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  • 1
    Electronic Resource
    Electronic Resource
    Production of the lymphokine, macrophage aggregating factor, is not inhibited by histamine (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 1230-1231 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Unlike the previously reported inhibitory effect of histamine on the production of the lymphokine, migration inhibitory factor, histamine did not inhibit the production of macrophage aggregating factor (MAgF). By contrast, both prostaglandin E2 and hydrocortisone inhibited MAgF production, in a dose-dependant manner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01959757
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  • 2
    Electronic Resource
    Electronic Resource
    Platinum-group-mineral inclusions in chromite from the bird river sill, Manitoba (1983)
    Springer
    Mineralium deposita 18 (1983), S. 245-255 
    Details
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Platinum-group minerals (PGM) have been identified as inclusions in chromite from the Bird River Sill, Manitoba. The inclusions are small (〈20 microns) and are commonly euhedral. The PGM inclusions are (Ru, Os, Ir) S2, laurite, and (Os, Ir, Ru alloy), rutheniridosmine: Laurites contain up to 2.99 wt. % palladium. Arsenic content is negligible and no platinum or rhodium has been detected. One platinum-group element alloy contains 0.96 wt. % rhodium but neither platinum nor palladium has been detected. Laurite inclusions in chromite from the ultramafic zone record two compositional trends; first increasing and then decreasing Ru/(Ru+Os+Ir) up section. PGM inclusions and other solid inclusions occur as discrete phases in chromite and are part of the chromite precipitation event. Increasing oxygen fugacity by wall rock assimilation or new magma injection initiates chromite precipitation, locally increasing the sulphur content of the magma to convert PGE alloys to sulphides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206212
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  • 3
    Electronic Resource
    Electronic Resource
    Segregation of linked probes to myotonic dystrophy in a family demonstrating that 152 and APOC2 are on the same side of DM on 19q (1988)
    Springer
    Human genetics 〈Berlin〉 80 (1988), S. 379-381 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The two markers most closely linked to the myotonic dystrophy (DM) locus on chromosome 19 are the gene that codes for apolipoprotein CII (APOC2) and the anonymous probe D19S19 (LDR152). Both of these markers show tight linkage to DM, with maximum lod scores of〉20 at recombination fractions of less than 0.05. We have identified, in a family in which DM segregates, an affected individual where a meiotic recombination event has occurred in which both of these linked markers have crossed over with the gene defect. This demonstrates that APOC2 and D19S19 are probably on the same side of DM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273655
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  • 4
    Electronic Resource
    Electronic Resource
    Properties of reticulum cell sarcomas in SJL/J mice (1983)
    Springer
    Immunogenetics 18 (1983), S. 399-413 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract While T cells from SJL and from F1 hybrids of SJL that do not express I-E antigens give strong proliferative responses to RCS, T cells from F1 hybrids expressing surface I-E do not. The nature of the stimulating antigen on the RCS cell surface was examined using monoclonal antibodies. Complete inhibition of the T-cell proliferative response was obtained with antibodies to I-A antigens, whereas antibodies to I-E antigens did not inhibit at all. This inhibition was mediated via an effect of the antibodies on the stimulating cells. Biochemical characterization of immunoprecipitated 125I- and 's S-labeled RCS antigens was performed using two-dimensional gel electrophoresis. Using this technique, I-A antigens were readily detected. However, neither Ia.7-specific antibodies nor antibodies specific for Eα : E β complexes precipitated any E alpha or E beta chains. Comparison of I-A antigens from RCS and normal SJL spleen cells revealed minor mobility differences in the gels, possibly due to differences in glycosylation, the significance of which needs to be further evaluated. Examination of RNA extracted from RCS, using E alpha and A alpha cDNA probes showed that RCS cells do not transcribe the E alpha gene as has been shown previously for normal H-2 s cells. Furthermore, DNA from RCS cells showed a defect in the E alpha gene similar to that known to exist in normal H-2 s cells. Our findings exclude the presence of E alpha on RCS cells and suggest a major role for I-A, either alone or in conjunction with another as yet unidentified cell surface antigen, in the stimulation of T cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00372472
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  • 5
    Electronic Resource
    Electronic Resource
    Murine invariant chain gene: Chromosomal assignment and segregation in recombinant inbred strains (1985)
    Springer
    Immunogenetics 22 (1985), S. 193-199 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00563518
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  • 6
    Electronic Resource
    Electronic Resource
    A simple method for elution of IgA deposits from the skin of patients with dermatitis herpetiformis (1989)
    Springer
    Archives of dermatological research 281 (1989), S. 406-410 
    Details
    ISSN: 1432-069X
    Keywords: Dermatitis herpetiformis ; Immunoglobulins ; Complement components ; Elution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To better understand the role of autoimmunity in the pathogenesis of dermatitis herpetiformis, linear IgA bullous dermatosis or other skin disorders, the antigenic specificity of the immune reactants bound in vivo in the skin must be identified. In order to do so, one must first be able to elute these immune reactants from the skin. We describe here a simple method of eluting not only specifically bound IgG, but also IgA and other immunoglobulins and complement components from skin biopsy material. The method involves cutaneous washing of the entrapped serum proteins in PBS pH 7 and pH 5 buffers followed by specific immunoglobulin elutions at pH 3 and 2. The IgA deposits which could not be removed by this treatment were eluted by a combination of low pH (0.5 M citrate pH 2) and a chaotropic agent (2 M NaCl). The relative concentration of IgA in eluates when quantitated by fluoroimmunoassay were three-to five-fold higher in dermatitis herpetiformis skin biopsy specimens, than in eluates of bullous pemphigoid or normal skin biopsy specimens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455326
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  • 7
    Electronic Resource
    Electronic Resource
    Non-tuberculous mycobacterial lymphadenitis in children (1989)
    Springer
    European journal of pediatrics 148 (1989), S. 751-754 
    Details
    ISSN: 1432-1076
    Keywords: Lymphadenopathy ; Atypical mycobacteria ; Non-tuberculous mycobacterial lymphadenitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eighty-six children (44 males, 42 females) were identified as having non-tuberculous mycobacterial lymphadenitis. The diagnostic criteria were either culture of the organism from the affected lymph node (n=68), or, when culture was negative, a positive skin test with non-tuberculous mycobacterial antigens and negative skin test responses to tuberculin purified protein derivative (PPD) in association with typical histological features (n=18). All children had histopathological findings of granulomatous inflammation with caseation and/or acid-fast bacilli. Eighty-two percent of the children were under 5 years of age at presentation and 30% were less than 2 years old. Most (79%) were city dwellers. Lymph node enlargement had been present for less than 6 months in almost all children (97.5%) and was almost exclusively in the face and neck region (97%). Disease was confined to the involved lymph nodes in 56% but had extended beyond the confines of the infected node to form a collar stud abscess in 38% and 6% presented with a skin sinus. Extranodal extension did not show any statistically significant association with the duration of lymphadenopathy. The duration of lymphadenopathy had been greater in those children in whom an organism was not isolated on culture resected tissue χ2, P〈0.01). All children were treated surgically, and recurrence occurred in five patients. This study describes the clinical and demographic characteristics of non-tuberculous mycobacterial lymphadenopathy in children in a population in which tuberculous adenitis is rare. Recognition of these features may allow earlier diagnosis and appropriate surgical therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443102
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  • 8
    Electronic Resource
    Electronic Resource
    A comparative study of the effects of aspirin and paracetamol (acetaminophen) on platelet aggregation and bleeding time (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 567-571 
    Details
    ISSN: 1432-1041
    Keywords: aspirin ; paracetamol ; plasma aspirin esterase activity ; bleeding time ; platelet aggregation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a double blind, randomised trial, the effects of 1 g aspirin and 1 g paracetamol were compared on bleeding time and platelet aggregation in 40 volunteers (20 females). Also investigated was the relationship between plasma aspirin esterase activity and both bleeding time and platelet aggregation after aspirin. Following 1 g aspirin there was a significant increase in bleeding time at 24 h (p〈0.01). A significant reduction (P〈0.01) in platelet aggregation with collagen was observed at 1, 6 and 24 h after aspirin, but no significant reduction (P〉0.05) was observed with ADP. Paracetamol had no effect on bleeding time or platelet aggregation. Plasma aspirin esterase activity ranged from 0.26–0.6 µmol/ml/min. A significant negative correlation (R=−0.55, P〈0.001) was observed between percentage increase in bleeding time (24 h) and plasma aspirin esterase activity. Further significant correlations were observed between plasma aspirin esterase activity and change in platelet aggregation with collagen at 1 h (R=0.68, P〈0.001), 6 h (R=−0.73, P〈0.001) and 24 h (R=−0.67, P〈0.001). These results suggest that it might be possible to predict an individual's haemostatic response to aspirin from knowledge of their plasma aspirin esterase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543486
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  • 9
    Electronic Resource
    Electronic Resource
    Efficient and selective population of high vibrational levels by stimulated near resonance Raman scattering (1987)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 87 (1987), S. 5064-5076 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We report the successful application of an optically pumped molecular beam laser for efficient and selective population transfer from v″=0 to high lying vibrational levels of Na2 in the electronic ground state. More than 50% of the molecules in a thermally populated rotational level of v″=0 can be transferred to a state v″(very-much-greater-than)1 with typically ≥75% of the molecules excited out of the initial state found in the predetermined end vibrational level and approximately ≤25% distributed over other levels according to the Franck–Condon factors. The applicability of this technique to the study of collision processes involving vibrationally highly excited levels is discussed. This work also contributes in general to a better understanding of optically pumped dimer lasers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.453674
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  • 10
    Electronic Resource
    Electronic Resource
    Mechanism of CO bond scission at alkali promoter sites—IRAS study of the system CO/K/Ni(111) (1987)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 86 (1987), S. 6523-6530 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: IRAS (infrared reflection absorption spectroscopy) has been employed to study the isotopic mixing reaction: 13C16O(a)+12C18O(a)→13C18O(a)+12C16O(a) on Ni(111) with preadsorbed K adatoms. Under high temperature conditions (T〉450 K) where the isotopically mixed CO is being desorbed, it has been shown that the isotopic exchange reaction cannot be detected by IRAS on the surface among CO molecules strongly interacting with K adatoms. This result implies that dissociation of CO occurs at K-promoted Ni sites followed by surface diffusion of C(a) and O(a) away from the K promoter site. Statistical recombination of C(a)+O(a) occurs with concomitant CO desorption on Ni(111) sites some distance from K centers. The empty K-promoted sites may be refilled by surface diffusion of CO from outside. Thus, alkali metal promotion of C–O bond scission may act via a "feeder-site'' mechanism connecting promoter atoms to external surface sites via surface diffusion of atomic C and O species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.452444
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