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  • 1
    Electronic Resource
    Electronic Resource
    Differential effects of the serotonin receptors on cultured rat cerebral cortical neurons (1997)
    Springer
    Cellular and molecular life sciences 53 (1997), S. 233-236 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Serotonin; ligand-gated receptor; G-protein-coupled receptor; patch-clamp; cerebral cortical neuron.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Effects of serotonin (5-HT) on cerebral cortical neurons were examined by patch clamp techniques. 5-HT produced a variety of responses such as outward (19/73 patches/neurons), slow inward (15/73 patches/neurons), fast inward (8/73 patches/neurons), and mixed currents (initially fast inward deflection followed by an outward response: 2/73 patches/neurons), with a latency of 12 sec, 15 sec, 0 sec, and 0 sec respectively, at a holding potential of −60 mV in whole-cell patches. The fast inward currents were again evoked by a selective 5-HT3 receptor agonist, 1-(m-chlorophenyl)-biguanide hydrochloride (CPBG). In the cell-attached patch clamp configuration, 5-HT inside the patch pipette elicited single channel currents with slope conductances of 42 pS and 132 pS (4/42 patches/neurons). CPBG inside the patch pipette evoked inward single channel currents with a lower slope conductance of 41 pS (3/23 patches/neurons). In contrast, application of 5-HT or a 5-HT2 receptor agonist, α-methyl-5-hydroxytryptamine-maleate, outside the patch pipette induced outward single channel currents with a major slope conductance of 140 pS (8/30 patches/neurons) or 135 pS (6/20 patches/neurons), respectively. These results indicate that the outward and fast inward currents may be mediated respectively by the 5-HT2 receptor, which is coupled to a G-protein, and by the 5-HT3 receptor, which contains the non-selective cation channel, and that the mixed type may be caused by both the 5-HT2 and 5-HT3 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00000596
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  • 2
    Electronic Resource
    Electronic Resource
    Giant cell tumor of bone in a child (1999)
    Springer
    International journal of clinical oncology 4 (1999), S. 403-406 
    Details
    ISSN: 1437-7772
    Keywords: Key words Giant cell tumor ; Child ; Bone tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Giant cell tumor (GCT) of bone was first established as a distinct clinicopathological radiographic entity in 1940 when Jaffe distinguished it from other lesions containing giant cells. GCT is rare in patients under 15 years of age. We report a case of GCT in a 10-year-old boy whose X-ray films showed osteolysis suggesting a malignant bone tumor. We believe this to be the youngest patient with giant cell bone tumor ever reported in the Japanese literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101470050093
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  • 3
    Electronic Resource
    Electronic Resource
    Prognostic implications of meningiomas in the elderly (over 70 years old) in the era of magnetic resonance imaging (1994)
    Springer
    Acta neurochirurgica 126 (1994), S. 59-62 
    Details
    ISSN: 0942-0940
    Keywords: Elderly meningioma ; clinical feature ; prognostic implication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary During the 5 years from 1987 to 1991, 89 elderly patients, aged 70 years and over, were admitted to departments of neurosurgery in Yamaguchi prefecture with meningioma. The clinical features and prognostic implications of meningioma in the elderly were assessed retrospectively. Seventy-eight (88%) of the 89 patients underwent surgery, which was a higher rate than has been previously reported. The length of clinical history was also shorter than in previous studies, and was partly due to the recent introduction of magnetic resonance imaging (MRI). The incidence of poor prognosis (severe disability, vegetative or dead) in the elderly and a younger group aged less than 70 years was 13% and 7%, respectively, but the difference was not statistically significant. In the surgically treated elderly group, age did not influence the patient's outcome. The factors affecting the outcome were pre-operative neurological deficit (p〈0.05), histological malignancy (p〈0.05), and multiple operations (p〈0.05). Twenty-seven of the elderly meningioma patients were in good physical condition with minimal neurological involvement. They underwent total removal of the tumour at the first operation, and the histological diagnosis was benign. Twenty-five of these 27 patients fell into the best outcome category. Therefore, age alone was not a factor preventing proper surgical treatment of meningioma in the elderly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476411
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  • 4
    Electronic Resource
    Electronic Resource
    Transferrin receptors in injured brain (1990)
    Springer
    Acta neuropathologica 79 (1990), S. 686-688 
    Details
    ISSN: 1432-0533
    Keywords: Transferrin receptor ; Brain injury ; Edema fluid ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent studies have demonstrated the presence of transferrin receptors (Tf-R) in the central nervous system. The present study of Wistar rats with experimentally induced brain injuries, using immunohistochemistry at the light microscopy level, demonstrated the presence of Tf-R in regenerated endothelial cells, reactive astrocytes and in other cells, probably macrophages. Although Tf-R were seen in proliferating cells, Tf-R were also observed in nonproliferating cells, many of them macrophages. The receptors perhaps bind transferrin in edema fluid and play an important role in lesion repair.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294248
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  • 5
    Electronic Resource
    Electronic Resource
    Primitive neuroectodermal tumor of the leptomeninges (1991)
    Springer
    Neuroradiology 33 (1991), S. 260-263 
    Details
    ISSN: 1432-1920
    Keywords: Primitive neuroectodermal tumor ; Leptomeninx ; CT ; MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Primitive neuroectodermal tumor (PNET) without an obvious intraparenchymal mass lesion and with diffuse spread in the subarachnoid space is rare. We report such a rare case and discuss the computed tomography (CT) and magnetic resonance (MR) features.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588232
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  • 6
    Electronic Resource
    Electronic Resource
    Laparoscopy preferable to imaging procedures in detecting metastases of a pancreas carcinoma to the liver (1994)
    Springer
    Surgical endoscopy and other interventional techniques 8 (1994), S. 1340-1342 
    Details
    ISSN: 1432-2218
    Keywords: Laparoscopy ; Imaging procedures ; Pancreas carcinoma ; Hepatic metastases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In two patients a pancreatic mass, 6 and 4 cm in diameter, respectively, was detected using imaging techniques. Computed tomography, ultrasound, and angiography revealed no evidence of a metastatic lesion in the liver. In the first patient, exploration was done prior to a possible radical operation. Multiple hepatic metastases forming thin, flat lesions on the surface of the liver were present and palliative surgery only was done. In the other patient, laparoscopy was done before surgical exploration and multiple hepatic metastases on the surface of the liver were clearly evident. Laparoscopy can help to avoid unnecessary explorations in patients with large pancreas cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00188297
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  • 7
    Electronic Resource
    Electronic Resource
    Laparoscopic splenectomy using a wall-lifting procedure (1999)
    Springer
    Surgical endoscopy and other interventional techniques 13 (1999), S. 1055-1056 
    Details
    ISSN: 1432-2218
    Keywords: Key words: Laparoscopy — Splenectomy — Wall-lifting — Pneumoperitoneum — Surgical technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. A laparoscopic splenectomy using a hanger wall-lifting procedure is herein described. The patient is placed in the right lateral position. The left lower chest and left abdominal wall are then lifted by three wires in two directions, left laterally and vertical to the abdominal wall. The view of the operative field thus obtained is excellent. The lifting wires and bars do not hinder the movement of the forceps, since the angles of the instruments to approach the spleen are different from those of the wires. A laparoscopic splenectomy using this wall-lifting procedure avoids the usual complications associated with pneumoperitoneum while still being technically comparable to a procedure with pneumoperitoneum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004649901170
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  • 8
    Electronic Resource
    Electronic Resource
    Hepatic metastasis after laparoscopic cholecystectomy for polypoid gallbladder cancer followed by radical surgery (1994)
    Springer
    Surgical endoscopy and other interventional techniques 8 (1994), S. 1436-1438 
    Details
    ISSN: 1432-2218
    Keywords: Hepatic metastasis ; Polypoid gallbladder cancer ; Radical surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract While laparoscopic cholecystectomy is being increasingly performed on patients with gallbladder disease, this approach in cases of polypoid lesions in the gallbladder may not always be justified. We report here a case of early development of intrahepatic metastasis after laparoscopic cholecystectomy for polypoid gallbladder cancer; wedge resection of the gallbladder bed and dissection of regional lymph nodes had to be done. When a malignancy of the gallbladder is suspected during preoperative examinations, open cholecystectomy should be done.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00187354
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  • 9
    Electronic Resource
    Electronic Resource
    Laparoscopic hepatic resection for hepatocellular carcinoma (1995)
    Springer
    Surgical endoscopy and other interventional techniques 9 (1995), S. 1289-1291 
    Details
    ISSN: 1432-2218
    Keywords: Hepatic resection ; Hepatocellular carcinoma ; Air embolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Despite recent progress in diagnostics for hepatocellular carcinoma, the rate of resectability remains low, mainly because of the advancement of the underlying liver disease. We report a case of a 54-year-old man with a hepatocellular carcinoma and poor liver function that was treated successfully with a laparoscopic hepatic resection. Laparoscopic hepatic resection is considered to be feasible with the aid of an ultrasonic dissector and a microwave coagulator; however, close attention should be paid to the development of air embolism and hepatic vein injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190161
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  • 10
    Electronic Resource
    Electronic Resource
    Fourfold symmetry in the ab-plane of the upper critical field for the high-Tc cuprates (1996)
    Springer
    Journal of low temperature physics 105 (1996), S. 533-538 
    Details
    ISSN: 1573-7357
    Keywords: 74.60.Ec ; 14.72.−h
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have found clear anisotropy in the ab plane with fourfold symmetry of the resistive superconducting transition under magnetic fields for single-crystal Pb2Sr2Y0.62Ca0,38Cu3O8, which is regarded as anisotropy of the upper critical field Hc2. This is not only qualitatively but also quantitatively similar to that formerly observed in La1.86Sr0.14CuO4. The observed fourfold symmetry is explained as being mainly due to the anisotropy of the superconducting energy gap owing to $$d_{x^2 - y^2 }$$ pairing. Hc2, one of the bulk properties, supports $$d_{x^2 - y^2 }$$ pairing in the high-Tc superconductivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00768440
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