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  • 1
    Electronic Resource
    Electronic Resource
    Kongenitale dyserythropoetische Anämien (1999)
    Springer
    Monatsschrift Kinderheilkunde 147 (1999), S. 992-999 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Kongenitale dyserythropoetische Anämie ; Ineffektive Erythropoese ; Erythrozytenmembran ; Eisenüberladung ; Key words Congenital dyserythropoietic anemia ; Ineffective erythropoiesis ; Iron overload ; Red cell membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The congenital dyserythropoietic anemias represent a group of rare inborn errors with ineffective erythropoiesis as the predominant mechanism of anemia. They are primarily classified into three types on the basis of characteristic abnormalities of the erythroblasts as shown by light and electron microscopy. There are distinct associated features such as pattern of heredity, cell kinetics and abnormalities of the cell membrane. In addition, patients with apparent CDA of heterogenous phenotype are observed, that cannot be attributed to any of the three types. Recently variant genes have been localized to different regions on chromosome 15 or 22. Cases of CDA were reported from many ethnics, in particular in families of meditarranean origin. Many patients load iron necessitating iron depletion. Gallstones are a frequent complication and are observed in childhood or adolescence. Therapeutic measures such as splenectomy, treatment by Interferon α or allogeneic bome marrow transplantation depend on the type and the severity of clinical expression, which shows large variations both within and between affected kindreds.
    Notes: Zusammenfassung Unter dem Begriff der kongenitalen dyserythropoetischen Anämien (CDA) wird eine geno- und phänotypisch heterogene Gruppe seltener angeborener Erkrankungen der Erythropoese zusammengefaßt. Sie sind durch eine Ineffektivität der Erythropoese und charakteristische morphologische Veränderungen der Erythroblasten gekennzeichnet, die eine Einteilung in 3 Typen erlauben. Damit assoziierte Merkmale betreffen den Erbgang, die Zellkinetik, Veränderungen der Erythrozytenmembran und die unterschiedliche Lokalisation des varianten Gens. Die Pathogenese ist nur teilweise bekannt. Bei dem meisten Patienten kommt es, teilweise bereits im Kindesalter, zur Gallensteinbildung und zur sekundären Hämochromatose, die eine Eisenentzugsbehandlung erfordert. Therapeutische Maßnahmen wie Splenektomie, Interferon-α-Behandlung oder allogene Knochenmarktransplantation richten sich nach dem CDA-Typ und der sehr unterschiedlichen Schwere der Erkrankung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050529
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  • 2
    Electronic Resource
    Electronic Resource
    Ausbildung in Onkologie (1999)
    Springer
    Der Onkologe 5 (1999), S. 637-641 
    Details
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Die onkologischen Erkrankungen gehören wegen ihrer Häufigkeit und ihrer Bedeutung für Morbidität und Mortalität zu den wesentlichen Herausforderungen, denen sich Absolventen des Medizinstudiums heute und in der Zukunft zu stellen haben. Die altersstandardisierte krebsspezifische Mortalität liegt in Deutschland bei 280/100.000 Einwohner jährlich; dies entspricht 250.000 Krebstodesfällen pro Jahr. Da etwa jede zweite Krebserkrankung geheilt wird, ist die Zahl der jährlich neudiagnostizierten Fälle etwa doppelt so hoch. Aufgrund des steilen Anstiegs des Krebsrisikos nach dem 60. Lebensjahr ist, trotz aller Bemühungen um eine verbesserte Primärprävention, mit weiter steigender Lebenserwartung eine weitere Zunahme wahrscheinlich. Globale Angaben zur Prävalenz sind nicht verfügbar und sagen wegen der unterschiedlichen natürlichen Prognose verschiedener Krebsformen wenig aus. Zweifellos ist unabhängig von der Inzidenzentwicklung jedoch auch hier mit einem weiteren Anstieg zu rechnen, da die Zahl der für viele Jahre erfolgreich palliativ behandelbaren, aber nicht geheilten Krebspatienten zunimmt. Die Onkologie ist weltweit ein Schwerpunktthema und bedarf der. Gestaltung eines onkologischen Curriculums in der ärztlichen Ausbildung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007610050419
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  • 3
    Electronic Resource
    Electronic Resource
    Die Bestimmung der Thrombozytenlebenszeit mit51Cr (1970)
    Springer
    Annals of hematology 21 (1970), S. 9-19 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A method is described which permits the determination of the survival time of autologous thrombocytes in patients with platelet counts as low as 5000 to 10 000/μl. 3 subjects with a normal platelet count and 15 patients with severe thrombocytopenia were studied. The life span of homologous platelets was determined in 6 patients also. The study with autologous platelets seems to give more reliable results in isoimmunized patients than the examination with homologous thrombocytes, perhaps in nonimmunized patients also, but more patients should be studied. The results obtained are discussed.
    Notes: Zusammenfassung Es wird eine Methode beschrieben, die die Bestimmung der Thrombozytenlebenszeit autologer Thrombozyten bei Patienten mit einer Thrombozytopenie von 5000–10 000 pro μl erlaubt. Es wurden 3 Personen mit normalen Thrombozytenzahlen und 15 Patienten mit ausgeprägter Thrombozytopenie untersucht. Bei 6 Patienten wurde außerdem eine Lebenszeitbestimmung von homologen Thrombozyten durchgeführt. Die gewonnenen Ergebnisse sprechen dafür, daß die Untersuchung mit autologen Thrombozyten bei gegenüber Thrombozyten isoimmunisierten Patienten zuverlässigere Ergebnisse bringt als das Studium mit Spenderthrombozyten, u. U. auch bei nicht isoimmunisierten Patienten, was jedoch durch weitere Untersuchungen belegt werden muß. Die gewonnenen Ergebnisse werden diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01633226
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  • 4
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1973)
    Springer
    Annals of hematology 26 (1973), S. 342-343 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01638701
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  • 5
    Electronic Resource
    Electronic Resource
    Autologous platelet transfusion in alloimmunized patients with acute leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 169-173 
    Details
    ISSN: 1432-0584
    Keywords: Autologous transfusion ; Platelets ; Immunization ; Acute leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Seventy-eight transfusions of autologous platelets were given to eight alloimmunized patients receiving curative chemotherapy for acute leukemia. Platelets were collected at regeneration of hematopoiesis after a chemotherapy cycle, cryopreserved with 5% dimethylsulfoxide in liquid nitrogen, and retransfused during bone marrow aplasia following the next treatment cycle. The in vitro platelet recovery after freezing, thawing, and washing was 85 ±4%. The in vivo corrected count increment 1 h after autologous platelet transfusions was 11±5×109/l. With the exception of moderate urticaria and slight nausea each after one transfusion, no immediate or chronic side effects occurred. The bleeding time was shortened and hemorrhage during bone marrow aplasia was prevented in all alloimmunized patients by autologous platelet transfusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01910313
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  • 6
    Electronic Resource
    Electronic Resource
    High-dose cytosine arabinoside and daunorubicin postremission therapy in adults with de novo acute myeloid leukemia Long-term follow-up of a prospective multicenter trial (1995)
    Springer
    Annals of hematology 71 (1995), S. 219-225 
    Details
    ISSN: 1432-0584
    Keywords: Key words De novo AML ; Adults ; HD-Ara-C/DNR consolidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A total of 149 consecutive de novo AML patients aged 50 years or less (median age = 37 years) were enrolled in this prospective multicenter trial initiated in May 1985. All patients received the same induction and early consolidation therapy with daunorubicin (DNR), cytosine arabinoside (Ara-C), and etoposide (DAV). High-dose Ara-C/DNR therapy included Ara-C at 3 g/m2, in 12 doses (HD-Ara-C/DNR I) and eight doses (HD-Ara-C/DNR II), followed by DNR 30 mg/m2 for 3 days. A complete remission (CR) was achieved in 104 (70%) patients; 61 complete responders received at least one cycle with HD-Ara-C/DNR. If those patients who were transplanted in first CR (n = 26), were not considered, the median relapse-free-survival (MRFS) of the remaining 78 patients was 15 months, with a probability of relapse-free survival (RFS) at 116 months of 30% (95% CI, 20–40%) after a median follow-up of 95 months. The MRFS of the HD-Ara-C/DNR consolidated patients was 25 months, with a probability of RFS at 116 months of 37% (95% CI, 24–50%). If all patients who were transplanted (n = 44) were not considered, the median survival time (MST) was 18 months with a probability of being alive at 118 months of 24% (95% CI, 16–33%). MST of the HD-Ara-C/DNR consolidated patients was 58 months with a survival probability of 46% (95% CI, 31–60%) at 118 months. Prognostic factor analysis did not reveal any significant influence of age, sex, FAB subtype, white blood cell count, hemoglobin level, thrombocyte count, LDH, or response to the first induction course on RFS of the HD-Ara-C/DNR consolidated patients. In summary, HD-Ara-C/DNR consolidation can improve the long-term outcome of a subgroup of de novo AML patients. Further improvement of the outcome seems to depend on the identification of patients with an inferior outcome under that strategy who might benefit from alternative treatment strategies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01744371
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  • 7
    Electronic Resource
    Electronic Resource
    Autologous platelet transfusion in alloimmunized patients with acute leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 169-173 
    Details
    ISSN: 1432-0584
    Keywords: Key words Autologous transfusion ; Platelets ; Immunization ; Acute leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Seventy-eight transfusions of autologous platelets were given to eight alloimmunized patients receiving curative chemotherapy for acute leukemia. Platelets were collected at regeneration of hematopoiesis after a chemotherapy cycle, cryopreserved with 5% dimethylsulfoxide in liquid nitrogen, and retransfused during bone marrow aplasia following the next treatment cycle. The in vitro platelet recovery after freezing, thawing, and washing was 85±4%. The in vivo corrected count increment 1 h after autologous platelet transfusions was 11±5×109/l. With the exception of moderate urticaria and slight nausea each after one transfusion, no immediate or chronic side effects occurred. The bleeding time was shortened and hemorrhage during bone marrow aplasia was prevented in all alloimmunized patients by autologous platelet transfusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01910313
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  • 8
    Electronic Resource
    Electronic Resource
    Allogenic bone marrow transplantation of chemotherapy for patients with acute myeloid leukemia in first complete remission: a decision analysis approach (1996)
    Springer
    Annals of hematology 72 (1996), S. 223-230 
    Details
    ISSN: 1432-0584
    Keywords: Key words Acute myeloid leukemia ; Bone marrow transplantation ; Decision analysis ; Decision-making
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The methodology of decision analysis was originally developed to improve clinical decisions of physicians for individual patients. However, it is also well suited to support consensus procedures. We have used this methodology to analyse the question whether allogeneic bone marrow transplantation (BMT) or consolidation chemotherapy (CCT) should be used as first line postremission treatment in patients with acute myeloid leukemia. Main risk factors relevant for the outcome after BMT and CCT are therapy-related mortality and leukemic relapse, respectively. If the possibility of salvage BMT for patients relapsing after CCT is included, the outcomes of the two strategies come rather close. However, they are clearly different in subtypes of leukemia with high or low risk of relapse, and in patients at high risk for BMT-related mortality. Sensitivity analysis considering the variation of more than one risk factor provides valuable information for decision making for both individual patients and particular subgroups of patients with acute myeloid leukemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050164
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  • 9
    Electronic Resource
    Electronic Resource
    High-dose cytosine arabinoside and daunorubicin postremission therapy in adults with de novo acute myeloid leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 219-225 
    Details
    ISSN: 1432-0584
    Keywords: De novo AML ; Adults ; HD-Ara-C/DNR consolidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A total of 149 consecutive de novo AML patients aged 50 years or less (median age = 37 years) were enrolled in this prospective multicenter trial initiated in May 1985. All patients received the same induction and early consolidation therapy with daunorubicin (DNR), cytosine arabinoside (Ara-C), and etoposide (DAV). High-dose Ara-C/DNR therapy included Ara-C at 3 g/m2, in 12 doses (HD-Ara-C/DNR I) and eight doses (HD-Ara-C/DNR II), followed by DNR 30 mg/m2 for 3 days. A complete remission (CR) was achieved in 104 (70%) patients; 61 complete responders received at least one cycle with HD-Ara-C/DNR. If those patients who were transplanted in first CR (n=26), were not considered, the median relapsefree-survival (MRFS) of the remaining 78 patients was 15 months, with a probability of relapse-free survival (RFS) at 116 months of 30% (95% CI, 20–40%) after a median follow-up of 95 months. The MRFS of the HD-Ara-C/DNR consolidated patients was 25 months, with a probability of RFS at 116 months of 37% (95% CI, 24–50%). If all patients who were transplanted (n=44) were not considered, the median survival time (MST) was 18 months with a probability of being alive at 118 months of 24% (95% CI, 16–33%). MST of the HD-Ara-C/DNR consolidated patients was 58 months with a survival probability of 46% (95% CI, 31–60%) at 118 months. Prognostic factor analysis did not reveal any significant influence of age, sex, FAB subtype, white blood cell count, hemoglobin level, thrombocyte count, LDH, or response to the first induction course on RFS of the HD-Ara-C/DNR consolidated patients. In summary, HD-Ara-C/DNR consolidation can improve the long-term outcome of a subgroup of de novo AML patients. Further improvement of the outcome seems to depend on the identification of patients with an inferior outcome under that strategy who might benefit from alternative treatment strategies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01744371
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  • 10
    Electronic Resource
    Electronic Resource
    The abundant presence of Söderström bodies in cytology smears of fine-needle aspirates contributes to distinguishing high-grade non-Hodgkin's lymphoma from carcinoma and sarcoma (1997)
    Springer
    Annals of hematology 74 (1997), S. 175-178 
    Details
    ISSN: 1432-0584
    Keywords: Key words Söderström bodies ; Cytology smears ; Non-Hodgkin's lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Söderström bodies, also termed lymphoglandular bodies (LGB) and detectable in fine-needle aspiration cytology smears, have long been accepted as indicative of lymphoid tissues. To investigate the validity of this association, we examined 588 cytologic smears from high-grade non-Hodgkin's lymphoma (NHL), carcinoma, and sarcoma. Slides with lymphocytes in the vicinity of carcinoma and sarcoma cells had been excluded. Two independent observers scored smears to number, size, color, form, and smear background of the LGB. In 68 of 359 (19%) nonlymphoid malignancies rare (defined as 〈1 LGB per high-power field) or occasional LGB (defined as 1–20 LGB per high-power field) were detectable. Half of these tumors consisted of melanomas, small cell lung carcinomas, and teratomas; the other half encompassed undifferentiated sarcomas. However, none of the smears obtained from carcinoma or sarcoma tissue had abundant LGB (defined as 〉20 LGB per high-power field). When number of LGB was estimated to be abundant, the sensitivity for diagnosing a lymphoma was 54%; however, specificity was 100%. The difference in showing LGB between high-grade NHL and carcinoma/sarcoma was highly significant (p=0.0001). The presence of abundant LGB in cytologic smears strongly suggests the diagnosis of lymphoma, while the absence of LGB nearly excludes this diagnosis. No trends were observed with the other criteria which were tested. LGB in aspiration cytology smears from malignant tumors thus represent a useful tool to distinguish high-grade NHL from carcinoma and sarcoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050278
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