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  • 1
    Electronic Resource
    Electronic Resource
    A convulsant, 3-mercaptopropionic acid, decreases the level of GABA and GAD in rat pancreatic islets and brain (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 217-219 
    Details
    ISSN: 1420-9071
    Keywords: Gamma-aminobutyric acid ; glutamate decarboxylase ; pancreatic islets ; brain ; 3-mercaptopropionic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract To investigate the properties of the gamma-aminobutyric acid (GABA) synthesizing enzyme, glutamate decarboxylase (GAD), in the brain and the pancreatic islets of the rat, GABA concentration in the brain and the pancreatic islets was measured after intraperitoneal administration of 3-mercaptopropionic acid (3-MP) at 25 mg/kg. 60 min after the administration of 3-MP, GABA concentration in the hypothalamus, the superior colliculus and the hippocampus of the brain decreased by 20–30% and in the pancreatic islets by 35%. The concentration in the pancreatic acini did not change. Western blotting showed that GAD activity in the pancreatic islets decreased after administration of 3-MP compared to the control. The activity of GAD in the pancreatic islets as well as brain can be modified by a convulsant, in this case 3-MP. These results suggest the properties of GAD may be similar in the pancreatic islets and brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01931099
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  • 2
    Electronic Resource
    Electronic Resource
    Radiographic findings of intractable gastric ulcers with H2-receptor antagonists (1996)
    Springer
    Abdominal imaging 21 (1996), S. 133-141 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Gastric ulcer〈+〉—〈+〉Intractable ulcer〈+〉—〈+〉H2receptor antagonists〈+〉—〈+〉Radiographic findings〈+〉—〈+〉Multivariate analysis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: To clarify the radiographic characteristics of intractable gastric ulcers with H2-receptor antagonists. Methods: The radiographic findings at the time of starting treatment were compared between 42 patients with gastric ulcers that did not heal within eight weeks of starting treatment with H2-receptor antagonists (the intractable group) and 58 patients whose ulcers healed within the eight-week period (the tractable group). Results: The following radiographic findings in the intractable group were observed at a significantly higher incidence than those in the tractable group and included: an ulcer located on the angle, linear ulcers, a greater depth, an uneven mound surrounding an ulcer, prominent folds' convergence, an overhanging gastric mucosa, an irregular ulcer base, a shortening of the lesser curvature and a U-shaped deformity of the angle. A multiple logistic regression analysis showed that the following three factors had a significant and independent delaying effect on healing: a U-shaped deformity of the angle, an uneven mound surrounding an ulcer and prominent folds' convergence. The relative risk of these factors were 12.7, 14.4 and 12.5, respectively. Conclusions: Intractable gastric ulcer with H2-receptor antagonists can be predicted based on the characteristic radiographic findings at the start of treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900028
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  • 3
    Electronic Resource
    Electronic Resource
    Angiomyolipoma of the liver: significance of CT and MR dynamic study (1998)
    Springer
    Abdominal imaging 23 (1998), S. 520-526 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Angiomyolipoma—Liver, US, CT, MRI, angiography.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Angiomyolipoma is a benign mesenchymal tumor that has been reported frequently in the kidney but rarely in the liver. In the present study, we present four cases of hepatic angiomyolipoma with different radiologic appearances, discuss differential diagnosis, and review previously reported cases. One of our cases was followed for 8 years. Computed tomography (plain, enhanced, and dynamic study), magnetic resonance imaging (T1-weighted spin echo, T2-weighted spin echo, and dynamic study), ultrasonography, and angiography were performed in all cases. Although different radiologic appearances were observed in the tumors, based on different proportions of fat, blood vessels, and muscle, three cases were diagnosed as angiomyolipoma. In one case, it was quite difficult to make radiologic diagnosis; hepatocellular carcinoma with fatty metamorphosis in part was most likely suspected, but histopathological examination revealed angiomyolipoma with few fat elements. In the present study, early and prolonged enhancement of the lesion with the special pattern of time density/intensity curve was significant for angiomyolipoma, and we suggest that preoperative radiologic diagnosis of the lesion is possible in most of the cases. However, it can be quite difficult to distinguish angiomyolipoma from some hepatocellular carcinomas with fatty metamorphosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900391
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  • 4
    Electronic Resource
    Electronic Resource
    Protein Kinase C-Independent Correlation Between P-Glycoprotein Expression and Volume Sensitivity of Cl− Channel (1997)
    Springer
    The journal of membrane biology 157 (1997), S. 63 -69 
    Details
    ISSN: 1432-1424
    Keywords: Key words: Cl− channel — P-glycoprotein — RVD — PKC — Human epidermoid cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. The possible correlation between P-glycoprotein (PGP) and volume-sensitive Cl− channel was examined in a pair of cell lines: a subline of the human epidermoid KB cell (KB-3-1) and the corresponding MDR1-transfected cell line (KB-G2). Western blot analysis and indirect immunofluorescence studies indicated that KB-G2, but not KB-3-1, exhibits the PGP expression. Patch-clamp whole-cell recordings showed that osmotic swelling activates Cl− currents not only in PGP-expressing but also in PGP-lacking cells. The amplitude of the maximal current was indistinguishable between both cells. Activation of protein kinase C (PKC) or loading with a PKC inhibitor failed to affect the swelling-induced activation of the Cl− currents in both cells. The relation between whole-cell Cl− currents and cell size measured simultaneously showed that volume sensitivity of the Cl− channel was augmented by the PGP expression irrespective of the activity of PKC on the plasma membrane. A similar increase in volume sensitivity of the Cl− channel was also induced by the expression of the ATP hydrolysis-deficient PGP mutant, K433M. We conclude that P-glycoprotein does not represent the volume-sensitive Cl− channel but that its expression modulates volume sensitivity of the Cl− channel in a manner independent of its ATPase activity or of the protein kinase C activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002329900216
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  • 5
    Electronic Resource
    Electronic Resource
    Na+ Sensitivity of ROMK1 K+ Channel: Role of the Na+/H+ Antiporter (1999)
    Springer
    The journal of membrane biology 172 (1999), S. 67-76 
    Details
    ISSN: 1432-1424
    Keywords: Key words: Na+ sensor — Inward rectifier K+ channel — ROMK — Na+/H+ antiporter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. To examine the extracellular Na+ sensitivity of a renal inwardly rectifying K+ channel, we performed electrophysiological experiments on Xenopus oocytes or a human kidney cell line, HEK293, in which we had expressed the cloned renal K+ channel, ROMK1 (Kir1.1). When extracellular Na+ was removed, the whole-cell ROMK1 currents were markedly suppressed in both the oocytes and HEK293 cells. Single-channel ROMK1 activities recorded in the cell-attached patch on the oocyte were not affected by removal of Na+ from the pipette solution. However, macro-patch ROMK1 currents recorded on the oocyte were significantly suppressed by Na+ removal from the bath solution. A blocker of Na+/H+ antiporters, amiloride, largely inhibited the Na+ removal-induced suppression of whole-cell ROMK1 currents in the oocytes. The pH-insensitive K80M mutant of ROMK1 was much less sensitive to Na+ removal. Na+ removal was found to induce a significant decrease in intracellular pH in the oocytes using H+-selective microelectrodes. Coexpression of ROMK1 with NHE3, which is a Na+/H+ antiporter isoform of the kidney apical membrane, conferred increased sensitivity of ROMK1 channels to extracellular Na+ in both the oocytes and HEK293 cells. Thus, it is concluded that the ROMK1 channel is regulated indirectly by extracellular Na+, and that the interaction between NHE transporter and ROMK1 channel appears to be involved in the mechanism of Na+ sensitivity of ROMK1 channel via regulating intracellular pH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002329900584
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  • 6
    Electronic Resource
    Electronic Resource
    Septic shock due toPseudomonas aeruginosa in a previously healthy woman (1995)
    Springer
    Intensive care medicine 21 (1995), S. 226-228 
    Details
    ISSN: 1432-1238
    Keywords: Pseudomonas aeruginosa ; Septicemia ; Septic shock
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pseudomonas aeruginosa septicemia rarely occurs in non-immunocompromised adults. We present a case of septic shock followingPseudomonas aeruginosa pneumonia in a previously healthy 48-year-old woman. The onset was sudden, with back pain, pyrexia and shock. Chest radiographs revealed pneumonia, andPseudomonas aeruginosa was identified from blood and sputum cultures. Therapy with dopamine, piperacillin and fluid replacement led to a prompt recovery. Laboratory tests failed to reveal any immunological deficits. Including this case, only five cases ofPseudomonas aeruginosa septicemia in patients though to be non-immunocompromised have been reported. Two remarkable features of this type ofPseudomonas infection are apparent: i) it commonly develops from pneumonia and ii) it has a better prognosis than that in immunocompromised hosts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01701476
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of trendelenburg versus passive leg raising: Autotransfusion in humans (1996)
    Springer
    Intensive care medicine 22 (1996), S. 613-614 
    Details
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01708113
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  • 8
    Electronic Resource
    Electronic Resource
    Detection of hydrogen isotope atoms by mass spectrometry combined with resonant ionization (1999)
    Springer
    Applied physics 69 (1999), S. 129-132 
    Details
    ISSN: 1432-0649
    Keywords: PACS: 79.20.D; 42.62.F; 62.80.K
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. We examined the application of mass spectrometric methods using resonant ionization by a tunable laser and proposed its use for analyzing hydrogen isotopes. We conducted resonance ionization mass spectrometry (RIMS) to detect gas-phase hydrogen isotope atoms. The ionization efficiency was increased by more than 1000 times that obtained with conventional methods using nonresonant ionization. Resonant laser ablation mass spectrometry (RLAMS) was applied for deuterium detection in solid samples. A graphite substrate implanted with deuterium was used for ordinary laser ablation mass spectrometry (LAMS) and RLAMS. The deuterium signal was observed very clearly by RLAMS, in contrast to LAMS. Mass spectrometry combined with resonance ionization was very useful for hydrogen isotope detection, because components with equal mass numbers were resolved and the method demonstrated higher ionization efficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003400050784
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  • 9
    Electronic Resource
    Electronic Resource
    WHICH PATIENTS ARE SUITABLE FOR CONTINENT DIVERSION OR BLADDER SUBSTITUTION FOLLOWING CYSTECTOMY OR OTHER DEFINITIVE LOCAL TREATMENT? (1995)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of urology 2 (1995), S. 0 
    Details
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1442-2042.1995.tb00483.x
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  • 10
    Electronic Resource
    Electronic Resource
    Long-Lasting Immune Response Induced by Recombinant Bacillus Calmette–Guérin (BCG) Secretion System (1996)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 43 (1996), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The recombinant bacillus Calmette–Guérin (rBCG) secretion system utilizing an extracellular α antigen of Mycobacterium kansasii (α-K) was characterized biochemically and immunologically. The human immunodeficiency virus type1 (HIV-1) p17gag B cell epitope fused to α-K was secreted in extremely large amounts. At least three mice out of seven inoculated with rBCG generated high titres of antibody to the epitope. The long-lasting antibody production persisted more than 14 months.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.1996.d01-28.x
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