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  • 1975-1979  (3)
  • 1970-1974  (5)
Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 8 (1978), S. 644-651 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mice exhibiting a spontaneous SLE-like lethal autoimmunity (female NZB/W hybrids) were given monthy doses of cyclophosphamide (CPA) 240 mg/kg p.o. starting at four months of age. Antibodies to DNA and sheep red blood cells (SRBC) were measured as well as general well being of the mice. The CPA-treated group demonstrated a marked increased in survival compared to the untreated controls with reduction of anti-DNA antibody levels but only a slight inhibition of the anamnestic response to SRBC immunization.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 250 (1974), S. 493-495 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The mechanism of chromate carcinogenicity is not understood. But considerable evidence exists which suggests that chemical carcinogens are also mutagens although the converse is not necessarily true5. We have, therefore, tested the hypothesis that some chromium compounds, including a known ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 86 (1979), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A method for recording the fetal electroencephalogram (EEG) during labour is described. Technical specifications for the construction of a suitable electrode are detailed. One hundred and twenty-three patients in labour were monitored using this technique and the success rate of obtaining records for analysis was 91 per cent.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A new pharmacological method for screening potential immunosuppressive drugs, the local graft-versus-host reaction in rats, has been used to evaluate the efficacy of cyclophosphamide applied at varous times in the development of this reaction. This drug was relatively ineffective when applied to the F1 hybrid recipient of the graft cells (splenic lymphocytes) prior to grafting, rather more effective when given only to the parental donor prior to harvesting the graft cells, and most effective when given to the recipient either immediately after the graft or after a delay of three days. Biliary and hepatic metabolites of cyclophosphamide diminished the competence of parental lymphocytes to evoke the graft response. By contrast, cyclophosphamide itself was devoid of such activity in vitro. Non-enzymic decomposition (hydroxylation) of cyclophosphamide with the Udenfriend system (Fe++, ascorbate, EDTA) efficiently generated in vitro graft-deactivating agents. Fortified liver preparations from normal female rats formed alkylating metabolites at a much slower rate, and adjuvant-arthritic male rats were less capable of generating graft deactivating cyclophosphamide metabolites in vitro, than liver preparations from normal male rats. However cyclophosphamide appeared to be no less effective in normal female or arthritic male rats in vivo, than in normal male rats, in controlling the graft-versus-host response. This lack of correlation between rates of hepatic cyclophosphamide metabolism and evident bioefficacy as an immunosuppressive drug is discussed, with special reference to similar findings by Sladek concerning rates of bioactivation and anti-tumor efficacy.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 4 (1974), S. 113-116 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Methotrexate administered to rats undergoing a local graft-versus-host reaction (GvHR) had two quite distinct effects on the lymphoid hypertrophy, that characterizes the GvHR, depending upon the timing of the drug administration: (1) When given after the GvHR is initiated, Methotrexate behaves as a normal cytostatic agent and strongly suppresses the lymphoid hypertrophy. (2) However, when administered before the GvHR is initiated, Methotrexate considerably stimulates the proliferative response of the spleen and draining lymph nodes. Arguments are presented that this latter (stimulatory) effect of Methotrexate may be due to drug action upon a nonimmunological component of the GvHR, contributed by the host, which normally resists/attenuates the aggressive potential of the grafted lymphocytes. The same regimen of Methotrexate had no effect on (1) the aggressive potential of lymphoid cells that passively transfer EAE, or (2) the humoral response to SRBC.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Theory of computing systems 6 (1972), S. 334-342 
    ISSN: 1433-0490
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Summary The following three results concerning tree automata are presented in this paper. (1) Rounds has presented the following open problem: For every recognizable setR, can we construct a deterministic finite-state transformation recognizingR? We show that this is not possible, in fact, even for a local set. However, the following is true: For every recognizable setR there is an inverse projectionR′ effectively obtained such thatR′ is recognized by a deterministic finite-state transformation. (2) Martin and Vere in their study of tree automata leave open the question of whether Generalized Syntax Directed Transductions (GSDT's) are closed under Arden's transformation or Greibach's transformation, and conjecture that they are not. We prove that this conjecture is true. It is also shown that GSDT's are not closed under transformation to LR(k) grammars. (3) Peters and Ritchie have shown that if, in a grammar where the generative rules are context-free, there are “recognition” rules which are context-sensitive, the language recognized is still context-free. A tree-automata-oriented proof is given by Rounds. We show that a similar result holds also for right linear grammars, i.e., if the generative rules are right linear, then using context-sensitive rules for “recognition”, one can still recognize only regular languages. Some other related results concerning context-sensitive extensions of subclasses of context-free languages are also presented.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 2 (1972), S. 236-240 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A sulfated polysaccharide containing approximately twelve glucose residues was sulfated with radioactive sulfate and its distribution in rats and dogs was studied. This compound appeared to have a great affinity for tissue. The tissue of greatest retention was the liver which exhibited increasing concentration per gram of tissue while the blood level was falling. Attempts were made to prevent or remove the radioactivity from the liver by altering the reticulo-endothelial system, but were unsuccessful.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Sozial- und Präventivmedizin 23 (1978), S. 8-13 
    ISSN: 1420-911X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Jahre 1974 wurde in Grossbritannien ein Gesetz über Arbeitsmedizin und Arbeitssicherheit eingeführt, das das Problem neu angeht und die Organisation der Arbeitsmedizin und Arbeitssicherheit in diesem Land auf lange Sicht in starkem Masse beeinflussen wird. Der Zweck dieser Arbeit ist es, die diesem Gesetz zugrundeliegenden Prinzipien darzustellen, auf die Auswirkungen des neuen Gesetzes auf Arbeitgeber, Betriebsleiter, Arbeitnehmer und ihre Organisationen hinzuweisen, und die Entwicklung zu besprechen, die seit 1974 im Rahmen der Organisation der Arbeitsmedizin und Arbeitssicherheit als Resultat der neuen Gesetzgebung zu verzeichnen sind.
    Abstract: Résumé L'introduction en 1974 du «Britain's Health and Safety at Work Act» a marqué dans les conceptions et l'approche de l'hygiène et de la sécurité professionnelles un changement qui aura à long terme des effets importants sur l'organisation de ces disciplines. Le propos de ce travail est de souligner les principes généraux de cette approche, contenus dans l'Acte de 1974, de montrer les implications de ce nouvel Acte sur les organisations d'employeurs, de chefs d'entreprises, d'employés et de représentants de l'administration, de discuter les développements dans l'organisation de l'hygiène et la sécurité du travail qui en résultent.
    Notes: Summary Britain's Health and Safety at Work Act introduced in 1974 marked a change in approach to occupational health and safety which is having important long-term effects on the organization of occupational health and safety in Britain. The purpose of this paper is to outline the broad principles of approach to health and safety at work contained within the 1974 Act; highlight the implications of the new Act for employers, managers, employees, and representative organizations, and discuss the developments in the organization of occupational health and safety as a result of the 1974 Act.
    Type of Medium: Electronic Resource
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