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  • 1
    Electronic Resource
    Electronic Resource
    Improved treadmill to avoid foot and tail injuries of small animals (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 140-141 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A treadmill was improved so as to eliminate foot and tail injuries in small test-animals. The improvement was inexpensive and easily fabricated by the researchers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01944576
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  • 2
    Electronic Resource
    Electronic Resource
    The increase of thiobarbituric acid reacting substances in rats with experimental chronic hypoxia (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 312-313 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Feeding under conditions of reduced oxygen supply prompted an increase in serum, arterial and brain tissue levels of thiobarbituric acid (TBA)-reacting substances. These observations indicated the possibility that hypoxia might be one of the factors predisposing to the accumulation of lipid peroxide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01949361
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  • 3
    Electronic Resource
    Electronic Resource
    An electrophysiological study on the myocardium of dystrophic mice (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 359-360 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Decreased resting potential and prolonged duration of the action potential were observed in left ventricular muscles of dystrophic mice, while there was no change in myocardial potassium content.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01949392
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  • 4
    Electronic Resource
    Electronic Resource
    Dermatopathological studies on skin lesions of MRL mice (1984)
    Springer
    Archives of dermatological research 276 (1984), S. 186-194 
    Details
    ISSN: 1432-069X
    Keywords: MRL/l mouse ; New Zealand mouse ; Lupus band test ; Anti-DNA antibodies ; Proteinuria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The MRL-lpr/lpr(MRL/l) mouse is a new animal model for human systemic lupus erythematosus (SLE) and skin lesions with hair loss and scab formation are one of the characteristic manifestations in this mouse. We investigated the histopathology of the skin lesions in MRL/l mice and studied the related autoimmune phenomenon. Light microscopical observations revealed hyperkeratosis, acanthosis, hypergranulosis, liquefaction, vasodilation in the dermis and T-cell infiltration into the dermis at the age of 5 months (mo). Immunohistological studies showed the presence of immunoglobulins and/or complement depositions at the dermal-epidermal junction (DEJ). In some mice there was deposition of immunoglobulin at the DEJ at 2 mo and in 90%–100% of MRL/l mice at over 5 mo. Temporal relationship was present among cutaneous immunoglobulin depositions, the occurrence of anti-DNA antibodies and proteinuria. These findings suggest that MRL/l mice might provide a new aid for studying the biological mechanisms of the development of skin lesions in human SLE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414018
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  • 5
    Electronic Resource
    Electronic Resource
    Activity of renal 25-hydroxyvitamin D3-1α-hydroxylase in a case of X-linked hypophosphataemic rickets (1984)
    Springer
    European journal of pediatrics 142 (1984), S. 219-222 
    Details
    ISSN: 1432-1076
    Keywords: Hypophosphataemic rickets ; 1,25(OH)2D ; 1α-hydroxylase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 1974, a 2-year-old boy was diagnosed as having X-linked hypophosphataemic rickets (XLH) because of severe rickets and hypophosphataemia. The vitamin D metabolite concentrations, blood and urine chemistry and renal 25-hydroxyvitamin D3 (25 OHD3)-1α-hydroxlase were measured in 1982 (about 2 weeks after withdrawal of medication). 1α-hydroxylase was 392 pg/mg tissue/20 min in the patient, which was high compared with aged-matched controls (69.7±28.5 pg/mg tissue/20 min, mean ±SD, n=7). Our present studies showed that the 1α-hydroxylase activity in the patient with XLH was elevated. Therefore, the normal or low 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) concentrations in XLH patients could be due to accelerated catabolism of 1,25-(OH)2D3 or abnormally regulated 25OHD3-1α-hydroxylase in response to hypophosphataemia, although significantly elevated above that in normal controls.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442454
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  • 6
    Electronic Resource
    Electronic Resource
    Dependence of the cardiovascular effects of pindolol on the individual sympathetic nervous activity (1982)
    Springer
    European journal of clinical pharmacology 22 (1982), S. 383-387 
    Details
    ISSN: 1432-1041
    Keywords: pindolol ; propranolol ; beta-adrenergic activity ; beta-adrenergic sensitivity ; beta-blocking agents ; intrinsic sympathomimetic action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To investigate the mechanism of the relative beta-antagonist and agonist properties of pindolol, the cardiovascular effects of i.v. pindolol 0.01 mg/kg were studied in 23 subjects with different baseline levels of cardiac beta-adrenergic function. Baseline cardiac beta-adrenergic activity was assessed by the decrease in heart rate following intravenous propranolol 0.2 mg/kg (ΔHRβ) after parasympathetic blockade with intravenous atropine 0.04 mg/kg. Cardiac beta-adrenergic sensitivity was defined by the positive chronotropic effect of a three minute infusion of isoprenaline 0.005 µg/kg/min. The chronotropic effect of intravenous pindolol was negatively correlated with resting beta-adrenergic activity (R=−0.81, p〈0.001). The traditional point of ΔHRβ, at which pindolol shifted from beta-antagonist to beta-agonist action, was 17 beats/min, i.e. pindolol decreased heart rate in subjects with ΔHRβ greater than 17 bpm, and increased heart rate in those with ΔHRβ less than 17 bpm. The chronotropic effect of intravenous pindolol, however, was positively correlated with beta-sensitivity (R=+0.73, p〈0.001). Thus subjects with the greatest increment in heart rate with isoprenaline had an increased heart rate with pindolol, while those with the lowest increment in heart rate with isoprenaline had a decreased heart rate with pindolol. Intravenous pindolol decreased cardiac index and increased total peripheral resistance in the group with ΔHRβ more than 17 bpm, and it had the contrary actions in the group with ΔHRβ less than 17 bpm. Blood pressure in both groups was not significantly changed by pindolol. Compared to endogenous catecholamines, pindolol was considered to possess higher beta-adrenocepter affinity and weaker beta-adrenoceptor stimulating action. Therefore, pindolol produced a net beta-blocking action in subjects with elevated cardiovascular sympathetic nervous activity and beta-stimulating action in subjects with reduced sympathetic nervous activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542539
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  • 7
    Electronic Resource
    Electronic Resource
    The Santiago Peak Volcanic rocks of the Peninsular Ranges batholith, Southern California: volcanic rocks associated with coeval gabbros (1984)
    Springer
    Bulletin of volcanology 47 (1984), S. 153-171 
    Details
    ISSN: 1432-0819
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Analyses of the latest Jurassic Santiago Peak volcanic rocks from the western zone of the Peninsular Ranges batholith reveal the existence of two independent groups; one comprising basalts and andesites of the island arc tholeiitic series, and the second made up of the dacites and rhyolites of the subalkaline (calc-alkaline?) series or silicic series. The basalts and andesites have V, Co and Ni contents similar to those estimated for the residual melts in equilibrium with the Peninsular Ranges gabbros. This fact together with the tholeiitic nature of the gabbros and the intimate spatial and temporal relationship between the SPV and the gabbros suggests that the basalts and andesites had a common origin with the gabbros. The mafic volcanism and plutonism seems to have occurred in a youthful island arc and the silicic volcanism in a mature island arc or a continental margin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01960546
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  • 8
    Electronic Resource
    Electronic Resource
    The replication of rocio virus in brain tissue of suckling mice. Study by electron microscopy (1983)
    Springer
    Archives of virology 78 (1983), S. 309-314 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary By electron microscopy studies, Rocio virus particles were about 43 nm and spherically shaped. They were found within the cisternae of the endoplasmic reticulum and Golgi complex of infected neurons. No precursor particles were detected nor virus budding was evident.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01311327
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  • 9
    Electronic Resource
    Electronic Resource
    Fuming nitric acid treatment of isotactic polypropylene film (1982)
    Springer
    Colloid & polymer science 260 (1982), S. 1101-1106 
    Details
    ISSN: 1435-1536
    Keywords: Fuming Nitric Acid ; Isotactic Polypropylene ; Proton Magnetic Relaxation ; Spin-Lattice Relaxation Time ; Spin-Spin Relaxation Time
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Fuming nitric acid treatment has been made on a melt-quenched and an annealed isotactic polypropylene film. The treated samples were characterized by measurements of weight loss, density, molecular weight, spin-lattice,T 1, and spin-spin,T 2, relaxation times. Concurrent with the increases in weight loss, density and a decrease in molecular weight, increases inT 1l andF c , a fraction of crystalline region, and decreases inT 2a andF a , a fraction of amorphous region, were observed as a consequence of the decrease in an amount of noncrystalline portions. However, unexpected fall inT 1l was also observed after about 2–3 hr of treatment time. These observations were discussed by the structural changes that took place during acid etching.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411228
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  • 10
    Electronic Resource
    Electronic Resource
    The kinetic study of thermal dehydration of oxalic acid dihydrate (1984)
    Springer
    Journal of thermal analysis and calorimetry 29 (1984), S. 1115-1122 
    Details
    ISSN: 1572-8943
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Kinetik der thermischen Dehydratisierung von kristallinen Pulvern von (COOH)2 · 2 H2O wurde thermogravimetrisch bei konstanter und linear ansteigender Temperatur untersucht. Es wurde festgestellt, da\ das Avrami-Erofeyev-Gesetz gefolgt wird und die Möglichkeit besteht, da\ gleichzeitig eine phasen grenzflÄchen-kontrollierte Reaktion verlÄuft. Dies wird durch die Beeinflussung der Geschwindigkeitskonstante durch die Partikelgrö\e unterstützt. Die AktivierungsenergieE für die Dehydratisierung wurde zu etwa 80 kJ mol−1 gefunden. Es ist wahrscheinlich, da\ die Effekte von Partikelgrö\e und Temperatur aufE durch den des HÄufigkeitsfaktorsA kompensiert werden.
    Abstract: РЕжУМЕ кИНЕтИкА тЕРМИЧЕскО И ДЕгИДРАтАцИИ кРИстАллИЧЕскИх пОР ОшкОВ ДИгИДРАтА ЩАВЕлЕВОИ кИслОты Бы лА ИсслЕДОВАНА МЕтОД ОМ тЕРМОгРАВИМЕтРИИ кА к пРИ пОстОьННОИ, тАк И лИНЕИНО УВЕлИЧИ ВАУЩЕИсь тЕМпЕРАтУР Ах. НАИДЕНО, ЧтО жАкОН АВРАМИ—ЕРО ФЕЕВА сОглАсУЕтсь с ВОжМОж НОстьУ, ЧтО кОНтРОлИР ОВАННАь РЕАкцИь ФАжА-гРАНИцА пРОтЕкАЕт ОДНОВРЕМЕННО. ЁтО пОД тВЕРжДАЕтсь ВлИьНИЕ М РАжМЕРА ЧАстИц НА кОНстАНтУ с кОРОстИ. ЁНЕРгИь АктИВАцИИE РЕАкцИИ Д ЕгИДРАтАцИИ БылА Уст АНОВлЕНА РАВНОИ пРИБлИжИтЕль НО 80 кДж · МОль−1. ВЕРОьтНО, стО ВлИьНИЕ РАжМЕРОВ ЧАстИц И тЕМпЕРАтУРы НА ЁНЕРг ИУ АктИВАцИИE кОМпЕНсИРУЕтсь ВлИ ь НИЕМ Их НА ЧАстОтНыИ М НОжИтЕльA.
    Notes: Abstract The thermal dehydration kinetics of crystalline powders of (COOH)2 · 2 H2O was examined by thermogravimetry both at constant and linearly increasing temperatures. An Avrami-Erofeyev law is found to hold with a possibility that a phase-boundary controlled reaction proceeds simultaneously. This is supported by the particle size effect on the rate constant. The activation energyE for the dehydration is estimated as around 80 kJ mol−1. It is likely that the effects of particle size and temperature onE are compensated by those on the frequency factorA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02188864
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