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  • 1
    Electronic Resource
    Electronic Resource
    Mucoepidermoid carcinoma of the esophagus —A case report (1985)
    Springer
    Surgery today 15 (1985), S. 55-59 
    Details
    ISSN: 1436-2813
    Keywords: esophageal carcinoma ; mucoepidermoid carcinoma ; adenosquamous carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We treated a 66-year old woman with mucoepidermoid carcinoma of the esophagus. The histologic features of this tumor seemed to originate from esophageal glands and their ducts. This deduction was based on the subepithelial growth pattern and the presence of in-situ carcinoma showing a glandular or squamous pattern at the location of the esophageal gland duct. Although the biological nature of this tumor was not elucidated, the prognosis is similar to that seen with the ordinary type of esophageal squamous carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02469858
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  • 2
    Electronic Resource
    Electronic Resource
    Antitumor effect of lipiodolized doxorubicin on VX2 carcinoma in rabbits (1985)
    Springer
    Surgery today 15 (1985), S. 89-91 
    Details
    ISSN: 1436-2813
    Keywords: Lipiodol Ultra-Fluid ; Doxorubicin ; Urografin ; selective cancer chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twelve-day-old VX2 carcinoma was inoculated in the hind leg of 24 rabbits and, after 12 days, Doxorubicin (Adriamycin) suspended in Lipiodol Ultra-Fluid (Lipiodol) was then given through the femoral artery. A selective deposit of the contrast material in the tumor for an extended time was evident on the x-rays and the antitumorous effect was remarkable. Lipiodolized antitumor agents warrant further investigation for possible clinical application.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02469864
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Radiation-induced esophageal carcinoma responded well to hyperthermic chemotherapy (1985)
    Springer
    Surgery today 15 (1985), S. 225-229 
    Details
    ISSN: 1436-2813
    Keywords: hyperthermia with chemotherapy ; esophageal cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 66-year-old man with multiple malignant lesions of the esophagus, as apparently induced by irradiation of 60 Gy of60Co for a mediastinal tumor at the age of 36 y.o., was a poor operative risk because of severe lung disease. This man was treated with a combination of hyperthermia, oral administration of oil Bleomycin-polyacrylate paste and intravenous infusion of cis-Platinum. During 20 administrations of hyperthermia conducted at 42–45°C for 30 min, 600 mg of oil Bleomycin and 200 mg of cis-Platinum, no complications occurred and the heat treatments were completed with no side effects. Repeatedly performed esophagogram and endoscopy showed a complete disappearance of three of the four lesions and a marked regression in the other one. There has been no regrowth or distant spread of the carcinoma up to the present 10 months of follow up. This combination of hyperthermia and chemotherapy may prove to be the optimal strategy for treatment of unresectable esophageal cancer, particularly when radiotherapy is contraindicated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02469892
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Prognostic study of intramucosal carcinoma of the stomach with DNA aneuploidy (1985)
    Springer
    Surgery today 15 (1985), S. 443-448 
    Details
    ISSN: 1436-2813
    Keywords: DNA analysis ; early gastric cancer ; prognosis ; growth pattern
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cell nuclear DNA content was microspectophotometrically measured in 70 patients with a gastric carcinoma lesion of less than 4.0 cm in diameter and with mucosal or minimal submucosal invasion. Two groups were prepared; low ploidy and high ploidy, according to the degree of dispersion on the DNA histogram. Twenty-four cases of high ploidy were reviewed from the aspects of clinicopathology and prognosis and the findings compared with data on 46 of low ploidy. The high ploidy group was characterized by an elevated lesion and a differentiated carcinoma while the low ploidy group had a depressed lesion and an undifferentiated carcinoma Postoperative recurrence was confirmed in none of the low ploidy cases and 2/24 of the high ploidy cases. The five and ten-year survival rates of the patients with high ploidy were 100 per cent and 91.1 per cent, respectively. Compared to the finding that patients with submucosal carcinoma of high ploidy survived at a rate of only 64.8 per cent in the 5-year follow-up, efforts should be directed toward a higher detection of gastric carcinoma with aneuploidy at the stage limited to within the intramucosal layer. Endoscopic treatment for early gastric carcinoma is not recommended, especially for a differentiated carcinoma, even if the invasion is confined to the mucosa, since it may include aneuploid carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470089
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  • 5
    Electronic Resource
    Electronic Resource
    Preoperative detection of a highly malignant type of early gastric carcinoma by cytophotometric DNA analysis (1986)
    Springer
    Surgery today 16 (1986), S. 169-174 
    Details
    ISSN: 1436-2813
    Keywords: DNA pattern ; growth pattern ; malignancy ; early gastric carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A cytophotometric DNA analysis was made of gastroendoscopically biopsied materials of 43 patients with early gastric carcinoma and the data were compared with the DNA patterns of the resected specimens of these patients. The DNA patterns could be classified into two types, Low Ploidy and High ploidy, according to the degree of dispersion of the DNA value. The Ploidy to Ploidy coincidence of the DNA patterns between biopsied material and the resected specimen in the same lesion was noted in 93 per cent (39/42). The DNA patterns of the resected specimens were consistent in the majority of cases, regardless of the areas examined, center or periphery, and mucosa or submucosa of the same lesion. This study provides evidence that a highly malignant type of early gastric carcinoma, Pen A type, could be differentiated in gastroendoscopically biopsied materials by a cytophotometric DNA analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02471089
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Postoperative adjuvant chemotherapy for gastric cancer, the second report. Analysis of data on 2873 patients followed for five years (1986)
    Springer
    Surgery today 16 (1986), S. 175-180 
    Details
    ISSN: 1436-2813
    Keywords: gastric cancer ; adjuvant chemotherapy ; futraful
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effectiveness of combination chemotherapy with mitomycin-C (MMC) plus futraful (N1-(2′-tetrahydrofuryl)-5-fluorouracil), as an adjunct to surgery for gastric cancer was investigated in a prospective randomized controlled study. Three thousand and thirty-three Japanese patients in 344 hospitals were entered and 2873 could be followed for 5 years. All patients had undergone gastrectomy from April 1977 to May 1979 and were assigned, at random, to either Groups A, B or C. In Group A, bolus MMC was administered with no further treatment. In Group C, oral futraful was given for one year, without MMC induction. In Group B, both a bolus MMC injection and oral futraful were prescribed. This randomized study showed no statistical difference in the 5 year survival rate among the three groups. However, in patients given MMC and put on oral futraful for one year, the 5 year survival rate for those with stage III gastric cancer or for those with positive lymphnode metastasis plus obvious serosal invasion seemed to be improved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02471090
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  • 7
    Electronic Resource
    Electronic Resource
    Development of erosive gastritis in a canine model of esophageal varices (1986)
    Springer
    Surgery today 16 (1986), S. 218-224 
    Details
    ISSN: 1436-2813
    Keywords: erosive gastritis ; esophageal varices ; hyperdynamic state ; gastric mucosal blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We designed a reproducible canine model of esophageal varices, based on the concept of a regional hyperdynamic state in the upper stomach. Arterialization of the left gastric vein concomitant with the distal splenorenal shunt led to a stable hyperdynamic state and reproducible esophageal varices occurred. In the long-term follow-up of these dogs with varices, the erosive gastritis seen in the upper stomach learly resembled clinically observed lesions. Hemodynamic and morphological studies revealed that gastric mucosa of these animals was in an ischemic state, even though there was a remarkable increase in blood flow in the submucosal area. It is suggested that the decrease in mucosal blood flow, as induced by the hyperdynamic state caused erosive gastritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02471096
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  • 8
    Electronic Resource
    Electronic Resource
    Esophageal varices produced in dogs (1985)
    Springer
    Surgery today 15 (1985), S. 81-88 
    Details
    ISSN: 1436-2813
    Keywords: variceal production ; hyperdynamic state ; arteriovenous shunt ; distal splenorenal shunt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In attempts to produce esophageal varices in dogs, we designed a procedure based on the concept of hyperdynamic flow. The first stage operation involved the achievement of an arteriovenous shunt between the left renal artery and the proximal splenic vein, in concert with the distal splenic venous-left renal venous shunt. About one month after the initial operation, sixteen of the twenty-eight dogs had tolerated the manipulations. Both shunts proved to be functioning well in six of sixteen survivors, in which an ameroid constrictor was placed around the splenic vein just proximal to the confluence of the left gastric vein. Again one month later, in five of these six, esophageal varices were evidenced, both endoscopically and histologically. Arterialization of left gastric vein concomitant with the distal splenorenal shunt, gave rise to a hyperdynamic state in the upper stomach and resulting in reproducible esophageal varices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02469863
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  • 9
    Electronic Resource
    Electronic Resource
    Hyperdynamic circulation in the left gastric venous area in patients with portal hypertension: Angiological assessment (1985)
    Springer
    Surgery today 15 (1985), S. 134-139 
    Details
    ISSN: 1436-2813
    Keywords: portal hypertension ; esophageal varices ; hyperdynamic circulation ; selective shunt ; celiac arteriography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The time of appearance of the left gastric vein on serial celiac arteriograms in patients with portal hypertension and esophageal varices was compared with that of the portal vein to assess regional hemodynamics in the left venous portion of the stomach, an area located in close proximity to the varices. In two thirds of all the patients with cirrhosis or non-cirrhotic idiopathic portal hypertension (IPH), the left gastric vein was visualized earlier or simultaneously than or with the portal vein, while in all but one patient with prehepatic portal obstruction, there was a delayed opacification of the left gastric vein. These results suggest the presence of a hyperdynamic circulatory state which promotes venous hypertension in the left gastric venous area of the stomach of a considerable number of patients with cirrhosis or IPH. In such a hemodynamic state, selective decompression of varices can be achieved by a left gastric venous caval shunt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02469743
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  • 10
    Electronic Resource
    Electronic Resource
    The clinical usefulness of preoperative CEA determination in gastric cancer (1987)
    Springer
    Surgery today 17 (1987), S. 342-347 
    Details
    ISSN: 1436-2813
    Keywords: carcinoembryonic antigen ; gastric cancer ; prediction of prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Between 1980 and 1984, preoperative serum carcinoembryonic antigen (CEA) was determined in 468 patients with gastric cancer to evaluate its clinical usefulness. The positive rate of preoperative CEA was 20.9 per cent in these 468 patients. A significantly higher CEA positive rate was obtained in those patients with liver metastasis (69.2 per cent), n3–4 (40.0 per cent), stage IV gastric cancer (37.0 per cent) and Pap, Tub1 histological type (26.3 per cent) (p〈0.01). It is interesting that the positive rate of the 49 unresectable patients was 51.0 per cent, which was significantly higher than 17.4 per cent of the 419 resectable cases (p〈0.01). CEA levels in 16 of the 39 patients with liver metastasis were more than 100 ng/ml. In contrast, serosal invasion and peritoneal metastasis were less correlated to the CEA positive rate. In the 419 resected cases, the 5 year survival rate in the higher CEA group of more than 50 ng/ml (35 cases) was 4.4 per cent, which was significantly lower than 64.0 per cent in the negative group (346 cases) (p〈0.01). These results show that CEA determination in patients with gastric cancer is useful for the prediction of prognosis, as well as for a diagnostic tool to discover the presence of liver or lymph node metastasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470632
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