application
    Materialart: Digitale Medien
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1153.pdf
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  • 9
    Digitale Medien
    Digitale Medien
    Biological Efficacy of Modified Structure of Polymer Surfaces for Bone Substitute (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 707-710 
    Details
    ISSN: 1013-9826
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Notizen: Hydroxyapatite (HA) coatings were introduced onto Poly L-lactic Acid (PLLA) polymerin a controlled manner by immobilized urease method with a shortened precipitation time.Osteoblastic-like cellular responses to the composite were examined in terms of cell proliferation,differentiation and cell morphology, as well as the expression of bone-associated genes. The cellsexhibited higher cellular proliferation at 2 and 4 days on the HA/PLLA composite compared toPLLA scaffold, while no significant difference was observed later at 6 days. The alkalinephosphatase (ALP) activity by cells at 7 days was statistically higher on HA/PLLA scaffold than onPLLA. Moreover, the gene expression of ALP and osteocalcin (OC) was up regulated on HA/PLLAcomposite by RT-PCR analysis. The preliminary study suggested that the use of the controlledmodification of hydroxyapatite coating on PLLA scaffold to produce HA/PLLA composite mightenhance cellular activity, indicating the potential use for bone substitute in tissue engineering
    Materialart: Digitale Medien
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.707.pdf
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  • 10
    Digitale Medien
    Digitale Medien
    The Osteogenic Potential of Stem Cell- and BMP2 Gene-Activating Bioceramic In Vivo (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 284-286 (Apr. 2005), p. 941-944 
    Details
    ISSN: 1013-9826
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Notizen: Stimulation of bone healing through local application of growth factors from implantsmay improve the clinical outcome in fracture treatments. However, the growth factors in reconstructive application require supraphysiologic dosing and considerable expense while hampering their clinical application. Genetic modification of mesenchymal stem cells (MSCs) to both produce and respond to osteogenic factors may have potential for use in enhancing bone healing. In this study, MSCs were genetically modified by a recombinant adenoviral containing the gene for human bone morphogenetic protein 2 (hBMP-2). The gene-transduced cells wereincorporated with a porous beta-tricalcium phosphate (TCP) as a novel complex. We investigated osteogeneic potential of gene-transduced MSCs/ceramic and the ability of the complex on facilitating bone formation in a radius segmental defect of rabbits. In vitro results showed that there were apparent hBMP2 gene expression and protein synthesis in MSCs with hBMP2 stably transfection, whereas negative expression of hBMP2 in controls. Histological studies demonstrated that gene-transfected MSCs/ceramic composite appeared an ability of heterotopic osteogenesis. In the segmental bone defects, endochondrial ossification at fracture sites was found in both transfected and untransfected MSCs-ceramic composites. While the composite with hBMP2 transfection showed the earliest and the most effective healing of the segmental bone defects both radiographically and morphologically. Our results show that genetically modified MSCs/ceramicshad enhanced osteogeneic capacity relative to unmodified MSCs or only ceramic implants. This study suggests that use of cell-and gene-activated bioceramics may offer promise for molecular design of implants to induce osteogenesis and enhance bone regeneration
    Materialart: Digitale Medien
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.284-286.941.pdf
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