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  • Carcinom  (2)
  • Colorectal carcinoma  (2)
  • 1
    ISSN: 1432-1335
    Keywords: Plasma glutamate levels ; Lymphocyte reactivity ; Immunodeficiency ; Colorectal carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Glutamate was recently found to inhibit the membrane transport of cystine and to impair the function of macrophages and lymphocytes in vitro. Elevated plasma glutamate concentrations in patients with advanced carcinoma were also found to be quantitatively correlated with reduced lymphocyte reactivity in these persons. We now investigated the questions whether glutamate levels in tumor patients would decline to approximately normal levels after tumor resection and, if so, whether this would be correlated with a recovery of lymphocyte reactivity. We report that plasma glutamate levels as well as the concomitantly elevated plasma lactate levels of patients with colorectal carcinoma return to practically normal levels within 1 week after curative surgery. This is accompanied by a rapid recovery of the lymphocyte reactivity against concanavalin A. Lymphocyte responses against pokeweed mitogen and phytohemagglutinin, in contrast, remain impaired for at least 6 months, indicating that elevated glutamate levels in patients with colorectal carcinoma are associated with a long-lasting defect in the immune system.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 124-128 
    ISSN: 1432-1335
    Keywords: Plasma glutamate ; Immunological reactivity ; Immunodeficiency ; Colorectal carcinoma ; Bronchial carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Elevated glutamate concentrations are commonly observed in tumor patients, and glutamate was recently found to competitively inhibit the membrane transport of cystine. We therefore investigated the possibility that elevated plasma glutamate levels may damage the immune system. The experiments in this report demonstrate a link between the individual plasma glutamate level and the individual immunological reactivity as measured by mitogenic responses. This correlation has been analyzed in 39 colorectal carcinoma patients, 40 oat cell carcinoma patients, 24 large cell lung carcinoma patients, and 31 apparently healthy persons (blood donors). Blood cells from all three groups of tumor patients in comparison with cells from healthy persons produced markedly reduced mitogenic responses against PWM, and all three groups of tumor patients had on average significantly elevated plasma glutamic acid concentrations. Our analysis revealed a linear regression of the logarithm of the individual plasma glutamate levels (before therapeutic treatment) on the logarithm of the corresponding mitogenic reactivity against PWM for the entire population of 134 persons tested (correlation coefficient-0.80; level of significance P〈0.00001). A statistically significant linear correlation with a similar regression equation was also observed in the group of the healthy blood donors (n=31); correlation coefficient-0.56; P〈0.01), indicating that this correlation is universal and not dependent on the presence of a tumor. Mitogenically stimulated murine lymphocyte cultures revealed an inverse correlation between glutamate concentration and cell proliferation in response to the mitogens PHA and PWM.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 347 (1978), S. 711-711 
    ISSN: 1435-2451
    Keywords: Gastrectomy ; Stomach cancer ; Cancer, reconstruction ; Chemotherapy ; Magen ; Carcinom ; Gastrektomie ; Magenersatz ; Chemotherapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Anhand des Krankengutes der chirurgischen Universitätsklinik Ulm von 1960–1976 werden die Behandlungsergebnisse und 5-Jahres-Überlebenszeiten von 947 Patienten, die wegen eines Magencarcinoms behandelt wurden, dargestellt. Besonders herausgestellt wird die Zunahme der Frühcarcinome infolge der intensivierten präoperativen Diagnostik. Die makroskopischen und histologischen Wachstumsformen werden aufgeführt und die sich daraus ergebenden Konsequenzen für die chirurgische Therapie abgeleitet. Es ergibt sich, daß bei Patienten unter 70 Jahren die Gastrektomie im Prinzip Anwendung finden sollte. Es wird auf die Vorteile geeigneter Rekonstruktionsverfahren hingewiesen. Ferner werden die gebräuchlichen Chemotherapie-Schemata aufgefuhrt und die an der Universität Ulm laufende adjuvante Studie erwähnt.
    Notes: Summary Based on 947 patients operated on for gastric carcinoma between 1960 and 1976, results and 5-years survival times are demonstrated. Due to intensified preoperative diagnostic methods, there is an increase in early gastric cancer. Adequate surgical measures are related to the specific morphologic and histologic behavior of the gastric cancer. It is concluded that total gastrectomy should be performed in patients under 70 years of age. Suitable reconstructive procedures seem to be of value. Furthermore, chemotherapeutic treatment is dicussed, and our controlled randomized adjuvant therapy study presented.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 349 (1979), S. 579-579 
    ISSN: 1435-2451
    Keywords: Stomach ; Cancer ; 5-years survival ; Operative procedure ; Magen ; Carcinom ; 5-Jahres-Überlebenszeit ; Operationsverfahren
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir analysierten beim Magencarcinom in einer retrospektiven Studie den Einfluß der operativen Verfahrenswahl auf die Überlebenszeit. Es ergaben sich folgende Feststellungen: Waren Lymphknoten befallen, war die 5-Jahres-Überlebenszeit höher nach Gastrektomie, verglichen mit der Magenresektion. Esbestand kein Unterschied, wenn die Lymphknoten nicht befallen waren. Beim Magenfrühcarcinom ist die 5-Jahres-Überlebenszeit unabhÄngig von der operativen Verfahrenswahl.
    Notes: Summary In a retrospective study we analysed the survival rate of gastric cancer patients correlated to surgical procedure. The conclusions are as follows: 5-year survival rate was higher after total gastrectomy vs. partial gastrectomy in tumors with involvement of lymph nodes. There was no difference in tumors without involved lymph nodes. 5-year survival rate in early gastric cancer does not depend on surgical procedure.
    Type of Medium: Electronic Resource
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