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  • 1
    Electronic Resource
    Electronic Resource
    Centroblastic lymphoma of the thyroid supervening long-lasting chronic lymphocytic leukemia (B-CLL) demonstration of biclonality by Immunohistochemical and gene rearrangement analysis (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 736-742 
    Details
    ISSN: 1432-1440
    Keywords: Thyroid lymphoma ; B-CLL ; Centroblastic lymphoma ; Immunohistochemistry ; Gene rearrangement analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 67-year-old woman suffering since 5 years from a so far nontreated B-CLL underwent hemithyroidectomy for a rapidly enlarging tumor. Histologically, the coincidence of a centroblastic lymphoma and thyroidal infiltration by the CLL was diagnosed. Immunohistology revealed typical immunoprofils for both, B-CLL and centroblastic lymphoma on the background of B cell differentiation antigens. The bitypical immunoglobulin light chain expression — λ on the B-CLL cells and κ on the centroblasts — suggested biclonality. This was confirmed by gene rearrangement analysis of peripheral leukemia cells and tumor tissue. Thus, the final diagnosis of a primary thyroidal lymphoma of the centroblastic type (stage IE) arising independently from a preexisting B-CLL was achieved. Consequently, the patient received local radiotherapy. In our opinion, the designation “Richter's Syndrome”, readily applied in the literature, is inappropriate for this tumor constellation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726417
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  • 2
    Electronic Resource
    Electronic Resource
    Thymic hyperplasia (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 49-52 
    Details
    ISSN: 1432-1440
    Keywords: Thymic hyperplasia ; Numeric thymic hyperplasia ; Thymic rebound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The condition of true thymic hyperplasia is defined as an increase of both size and weight of the gland while it maintains normal microscopic architecture. It occurs in three different clinicopathologic forms: (1) True thymic hyperplasia without any other disease is extremely rare and only seven well documented examples could be found in a review of the literature. (2) Enlargement of the thymus gland is reported as a form of rebound phenomenon in a number of conditions like recovery from severe stress situations, after administration of steroids, and after treatment of malignant tumors. (3) Finally, thymic hyperplasia has been described in association with endocrine abnormalities, sarcoidosis, and Beckwith-Wiedeman syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745472
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  • 3
    Electronic Resource
    Electronic Resource
    Thymic hyperplasia (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 53-60 
    Details
    ISSN: 1432-1440
    Keywords: Thymic hyperplasia ; Lymphofollicular hyperplasia of the thymus ; Immunohistology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The so-called lymphofollicular hyperplasia, which is caused by the occurrence of hyperplastic lymph follicles within the organ, is constantly associated with autoimmune diseases (e.g., myasthenia gravis) and in rare instances with malignant tumors. The architecture of lymphofollicular hyperplasia was studied immunohistochemically using antibodies against epithelial, vascular, lymphocytic, and histiocytic antigens. There is evidence, that the configuration, microtopography, cellular composition, and immunohistological findings of the lymph follicles with germinal centers in the myasthenic thymus are essentially the same as in those occurring in lymph nodes and in other lymphatic tissue. Furthermore it could be shown that the follicles originate in the interlobular septal space and displace the thymic parenchyma by extension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745473
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  • 4
    Electronic Resource
    Electronic Resource
    Kinetic oscillations in the catalytic CO oxidation on Pt(100): Periodic perturbations (1987)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 87 (1987), S. 742-749 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Periodic modulations of oxygen pressure or temperature were applied in the catalytic oxidation of CO on a Pt(100) surface under isothermal, low pressure conditions. Transitions from aperiodic autonomous oscillations to regular phase-locked behavior could be observed. Computer simulations using a stochastic cellular automaton model yielded qualitatively similar results. The spatial distribution in both experiment and simulation varies essentially in phase over the whole surface area under the influence of the periodic perturbation, while wave propagation in the autonomous system causes more irregular overall behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.453572
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  • 5
    Electronic Resource
    Electronic Resource
    Kinetic oscillations in the catalytic CO oxidation on Pt(100): Computer simulations (1986)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 85 (1986), S. 5328-5336 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The previously observed phenomena of temporal and spatial self-organization during the catalytic oxidation of CO on a Pt(100) surface were computer simulated by use of the cellular automaton technique. The underlying model is footed on the knowledge about the individual reaction steps (adsorption, desorption, surface structural transformation, etc.), which in turn formed the basis of a previous theoretical treatment in terms of the formulation and solution of a set of coupled differential equations. The present result nicely show the formation and propagation of two-dimensional patterns, and they reproduce qualitatively well all the experimental observations. The development of macroscopic patterns even with an a priori perfectly homogeneous surface is a particularly interesting effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.451676
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  • 6
    Electronic Resource
    Electronic Resource
    Mechanisms of spatial self-organization in isothermal kinetic oscillations during the catalytic CO oxidation on Pt single crystal surfaces (1989)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 90 (1989), S. 510-521 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The rate of catalytic CO oxidation on Pt(100) and (110) surfaces at low pressures (≤10−4 Torr) and under isothermal conditions may exhibit sustained temporal oscillations which are coupled with periodic transformations of the surface structures between reconstructed and nonreconstructed phases, the latter exhibiting higher oxygen sticking coefficients and hence higher reactivity. With Pt(100) the two surface phases exhibit a much larger difference in reactivity (=oxygen sticking coefficient) than with Pt(110), which effect accounts for the qualitative differences in the oscillatory behavior: if two of the control parameters (say pO2, T) are kept fixed, the third (pCO) may be varied with Pt(100) over a fairly wide range without leaving the oscillatory region. Minor (〈1%) fluctuations of the partial pressures associated with the varying reaction rate are hence without any noticeable effect. Coupling between surface reaction and diffusion causes wave propagation of the surface phase transformations and therefore spatial self-organization, as demonstrated by scanning LEED experiments. With Pt(110), on the other hand, the oscillatory region is very narrow. In this case mass transport through the gas phase as caused by the small pressure variations associated with the reaction lead to synchronization between different parts of the surface. Computer simulations with the cellular automaton technique confirm qualitatively the experimental findings and support the conclusions reached.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.456501
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  • 7
    Electronic Resource
    Electronic Resource
    THE INFORMATION CONTENT OF CORPORATE DISCLOSURES OF DIVISIONALIZATION DECISIONS [1] (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of management studies 22 (1985), S. 0 
    Details
    ISSN: 1467-6486
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-6486.1985.tb00078.x
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  • 8
    Electronic Resource
    Electronic Resource
    Expression of cortical and medullary thymic epithelial antigens in thymomas. An immunohistological study of 14 cases including a characterization of the lymphocytic compartment (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 14 (1989), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Four monoclonal antibodies against antigens expressed differentially by the normal thymus epithelium, which define the cortical, medullary and subcapsular compartments, were used for immunohistological characterization of the epithelial cells in 14 thymomas. Furthermore, thymoma-associated lymphocytes were studied with monoclonal antibodies directed against T-lymphocyte differentiation antigens (CD1a, CD3, T-cell antigen receptor). Only four of the 14 thymomas could be classified into either medullary or cortical type thymoma based on the immunophenotype of epithelial cells. Ten cases escaped immunophenotypical classification due to co-expression of medullary and cortical antigens by the tumour cells. This aberration from the normal phenotype might indicate the failure of differentiation of such tumours. The immunophenotype of the associated lymphocytes, on the other hand, made it possible to classify the tumours as cortical (5 cases), mixed (2) and medullary (3) thymomas. Four thymomas escaped this classification scheme due to the absence of lymphocytes (2) or to a hybrid immunophenotype (2). Nevertheless, thymocytes of cortical type clearly predominated and were seen in all thymomas with associated lymphocytes. This feature may constitute a good diagnostic tool in differential diagnosis since, in 28 mediastinal or extramediastinal metastasis of tumours not derived from thymic epithelium and associated with various numbers of lymphocytes, none of them were found to contain CD1a positive lymphocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1989.tb02181.x
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  • 9
    Electronic Resource
    Electronic Resource
    The dependence of partition coefficients on differences of ionic volumes in crystal-melt systems (1988)
    Springer
    Contributions to mineralogy and petrology 99 (1988), S. 62-69 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Plots of partition coefficients versus differences of ionic volumes have been constructed from reported values in olivine-, pyroxene-, hornblende-, biotite-, and plagioclase-groundmass systems. The trend behaviour of partition coefficients as a function of the differences of ionic volumes is largely mineralogically controlled. The slopes of the trend lines can be related to the volume work resulting either from (i) expansion of the host lattice surrounding the substituting ions or (ii) collapse of the surrounding lattice if small ions are incorporated. When the volume work is in the order of the enthalpy of melting, ion selectivity ceases. If melts change from basic to highly acidic the chemical control of element partitioning by complex formation in the fluid phase is recognizable. Mineralogical versus chemical control is discussed by means of the trends of the partition coefficients of REE. The proposed ln D vs. Δr 3 plots improve the physical interpretation of element partition, delineates methods for interpolation or extrapolation of unknown data. Deviations of extreme data from linear relations demonstrate the constraints of our knowledge on diadochy. Rules of element partition as recently proposed by Philpotts (1978) are critically discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00399366
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  • 10
    Electronic Resource
    Electronic Resource
    Evidence for an osteoblast-activating factor in a patient with peripheral T-cell lymphoma and osteosclerosis (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 402-407 
    Details
    ISSN: 1432-1440
    Keywords: T-cell lymphoma ; Osteosclerosis ; Lymphokines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A patient with peripheral T-cell Lymphoma and aquired, systemic osteosclerosis is described. Bone histology showed a spectacular activation of osteoblasts accompanyed by massive new bone formation. Alkaline phosphatase in serum was elevated and increased to 〉2000 U/l when the lymphoma became refractory to chemotherapy. In the patient's serum an osteoblast-activating factor could be demonstrated using a rat osteogenic osteosarcoma cell line (ROS 17/2.8). The factor was absent during remission of the tumor. We conclude that osteosclerosis was a paraneoplastic syndrome in this patient due to the secretion of an osteoblast-stimulating factor by the T-cell lymphoma. This situation is similar to the secretion of osteoclast-activating factors described in B-cell lymphomas, particularly multiple myeloma. The characterization of such a factor could be of therapeutic relevance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711269
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