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  • 1
    Electronic Resource
    Electronic Resource
    Primary spinal leptomeningeal gliomatosis presenting visual disturbance as the initial symptom: Case report (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 480-481 
    Details
    ISSN: 0942-0940
    Keywords: Astrocytoma ; intracranial hypertension ; leptomeningeal gliomatosis ; spinal cord tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report a case of diffuse leptomeningeal gliomatosis which spread from the cervical to the sacral spine. A 60-year-old man was admitted with visual disturbance due to papilledema. Magnetic resonance imaging revealed holocord leptomeningeal gliomatosis without a definite intraparenchymal lesion, and the patient's neurological examination was unremarkable except for papilledema. Intracranial hypertension secondary to spinal tumor is well known but unusual, and the mechanism is still unclear. In our case, an elevated protein concentration of cerebrospinal fluid is suggested as the cause of intracranial hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01420313
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  • 2
    Electronic Resource
    Electronic Resource
    Myofibril-Bound Serine Proteinase (MBP) and its Degradation of Myofibrillar Proteins (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 64 (1999), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Proteolysis of a myofibril-bound serine proteinase (MBP) from carp Cyprinus carpio on myofibrillar proteins and their gel formation ability were investigated. MBP readily decomposed myosin heavy chain as indicated by SDS-PAGE. In the preparation of kamaboko, the gel formation ability was diminished by addition of MBP. The optimum degradation temperatures of MBP to myosin heavy chain in myofibril and kamaboko gel were 55°C and 60°C, respectively. The degradation effects of MBP on actin, α-actinin and tropomyosin were studied by the immunoblotting method. Because of its myofibril-bound and myofibrillar protein degradation characteristics, MBP was regarded as the proteinase most probably involved in the modori effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1999.tb15102.x
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  • 3
    Electronic Resource
    Electronic Resource
    Pigmented eccrine porocarcinoma: a mimic of malignant melanoma (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 27 (1995), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1995.tb00298.x
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  • 4
    Electronic Resource
    Electronic Resource
    Mixed tumours of the skin: a histopathological, enzyme-histochemical and immunohistochemical study (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 26 (1995), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Twenty-eight cases of mixed tumour of the skin were studied and subclassified into three types: eccrine (1 case), indeterminate (7), and apocrine type (20). The indeterminate type was defined as mixed tumours having tubulo-alveolar patterns with two layers of epithelium, but without apocrine secretion or pilosebaceous differentiation. Enzyme-histochemical studies were performed on four cases (one indeterminate, three apocrine): in the indeterminate type the tubular epithelial cells showed eccrine differentiation while in the apocrine type tubules were found showing the direction of differentiation to be toward the apocrine gland, but tubules with eccrine differentiation were intermingled in all three. Immunohistochemically, no differences were observed between the indeterminate and the apocrine type: hints of eccrine features were observed in both groups. Thus, the indeterminate type could be an eccrine tumour and the apocrine type showed direction of differentiation toward both eccrine and apocrine glands. It is concluded that mixed tumours of the skin are fundamentally eccrine neoplasmas, and that the apocrine features may represent apocrine metaplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1995.tb00644.x
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  • 5
    Electronic Resource
    Electronic Resource
    A multiparametric analysis of occlusal and periodontal jaw reflex characteristics in young adults with normal occlusion (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 24 (1997), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: summary Periodontal jaw reflex, duration of percussion sounds, tooth mobility, and time-moment analysis of occlusal contacts by the T-scan system was recorded in nine periodontally healthy volunteers. The results showed that (i) reflex responses to the pressure applied to the uppercentageral incisors in the lingolabial direction varied, depending on the background jaw-clenching force (BCF) of the same-sided first molars. The BCF levels to elicit excitatory reflexes were 6–8Kgf, and inhibitory reflexes were clearly elicited with a BCF of l0Kgf and beyond. (ii) Duration of percussion sounds via an occlusal sound analyser (4.73–4.84mS: upper first molars. 4.89–5.00mS: uppercentageral incisors) and tooth mobility using a ‘Periotest’ (3.3–3.5: upper first molars, 5.5–5.6: uppercentageral incisors) showed a normal value. (iii) The time moments of occlusal contacts were symmetrical toward the midsagittal axis of the occlusal plane. The centre of the anterioposteriol occlusal contacts was located in the first molar regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1997.tb00381.x
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  • 6
    Electronic Resource
    Electronic Resource
    Changes in gnathosonic and tooth contact characteristics induced by experimental occlusal interferences created using a full-cast double crown (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 22 (1995), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Occlusal sounds, contact timings and time moments were measured and analysed on 10 subjects onto whom an occlusal interference was created experimentally. A full-cast double crown was unilaterally set on the upper first molar of each subject, then gradually elevated for 0.06, 0.10, 0.20 and 0.30 mm by inserting a pre-calibrated metal folio. Occlusal sound was measured with an analyser designed for the purpose. Timings and time moments were analysed with a T-scan system. All measurements were performed at least 10 times per subject. The results showed that prolonged occlusal sound duration, changes in acoustic signal waveform and increased shift of the centre of effort were observed concomitantly with crown elevation. Differences in these values at 0.06mm as compared with those at baseline were not statistically significant. This could be explained through a physiological compensation by the periodontal ligament. The differences with baseline were statistically significant from 0.10mm ongoing. The distribution of occlusal conacts was determined by the use of a newly developed parameter. Referred to as ‘Tap Score’, the parameter consists of converting contact timings occuring in seven ranges into least-square-based weighted scores. Analysis of the tap score disclosed evident imbalance between the crowned and the non-crowned side starting from 0.10mm elevation, whereby a forward shift of the major contact point was observed on the non-crowned side. Our study demonstrated that evident changes in gnathosonic and T-scan parameters are likely to occur at a crown elevation within a 0.06–0.10 mm range. Not only did the results show the analytical capacity of the combined use of occlusal sound analyser and T-scan, but also they confirmed that a method using simple chairside devices, e.g. T-scan and Dental Sound Checker, could be helpful in bringing further understanding and information on occlusal interference.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1995.tb01565.x
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  • 7
    Electronic Resource
    Electronic Resource
    Expression of cathepsin D and B in invasion and metastasis of squamous cell carcinoma (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 137 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To determine the involvement of proteinases with hydrolytic activity towards extracellular matrix and basement membrane, in invasion and metastasis of tumour cells, the expression of cathepsin D, an aspartic proteinase, and cathepsin B, a cysteine proteinase, was studied. Formalin-fixed paraffinembedded specimens from 13 patients who had squamous cell carcinomas (SCC) with local recurrence, skin and/or lymph node metastasis were examined. Cathepsin D stained intensely as a granular pattern (mature enzyme) in tumour cells of 69% of primary lesions and all the secondary lesions of the patients with SCC. Cathepsin B stained more intensely in SCC cells of all of the primary and secondary lesions than in normal epidermis: staining patterns were almost diffuse (procathepsin B). Granular and diffuse patterns (mature enzyme of cathepsin D and procathepsin B, respectively) appeared in the outer and inner parts of tumour islands, respectively. The presence of the active mature form of cathepsin D and procathepsin B in metastatic skin lesions of SCC was confirmed by Western blotting analysis. The presence and localization of the active mature form of cathepsin D suggests that activated cathepsin D may be involved in the invasion and metastasis of SCC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1997.18501943.x
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  • 8
    Electronic Resource
    Electronic Resource
    Gas-source molecular beam epitaxy of wide-band-gap Zn1−xHgxSe (x=0–0.14) (1995)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 66 (1995), S. 3337-3339 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Epitaxial layers of wide-band-gap Zn1−xHgxSe (x=0–0.14) have been grown on GaAs (001) substrates by gas-source molecular beam epitaxy. The epilayers show near-band-edge emission whose emission energy shifts toward lower energies effectively with incorporation of a small amount of Hg. We demonstrate that light emission at a visible spectral region from blue to red can be realized at room temperature with the Zn1−xHgxSe layers by controlling Hg contents between 0 and 0.06. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.113749
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  • 9
    Electronic Resource
    Electronic Resource
    Cathepsin B and D expression in squamous cell carcinoma (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To elucidate involvement ol protcinascs in malignancy of keratinocytes. expression ol catbepsin B, a cysteine proteinase. and catbepsin D. an aspartic proteinase. was ascertained in lormalin-lixed paraffin-embedded specimens of nortnal skin, squamous cell carcinoma (SCC). Bowen's disease, seborrboeic keratosis and basal cell carcinoma (BCC). Presence of procalbepsin B and an intermediate form of catbepsin D was coiilirmed by Westerti blolling and enzytne activity analysis. Cathepsin B stained more Intensely In SCC tumour cells tban in normal epidermis: staining patterns were diffuse, grantilar or botb. Diflusc and granular patterns (procatbcpsin B and mature enzyme, respectively) appeared in inner and outer parts of tumour islands, respectively. Five of 20 cases of Bowen's disease sbowed diffuse enhanced catbepsin B expression: 20 cases of seborrhoeic keratosis or BCC did not. Cathepsin D stained intensely in tumour cells of half the SCC cases. The staining manner and distribution of cathepsins B and D was similar in the cytoplasm of cancer cells. No enhanced staining of cathepsin I) was seen in any cases of Bowen's disease, seborrhoeic keratosis. or BCC. Coexistence and localization of active mature forms of cathepsins B and D suggests that cooperation between tbe two enzymes may play an important part in invasion of SCC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.d01-1093.x
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  • 10
    Electronic Resource
    Electronic Resource
    Nodular granulomatous phlebitis of the skin: a fourth type of tuberculid (1997)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 30 (1997), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We present five cases of granulomatous phlebitis of the skin and compare them with a case of miliary tuber-culosis with granulomatous phlebitis. All five patients were hypersensitive to purified protein derivative, but without active tuberculosis. Although anti-tuberculous drugs were effective, no tubercle bacilli were isolated from the skin. Clinically, subcutaneous nodules were felt along the course of the leg vein. Histologically, epithelioid cell granulomas with Langhans’ giant cells were observed within the walls of the cutaneous veins. In a later stage, granulomatous panniculitis was often associated. Using the polymerase chain reaction method, Mycobacterium tuberculosis DNA was detected in four of the five cases of granulomatous phlebitis of the skin. Granulomatous phlebitis of the skin seems to represent a relatively early phase of delayed-type hypersensitivity reactions to Mycobacterium tuberculosis and may represent a distinct entity different from other types of tuberculid—a new tuberculid. Nevertheless, before making the diagnosis, the possibility of true tuberculosis must always be excluded. Nodular granulomatous phlebitis of the skin would be an appropriate name for the newly described condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.1997.d01-575.x
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