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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 13 (1965), S. 410-414 
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 88 (1966), S. 1953-1958 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 38 (1966), S. 913-915 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 88 (1966), S. 2591-2593 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 90 (1968), S. 5232-5236 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 11 (1968), S. 122-139 
    ISSN: 1432-0533
    Keywords: Juvenile Lipidosis ; Electron Microscopy ; Histochemistry ; Biochemistry ; Granular Lipid Inclusions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Elektronenmikroskopische, histochemische und biochemische Untersuchungen eines Falles von juveniler Lipidose werden mitgeteilt. Die neuronalen Einschlüsse sind zumeist von einer unit membrane umgeben und zeigen fingerabdruckähnliche Muster. Membranovesiculäre Körperchen finden sich ebenfalls in den Nervenzellperikaryen; typische granuläre Lipofuscinkörperchen werden aber nicht gesehen. Die Astrocyten der Rinde enthalten eine ähnliche Art von Einschlüssen, von denen aber die Einschlüsse in den Astrocyten der Marksubstanz völlig verschieden sind. Die Lokalisation der Aktivität von saurer Phosphatase in allen Einschlußtypen läßt an ihre mögliche lysosomale Natur denken. Die biochemische Analyse deckt keine spezifischen Abweichungen auf.
    Notes: Summary Electron microscopic, histochemical and biochemical studies of a case of juvenile lipidosis have been presented. The neuronal inclusions were mostly unit membranebound with fingerprint-like patterns. Membrano-vesicular bodies were also found in the neuronal perikarya, but “typical” granular lipofuscin bodies were not seen. Cortical astrocytes contained a similar type of inclusion but the inclusions in the astrocytes in the white matter were quite different. The localization of acid phosphatase activity in all types of inclusions suggests their possible lysosomal nature. Biochemical analysis failed to pin-point any specific abnormalities.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 12 (1969), S. 218-226 
    ISSN: 1432-0533
    Keywords: Muscle ; Actin ; Z-Line ; Myofibril ; Loss of Myofilaments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Verlust der I-Band-Myofilamente und des Materials im Z-Streifen werden bei drei verschiedenen pathologischen Zuständen beschrieben. dystrophischer Myotonie, subakuter spinaler Strangdegeneration und myatrophischer Lateralsklerose. Im Falle einer myatrophischen lateralsklerose wird auch eine Hypertrophie des Z-Streifens beschrieben. Es wird eine mögliche cyclische Alteration des Z-Streifens als Reaktion auf verschiedene, bisher unbekannte pathologische Reize und in Verbindung damit ein Verlust der Myofilamente des I-Bandes vermutet.
    Notes: Summary Loss of I-band myofilaments and Z-line material is described in three different pathological conditions; namely, dystrophia myotonica, sub-acute combined degeneration of the spinal cord and amyotrophic lateral sclerosis. In the case of amyotrophic lateral sclerosis hypertrophy of the Z-line is also described. A possible cyclical alteration in the Z-line in response to, so far unknown, pathological stimuli is suggested and in conjunction with this possible loss of I-band myofilaments.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 12 (1969), S. 183-188 
    ISSN: 1432-0533
    Keywords: Dystrophia myotonica ; Electron Microscopy ; Sarcolemmal Nuclei ; Myofibrillar Material
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In fünf Fällen von Dystrophia myotonica zeigte die elektronenoptische Untersuchung von bioptisch entnommenem Material zentrale und subsarkolemmale Kerne, die komplexe vacuoläre Areale um myofibrilläres Material enthalten. Diese bisher nicht beobachtete Veränderung könnte durch Verlagerung von myofibrillärem Material in den Kern während seiner Wanderung in das Faserzentrum durch Invagination, aber nicht Durchbrechung der Kernmembran bedingt sein.
    Notes: Summary In five cases of dystrophia myotonica electron microscope preparations of muscle taken at biopsy showed both centrally placed and subsarcolemmal nuclei containing complex vacuolar areas enclosing myofibrillar material. It is suggested that this appearence, which has not been seen in any other condition, may be due to the forcing of myofibrillar material into the nucleus during its migration to the centre of the fibre invaginating but not breaching its membrane.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 4 (1965), S. 436-441 
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electron microscopy of motor end plates from cases of Guillain-Barré syndrome and myasthenia gravis showed that shrinkage of the terminal axonic expansions was accompanied by replacement of the expansion in its synaptic position by Schwann cell cytoplasm.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 5 (1965), S. 225-242 
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. In einer großen Serie von Muskelbiopsien von Fällen pseudohypertrophischer Muskeldystrophie zeigten vital gefärbte Präparate fast ausnahmslos Veränderungen an den motorischen Nervenendungen. 2. Die motorischen Endplatten zeigten entweder schwach gefärbte Anschwellung und Fusion der Endausbreitung mit Vereinfachung der Endverzweigungen oder Schrumpfung und dunkler Anfärbung der Endausbreitung, wodurch die Endplatten ein stumpfartiges Aussehen erhielten. Diese zweite Art der Veränderung zeigte sich vor allem an atropischen Muskelfasern. 3. Elektronmikroskopische Präparate lassen vermuten, daß die Vitalität der Neurone nicht vermindert ist und die beobachteten Veränderungen Sekundärerscheinungen einer primären Muskelfasererkrankung darstellen, die solchermaßen ein weiteres Beispiel für die Labilität der Struktur der motorischen Endplatten in bezug auf ihre Reaktionsfähigkeit bei Veränderungen ihrer Umgebung liefern.
    Notes: Summary 1. In a large series of muscle biopsies from cases of pseudohypertrophic muscular dystrophy vitally stained preparations almost invariably showed changes in the terminal motor innervation. 2. The motor end plates showed either pale staining swelling and fusion of the terminal expansions with some simplification of the terminal arborisation or shrinkage and dark staining of the terminal expansions giving the end plate a stumpy appearance. This second change was mainly seen on atrophic muscle fibres. 3. Electron microscopic preparations suggested that the vitality of the neurone was not diminished and the changes seen were secondary to primary disease of the muscle fibre thus providing yet another example of the lability of the structure of the motor end plate in response to changes in its environment.
    Type of Medium: Electronic Resource
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