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  • 1
    Digitale Medien
    Digitale Medien
    Terminal Differentiation of Cord Blood Lymphocytes Induced by Thymosin Fraction 5 and Thymosin Alpha1 (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 21 (1985), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Cord blood lymphocytes (CBL) have been shown to be functionally immature compared with normal circulating adult lymphocytes (NAL). Differentiation of T cells is associated with changes in surface antigenic markers and in the pattern of purine degradative enzymes. Previous studies have demonstrated that thymosin fraction 5 (TMS-F5) and thymosin alphal (TMS-α1 can induce in vitro differentiation of murine T-cell precursors and human thymocytes. We have investigated the effects of TMS-F5 and TMS-a, on the pattern of the purine degradative enzymes adenosine deaminase, purine nucleoside phosphorylase, and ecto-5′-nucleotidase (5′NT) of CBL and on the phenotypic markers from the OKT series 3,4,8 and 11. Other than a significantly reduced level of 5′NT activity (P〈0.001) and an elevated percentage of OKT4+cells (P〈0.01), CBL demonstrated the same immunological and biochemical patterns as NAL. Incubation of CBL with TMS-F5 (150 jug/ml) and TMS-α1 (1 μ/ml) for 40 h caused a significant rise in 5′NT level and decrease of cells positive for OKT4, resulting in a pattern characteristic of NAL. Thus TMS-F5 might induce the terminal differentiation of CBL, and TMS-α1 seemed to be the active component.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1985.tb01424.x
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  • 2
    Digitale Medien
    Digitale Medien
    Beschreibung eines vereinfachten Makrophagenmigrationshemm-Testes zur Messung zellvermittelter Immunreaktionen beim Menschen (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 397-399 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Macrophage migration inhibitory factor (MIF) ; macrophage migration inhibition test ; MEM-test ; cell mediated immunity ; tumour immunity ; Makrophagenmigrations-Inhibitions-Faktor (MIF) ; Makrophagenmigrationshemm-Test ; MEM-Test ; zellvermittelte Immunität ; Tumorimmunologie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Ein direkter Makrophagenmigrationshemm-Test mit heterologen Zellen (DMMTH) wird in einer Agarose-Tropfentechnik ausgeführt. Eine Suspension aus Peritonealmakrophagen des Meerschweinchens und Humanlymphozyten wird in 0,2%iger Agarose aufgeschwemmt, die mit einer automatischen Dosiervorrichtung tropfenförmig auf Platten für den Leukozytenwanderungstest aufgetragen wird. Die aus den erstarrten Tropfen erfolgende Auswanderung der Makrophagen kann planimetrisch gemessen werden. Die Streubreite der Zellkulturen beträgt im Mittel 8,6%. Eine signifikante Wanderungshemmung durch die Freisetzung des Migrations-Inhibitions-Faktors wird beobachtet, wenn sensibilisierte Humanlymphozyten mit dem in die Agaroselösung eingebrachten spezifischen Antigen reagieren. An Mantoux-positiven Probanden wurde die Sensitivität des Testes gezeigt.
    Notizen: Summary A macrophage migration inhibition test using heterologous cells (DMMTH) is performed in an agarose-droplet technique. A suspension consisting of peritoneal exsudate cells from Guinea pig and human lymphocytes, mixed with 0,2 percent agarose is dispensed in droplets with a dispenser into culture chambers used for the leukocyte migration inhibition test. Macrophages migrate out of the gelified droplets. Migration areas can be measured by planimetry. Migration areas are exact to 8.6 percent. A significant migration inhibition, caused by migration inhibitory factors is observed after the reaction of the specific antigen with sensitized lymphocytes in the agarose droplet. The sensitivity of the test has been demonstrated in Mantoux positive persons.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01468680
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  • 3
    Digitale Medien
    Digitale Medien
    2′-Deoxycoformycin (pentostatin) in hairy cell leukemia: Response in patients refractory to interferon alpha (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 975-979 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Deoxycoformycin ; Hairy cell leukemia ; Refractory treatment
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Three patients with advanced hairy cell leukemia received low-dose deoxycoformycin treatment after failure to respond to therapy with interferon alpha. Patients 1 and 2 had progressive disease after splenectomy and subsequent treatment with recombinant interferon alpha (for 7 and 3 months, respectively). DCF was administered at 4 mg/m2 weekly for 3 weeks, and then once every week for 6 weeks. Patient 1 was in complete remission after 9 weeks of treatment and patient 2 in partial remission with normalization of peripheral blood counts. The third patient, also splenectomized, developed hepatotoxicity after therapy trial with interferon for 24 days and no objective improvement was observed at this stage. She subsequently responded to DCF treatment with improvements in blood counts and bone marrow. This report demonstrates that DCF is highly effective in hairy cell leukemia and non-cross-resistant with interferon alpha.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01717832
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  • 4
    Digitale Medien
    Digitale Medien
    Leukocyte alkaline phosphatase in malignancies (1979)
    Springer
    Annals of hematology 39 (1979), S. 141-145 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Alkalische Leukozytenphosphatase (ALP) ; maligne Erkrankungen ; Metastasen ; Leukocyte alkaline phosphatase (LAP) ; Malignant disease ; Metastases
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary The leukocyte alkaline phosphatase (LAP) levels were determined in 183 patients with malignant diseases and 71 normal controls. The median LAP scores were 64 units (range 0 to 290) for the patients and 55 (range 2 to 158) for the controls, respectively, and no significant difference could be established. When analyzed according to primary malignancy, only in patients with Hodgkin's disease (n = 14) was the median value higher than normal (p 〈 0.001). In patients with distant metastases (n = 48), higher LAP levels were demonstrated (M = 76, range 21 to 290) as compared to patients with no evidence of metastases (M = 53, range 0 to 229), (p 〈0.01). Thus, LAP activity has very limited value in the diagnosis of malignancies. Its elevation in the presence of malignant disease might, however, indicate metastases.
    Notizen: Zusammenfassung Bei 183 Patienten mit malignen Erkrankungen und 71 Kontrollpersonen wurde der ALP-Index untersucht. Der Median für die Patienten war 64 (range 0–290) und für die Kontrolle 55 (range 2–158). Dieser Unterschied ist jedoch statistisch nicht signifikant. Bei der Analyse der ALP-Indices nach Tumorgruppen konnte eine signifikante Erhöhung des ALP-Index nur bei Morbus Hodgkin (n = 14) festgestellt werden (p 〈0,001). Der ALP-Index war auch bei Patienten mit Metastasen (n = 48) (M = 76, range 21 zu 290) im Vergleich zum ALP-Index bei Patienten ohne Metastasen (n = 118, M = 53 range 0–229) erhöht (p 〈0,01). Die ALP-Aktivität hat also nur einen beschränkten Wert in der Diagnostik bei malignen Erkrankungen. Eine Erhöhung kann jedoch auf das Vorliegen von Metastasen hinweisen.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01008089
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  • 5
    Digitale Medien
    Digitale Medien
    Respiratory distress as primary symptom of relapse in a patient with non-hodgkin lymphoma (1985)
    Springer
    Annals of hematology 51 (1985), S. 287-289 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Immunoblastic lymphoma ; Respiratory distress ; Endotracheal lymphoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A report on a 74-year old woman with high-grade malignant non-Hodgkin lymphoma in clinical remission, who suddenly developed episodes of severe dyspnea and wheezing. Clinical and roentgenographic investigations including tomography of the trachea failed to demonstrate any lesion. Fiberoptic bronchoscopy revealed and endotracheal, polyp-like lymphoma 3 cm above the carina, which was immediately operated. Other sites of relapse (submandibular lymphnodes) were found 2 weeks after the operation. Second-line chemotherapy (IMVP 16) was able to induce a second remission.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00320523
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  • 6
    Digitale Medien
    Digitale Medien
    Evidence for an osteoblast-activating factor in a patient with peripheral T-cell lymphoma and osteosclerosis (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 402-407 
    Details
    ISSN: 1432-1440
    Schlagwort(e): T-cell lymphoma ; Osteosclerosis ; Lymphokines
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A patient with peripheral T-cell Lymphoma and aquired, systemic osteosclerosis is described. Bone histology showed a spectacular activation of osteoblasts accompanyed by massive new bone formation. Alkaline phosphatase in serum was elevated and increased to 〉2000 U/l when the lymphoma became refractory to chemotherapy. In the patient's serum an osteoblast-activating factor could be demonstrated using a rat osteogenic osteosarcoma cell line (ROS 17/2.8). The factor was absent during remission of the tumor. We conclude that osteosclerosis was a paraneoplastic syndrome in this patient due to the secretion of an osteoblast-stimulating factor by the T-cell lymphoma. This situation is similar to the secretion of osteoclast-activating factors described in B-cell lymphomas, particularly multiple myeloma. The characterization of such a factor could be of therapeutic relevance.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01711269
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