Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Multifokale atriale Tachykardie im Kindesalter Darstellung zweier Fallbeispiele und Übersicht über die Literatur (1999)
    Springer
    Monatsschrift Kinderheilkunde 147 (1999), S. 1074-1080 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Multifokale atriale Tachykardie (MAT) ; Chaotische Vorhoftachykardie ; Antiarrhythmische Therapie ; Säugling ; Angeborene Herzfehler ; Key words Multifocal atrial tachycardia (MAT) ; Chaotic atrial rhythm ; Antiarrhythmic therapy ; Infancy ; Congenital heart defects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Definition: Multifocal atrial tachycardia (MAT) (also called chaotic atrial rhythm or mechanism) is a rare rhythm disturbance in infancy and childhood. It usually occurs as a sequela of chronic obstructive lung disease in adults with an incidence of about 0,5% and a high mortality rate. In infancy, the incidence has been estimated to be about 0,2%, mainly found in young infants. Diagnosis: It is characterized by an atrial frequency greater than 100 per minute, 3 or more different p-wave contours, variable PP, RR and PR-intervals, and a discrete isoelectric baseline. The origin of the arrhythmia remains unclear but atrial distension may play a significant role. Discussion: We report on the clinical course and management of two patients and also review the relevant literature.
    Notes: Zusammenfassung Definition: Die multifokale atriale Tachykardie (MAT) bzw. chaotische atriale Tachykardie oder chaotische Vorhoftachykardie ist im Kindesalter selten. Im Erwachsenenalter ist sie vorwiegend bei Patienten mit akuten oder chronischen Lungenerkrankungen beschrieben und mit einer hohen Letalität behaftet. Im Gegensatz zum Auftreten im Erwachsenenalter besitzt die MAT im Kindesalter durchweg eine gute Prognose. Diagnose: Elektrokardiographisch ist die MAT durch mindestens 3 unterschiedlich konfigurierte P-Wellen charakterisiert, die nicht der elektrischen Sinusachse entsprechen. Es besteht eine isoelektrische Linie zwischen den P-Wellen, die Vorhoffrequenz beträgt normalerweise mehr als 100 Schläge/min mit variablen P-P-, P-R- und R-R-Intervallen. Die Genese dieser Tachyarrhythmie ist unklar, eine Vorhofbelastung als Auslöser ist jedoch wahrscheinlich. Diskussion: Die möglichen Ursachen und Therapiestrategien bei chaotischer Vorhoftachykardie werden anhand zweier Kasuistiken diskutiert und eine Übersicht über die vorliegende Literatur gegeben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050541
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effects of (+)- and (±)-sotalol on repolarizing outward currents and pacemaker current in sheep cardiac Purkinje fibres (1989)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 340 (1989), S. 696-704 
    Details
    ISSN: 1432-1912
    Keywords: Sheep Purkinje fibre ; Outward currents ; Pacemaker current ; (+)-Sotalol ; (±)-Sotalol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study was aimed to differentiate the action of (+)- and (±)-sotalol (10–1000 μmol/l) on membrane currents which are active during the repolarization of cardiac action potentials Effects where studied in shortened sheep cardiac Purkinje fibres with the two-microelectrode voltage-clamp technique Action potentials were activated at a frequency of 0.25 Hz and membrane currents at 0.03 Hz or 0.05 Hz in most experiments. Out of the currents investigated the transient outward current (ito) reacted most sensitively to (+)- and (±)-sotalol. Ito-amplitude was decreased on the average to 77% of reference at 10 μmol/l and to 53% at 1000 μmol/l (+)- or (±)-sotalol. The maximally available ito-current was decreased but the voltage-dependent control of inactivation was left nearly unchanged. The initial inwardly rectifying current (iKi), which propels the last repolarization phase of the action potential and controls resting potential to a large extent was reduced on the average to 93% of reference at 10 μmol/l and to 62% at 1000 μmol/l (+)- or (±)-sotalol. Time-dependent (delayed) outward current (iK) was on the average not affected by (+)- or (±)-sotalol up to 100 μmol/l and was decreased to 84% of reference current under the influence of 1000 μmol/l. An initial outward current, which is activated at positive membrane potentials (iinst) was not clearly affected by (+)- or (±)-sotalol at concentrations up to 1000 μmol/l Pacemaker current (if) was not influenced by the drugs up to 100 μmol/l. Only at 1000 μmol/l was the amount of available if-current decreased to 79% of reference. (The potential-dependent control of activation was not affected) Time constants of time-dependent currents ito, iK and if did not change in concentrations up to 1000 μmol/l of the drug. Action potential duration increased at (+)- or (±)-sotalol concentrations ≥ 10 μmol/l and maximal prolongation was achieved at concentrations of 100–300 μmol/l Resting potential remained nearly unchanged at these concentrations, but the membranes depolarized at 1000 μmol/l. According to our data action potential prolongation in sheep Purkinje fibres under the influence of (+)- and (±)-sotalol correlates to the drug-induced block to ito-current and inwardly rectifying iK1-current.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00717747
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...