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  • 1
    Electronic Resource
    Electronic Resource
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 16 (1996), S. 0 
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sumatriptan, a selective 5-hydroaytryptamine (5HT1D)-receptor agonist, has recently been introduced in the pharmacotherapy of acute migraine attacks. The potential vasoactive effect of sumatriptan on human dural vessels in vivo, however, is still a matter of controversy. We investigated the effects of sumatriptan on dural vessels after subcutaneous or intra-arterial injection. During interventional angiography, the middle meningeal artery (MMA) of nine patients was catheterized with a microcatheter using the transfemoral route. Three MMA were entirely normal, two supplied a dural arteriovenous fistula (AVF) and four were transdural feeders to a brain arteriovenous malformation (AVM). Sumatriptan was injected either into the subcutaneous tissue of the right shoulder (6 mg, two patients) or into the catheterized MMA (2 mg, six patients). The substance caused a marked vasoconstriction of the three normal MMA, visible angiographically and confirmed by intravascular Doppler ultrasonography. Vasoconstriction was still present in the last angiogram obtained 15 min post-injection. Slightly hypertrophied feeders to dural AVF and to brain AVM showed some vasoconstriction in one and four patients, respectively. In two patients with markedly hypertrophied dural feeders to a dural AVF and to a brain AVM, respectively, rapid shunting probably prevented obvious vasoactive effects of sumatriptan. The data obtained by angiography and intravascular Doppler ultrasonography provide strong evidence that sumatriptan has a vasoconstrictive effect on normal as well as hypertrophied dural vessels.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1920
    Keywords: Aneurysm ; Transcranial colour-coded duplex sonography ; Embolisation ; Subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined 72 patients with 89 angiographically confirmed intracranial aneurysms, using transcranial colour-coded duplex sonography (TCCD) to determine the location and size of the aneurysm. The patients were admitted for coil embolisation of their aneurysm following subarachnoid haemorrhage or because of a cranial nerve palsy. Using a 2/2.25 MHz transducer, 42 aneurysms (47%) were seen satisfactorily through the temporal bone window or foramen magnum. In 24 cases (27%) image quality was insufficient as a result of a poor bone window, of the aneurysm having a diameter of less than 6 mm or of its being in an unfavourable location. In 23 other cases (26%) it was not possible to detect the aneurysm. Thrombosed structures could be demonstrated using TCCD in 8 of 12 giant intracavernous or basilar artery aneurysms, and in 15 of 19 aneurysms treated by platinum coil embolisation. TCCD offers a noninvasive method for monitoring progressive intra-aneurysmal thrombosis following coil embolisation and for follow-up of patients with untreatable fusiform aeurysms, should this be required. Detection of small aneurysms is limited by spatial resolution and insonation angles.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 38 (1996), S. S111 
    ISSN: 1432-1920
    Keywords: Key words Vitamin E deficiency ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe a patient with a progressive neurological disorder consisting of ataxia, loss of proprioception and pyramidal tract dysfunction in his sixth decade. He had severe vitamin E deficiency due to fat malabsorption secondary to chronic inflammatory bowel disease. Sural nerve biopsy revealed a reduced number of myelinated fibres. MRI of the cervical spine showed high-signal lesions on T2-weighted images in the posterior columns, correlating well with the clinical findings.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 38 (1996), S. S111 
    ISSN: 1432-1920
    Keywords: Vitamin E deficiency ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe a patient with a progressive neurological disorder consisting of ataxia, loss of proprioception and pyramidal tract dysfunction in his sixth decade. He had severe vitamin E deficiency due to fat malabsorption secondary to chronic inflammatory bowel disease. Sural nerve biopsy revealed a reduced number of myelinated fibres. MRI of the cervical spine showed high-signal lesions on T2-weighted images in the posterior columns, correlating well with the clinical findings.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1920
    Keywords: Key words Aneurysm ; Transcranial colour-coded duplex sonography ; Embolisation ; Subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined 72 patients with 89 angiographically confirmed intracranial aneurysms, using transcranial colour-coded duplex sonography (TCCD) to determine the location and size of the aneurysm. The patients were admitted for coil embolisation of their aneurysm following subarachnoid haemorrhage or because of a cranial nerve palsy. Using a 2/2.25 MHz transducer, 42 aneurysms (47 %) were seen satisfactorily through the temporal bone window or foramen magnum. In 24 cases (27 %) image quality was insufficient as a result of a poor bone window, of the aneurysm having a diameter of less than 6 mm or of its being in an unfavourable location. In 23 other cases (26 %) it was not possible to detect the aneurysm. Thrombosed structures could be demonstrated using TCCD in 8 of 12 giant intracavernous or basilar artery aneurysms, and in 15 of 19 aneurysms treated by platinum coil embolisation. TCCD offers a noninvasive method for monitoring progressive intra-aneurysmal thrombosis following coil embolisation and for follow-up of patients with untreatable fusiform aneurysms, should this be required. Detection of small aneurysms is limited by spatial resolution and insonation angles.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 3 (1967), S. 244-263 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Six cases are described in which defects of the femora are associated with deformities of the upper limbs. From the available literature all cases (55) were selected in which femoral defects were associated with upper limb deformities. It became apparent that most if not all of these cases belong to a well defined syndrome. Arm deformities associated with femoral defect do not usually include the most common types, but specific rare types, namely amelia, peromelia ending at the level of the elbow, brachioradial synostosis and ulnar defects. In the syndrome in question sometimes either arm shows a different type of these deformities, which is further evidence that all cases may be considered to represent one category. In the majority of cases there is also a defect of the fibula and the fibular rays. The etiology is unknown. Familial occurrence has not been observed. Parental age does not appear to be a factor. In no case was there a thalidomide history. A history of radiation exposure during pregnancy was present in two previously published cases. Other limb deformities associated with radiation exposure in utero are quoted from the literature. Some of them are similar, but not exactly identical to the syndrome in question. Thalidomide deformities, in which the radial and tibial rays are preferentially affected, are clearly distinct. Similar defects of the femorae and fibulae but not of the arms are occasionally seen in children born to diabetic mothers.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 8 (1998), S. 749-755 
    ISSN: 1432-1084
    Keywords: Key words: Leucoencephalopathy ; Heroin ; Cerebellum ; CT ; MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. This is a report of clinical, CT and MRI findings in a patient with toxic spongiform leucoencephalopathy after heroin ingestion. The disease is observed in drug addicts who inhale pre-heated heroin. The clinical onset, which usually occurs some days or even longer after the last heroin consumption, is characterized by a cerebellar syndrome. The cerebellar hemispheres, the cerebellar and cerebral peduncles and the pyramidal tract may be affected. Spongiform demyelination is the morphological substrate of the lesions, which are not contrast enhancing, hypodense on CT and hyperintense on T2-weighted MRI. The frequently perfect symmetry of the affection of functional systems points to a toxic and/or metabolic pathophysiological mechanism.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Der Nervenarzt 70 (1999), S. 870-877 
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Pseudoaneurysma ; Dissektion ; Extrakranielle A. carotis interna ; Stent ; Guglielmi Detachable Coils ; Key words Pseudoaneurysm ; Dissection ; Extracranial carotid artery ; Stent ; Guglielmi detachable coils (GDC)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Pseudoaneurysms of the extracranial internal carotid artery (ICA) can be caused by external injury or may be due to spontaneous dissection. Pseudoaneurysms bear an increased risk of arterio-arterial embolism. Treatment of pseudoaneurysms is influenced by the location and the type of injury, associated injurys, collaterals to the ipsilateral hemisphere, neurological signs and symptoms, growth of the lesion and patient age. Potential treatment regimen include conservative and medical approaches with anticoagulation and antiplatelet therapy, extra-intracranial bypass, resection of the pseudoaneurysm with vessel reconstruction, ligation or endovascular balloon occlusion of the ICA. Pseudoaneurysms of the ICA adjacent to the scull base require a major surgical procedure. If there are contraindications for vessel occlusion conservative or medical treatment used to be the only therapeutic alternatives. We report the treatment of two patients with extracranial ICA pseudoaneurysms after blunt injury with stent placement (in one case combined with coil embolization) as a further treatment option.
    Notes: Zusammenfassung Pseudoaneurysmen der extrakraniellen A. carotis interna können traumatisch verursacht sein oder sind die Folge einer spontanen Gefäßdissektion. Von ihnen geht die Gefahr thrombembolischer Verschlüsse nachgeschalteter Gefäße aus. Die Möglichkeit und Art der Behandlung ist abhängig von der Lokalisation und der Art der Verletzung, der Kollateralversorgung der abhängigen Hemisphäre, der klinischen Symptomatik, dem Nachweis einer Größenänderung des Aneurysmas sowie von dem Alter des Patienten. In erster Wahl werden die Patienten mit Antikoagulanzien und/oder Thrombozytenaggregationshemmern behandelt. Kommt es unter dieser Therapie zu einer Größenzunahme des Pseudoaneurysmas bzw. zu weiteren Thrombembolien oder bestehen Kontraindikationen gegen die medikamentöse Behandlung, sind invasive Behandlungsverfahren angezeigt. In Betracht kommen die Ligatur des aneurysmatragenden Gefäßes, ggf. nach Anlage eines extra-intrakraniellen Bypasses, die Aneurysmaresektion mit Gefäßrekonstruktion der A. carotis interna und die endovaskuläre Ausschaltung des Aneurysmas, ggf. einschließlich der A. carotis interna. Pseudoaneurysmen unmittelbar unterhalb der Schädelbasis sind chirurgisch nicht oder nur mit hohem Aufwand behandelbar. Zur Ausschaltung solcher Pseudoaneurysmen unter Erhalt der A. carotis interna bietet sich heute die Stentimplantation in das disseziierte Gefäß an. Wir berichten über zwei Patienten mit stumpfen Verletzungen der A. carotis interna mit basisnahen Pseudoaneurysmen. Die endovaskuläre Stentimplantation, ggf. kombiniert mit Coilokklusion, ist eine neue Behandlungstechnik, deren Wirksamkeit und Sicherheit im Vergleich mit den anderen invasiven Verfahren und der medikamentösen Behandlung allerdings noch zu überprüfen ist.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Aneurysma ; Transkranielle Duplexsonographie ; Embolisation ; Subarachnoidalblutung ; Key words Aneurysm ; Transcranial Duplex sonography ; Coil embolization ; Subarachnoid hemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We investigated 88 Patients with a total of 102 angiographically diagnosed intracranial aneurysms by means of transcranial colour coded Duplex sonography (TCCD) during a time period of 15 months. Both the size and teh localization of teh aneuryms were determined. Seventy aneurysms (77%) with a diameter of 16±8 mm (6-55mm) were detectable, with excellent visualization in 36 (42%), moderate visualization in 34 (40%), and no sufficient visualization in 16 (16%) aneurysms, respectively. In another 16 cases (16%) there was no sufficient vone window. Thrombotic material inside the aneurysm was detectable in 16/20 cases (75%), visualization of coil embolized aneurysms in 12/25 patients (48%). TCCD allows the follow up of cerebral aneurysms, with the detection of thrombosis and treatment effects after embolization. The method is not valid for the detection of intracranial aneurysms
    Notes: Zusammenfassung Innerhalb eines Zeitraumes von 15 Monaten wurden 88 Patienten mit 102 angiographisch nachgewiesenen intrakraniellen Aneurysmen unter Verwendung einer 2-MHz-Sonde mit der transkraniellen farbkodierten Duplexsonographie (TCCD) untersucht. Es wurden die Größe und der genaue Aneurysmasitz bestimmmt. Insgesamt konnten 70 (77%) Aneurysmen mit einem Durchmesser von 16±8 mm (6–55 mm) dargestellt werden. Eine sehr gute Darstellung der Aneurysmen gelang bei 36 (42%), eine mäßige bei 34 (40%) Aneurysmen, 16 (16%) Aneurysmen konnten trotz ausreichender Bildqualität nicht dargestellt werden. Bei weiteren 16 (16%) Aneurysmen war kein ausreichendes Knochenfenster vorhanden. Thrombosierte Anteile innerhalb der Aneurysmen konnten bei 16 (75%) von 20, der mit Coils behandelte Anteil bei 12 (48%) von 25 Aneurysmen erfolgreich dokumentiert werden. Die Methode ist zum Nachweis von teilthrombosierten Anteilen, von Behandlungserfolgen nach Coilembolisation und zur Verlaufskontrolle nicht behandelbarer Aneurysmen geeignet. Die Darstellbarkeit kleiner Aneurysmen ist begrenzt durch das Auflösungsvermögen und die teilweise ungünstigen Beschallungswinkel, somit eignet sich die TCCD nicht als Screeningmethode zum Nachweis von Aneurysmen.
    Type of Medium: Electronic Resource
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