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  • 1
    Digitale Medien
    Digitale Medien
    Effects of substitutions of glycine and asparagine for serine^1^3^2 on activity and binding of human lipoprotein lipase to very low density lipoproteins
    Amsterdam : Elsevier
    FEBS Letters 298 (1992), S. 36-38 
    Details
    ISSN: 0014-5793
    Schlagwort(e): Catalytic site ; Lipoprotein lipase ; Very low density lipoprotein
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(92)80017-B
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  • 2
    Digitale Medien
    Digitale Medien
    Acetylcholine-induced change in intracellular Cl− activity of the mouse lacrimal acinar cells (1985)
    Springer
    Pflügers Archiv 405 (1985), S. 108-111 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Lacrimal gland ; Cl− activity ; Acetylcholine ; Cl− permeability ; Ca2+ ionophore
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Using double-barreled Cl−-sensitive microelectrodes, intracellular Cl− activity (A Cl i ) in the mouse lacrimal acinar cells in vitro was determined in both resting and secretory phases. In the resting stateA Cl i was 31 mmol/l which was 1.4 times higher than that predicted for the passive distribution according to the membrane potential (V m) of −41 mV. Addition of acetylcholine (ACh, 1μM) hyperpolarizedV m to −63 mV and decreasedA Cl i to 20 mmol/l which was still twice the equilibrium activity. A-23178 produced similar changes inV m andA Cl i to those induced by ACh. It was concluded that Cl− was actively accumulated in the acinar cells and, in the secretory phase, Cl− efflux was enhanced by the increased driving force and Ca2+-mediated increase in the Cl− permeability across the cell membrane.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00584530
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  • 3
    Digitale Medien
    Digitale Medien
    Lipoprotein lipase mass and activity in severe hypertriglyceridemia
    Amsterdam : Elsevier
    Clinica Chimica Acta 216 (1993), S. 113-123 
    Details
    ISSN: 0009-8981
    Schlagwort(e): ELISA ; Functionally defective LPL ; Human post-heparin plasma LPL ; Immunoassay ; Lipoprotein lipase
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(93)90144-S
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  • 4
    Digitale Medien
    Digitale Medien
    Microfluorimetric imaging study of the mechanism of activation of the Na+/H+ antiport by muscarinic agonist in rat mandibular acinar cells (1991)
    Springer
    Pflügers Archiv 419 (1991), S. 338-348 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Na+/H+ exchange ; Intracellular pH regulation ; Salivary gland ; Protein kinase C ; Intracellular Ca2+ ; Acetylcholine ; Ionomycin ; Phorbol esters
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The mechanism of regulation of intracellular pH (pHi) in dispersed acini from the rat mandibular salivary gland has been studied with a microfluorimetric imaging method and the pH probe 2′,7′-bis(2-carboxyethyl)-5(and −6)-carboxyfluorescein. The pHi in the TRIS/HEPES-buffered standard solution was 7.29±0.01. Addition of 1 μmol/l acetylcholine (ACh) or ionomycin caused a sustained increase in the pHi. These agents decreased pHi in the absence of external Na+ or in the presence of amiloride. The rate of pHi recovery from an acid load after NH 4 + prepulse was a linear function of pHi and increased as pHi became more acidic. Addition of ACh shifted the relationship towards a more alkaline pHi range. The increase in pHi induced by ACh or ionomycin was not inhibited by the protein kinase C inhibitors staurosporine (10 nM) and 1-(5-isoquinolinesulfonyl)-1-methylpiperazine (50 μmol/l). Addition of 0.1–1 μmol/l phorbol 12-myristate 13-acetate (TPA) had little effect on pHi within 10 min; however, exposure to TPA for 120 min resulted in a significant rise in pHi. In Ca2+-free solution with 50 μmol/l 8-(diethylamino)-octyl-3,4,5-trimethoxybenzoate, the ACh-induced rise in both pHi and cytosolic Ca2+ concentration was suppressed. ACh and ionomycin caused an increment of amiloride-sensitive acid output into the extracellular fluid, while 20 μmol/l 1-oleoyl-2-acetylglycerol had little effect on it. It was concluded that (a) stimulation with ACh activated the Na+/H+ antiport in the plasma membrane, (b) ACh also stimulated the intracellular acid production but acid extrusion by the Na+/H+ antiport prevented the cell from intracellular acidification, and (c) the major route of signal transduction for the ACh-induced activation of the Na+/H+ antiport was independent of protein kinase C but was dependent on the rise in cytosolic Ca2+ concentration. The implication of the cytosolic acidification and cell volume change in pHi regulation is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00371116
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  • 5
    Digitale Medien
    Digitale Medien
    Bimetallic cluster cations ejected from a liquid metal ion source: Li-Na and Li-Mg (1991)
    Springer
    The European physical journal 19 (1991), S. 129-131 
    Details
    ISSN: 1434-6079
    Schlagwort(e): 36.40 ; 79.70 ; 35.20X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Cluster ions of alloys (Li-Na, Li-Mg) have been produced by a liquid metal ion source (LMIS), and analyzed by mass spectrometry. For the Li-Na system, bimetallic clusters with various compositions were formed, and dominant bimetallic species were Na2Li+, NaLi+, NaLi 2 + and NaLi 8 + with this sequence of ion intensity. These clusters are systems containing 2 or 8 valence electrons except for NaLi+. For the Li-Mg, observed bimetallic clusters were limited to only three species (MgLi+, MgLi 2 + and Mg2Li+), but unexpectedly small multiply charged homonuclear clusters, Mg 2 2+ and Mg 3 2+ , were observed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01448272
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  • 6
    Digitale Medien
    Digitale Medien
    Magic numbers in sims of Mn similar to those of charged Ar clusters (1991)
    Springer
    The European physical journal 19 (1991), S. 189-190 
    Details
    ISSN: 1434-6079
    Schlagwort(e): 36.40 ; 35.20X ; 79.20X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Manganese cluster ions Mn k + (k≲60) have been produced by 7 keV Xe ion bombardment and analyzed by a double-focusing mass spectrometer. Discontinuous variations of intensity are found atk=5, 14, 16, 29, 34, 45 and 54. Most of these magic numbers coincide with or differ by only one from those observed in Ar k + . The similarity in magic numbers between Mn k + and Ar k + indicates that the bonding nature in the charged Mn clusters is similar to that in the charged Ar clusters; The polarization force between a positive ion in the center of a cluster and surrounding neutral atoms is dominant binding force.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01448288
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