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  • 1
    Electronic Resource
    Electronic Resource
    Platelet factor 4 and the response to plasma exchange in the treatment of thrombotic thrombocytopenic purpura (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 551-555 
    Details
    ISSN: 1432-1440
    Keywords: Thrombotic thrombocytopenic purpura ; Plasma exchange ; Platelet factor 4
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report two patients with thrombotic thrombocytopenic purpura who were subjected to plasma exchange. In one case, the plasma levels of platelet factor 4, measured shortly after plasma exchange, increased significantely during plasma exchange. This was followed, however, by a failure to respond to therapy. Repeated plasmapheresis over 3 weeks gave no therapeutic benefit and reversible deep coma occurred. This patient recovered completely after treatment with vincristine. In the second patient, a decline in platelet factor 4 was observed after plasma exchange. This was accompanied by improvement of the patient's condition and a slow rise in platelet count. Plasma exchange was again carried out in this patient because of a recurrence of thrombotic thrombocytopenic purpura 3 years later; again decreased platelet factor 4 plasma levels were observed after plasma exchange and again a therapeutic response followed. Platelet factor 4, therefore, seems to be an effective and early index for the therapeutic benefit of plasma exchange in thrombotic thrombocytopenic purpura.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01719782
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  • 2
    Electronic Resource
    Electronic Resource
    Electron microscopy of defects and disorder in BaGa12O19 (1985)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 41 (1985), S. 108-112 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108768185001720
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  • 3
    Electronic Resource
    Electronic Resource
    Repeated high-dose cyclophosphamide administration in bone marrow transplantation: exposure to activated metabolites (1987)
    Springer
    Cancer chemotherapy and pharmacology 20 (1987), S. 248-252 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Blood levels of cyclophosphamide (CP) and activated metabolites were measured in 11 patients undergoing a 2- to 4-day conditioning chemotherapy for bone marrow transplantation. Urinary excretion of CP was determined in five patients. CP half-life decreased after pretreatment from an average of 7.1 h on the 1st day to 5.5 h on the 2nd day (P〈0.005) and to 4.3 h on the 4th day (P〈0.005). No characteristic changes in urinary excretion could be observed. At the same time the exposure to nonprotein-bound activated metabolites increased from 10.5 to 19.5 and 26.0 nmolxh/ml respectively (P〈0.005 andP〈0.04). Thus, in contrast to in vitro and animal studies, no evidence for an inhibition of activating enzymes could be found. On the contrary, pretreatment seems to enhance the production of the cytotoxic metabolites. The possible explanation of these changes by enzyme induction and by the role of saturated protein binding sites is discussed. Exposure to active metabolites might be altered by dose splitting or even by a change in the duration of the infusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00570495
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  • 4
    Electronic Resource
    Electronic Resource
    Alkylating activity in serum, urine, and CSF following high-dose ifosfamide in children — a comment (1989)
    Springer
    Cancer chemotherapy and pharmacology 24 (1989), S. S7 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253228
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  • 5
    Electronic Resource
    Electronic Resource
    Influence of mesna and cysteine on the systemic toxicity and therapeutic efficacy of activated cyclophosphamide (1987)
    Springer
    Journal of cancer research and clinical oncology 113 (1987), S. 160-165 
    Details
    ISSN: 1432-1335
    Keywords: Activated cyclophosphamide ; Thiols-Mesna ; Mouse model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Presumably the coadministration of the uroprotector mesna in cyclophosphamide treatment does not influence the systemic activity of its activated metabolite. This was newly investigated in a mouse model. The LD50 values of i.p. administered mafosfamide, a derivative of act. CP, were increased by the simultaneous i.p. administration of mesna (mafosfamide: mesna 1: 2 on a molar weight basis) from 590 mg/kg to 750 mg/kg, and after i.v. injection of cytostatic and thiol from 505 mg/kg to 810 mg/kg. Administration of 2 × molar cysteine i.v. or i.p. to mafosfamidetreated animals was even more effective against its lethal toxicity (LD50 i.p. 1800 mg/kg and i.v. 1130 mg/kg). Bone marrow toxicity (severe leukocytopenia) was partially abolished by both thiols. Also the therapeutic efficacy of act. CP against L1210 leukemia in DBA2 mice was reduced by 50% in the presence of cysteine and of mesna. Compared with mesna the higher detoxification effect of cysteine is attributed to its longer half-life (t 1/2 20 min vs 12 min of mesna) and presumably an accumulation of cysteine in some cell systems (distribution coefficient 1.20 ml/g vs 0.68 ml/g of mesna). Nevertheless, our study clearly demonstrates a distinct systemic deactivation of act. CP by mesna, which might be of clinical relevance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391439
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  • 6
    Electronic Resource
    Electronic Resource
    On the directional sensitivity of hot-wires: a new look at an old phenomenon (1988)
    Springer
    Experiments in fluids 6 (1988), S. 553-560 
    Details
    ISSN: 1432-1114
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The directional response of a constant temperature hotwire anemometer to variations in pitch and yaw is reviewed, and a new data reduction technique for obtaining velocity vector data in a steady flow is described. Sequential sampling of the signal as the probe shaft is rotated through 360° provides data to yield a three-dimensional velocity vector. Jorgensen's expression was found to be suitable for the data reduction using independently measured pitch and yaw coefficients. Within the range of velocity and flow direction investigated, the velocity magnitude and direction can be determined to within 2% and 2° respectively if the yaw coefficient is neglected. This measurement method is currently being used to determine velocity distributions on the intake-valve/cylinder boundary for different induction system designs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00196602
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of fosfomycin, mesna, and sodium thiosulfate on the toxicity and antitumor activity of cisplatin (1988)
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 497-501 
    Details
    ISSN: 1432-1335
    Keywords: Cisplatin ; Fosfomycin ; Mesna ; Sodium-thiosulfate ; Detoxification ; Antitumor effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fosfomycin and mesna were investigated in rats and mice concerning their detoxifying effects on cisplatin toxicity in comparison to sodium thiosulfate, a known protector against cisplatin nephrotoxicity. After separate i.p. injection of cisplatin and fosfomycin (500 mg/kg) or mesna (800 mg/kg) a slight increase in the 50% lethal dose of cisplatin was found in all animals. In mice sodium thiosulfate proved to be far more effective in preventing lethal toxicity and nephrotoxicity as measured by blood urea nitrogen increase. Fosfomycin and mesna were almost without influence on cisplatin treatment of L-1210 leukemia whereas their inhibition of the antitumor effect against S-180 ascites sarcoma (increase of in cisplatin dose to cure 50% of animals from 2.0 mg/kg to 3.5/4.7 mg/kg cisplatin) was similar to thiosulfate, which showed a strong inhibiting effect in the treatment of both tumors. In rats fosfomycin distinctively reduced the antitumor efficacy of cisplatin against Yoshida ascites sarcoma. Thus the concurrent injection of fosfomycin and mesna reduced both the toxicity and the antitumor activity of cisplatin. Therefore their simultaneous administration in addition to cisplatin via the same injection route should be avoided. Due to the weak detoxifying efficacy of fosfomycin and mesna they cannot be used instead of sodium thiosulfate for renal protection against cisplatin toxicity in local i.p. treatment modalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391499
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  • 8
    Electronic Resource
    Electronic Resource
    Distribution of albumin in normal and regenerating livers of mice (1985)
    Springer
    Histochemistry and cell biology 83 (1985), S. 165-169 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The conditions affecting the immunohistochemical identification of albumin in livers of male NMRI-mice were investigated by light microscopy. In normal livers albumin is randomly distributed, revealing a pancytoplasmic nearly homogen reaction in groups of hepatocytes or single parenchymal cells. However, combined autoradiographic studies after pulse labelling with 3H-valin and perfusion experiments with human albumin indicate that this distribution is caused by albumin from blood plasma and does not reflect true protein synthesis. After perfusion of the livers followed by immunohistochemical amplification techniques which allowed to dilute the primary antibody up to 1:30,000, albumin could be detected nearly in all liver parenchymal cells as granular deposits decreasing in its density from periportal fields towards the terminal hepatic venules. In regenerating livers due to partial hepatectomy no remarkable differences in granular albumin deposits between G1- and S-phase of the cell cycle could be detected as was demonstrated by combined immunohistochemistry and 3H-dThd-autoradiography. However, during mitosis the content of albumin was often considerably reduced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00495148
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  • 9
    Electronic Resource
    Electronic Resource
    Translocation of c-abl oncogene and PDGFB (c-sis) gene in a case of CML with 46, XY, t(22;22) (1989)
    Springer
    Annals of hematology 58 (1989), S. 279-285 
    Details
    ISSN: 1432-0584
    Keywords: Variant Philadelphia translocation ; PDGFB ; CML ; c-abl
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a case of CML with a variant Philadelphia translocation (Ph1 or Ph) t (22;22) (q11;q13) in bone marrow cells and unstimulated peripheral blood cells, no cytogenetically detectable involvement of chromosome 9 was observed. Southern blot experiments using probes specific for bcr and c-sis however revealed rearrangement of the bcr, but not of PDGFB (c-sis) gene. Northern blot analysis of bone marrow RNA showed a very weak signal with the c-sis probe, while in a lymph-node biopsy PDGFB m-RNA could not be detected. Chromosomal in situ hybridization gave evidence for translocation of c-abl from chromosome 9 to Ph and of PDGFB from chromosome 22 to chromosome 9, as the result of a threefold translocation t(9;22;22).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320166
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  • 10
    Electronic Resource
    Electronic Resource
    Exercise versus immersion: antagonistic effects on water and electrolyte metabolism during swimming (1988)
    Springer
    European journal of applied physiology 57 (1988), S. 248-253 
    Details
    ISSN: 1439-6327
    Keywords: Aldosterone ; Antidiuretic hormone ; Blood volume ; Kidney
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Changes in blood composition, renal function, aldosterone and antidiuretic hormone (ADH) concentrations were investigated in 10 untrained male subjects when swimming (60 min at a heart rate of about 155 beats·min−1, water temperature 28° C) and during the subsequent 3 h in a sitting position. Many specific effects of either exercise or immersion were abolished or attenuated; no significant changes in plasma aldosterone, [ADH], [K+], [Cl−], or of urinary volume, glomerular filtration rate, free water or osmolar clearance were observed. The urine was diluted resulting in lowered [Na+]. In blood some quantities which are only slightly influenced by immersion increased during swimming ([Na+], [Lac−], [H+], osmolality, [creatinine]). Exercise induced plasma volume loss, calculated from increasing [Hb], was small (110 ml), probably because interstitial fluid enters the vascular space during the initial phase of immersion. One might anticipate that the training effects on fluid and electrolyte metabolism and circulation are different when swimming and when performing endurance sports on land.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00640671
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