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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Langmuir 5 (1989), S. 1326-1331 
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 146 (1987), S. 531-532 
    ISSN: 1432-1076
    Keywords: Varicella ; Thrombocytopenia ; Gamma globulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thrombocypenic purpura was noted in a 3-year-old Japanese girl with an active varicella infection. The administration of intravenous gamma globulin (IVG) drastically improved bleeding manifestations as well as the active varicella infection. We believe that IVG should be the first choice of therapy for thrombocytopenic purpura associated with active infections.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 146 (1987), S. 601-602 
    ISSN: 1432-1076
    Keywords: Facial palsy ; Kawasaki disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of facial palsy was reported initially in 1974 by Murayama [8] as one of the neurological manifestations in Kawasaki disease. Thereafter, an additional nine case have been documented in Japan. This facial palsy, in the revised “Diagnostic Guideline of Kawasaki Disease” released in 1984, has been added recently as one of the neurological signs and symptoms of Kawasaki disease. This is a report on two cases of Kawasaki disease showing facial palsy with indurative oedema during their clinical course, and also a clinical review of the ten previously reported cases of facial palsy complicating Kawasaki disease.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 148 (1989), S. 525-526 
    ISSN: 1432-1076
    Keywords: Systemic lupus erythematosus ; Crohn disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 15-year-old girl with systemic lupus erythematosus (SLE) in remission for 3 years showed abdominal pain and bloody stools. No evidence for exacerbation of SLE was obtained. An air-contrast barium enema examination and colonoscopy revealed findings typical of Crohn disease. Despite the rarity of the combination, patients with SLE showing gastrointestinal manifestations might need evaluation for Crohn disease.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1076
    Keywords: Systemic lupus erythematosus ; Activated T cells ; Human leukocyte antigens-DR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Correlation between T cell phenotypes, especially activated T cells expressing early (EA1) and late (HLA-DR) activation antigens and clinical features were investigated in 22 patients with systemic lupus erythematosus (SLE) of childhood onset. Percentages of T cells expressing EA1 and HLA-DR in 22 patients with SLE were significantly higher than those in controls. Comparison of T cell phenotypes between patients with active and inactive SLE showed that eight patients with active disease had significantly increased percentages of HLA-DR positive T cells than 14 with inactive disease (P〈0.01). Serial examinations showed that the percentages of HLA-DR positive T cells were decreased after therapy in seven with active non-renal or active non-renal and renal diseases but not in one with only active renal disease. A possible significance of T cells expressing EA1 and HLA-DR in the management of patients with SLE is discussed.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 149 (1989), S. 18-19 
    ISSN: 1432-1076
    Keywords: Plasma renin activity ; Plasma aldosterone concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Infants and toddlers often start crying at venopuncture and the stress of crying has been known to increase the levels of plasma renin activity (PRA) and plasma aldosterone concentration (PAC), but no precise information is available. We measured the levels of PRA and PAc in blood samples taken from 30 infants and toddlers within 1 min after the onset of crying, as induced by venopuncture, and 3 and 5 min after continuation of crying (PRA1.0, PRA3.0, PRA5.0, and PAC1.0, PAC3.0, PAC5.0). The age of these subjects ranged from 1 to 30 months (median 16 months). PRA1.0, PRA3.0 and PRA5.0 were 4.0±1.8 ng/ml per hour, 5.5±2.7 ng/ml per hour, and 7.8±4.2 ng/ml per hour, respectively. PAC1.0, PAC3.0 and PAC5.0 were 210±110 pg/ml, 231±118 pg/ml and 269±145 pg/ml, respectively. Both PRA and PAC increased with elapsing time. The increase in PRA was marked after a short episode of crying, but that in PAC was of a mild degree.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1076
    Keywords: Protein phosphorylation ; Neutrophil ; Chronic granulomatous disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The phosphorylation and dephosphorylation of proteins in neutrophils from normal children and patients with chronic granulomatous disease (CGD) were studied with two-dimensional gel electrophoresis and autoradiography, followed by densitometric scanning. In normal neutrophils the radio-activities of 11 spots among approximately 50 radioactive spots were changed by stimulation with phorbol 12-myristate 13-acetate (PMA) and 6 of the 11 spots were also changed by stimulation with N-formyl-methionyl-leucyl-phenylalanine (FMLP) and NaF. The phosphorylation of only two spots (Mr=48000 and 62000) was inhibited by 2-deoxyglucose and N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide (W-7), which inhibits superoxide production, while it was not affected by dibutyryl cAMP, KCN and ethyleneglycol-bis-(β-aminoethylether)-N,N′-tetraacetic acid (EGTA), which do not affect superoxide production. The observation indicates that the Mr=48000 and 62000 proteins may be involved in the activation process of superoxide production. When the neutrophils of four male and two female CGD patients were examined, the changes in 11 spots on stimulation were similar to those of normal children, indicating that the (de)phosphorylation of the proteins which seems to be involved in the activation process is not affected in CGD neutrophils.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 145 (1986), S. 401-402 
    ISSN: 1432-1076
    Keywords: Concentration ; pH ; Phenobarbital ; Saliva ; Serum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty epileptic children taking phenobarbital (PB) were evaluated for the concentration of PB in their saliva (Sa), total serum concentration (TS), free serum concentration (FS), and also the pH of the saliva samples. The Sa/TS ratio was 43.0±5.2% (mean±SD), and showed a close relationship between the two (r=0.98). The free serum concentrations for PB were also observed to be closely correlated to the saliva concentration (r=0.99), as well as to the total serum concentration, with the FS/TS ratio being 45.0±5.6%. However, no obvious relationship between the salivary pH and the Sa/TS ratio for PB was observed. This suggested the usefulness of monitoring the PB saliva concentrations in clinical management of epilepsy.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 147 (1988), S. 516-517 
    ISSN: 1432-1076
    Keywords: C7 deficiency ; haematuria ; Chronic glomerulonephritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 14-year-old boy had persistent haematuria along with complete C7 deficiency. No significant changes in glomeruli and tubules were found in a renal biopsy specimen by light microscopy and immunofluorescence gave negative results for immune deposits. Electron microscopic examination demonstrated an attenuation of the glomerular capillary basement membrane without lamination and a diagnosis of thin basement membrane disease was made. It would be difficult to conclude that patients with C7 deficiency were predisposed to develop glomerulonephritis caused by immunologic aberrations. A family study failed to provide evidence of an association of C7 deficiency and thin basement membrane disease.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1076
    Keywords: Kawasaki disease ; Thrombocytopenia ; Aneurysm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thrombocytopenia was observed in 10 (2.0%) of 486 children with Kawasaki disease. In nine of the ten, the minimal paltelet count of 94000±38000 (SD)/mm3 was seen on day 6.8±2.2 (SD) of illness and the platelet counts were elevated to the normal level in 1–2 weeks. Thrombocytopenia in the nine appeared to be caused via coagulation-mediated platelet consumption, while the remaining child was diagnosed as having idiopathic thrombocytopenic purpura. One of the two who had severe coagulation-mediated thrombocytopenia of less than 50000/mm3 developed coronary aneurysms persisting over 1 year.
    Type of Medium: Electronic Resource
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