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  • 1
    Electronic Resource
    Electronic Resource
    Induction of Immunological Tolerance to Single-stranded and Double-stranded DNA (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 16 (1982), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Single-stranded (ss) and double-stranded (ds) DNA were conjugated with the copolymers of d-glutamic acid and d-lysin (d-GL). Administration of ss-DNA-d-GL conjugates to C3H/He and NZB/W F1 mice could render the mice tolerant to both direct and indirect anti-ss-DNA antibody-forming cell responses, irrespective of their immune status. Repeated administration of ss-DNA- or ds-DNA-d-GL conjugates decreased the levels of anti-ss-DNA and anti-ds-DNA antibody titres and reduced the occurrence of ss-DNA and ds-DNA antibody-forming cells even in old female NZB/W F1 mice that had already developed an autoimmune state with lupus nephritis. The unresponsiveness was DNA-specific, and the state of tolerance was stable in vitro at the cellular level after the removal of the tolerogen. This tolerance model would be useful in analysing the regulatory mechanisms in anti-ss-DNA and anti-ds-DNA antibody production, and application of this kind of therapy in the treatment of systemic lupus erythematosus is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1982.tb00714.x
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  • 2
    Electronic Resource
    Electronic Resource
    Clinico-pathological features of squamous cell carcinoma of the oral cavity in patients 〈40 years of age (2005)
    Oxford, UK : Munksgaard International Publishers
    Journal of oral pathology & medicine 34 (2005), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Considerable controversy exists in the literature regarding the clinical course of young patients with oral squamous cell carcinoma (SCC). The purpose of this study was to evaluate the clinico-pathological features of oral SCC among young people.Methods:  From a cohort of 529 patients diagnosed with SCC, 35 (6.6%) were under the age of 40 years. This group was compared to a control group of 110 cases aged over 40 to determine if there were any differences in clinicopathological features between the two groups.Results:  In the young group there were 20 males and 15 females. The site was most frequently the tongue (51.3%), followed by the floor of the mouth, the buccal mucosa, and the upper and lower alveolus and gingiva. The local and regional control rate was 64.8% which was similar to that of older patients in this series.Conclusions:  The prognosis of oral SCC in the young patients does not appear to be different from that of the older population. Univariate analysis showed that clinical stage and the mode of invasion were the most significant prognostic factors in both younger and older patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.2004.00291.x
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  • 3
    Electronic Resource
    Electronic Resource
    Fibulin-5 deposition in human skin: decrease with ageing and ultraviolet B exposure and increase in solar elastosis (2005)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 153 (2005), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Fibulin-5 was recently found as a secreted extracellular matrix protein that functions as a scaffold for elastic fibres. However, the distribution of fibulin-5 in human skin and its changes during the ageing process are not known.Objectives  To explore the involvement of fibulin-5 in skin ageing, the age-dependent changes in fibulin-5 localization in human skin were examined compared with those of other elastic fibre components including elastin, fibrillin-1 and fibulin-2.Methods  The distribution of elastin, fibrillin-1, fibrillin-2, fibulin-2 and fibulin-5 was investigated by means of immunohistochemistry using their specific antibodies. Skin samples were recovered from 12 healthy subjects undergoing plastic surgery. Ultraviolet (UV) B-irradiated or control nonirradiated buttock skin samples were obtained from two healthy volunteers at 2 days after the irradiation at 2 minimal erythemal doses.Results  In the reticular dermis of young sun-protected skin from the upper arm, fibulin-5 colocalized with the other elastic fibre components, while in the papillary dermis fibulin-5 showed candelabra-like structures perpendicular to the epidermis with an unstained area just beneath the epidermis, which was similar to that of elastin but not fibrillin-1. Fibulin-5 in the reticular dermis decreased and disappeared with age even in sun-protected skin from the thigh, abdomen and upper arm. In sun-exposed skin, fibulin-5 was extremely reduced in the dermis of cheek skin even from a 20-year-old man. UVB irradiation reduced fibulin-5, fibulin-2 and elastin markedly, moderately and weakly, respectively, compared with levels in control nontreated skin. Interestingly, the deposition of fibulin-5 was increased in solar elastosis, like that of other elastic fibre components.Conclusions  These results suggest that fibulin-5 is a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06716.x
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  • 4
    Electronic Resource
    Electronic Resource
    Statistical consideration of using colony diameter as a measure of mycoplasmal growth (1983)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 19 (1983), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1983.tb00500.x
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  • 5
    Electronic Resource
    Electronic Resource
    The calibrated map of the HII region S237 in Hα emission (1981)
    Springer
    Astrophysics and space science 78 (1981), S. 235-242 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The calibrated Hα-map of S237 and its profiles in section through the nebular center are presented. The core-envelope structure and central open shell appearance are noticed. Physical parameters such as emission measure and mass of ionized gas are deduced and compared with results of radio observations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00654036
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  • 6
    Electronic Resource
    Electronic Resource
    The dust distribution in some smallHII regions (1983)
    Springer
    Astrophysics and space science 89 (1983), S. 407-419 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Based on the calibrated maps in the Hα andV bands, simple shell models for the distributions of ionized gas and dust are calculated for the smallHii regions S237 and S254–S257. In deriving the dust distribution from theV-band maps, it is assumed that scattering particles are made of dirty ice. The results of calculation show that a dust depletion zone should be placed in the central region of each of the observedHii regions. The formation of this dust depletion zone and the evolutionary state of theseHii regions are briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00655994
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  • 7
    Electronic Resource
    Electronic Resource
    Accumulation route and chemical form of mercury in mushroom species (1980)
    Springer
    Bulletin of environmental contamination and toxicology 25 (1980), S. 382-388 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01985542
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  • 8
    Electronic Resource
    Electronic Resource
    Abstracts of the Seventeenth Annual Meeting of the Japanese Society of Biometeorology, Osaka, 21–22 November 1978 (1981)
    Springer
    International journal of biometeorology 25 (1981), S. 77-107 
    Details
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02184444
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  • 9
    Electronic Resource
    Electronic Resource
    Blood-nerve barrier in the Vater-Pacini corpuscle of cat mesentery (1984)
    Springer
    Anatomy and embryology 169 (1984), S. 237-247 
    Details
    ISSN: 1432-0568
    Keywords: Vater-Pacini corpuscle ; Cat mesentery ; Freeze-fracture ; Tracer experiments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Correlated thin-section, freeze-fracture and tracer examinations were used to examine the blood-nerve barrier of the Vater-Pacini corpuscles in cat mesentery. A laminar inner core and a multilayered outer core enfolded the terminal nerve fiber of the corpuscle. The lamellar cells of both cores were characterized by numerous vesicular membrane invaginations. Freeze-fracture images and tracer experiments employing lanthanum nitrate proved that these invaginations are static structures mediating in neither active pinocytosis nor the transcellular transport of metabolites. In both inner and outer cores, lamellar cells were connected to one another by tight junctions of either the zonula or the fascia type, that occurred between lamellar-cell processes within the lamella and between the cells of adjacent lamellae. Intravascularly applied lanthanum lay at the out-ermost regions of the corpuscles without entering their internal zones, apparently because lamellar-cell tight junctions hindered further penetration. The results of our investigations suggest strongly that the Vater-Pacini corpuscle lamellae enfolding the nerve terminal form an effective diffusion barrier against the permeation of tissue fluids, thus preserving the corpuscle internal circumference.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315629
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  • 10
    Electronic Resource
    Electronic Resource
    Ultrafine Grained Steels due to Super Short Interval Multi-Pass Rolling in Stable Austenite Region (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 539-543 (Mar. 2007), p. 4698-4703 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Ultrafine-grained steel sheets with the chemical composition of 0.15%C-0.74%Mn-0.01%Si have been prepared using a laboratory rolling mill by Super Short Interval Multi-passRolling (SSMR) process, in which the inter-pass time is extremely shortened to enhance thecumulative strain. The SSMR process with a finish rolling around Ae3 leads to ultrafine equiaxedferrite structure with 1μm in average grain size. In order to clarify the grain refinement mechanismin the SSMR process, the deformation substructure in deformed austenite was simulated using70%Ni-30%Fe, which was a fcc alloy with equivalent stacking fault energy to C-Mn steels. TEMobservations have shown that the dislocation substructure in the Ni-Fe alloy hot-rolled by SSMRprocess mainly consists of dislocation cells, of which size are refined to less than 1μm withshortening inter-pass time. It is concluded that the SSMR process can accumulate the deformationstrain in austenite enough to densely nucleate ferrite inside austenite grains
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/15/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.539-543.4698.pdf
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