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  • 1
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1975)
    Springer
    Computing 15 (1975), S. 287-290 
    Details
    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02242375
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    Paper (German National Licenses)
    Fulltext
  • 2
    Book
    Book
    Datenschutz und Datensicherung (1976)
    Koeln :Bachem,
    Details
    Title: Datenschutz und Datensicherung
    Author: Dierstein, R.
    Contributer: Fiedler, H. , Schulz, A.
    Publisher: Koeln :Bachem,
    Year of publication: 1976
    Pages: 329 S.
    Type of Medium: Book
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    ZIB Catalog
    Zuse Institute Berlin get availability status
  • 3
    Electronic Resource
    Electronic Resource
    Immunoreaktives Parathormon, 25-Hydroxycalciferol und Knochenhistologie bei renaler Osteopathie (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 625-632 
    Details
    ISSN: 1432-1440
    Keywords: Renal osteodystrophy ; Parathyroid hormone ; Vitamin D ; 25-Hydroxycalciferol ; Bone biopsy ; Renale Osteopathie ; Parathormon ; Vitamin D ; 25-Hydroxycalciferol ; Knochenbiopsie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 32 Patienten mit renaler Osteopathie wurden die Serumspiegel des immunoreaktiven Parathormons (iPTH) und des 25-Hydroxycalciferol (25(OH)D) bestimmt und mit den Ergebnissen der Knochenbiopsie und anderen klinischen Parametern korreliert. Das iPTH entsprach den Ergebnissen der Knochenhistologie, zeigte jedoch keine Beziehung zum Serumcalcium und der alkalischen Phosphatase, während eine statistisch signifikante Korrelation mit dem Serumphosphat bestand. Die 25(OH)D-Spiegel verhielten sich unabhängig vom histologischen Nachweis einer Osteomalazie oder vermehrter Knochenresorption, es fand sich eine Beziehung zwischen dem Vitamin-D-Metaboliten und dem Serumcalcium. Da die iPTH- und die 25(OH)D-Spiegel eine signifikante inverse Korrelation zeigten, wurde ein inhibitorischer Effekt des 25(OH)D auf die Nebenschilddrüsenfunktion bei Niereninsuffizienz diskutiert.
    Notes: Summary Immunoreactive parathyroid hormone (iPTH) and 25-hydroxycalciferol (25(OH)D) serum levels were determined in 32 patients with renal osteopathy, they were correlated with the results of bone biopsy and other clinical parameters. iPTH was closely related to bone histology, it did not correspond to serum calcium and alkaline phosphatase, but the correlation to serum phosphate was statistically significant. 25(OH)D levels were not related to the histological findings of osteomalacia or increased bone resorption, while a correlation between the vitamin D metabolite and serum calcium could be observed. Since iPTH and 25(OH)D levels exhibited a significant correlation, an inhibitory effect of 25(OH)D on parathyroid gland function in renal failure was discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01469028
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Bone cells and remodelling surfaces in acromegaly (1976)
    Springer
    Calcified tissue international 22 (1976), S. 255-259 
    Details
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064075
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Ultrastructural study of tumor cell differentiation in osteosarcoma of jaw bones (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 7 (1978), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Two ostcosarcomas of jaw bones have been studied by electron microscopy. The objectives were to examine the specific cell types in relation to functions and ultrastructural features, and to examine matrices produced by tumor cells.The osteosarcoma cells were subdivided into four cell types: anaplastic, chondroblastic, osteoblastic, and ostcocytic–giant cells were not considered in the present investigation.Compared to normal bone cells, no specific sign of malignancy was found. However, tumor cells seem to lose functional abilities, i.e. a modification of matrix. Consequently, tumor matrix has altered organic and inorganic components with impairment of collagen maturation and matrix mineralization. The alteration in both processes may be related to a diminished production of proteoglycans.The cytogenic hypothesis of a tumor stem cell may be supported by the identification of anaplastic osteosarcoma cells resembling immature reticulum cells. One may speculate on transformation of this cell type as a genetically predetermined osteoprogenitor cell of malignant potential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1978.tb01581.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Morbus Paget des Knochens (1977)
    Springer
    Virchows Archiv 376 (1977), S. 309-328 
    Details
    ISSN: 1432-2307
    Keywords: Paget's disease ; Osteoclasts ; Ultrastructure ; Cytogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Frage der Cytopathogenese der Riesenosteoclasten beim Morbus Paget des Knochens wurden elektronenmikroskopische Untersuchungen an menschlichen Knochenbiopsien durchgeführt. Anteile von 26 aus diagnostischen Gründen entnommenen Beckenkammbiopsien wurden nach einem besonderen PrÄparationsverfahren unentkalkt für die Elektronenmikroskopie aufgearbeitet. Die Paget-Osteoclasten zeichnen sich durch eine hohe Kernzahl aus. Einzelne Zellkerne besitzen parakristalline Einschlüsse, die Hinweis auf eine Virusinfektion der Zellen sein können. Die Riesenosteoclasten zeigen eine gesteigerte Zellbeweglichkeit und hohe Resorptionsleistung durch Dissektion von Knochenfragmenten aus den endostalen OberflÄchen. Zwischen einkernigen Zellen und Osteoclasten finden sich ultrastrukturell Zellmembraninterdigitationen, die dem Vorgang der Zellfusion entsprechen. Die hÄufige Beobachtung dieser Zellmembrankontakte spricht für eine erhöhte Zellfusionstendenz von einkernigen VorlÄuferzellen der Osteoclasten beim Morbus Paget. Die VorlÄuferzellen stammen aus dem pericapillÄren Bereich und entsprechen morphologisch den Pericyten. Die Annahme einer gesteigerten Zellfusionsrate von einkernigen OsteoclastenvorlÄuferzellen würde die Entwicklung der Riesenosteoclasten erklÄren, die für den Morbus Paget des Knochens typisch sind. Ob diesem Vorgang ein durch Viren ausgelöster cytopathogener Effekt zugrunde liegt, mu\ durch weitere Untersuchungen an den parakristallinen Einschlüssen der Osteoclastenkerne geprüft werden.
    Notes: Summary The cytogenesis of giant osteoclasts in Paget's disease of bone was studied by means of electron microscopy. 26 iliac crest biopsies were made and divided for light and electron microscopic investigation. A special procedure was used for electron microscopic preparation of bone without previous decalcification. Paget osteoclasts are characterized by their high content of nuclei. Several nuclei may show paracrystalline inclusions pointing to a possible virus infection of these cells. Giant osteoclasts have an increased mobility and a high resorptive activity, manifest by the dissection of bone fragments from endosteal bone surfaces. Cell membrane interdigitations between mononuclear cells and osteoclasts occur as a morphologic concomitant of cell fusion. Frequent occurence of such cell membrane contacts seem to indicate an increased tendency to cell fusion among the mononuclear precursors of Paget-osteoclasts. Precursor cells are located in the pericapillary region, and morphologically resemble pericytes. The assumption of an increased rate of cell fusion amoungst the precursor cells of osteoclasts might explain the development of giant osteoclasts in this disease. Further studies of the paracrystalline nuclear inclusions of Pagetosteoclasts are necessary to determine whether this process can be considered to be a cytopathogenic effect of virus infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432301
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1975)
    Springer
    Computing 15 (1975), S. 365-371 
    Details
    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02260320
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Changes of bone remodelling surfaces and bone structure in Paget's disease following long-term treatment with calcitonin (1976)
    Springer
    Calcified tissue international 22 (1976), S. 359-361 
    Details
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064100
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Das zentrale Riesenzellgranulom (1976)
    Springer
    Virchows Archiv 371 (1976), S. 161-170 
    Details
    ISSN: 1432-2307
    Keywords: Giant cell granuloma ; Histochemistry ; Ultrastructure ; Cell function ; Osteoclasts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die mehrkernigen Riesenzellen des zentralen Riesenzellgranuloms entstehen durch Zellfusion aus den Pericyten der Kapillaren. In der vorliegenden Studie werden die Funktionsmerkmale der Riesenzellen durch Kombination histologischer, histochemischer und elektronenmikroskopischer Methoden untersucht. In den mehrkernigen Riesenzellen ließen sich in Übereinstimmung mit älteren Untersuchungen die lysosomalen Enzyme saure Phosphatase und Aminopeptidase nachweisen. Das lysosomale System der Riesenzellen befähigt diese zur aktiven Phagocytoseleistung. Darüber hinaus können sich die Riesenzellen neugebildeten Geflechtknochenbälkchen anlagern und osteoclastäre Funktionen übernehmen. Die enzymhistochemische und funktioneile Ähnlichkeit mit den mehrkernigen Osteoclasten wirft die Frage nach einer vergleichbaren Cytogenese beider Zellformen auf.
    Notes: Summary Multinucleated giant cells in giant cell granuloma are formed by cell fusion of capillary pericytes. In our present study we tried to analyze cell function and activity by histologic, histochemical, and electronmicroscopic examination of giant cells. Lysosomal enzymes such as acid phosphatase and amino-peptidase were found in giant cells which is in agreement with former work. By their lysosomal system giant cells are proved phagocytic. In addition, giant cells being localized at trabecular surfaces of newly formed woven bone may develop osteoclastic functions. The enzymatic and functional resemblance of giant cells and multinucleated osteoclasts points to the possibility of a similar cytogenesis of both cell types.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00444932
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Activity of osteoclastic bone resorption in primary hyperparathyroidism — a comparative electron microscopic and histomorphometric study (1976)
    Springer
    Calcified tissue international 22 (1976), S. 307-310 
    Details
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064085
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    Paper (German National Licenses)
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