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  • Experimental chemotherapy  (2)
  • Metastatic breast cancer  (2)
  • 1
    Electronic Resource
    Electronic Resource
    On the role of additive hormone monotherapy with tamoxifen, medroxyprogesterone acetate and aminoglutethimide, in advanced breast cancer (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 959-966 
    Details
    ISSN: 1432-1440
    Keywords: Metastatic breast cancer ; Hormone monotherapy ; Tamoxifen ; Medroxyprogesterone acetate ; Aminoglutethimide ; Remission rates and duration ; Survival times
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We analyzed the results of clinical studies on the therapeutic efficacy of hormone monotherapy with tamoxifen, medroxyprogesterone acetate, and aminoglutethimide in metastatic breast cancer, which were published between 1971 and 1986 and involved altogether 7000 patients. The overall response rates in patients treated with these hormonal single agents at various dose levels ranged from 31%–42%. When only estrogen receptor-positive patients were considered, the response rates lay between 41% and 54% in groups which were treated with the antiestrogenic agents tamoxifen or aminoglutethimide. The duration of remission was 12 months for tamoxifen- and aminoglutethimide-treated women, whereas medroxy-progesterone acetate effected remissions lasting from 6–16 months. The overall mean survival from start of therapy in tamoxifen- and aminoglutethimide-treated groups was 20 months, whereas information concerning this therapeutic parameter was available only in a minority of medroxyprogesterone acetate-treated groups. With respect to the response by site of metastatic lesions, all three agents caused a significantly higher degree of remissions in the soft tissue as compared to visceral disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01717830
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Chemotherapy studies in autochthonous rat tumors: Carcinomas of the forestomach (1979)
    Springer
    Journal of cancer research and clinical oncology 95 (1979), S. 39-42 
    Details
    ISSN: 1432-1335
    Keywords: Tumors of the forestomach ; Acetoxymethyl-methyl nitrosamine ; Experimental chemotherapy ; Bleomycin, methotrexate, 5-fluorouracil, 1,2-bis-(2-chloroethyl)-1-nitrosourea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tumors of the forestomach were induced in male Sprague-Dawley rats by oral application of acetoxymethyl-methylnitrosamine (AMMN) in single weekly doses of 3.5 mg/kg body weight for 10 weeks. 100±5 days after the beginning of carcinogen treatment exploratory laparotomy was performed. One hundred animals in the same stage of tumor development were divided at random into one control group and four groups treated with cytostatics. Bleomycin (BLM), methotrexate (MTX), 5-fluorouracil (5FU), and 1,2-bis-(2-chloroethyl)-1-nitrosourea (BCNU) were tested in groups of 20 rats each. Only in animals receiving repeated doses of BLM a slight tumor response was observed but no increase in median survival times was seen. No therapeutic effects of the other drugs used were demonstrable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00411107
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    No relevant influence on overall survival time in patients with metastatic breast cancer undergoing combination chemotherapy (1988)
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 183-185 
    Details
    ISSN: 1432-1335
    Keywords: Cytotoxic chemotherapy ; First line ; Second line ; Metastatic breast cancer ; Overall survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The results of clinical studies dealing with first and second line chemotherapy of metastatic breast cancer published between 1975 and early 1986 which involved 9350 women were reviewed. Our special aim was to evaluate combination chemotherapy and its influence on overall survival in late stage breast cancer patients. No significant improvement in overall survival times was found in this selected group of patients who were treated with intense palliative chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417834
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Cytostatic activity of steroid linked nitrosoureas (1984)
    Springer
    Journal of cancer research and clinical oncology 108 (1984), S. 164-168 
    Details
    ISSN: 1432-1335
    Keywords: Steroidal alkylating agents ; receptor agents ; Steroids ; Nitrosoureas ; CNC-l-alanine esters ; Experimental chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary First investigations on the therapeutic activity of a new group of steroid-linked N-(2-chloroethyl)-N-nitrosocarbamoyl-l-alanine esters (CNC-l-alanine esters) in a nitrosourea-sensitive rat leukemia (L 5222) characterized by a relatively high content of glucocorticoid binding sites are presented. Despite a considerable range of optimal and toxic doses of the different analogs, the respective therapeutic ratios do not appear to be significantly influenced by the nature of the carrier molecules to which CNC-l-alanine is attached. However several steroid-linked representatives are distinctly more active than CNC-l-alanine. The androsterone-3-ester and the dihydrotestosterone-17-ester, in particular effected high percentages of cures in contrast to CNC-l-alanine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390991
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    Paper (German National Licenses)
    Fulltext
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