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  • 1
    ISSN: 1432-0428
    Keywords: Pancreatic islets ; insulin secretion ; insulin content ; glucagon secretion ; glucagon content ; wistar rats ; sand rats ; glucose ; arginine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Isolated pancreatic islets of normoglycemic sand rats do not respond to 2.5 mM glucose with an enhanced glucagon secretion, which could be observed in normal Wistar rats. Arginine stimulates glucagon release in the presence of 2.5 mM glucose in Wistar rats as well as in sand rats. The secretion pattern is not caused by insulin deficiency since sand rat islets are characterized by an increased insulin secretion rate in vitro. This paradoxical glucagon secretion is not caused by a changed glucagon content but might be related to this species which is able to develop a diabetic syndrome spontaneously.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Computing 14 (1975), S. 131-139 
    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Abstract An extension of an algorithm for inverting symmetric matrices is given which can be used even if during the inversion no pivots ≠ 0 of the diagonal are found. A proof for this method is given together with an ALGOL procedure.
    Notes: Zusammenfassung Die Erweiterung eines Algorithmus zur Inversion symmetrischer Matrizen wird beschrieben. Die Symmetrie der Matrizen bleibt auch dann erhalten, wenn in der Hauptdiagonalen keine Pivots ≠ 0 gefunden werden. Es wird bewiesen, daß das Verfahren richtig ist. Außerdem wird eine ALGOL-Prozedur für die in situ Inversion angegeben.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Computing 23 (1979), S. 31-41 
    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Abstract We consider a system carrying a number of in the worst case periodically activated tasks with fixed priorities. We show that the strategy of giving higher priority to tasks with shorter guaranteed response times is optimal in the sense that, if this strategy fails, all others will fail too. Furthermore, we give an algorithm for choosing a subset of tasks of which response times can be guaranteed.
    Notes: Zusammenfassung Wir betrachten ein System von Prozessen mit festen Prioritäten, die im ungünstigsten Fall periodisch aktiviert werden. Wir zeigen: Die Strategie, Prozessen mit kleinerer Garantiezeit höhere Priorität zu geben, ist optimal bezüglich des Einhaltens der Garantiezeiten, d. h. falls diese Strategie Zeitbedingungen verletzt, so tut dies auch jede andere Strategie. Außerdem wird ein Verfahren angegeben, das aus einer Prozeßmenge eine Teilmenge auswählt, die zeitgarantierbar ist.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 27 (1984), S. 163-165 
    ISSN: 1432-0428
    Keywords: Insulin-dependent diabetes ; rat ; autoimmunization ; streptozotocin ; polyclonal lymphocyte activation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The non-specific activation of the immune system by administration of complete Freund's adjuvant was examined in Wistar rats as a possible means of amplification of the specific immune response directed to pancreatic β cells caused by low dose non-diabetogenic multiple injections of streptozotocin. Rats were given intraperitoneally 0.5 ml of complete Freund's adjuvant to induce polyclonal lymphocyte activation and, 1 day later, the animals were given an intraperitoneal injection of 15 mg streptozotocin/kg body weight (group 1). This combined treatment was given twice at weekly intervals. In two further groups, rats were treated with complete Freund's adjuvant alone (group 2) or streptozotocin alone (group 3) with the same doses and at the same times. Only the rats in group 1 developed delayed but severe and persistent hyperglycaemia. In addition, significant complement-dependent cytotoxicity was detected in nine out of 15 rats (60%) in group 1 in islet cells, but not in spleen lymphocytes. The pancreatic insulin content of the rats in group 1 was depleted by up to 3.1 ± 0.5%. With these experiments, a new animal model for insulin-dependent diabetes is described; complete Freund's adjuvant/streptozotocin diabetes. In many aspects, this model of diabetes parallels the development of insulin-dependent diabetes in man, including the humoral autoimmunity to islet cell antigens.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 229 (1983), S. 237-245 
    ISSN: 1432-1459
    Keywords: Disability evaluation ; Isoniazid ; Huntington's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über 11 Patienten mit Huntingtonscher Krankheit berichtet, die in hoher Dosierung Isoniazid erhielten. Neben der klinischen Beurteilung erfolgte eine Quantifizierung des Behinderungsgrades. 4 Patienten wiesen eine eindeutige Besserung der Symptome und eine Abnahme der Behinderung auf. Ein Patient mit der rigiden Form (Westphal-Variante) verschlechterte sich und die restlichen 6 Patienten zeigten keine Änderung des Zustandsbildes. Es scheint, daß besonders die Patienten auf die Isoniazidtherapie ansprechen, bei denen die psychische Beeinträchtigung im Vordergrund steht.
    Notes: Summary Eleven patients with Huntington's disease were treated with high doses of isoniazid. In addition to the clinical assessment, the functional capacity was evaluated quantitatively. The symptoms of four of the patients showed a marked improvement and their functional capacity increased. The condition of one patient with the rigid form (Westphal's variant) deteriorated, and the remaining six patients showed no change. Patients with prominent mental disturbances appeared to respond best to isoniazid therapy.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 223 (1977), S. 131-138 
    ISSN: 1433-8491
    Keywords: Sleep EEG ; Circulation Disturbances ; Correlation to Psycho-organic Impairment ; Schlaf-EEG ; cerebrale Durchblutungsstörungen ; Bezieziehungen zu psychoorganischen Veränderungen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 30 bewußtseinsklaren Patienten (24 Männer, 6 Frauen) im Alter von 30–74 Jahren mit ischämischen Großhirnhemisphärenläsionen wurden durchschnittlich 45 Tage nach Krankheitsbeginn polygraphische Nachtschlafregistrierungen durchgeführt. Die Schlaf-EEG-Veränderungen waren gekennzeichnet durch eine Verlängerung der Einschlaf- und Wachzeiten sowie eine Abnahme des tiefen synchronen Schlafes. Korrelationsstatistische Untersuchungen zeigen, daß ältere Patienten längere Wachzeiten haben, ebenso wie Kranke mit hohen komplexen Reaktionszeiten und einer euphorischen Stimmungslage, die als Ausdruck einer hirnorganischen Leistungsbeeinträchtigung interpretiert werden können. Demgegenüber tritt die Schwere des klinisch-neurologischen Syndroms für Art und Schwere der Schlafstörung zurück.
    Notes: Summary In 30 conscious patients (24 men, 6 women) aged 30–74 years suffering from ischemic lesions in the cerebral hemispheres, polygraphic night sleep recordings were performed about 45 days after the beginning of the illness. The alterations in sleep were characterized by a delay in the onset of sleep, prolonged waking periods, and a reduction of deep synchronous sleep. Statistical analysis revealed a relationship between prolonged waking time with higher age as well as with high complex reaction time and euphoric state of mind, which can be considered as a sign of psycho-organic impairment. In contrast thereto, the degree of the neurological symptomatology is of less importance for the kind and extent of the sleep disturbances.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 15 (1982), S. 95-110 
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using a transmission type polarimeter, an asymmetry has been found that can be ascribed to a circularly polarized component in the bremsstrahlung beam of unpolarized relativistic electrons from the Mainz electron linac, in the region of electron energiesE el between 140 and 400 MeV. The experiment is described in detail. Systematical errors are discussed. For a comparison with electroweak theory, an exact calculation for small photon emission angles (of the order ofm c 2/E el) is needed.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 301 (1980), S. 139-140 
    ISSN: 1618-2650
    Keywords: Best. von Molekulargewichten ; Sedimentationsgeschw., Ultrazentrifuge
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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