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  • 1
    Electronic Resource
    Electronic Resource
    Excitatory effect of histamine on EEGs of the cortex and thalamus in rats (1989)
    Springer
    Inflammation research 27 (1989), S. 127-130 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract When low frequency electrical stimulations were repeatedly applied to the rat midbrain reticular formation, the EEG spectral power recorded at the cortex and thalamus increased markedly, especially in the low frequency bands (0–6 Hz). The intraventricular administration of histamine (Hi) inhibited this increase. Hi-induced inhibition was antagonized by simultaneous injection of an equimolar dose of either pyrilamine or diphenhydramine, but not by that of cimetidine. In accordance with this, 2-methylHi decreased the power in the slow wave region, while 4-methylHi was not effective. It was assumed that the EEG arousal effect of Hi is exerted via H1 receptors but not related to H2 receptors. Adverse effects of H1 blockers on the brain, such as drowsiness, may be produced as a consequence of this inhibitory action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02222218
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  • 2
    Electronic Resource
    Electronic Resource
    The second nation-wide survey in Japan of vitamin K deficiency in infancy (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 472-477 
    Details
    ISSN: 1432-1076
    Keywords: Vitamin K deficiency ; Intracranial haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Throughout Japan a total of 543 cases of vitamin K deficiency occurring in infants over 2 weeks of age were reported from January 1981 to June 1985. Of these cases, 427 showed no obvious reasons for vitamin K deficiency; this sort of case is known as “idiopathic vitamin K deficiency in infancy”. Another 57 cases had bleeding episodes due to vitamin K deficiency associated with obvious hepatobiliary lesions, chronic diarrhoea, long-term antibiotic therapy, etc; this sort is called “secondary vitamin K deficiency in infacy”. The third group, consisting of 59 cases, was made up of the socalled “near miss” type, in which a haemorrhagic tendency, without any obvious clinical haemorrhage, was discovered by Normotest, at the time of mass screening in most cases. In the idiopathic group, 269 cases (63.0%) developed bleeding episodes between the 1st and 2nd months of age, and 387 cases (90.0%) were entirely breast-fed. Intracranial baemorrhage was observed in 353 cases (82.7%) of this group. Moreover, slight elevation of serum transaminase and direct type bilirubin levels were observed in the idiopathic group. Liver dysfunction of unknown origin may play some role in the onset of vitamin K deficiency in infancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441969
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  • 3
    Electronic Resource
    Electronic Resource
    Microsurgical anatomy around the origin of the ophthalmic artery with reference to contralateral pterional surgical approach to the carotid-ophthalmic aneurysm (1985)
    Springer
    Acta neurochirurgica 76 (1985), S. 82-89 
    Details
    ISSN: 0942-0940
    Keywords: Microsurgical anatomy ; ophthalmic artery origin ; carotid-ophthalmic aneurysm ; contralateral pterional approach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The supraclinoid segments of the internal carotid artery (ICA) and their surrounding structures were examined under magnification in 25 adult cadavers. Attention was paid to anatomical variations and relationships concerning ipsilateral and contralateral pterional microsurgical approaches to these regions, especially to the origin of the ophthalmic artery. Eighty-four percent of the ophthalmic arteries arose from the supraclinoid segment of the ICA. In the ipsilateral pterional approach, mobilization of the ipsilateral optic nerve was required to see the origin of the ipsilateral ophthalmic artery and the medial aspect of the proximal portion of the supraclinoid segment of the ICA. In the contralateral pterional approach, on the other hand, these areas on the contralateral side could be identified under the optic nerve with minimal or without retraction of the contralateral optic nerve. This was because 71% of the ophthalmic arteries arose from the supero-medial aspect of the ICA, and because there was nothing to intercept the view of the medial aspect of the ICA under the optic nerve. This study supports the usefulness of the contralateral pterional approach to the origin of the ophthalmic artery and the medial aspect of the supraclinoid segment of the ICA. This approach could be useful in certain cases of carotid-ophthalmic aneurysm. The authors' experience with the contralateral pterional approach to carotid-ophthalmic aneurysms is also described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01418465
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  • 4
    Electronic Resource
    Electronic Resource
    Fokker–Planck calculation of hot electron buildup in the thermal barrier region of a tandem mirror (1987)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 30 (1987), S. 1142-1151 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The hot electron buildup by second harmonic electron cyclotron resonance heating in the thermal barrier region of a tandem mirror has been studied by using a Fokker–Planck code with a self-consistent potential profile taken into account. It has been found that the evolution of the hot electron population and the potential profile consists of two phases. In the first phase the rf diffusion is dominant and a quick increase in both the hot electron density and the mean energy is observed. No further increase in the mean energy is observed thereafter. The potential is deepest during the first phase. The second phase starts in the mean free time of the pitch angle scattering of hot electrons on cold electrons and ions. In this phase the hot electron population increases at the rate of the pitch angle scattering. The potential dip becomes shallow because of the accumulation of pitch-angle-scattered passing ions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.866313
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  • 5
    Electronic Resource
    Electronic Resource
    Deposition of a Si monolayer on sapphire using an ArF excimer laser for Si epitaxial growth (1988)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 64 (1988), S. 2087-2091 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Si monolayer deposition on sapphire substrates was investigated by in situ x-ray photoelectron spectroscopy (XPS). Si deposition was carried out using direct photolysis of Si2H6 by irradiation of 193 nm ArF excimer laser light (1–2 W/cm2 , 70 Hz) at room temperature in a high-vacuum chamber. At first, decomposed Si atoms bound strongly with O atoms on sapphire until the entire sapphire surface was covered, then SiSi bonds were formed. From the growth mode analysis of the early stage of Si deposition, it can be seen that the growth mode of the deposited layer is a layer-by-layer mode (the Frank–Van der Merwe-type growth). The thickness of the deposited Si layers can be controlled on an atomic scale. As these features are suitable for Si-on-sapphire (SOS) epitaxial growth with predeposited layers, SOS epitaxial growth was demonstrated and the SOS films were characterized by replica electron microscopy and fabricating a metal-oxide-semiconductor field-effect transistor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.341717
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  • 6
    Electronic Resource
    Electronic Resource
    Development of cell systems to study viral gene transcription at the initial phase of Epstein-Barr virus infection (1987)
    Springer
    Virus genes 1 (1987), S. 73-82 
    Details
    ISSN: 1572-994X
    Keywords: EBV ; gene expression ; immortalization ; cDNA cloning ; Northern blot hybridization ; tonsil lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two infection systems have been introduced in order to study viral gene expression at the initial period of Epstein-Barr virus (EBV) infection which leads to immortalization. The data indicate that major viral gene expression in tonsil lymphocytes at 2 days post-infection (p.i.) with EBV is very similar to that observed in latently infected cells. Both tonsil lymphocyte and BJAB cell (lymphoblastoid cells free of EBV genome) infection with EBV induced similar viral gene transcription. Twelve cDNA clones were prepared from poly(A) RNA of tonsil lymphocytes infected with EBV 2 days p.i. by hybridization with BamHI fragments of EBV DNA. Some cDNAs were derived from primary transcripts of the BamHI-WYHK region, suggestive of splicing of a large transcript. It is possible that a number of cDNA clones may be derived from cellular genes. The derivation of these cDNA clones is being studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00125687
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  • 7
    Electronic Resource
    Electronic Resource
    Quantitation of specific binding of erythropoietin to human erythroid colony-forming cells (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 137 (1988), S. 337-345 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Highly purified human erythroid colony-forming cells (ECFC), which consist predominately of colony-forming units-erythroid (CFU-F), were prepared from human blood and used to study the binding and processing of erythropoietin (Ep). When radioiodinated human recombinant Ep (125I-rEp) was incubated with these cells, binding was specific and saturable. Specific binding was directly proportional to cell concentration and did not occur with other human cells. Saturation of specific binding at 3°C occurred at 1 nM (3.9/U/ml), and Scatchard analysis revealed two classes of binding sites on the cell surface. Of a total of 1,050 binding sites per ECFC, one-fifth had a Kd of 0.10 nM, while the remainder had a Kd of 0.57 nM. Specific binding was twofold greater at 37°C than at 3°C, and removal of surface-bound Ep with acid indicated that 125I-rEp was internalized into the cells after incubation at 37°C. Further incubation at this temperature showed a decline of cellular radioactivity, with a release of small molecular weight degradation fragments into the medium. These studies demonstrate two classes of receptors for Ep on normal human ECFC. Internalization and degradation of EP occur, and the biologic effect of the hormone is produced by a small number of Ep molecules, as demonstrated in murine erythroid progenitor cells.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041370218
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