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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    World journal of surgery 9 (1985), S. 171-179 
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé Pour apprécier l'état actuel des traitements chirurgicaux appliqués aux varices oesophagiennes au Japon une étude nationale basée sur les résultats cliniques a été entreprise par la Société Japonaise d'étude de l'hypertension portale. Les données recueillies concernent 3588 malades atteints d'hypertension portale et traités par des méthodes chirurgicales non décompressives de janvier 1967 à janvier 1982 dans 52 unités chirurgicales. La mortalité opératoire s'est élevée à 8,3%, le taux de survie à 68,6%, la récidive hémorragique postopératoire à 6,9% et le syndrome d'Eck à 4,8%. La mortalité opératoire concernant 506 malades opérés d'urgence s'est élevée à 24,8%. Aucune différence notable n'a été remarquée entre les résultats des interventions interrompant la continuité veineuse et ceux des opérations de dérivation sélective. En revanche, les résultats de ces deux méthodes ont été très supérieurs aux résultats des opérations de décompression portale pratiquées avant 1967. La transection oesophagienne avec une large dévascularisation pratiquée par voie thoracique et voie abdominale et les dérivations sélectives (dérivation entre la veine coronaire stomachique et la veine cave d'une part, dérivation spléno-rénale distale d'autre part) ont permis de réduire la fréquence de la récidive hémorragique par rapport à celle imputable à la dévascularisation isolée par la seule voie abdominale ou thoracique.
    Kurzfassung: Resumen La disminución en la perfusión portal del hígado puede ser el principal factor causante del deterioro en la función hepática y de la encefalopatía que se presentan después de cirugía descompresiva. En el Japón los procedimientos portales no descompresivos y las anastomosis selectivas, las cuales se encuentran incluídas en el concepto de la cirugía portal no descompresiva, son ampliamente utilizados en la prevention de hemorragia varicosa evitando causar el síndrome de Eck. Se reporta aquí la información más comprensiva sobre cirugía portai no descompresiva utilizando procedimientos directos de interrupción y anastomosis selectivas. Con el objeto de evaluar el estado actual del tratamiento quirúrgico de las várices esofágicas en el Japón, la Sociedad Japonesa de Investigación en Hipertensión Portal emprendió una investigación nacional sobre resultados clínicos. Se recolectaron datos sobre 3.588 pacientes con hipertensión portal sometidos a cirugía portal no descomprensiva entre enero de 1967 y enero de 1982 en 59 instituciones participantes. La mortalidad operatoria fué de 8.3%, la tasa de supervivencia 68.6%, la tasa de hemorragia postoperatoria 6.9% y el síndrome de Eck 4.8%. La mortalidad operatoria en 506 pacientes sometidos a operación de emergencia fué de 24.8%. No se observé una diferencia mayor entre los procedimientos de interrupción directa y las anastomosis selectivas. Los resultados globales de la cirugía portai no descomprensiva fueron muy superiores a los resultados de la cirugía portal no descomprensiva fueron muy superiores a los resultados de la cirugía portai descompresiva realizada antes de 1967. La transección esofágica con devascularización amplia por vía torácica o por vía abdominal y las anastomosis selectivas (vena gástrica izquierda a vena cava y espleno-renal distal) resultaron en una menor incidencia de sangrado recurrente en el seguimiento a largo plazo, en comparación con la devascularización, utilizando sólo la vía abdominal o la vía torácica.
    Notizen: Abstract To assess the current status of surgical treatments for esophageal varices in Japan, a nationwide survey on the clinical results was performed by the Japanese Research Society for Portal Hypertension. Data were collected in 59 participating institutions on 3,588 patients with portal hypertension, subjected to portal nondecompression surgery between January, 1967, and January, 1982. In these patients the operative mortality rate was 8.3%, the survival rate was 68.6%, the postoperative bleeding rate was 6.9%, and the incidence of Eck's syndrome was 4.8%. Operative death occurred in 24.8% of 506 patients undergoing emergency operations. No gross difference was noted in these data between direct interruption procedure and selective shunt surgery. The overall results of portal nondecompression surgery were far superior to results of portal decompression surgery, done before 1967. Esophageal transection with wider devascularization from both thoracic and abdominal approaches and selective shunt (left gastric venous caval shunt and distal splenorenal shunt) led to a diminished incidence of recurrent bleeding in the later follow-up period, as compared to devascularization, using a sole abdominal or thoracic approach.
    Materialart: Digitale Medien
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  • 2
    ISSN: 1436-2813
    Schlagwort(e): portal hypertension ; esophageal varices ; hyperdynamic circulation ; selective shunt ; celiac arteriography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The time of appearance of the left gastric vein on serial celiac arteriograms in patients with portal hypertension and esophageal varices was compared with that of the portal vein to assess regional hemodynamics in the left venous portion of the stomach, an area located in close proximity to the varices. In two thirds of all the patients with cirrhosis or non-cirrhotic idiopathic portal hypertension (IPH), the left gastric vein was visualized earlier or simultaneously than or with the portal vein, while in all but one patient with prehepatic portal obstruction, there was a delayed opacification of the left gastric vein. These results suggest the presence of a hyperdynamic circulatory state which promotes venous hypertension in the left gastric venous area of the stomach of a considerable number of patients with cirrhosis or IPH. In such a hemodynamic state, selective decompression of varices can be achieved by a left gastric venous caval shunt.
    Materialart: Digitale Medien
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  • 3
    ISSN: 1436-2813
    Schlagwort(e): esophageal carcinoma ; mucoepidermoid carcinoma ; adenosquamous carcinoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We treated a 66-year old woman with mucoepidermoid carcinoma of the esophagus. The histologic features of this tumor seemed to originate from esophageal glands and their ducts. This deduction was based on the subepithelial growth pattern and the presence of in-situ carcinoma showing a glandular or squamous pattern at the location of the esophageal gland duct. Although the biological nature of this tumor was not elucidated, the prognosis is similar to that seen with the ordinary type of esophageal squamous carcinoma.
    Materialart: Digitale Medien
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  • 4
    ISSN: 1436-2813
    Schlagwort(e): Lipiodol Ultra-Fluid ; Doxorubicin ; Urografin ; selective cancer chemotherapy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Twelve-day-old VX2 carcinoma was inoculated in the hind leg of 24 rabbits and, after 12 days, Doxorubicin (Adriamycin) suspended in Lipiodol Ultra-Fluid (Lipiodol) was then given through the femoral artery. A selective deposit of the contrast material in the tumor for an extended time was evident on the x-rays and the antitumorous effect was remarkable. Lipiodolized antitumor agents warrant further investigation for possible clinical application.
    Materialart: Digitale Medien
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  • 5
    ISSN: 1436-2813
    Schlagwort(e): K-18 ; hyperthermia ; Lewis lung carcinoma ; mice
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We investigated the synergistic anti-tumor effects of K-18 (conjugate of human γ-globulin and melphalan) and concomitantly administered hyperthermia on Lewis lung carcinoma in mice. The antitumor effect of a subeffective dose of K-18 or an equivalent dose of melphalan alone was enhanced by local hyperthermia. K-18 administration demonstrated a greater potentiation for inhibition of tumor growth than that of melphalan alone. Local hyperthermia plus K-18 reduced the dose of melphalan required for tumor growth inhibition by melphalan alone. The combined application of K-18 and hyperthermia for treating cancer warrants further study.
    Materialart: Digitale Medien
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  • 6
    ISSN: 1436-2813
    Schlagwort(e): esophageal cancer ; mortality ; cough dynamics ; elongated gastric tube
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Since the late 1970's, there has been a remarkable decrease in the mortality of patients with esophageal cancer. Factors such as progress in pre- and post-operative management, operative technique, and anesthesia all play a contributory role in this improvement. Among 251 Japanese patients with esophageal carcinoma who underwent esophageal resection and reconstruction in our department of surgery since 1965, those treated from 1965–74 and others treated from 1975–1984 were investigated in detail. It became clear that pulmonary complications and anastomotic leakage were the two major complications related to operative mortality. The former has decreased by intensive postoperative care with strong emphasis on cough dynamics, and the latter because of the long gastric tube we devised and which has a good blood supply. These positive events make feasible early postoperative irradiation and cancer chemotherapy.
    Materialart: Digitale Medien
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  • 7
    ISSN: 1436-2813
    Schlagwort(e): hyperthermia with chemotherapy ; esophageal cancer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A 66-year-old man with multiple malignant lesions of the esophagus, as apparently induced by irradiation of 60 Gy of60Co for a mediastinal tumor at the age of 36 y.o., was a poor operative risk because of severe lung disease. This man was treated with a combination of hyperthermia, oral administration of oil Bleomycin-polyacrylate paste and intravenous infusion of cis-Platinum. During 20 administrations of hyperthermia conducted at 42–45°C for 30 min, 600 mg of oil Bleomycin and 200 mg of cis-Platinum, no complications occurred and the heat treatments were completed with no side effects. Repeatedly performed esophagogram and endoscopy showed a complete disappearance of three of the four lesions and a marked regression in the other one. There has been no regrowth or distant spread of the carcinoma up to the present 10 months of follow up. This combination of hyperthermia and chemotherapy may prove to be the optimal strategy for treatment of unresectable esophageal cancer, particularly when radiotherapy is contraindicated.
    Materialart: Digitale Medien
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  • 8
    ISSN: 1436-2813
    Schlagwort(e): carcinoembryonic antigen ; gastric cancer ; recurrence
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In an attempt to assess the usefulness of carcinoembryonic antigen (CEA) for predicting the progression of gastric cancer, CEA productivity was evaluated according to serum CEA levels, at the time of recurrence or relapse. In cases of a recurrence, abnormal CEA levels were observed in 14 of 17 (82.4 per cent) with differentiated carcinoma and in 9 of 21 (42.9 per cent) with undifferentiated carcinoma. Preoperative abnormal CEA levels were observed in only 6 of 41 patients (14.6 per cent). A median lead time of manifestation of recurrence was 5 months. In those with relapse, 9 of 11 (81.8 per cent) patients with differentiated carcinoma and 13 of 18 (72.2 per cent) with an undifferentiated carcinoma had abnormal CEA levels. Preoperative abnormal CEA levels were observed in 24 of these 89 patients (27.0 per cent). Postoperative monitoring of CEA seems to be useful for early recognition of gastric cancer progression, irrespective of the preoperative CEA levels.
    Materialart: Digitale Medien
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  • 9
    ISSN: 1436-2813
    Schlagwort(e): DNA analysis ; early gastric cancer ; prognosis ; growth pattern
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Cell nuclear DNA content was microspectophotometrically measured in 70 patients with a gastric carcinoma lesion of less than 4.0 cm in diameter and with mucosal or minimal submucosal invasion. Two groups were prepared; low ploidy and high ploidy, according to the degree of dispersion on the DNA histogram. Twenty-four cases of high ploidy were reviewed from the aspects of clinicopathology and prognosis and the findings compared with data on 46 of low ploidy. The high ploidy group was characterized by an elevated lesion and a differentiated carcinoma while the low ploidy group had a depressed lesion and an undifferentiated carcinoma Postoperative recurrence was confirmed in none of the low ploidy cases and 2/24 of the high ploidy cases. The five and ten-year survival rates of the patients with high ploidy were 100 per cent and 91.1 per cent, respectively. Compared to the finding that patients with submucosal carcinoma of high ploidy survived at a rate of only 64.8 per cent in the 5-year follow-up, efforts should be directed toward a higher detection of gastric carcinoma with aneuploidy at the stage limited to within the intramucosal layer. Endoscopic treatment for early gastric carcinoma is not recommended, especially for a differentiated carcinoma, even if the invasion is confined to the mucosa, since it may include aneuploid carcinoma.
    Materialart: Digitale Medien
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  • 10
    ISSN: 1436-2813
    Schlagwort(e): DNA pattern ; growth pattern ; malignancy ; early gastric carcinoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A cytophotometric DNA analysis was made of gastroendoscopically biopsied materials of 43 patients with early gastric carcinoma and the data were compared with the DNA patterns of the resected specimens of these patients. The DNA patterns could be classified into two types, Low Ploidy and High ploidy, according to the degree of dispersion of the DNA value. The Ploidy to Ploidy coincidence of the DNA patterns between biopsied material and the resected specimen in the same lesion was noted in 93 per cent (39/42). The DNA patterns of the resected specimens were consistent in the majority of cases, regardless of the areas examined, center or periphery, and mucosa or submucosa of the same lesion. This study provides evidence that a highly malignant type of early gastric carcinoma, Pen A type, could be differentiated in gastroendoscopically biopsied materials by a cytophotometric DNA analysis.
    Materialart: Digitale Medien
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