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  • 1
    Digitale Medien
    Digitale Medien
    Role of .sigma.-Donation in the Stereocontrol of Hydrogen-Transfer Reactions Involving Acyclic Radicals (1995)
    s.l. : American Chemical Society
    The @journal of organic chemistry 60 (1995), S. 288-289 
    Details
    ISSN: 1520-6904
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/jo00107a002
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  • 2
    Digitale Medien
    Digitale Medien
    Elementary and macroscopic two-level fluctuations in high-Tc superconductors (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 80 (1996), S. 2939-2948 
    Details
    ISSN: 1089-7550
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: The relation between random telegraph noise and 1/f-type background voltage fluctuations in current biased high-Tc films has been investigated. The experiments have revealed that the telegraph noise in high-Tc superconducting films is due to a combined action of a macroscopic two-level fluctuator and a detector. The macroscopic telegraph signal does not constitute an elementary contribution to 1/f noise. However, the behavior of telegraph and 1/f-like voltage fluctuations have shown astonishing similarities. Telegraph voltage amplitudes and 1/f power spectrum magnitude scale linearly with changing current flow above almost identical threshold currents. The telegraph signal symmetry characteristics have been found to be linear also but with distinctively different offset currents. Analysis of the measured characteristics indicates that the telegraph and 1/f fluctuations are due to different flux fluctuators coupled to observable voltages by the same detector mechanism. © 1996 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.363150
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  • 3
    Digitale Medien
    Digitale Medien
    Hierarchic T-Cell Help to Non-Linked B-Cell Epitopes (1996)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 44 (1996), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The induction of antibodies against peptides requires the presence of a T helper cell epitope. In the absence of an added T-cell epitope only 10% of the mice, or less depending on the strain, gave an antibody response to a series of peptides of the measles virus (MV) fusion (F) protein. After co-immunization with a non-covalently coupled T-cell epitope more than 60% of the peptides became immunogenic. Considerable differences became apparent when BALB/c mice were immunized with peptides in the presence of different T-cell epitopes. An immunodominant T-cell epitope of the MV-F protein was more efficient than a subdominant or a cryptic T-cell epitope in providing help to a non-linked B-cell epitope. There is both a ranking order of the amount of help which B-cell epitopes require and a ranking order for the help T-cell epitopes are able to provide. The capability of a T-cell epitope to provide help to a B-cell epitope correlated with its own immunogenicity, i.e. the intensity of the antibody response to the peptide representing the T-cell epitope. The data suggest that for each MHC class II allele there is an optimal T-cell epitope which can provide help to a maximal number of B-cell epitopes and that such a peptide can be identified by its ability to induce antibodies against itself. By using this strategy, the authors were able to induce antibodies which cross-reacted with the MV.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-3083.1996.d01-336.x
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  • 4
    Digitale Medien
    Digitale Medien
    Degradation of desferrioxamines by Azospirillum irakense: Assignment of metabolites by HPLC/electrospray mass spectrometry (1999)
    Springer
    BioMetals 12 (1999), S. 255-264 
    Details
    ISSN: 1572-8773
    Schlagwort(e): Azospirillum ; degradation ; ferrioxamines ; siderophores
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract Based on a recent finding that an Azospirillum isolate ASP-1 possessing high 16S rDNA similarity to Azospirillum irakense was able to degrade desferrioxamine type siderophores (Winkelmann et al. BioMetals 9, 78-83, 1996), various members of the genus Azospirillum were analyzed for their ability to degrade desferrioxamines. While the desferrioxamine-degrading activity was absent or scarcely detectable in strains of A. lipoferum, A. brasilense, A. amazonense, degradation activity seemed to be confined to the species A. irakense (KBC-1, KA3). Also the identity of strain ASP-1 as A. irakense could be confirmed by species-specific oligonucleotide hybridization, InterLINE PCR fingerprinting and carbon source utilization pattern (BIOLOG) analysis. Products of desferrioxamine B degradation were analyzed by analytical HPLC and HPLC/electrospray mass spectrometry. Using whole cells and purified enzyme it was shown that the trihydroxamate desferrioxamine B (561 amu) is split at the N-terminal amide bond yielding a monohydroxamate (MH1, 219 amu) and a dihydroxamate (DH1, 361 amu) metabolite. A second monohydroxamate (MH2, 319 amu) resulted from DH1 after splitting the acetylhydroxamate bond. Minor amounts of a further dihydroxamate (DH2, 419 amu) originated from splitting the second amide bond in desferrioxamine B. In addition to desferrioxamine B, several other linear and cyclic desferrioxamines and derivatives were degraded, whereas desferricoprogen and desferri-ferrichrome were not degraded, indicating high substrate specificity of the desferrioxamine hydrolase in A. irakense species. A simple microtiter plate assay was developed which can be used to phenotypically discriminate and identify species of A. irakense from other Azospirillum species by their characteristic feature of desferrioxamine degradation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1009242307134
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  • 5
    Digitale Medien
    Digitale Medien
    Fermentative Vorgänge im Ovar (1959)
    Springer
    Archives of gynecology and obstetrics 193 (1959), S. 284-287 
    Details
    ISSN: 1432-0711
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00837197
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  • 6
    Digitale Medien
    Digitale Medien
    Production of rhizoferrin and new analogues obtained by directed fermentation (1996)
    Springer
    Applied microbiology and biotechnology 45 (1996), S. 664-670 
    Details
    ISSN: 1432-0614
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Abstract  The Zygomycete Cunninghamella elegans produces the polycarboxylate siderophore rhizoferrin. Production depends mainly on iron concentration in the medium. With an optimized production medium the yield of rhizoferrin in a bioreactor could be increased to more than 4 g/l. Supplementation of the basic production medium with different precursors led to the formation of nine new rhizoferrins. Both the diaminobutane backbone and the citric acid side-chains of rhizoferrin could be substituted by appropriate analogues. These substitutions led to new siderophores either with a variable length of diamine bridge or with fewer or different functional groups. The proportion of the new diamine analogues relative to the total rhizoferrin could be markedly increased by the use of α-difluoromethylornithine, an inhibitor of the ornithine decarboxylase.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002530050745
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  • 7
    Digitale Medien
    Digitale Medien
    MS-Pep: a computer program for the interpretation of mass spectra of peptide libraries (1997)
    Springer
    Fresenius' journal of analytical chemistry 359 (1997), S. 10-14 
    Details
    ISSN: 1432-1130
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Electrospray mass spectrometry (ESI-MS) is an established method for the qualitative analysis of synthetic peptide libraries and combinatorial mixtures or collections of small organic compounds. However, the calculation of the mass distribution of even small peptide mixtures is a time-consuming and error-proned task. Therefore, the computer program MS-Pep has been developed, which calculates the masses of expected peptides, byproducts and the mass distributions of peptide libraries.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002160050528
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  • 8
    Digitale Medien
    Digitale Medien
    Late results after resection of benign hepatic tumors: clinical and radiological findings (1997)
    Springer
    European radiology 7 (1997), S. 327-332 
    Details
    ISSN: 1432-1084
    Schlagwort(e): Key words: Liver neoplasms ; Surgery ; Echinococcosis ; Focal nodular hyperplasia ; Hemangioma ; US ; CT
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. The purpose of our work was to provide data on the recurrence of resected benign hepatic lesions and to evaluate the value of follow-up examinations in this group of patients. From August to October 1993, 75 patients who had been admitted for liver surgery for benign tumors between 1975 and 1993 were controlled by physical examinations, serological tests, US, and, in the case of equivocal US findings, by CT. The histological diagnoses of the operative specimen included hydatidosis in 43 patients, focal nodular hyperplasia (FNH) in 12 patients, liver cell adenoma in 8 patients, cavernous hemangioma in 8 patients, and congenital cyst in 4 patients. Hepatic scars were observed in 36 of the 75 patients. Four cases of intrahepatic recurrence and 1 case of intraperitoneal spread were observed in the 42 patients with recent hydatosis. Long-term postoperative controls (specific serological tests, US) are necessary in the management of patients with hydatid disease. Follow-up examinations are not indicated in asymptomatic patients who have been operated on for FNH, hemangioma, or congenital cysts.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s003300050160
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  • 9
    Digitale Medien
    Digitale Medien
    Two types of modified cardiac Na+ channels after cytosolic interventions at the α-subunit capable of removing Na+ inactivation (1997)
    Springer
    European biophysics journal 25 (1997), S. 189-200 
    Details
    ISSN: 1432-1017
    Schlagwort(e): Key words Single cardiac Na+ channels ; Site-directed antipeptide antibody ; Proteolysis ; Protein reagents ; Calpain ; Stochastic mode switching
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Physik
    Notizen: Abstract Failure of inactivation is the typical response of voltage-gated Na+ channels to the cytosolic presence of proteolytic enzymes, protein reagents such as N-bromoacetamide (NBA) or iodate, and antibodies directed against the linker between domains III and IV of the α-subunit. The present patch clamp experiments with cardiac Na+ channels aimed to test the hypothesis that these interventions may provoke the occurrence of non-inactivating Na+ channels with distinct kinetic properties. A site-directed polyclonal antibody (anti-SLP2, target sequence 1481–1496 of the cardiac Na+ channel α-subunit) eliminated fast Na+ inactivation to induce burst activity which was accompanied by the occurrence of two open states. A deactivation process terminated channel activity during membrane depolarization proceeding with time constants of close to 40 ms (at –40 mV). NBA-modified and iodate-modified Na+ channels were kinetically indistinguishable from the anti-SLP2-modified type since they likewise deactivate and, thus, attain an only moderate Po of close to 20%. This is fundamentally different from the behaviour of enzymatically-modified Na+ channels: after cytosolic proteolysis with α-chymotrypsin, trypsin or pronase, mean Po during membrane depolarization amounted to approximately 40% because deactivation operated extremely slowly and less efficiently (time constants 100–200 ms at –40 mV, as a minimum) or was virtually non-operating. In-vitro cleavage of the synthetic linker sequence 1481–1496 confirmed that this part of the α-subunit provides a substrate for these peptidases or reactants for NBA but cannot be chemically modified by iodate. This iodate resistance indicates that iodate-modified Na+ channels are based on a structural alteration of still another region which is also involved in Na+ inactivation, besides the linker between domains III and IV of the α-subunit. Endogenous peptidases such as calpain did not affect Na+ inactivation. This stresses the stochastic nature of a kinetic peculiarity of cardiac Na+ channels, mode-switching to a non-inactivating mode.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002490050031
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  • 10
    Digitale Medien
    Digitale Medien
    The carboxylate type siderophore rhizoferrin and its analogs produced by directed fermentation (1995)
    Springer
    Journal of industrial microbiology and biotechnology 14 (1995), S. 105-112 
    Details
    ISSN: 1476-5535
    Schlagwort(e): Iron chelators ; Rhizoferrin ; Rhizoferrin analogs ; Carboxylate siderophores ; Directed fermentation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Summary Rhizoferrin is a novel carboxylate-type siderophore which has recently been isolated fromRhizopus microsporus and other fungi of the Mucorales (Zygomycetes). The present investigation shows that a variety of rhizoferrin analogs can be produced by directed fermentation. Thus both the diaminobutane backbone and the citric acid side chains of rhizoferrin have been substituted by diamine and citric acid analogs added to the culture medium. The new ligands as well as their iron complexes have been characterized by physicochemical methods. Conditions of precursor incorporation and implications for the biosynthesis of the new siderophores are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01569891
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