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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 60 (1982), S. 207-210 
    ISSN: 1432-1440
    Keywords: Activated charcoal ; Bentonite ; Fuller's earth ; Herbicides ; Paraquat ; Poisoning ; Aktivkohle ; Bentonit ; Fuller-Erde ; Herbizide ; Paraquat ; Vergiftung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In vitro-Untersuchungen haben ergeben, daß die Adsorptionskapazität von Aktivkohle (‘Kohle-Compretten’, ‘Ultracarbon’, E. Merck, Darmstadt, FRG), ebenso groß ist, wie diejenige von ‘Fuller's Earth’ (Surrey powder, Laporte Ind. Ltd., Luton, GB) und ‘Bentonit BP W.B.’ (Steetly Minerals Ltd., Milton Keynes, GB). ‘Fullererde’ einer anderen Firma hatte so geringe Adsorptionsfähigkeit, daß sie zur Behandlung der Paraquat-Vergiftung nicht geeignet ist. In Tierversuchen konnte gezeigt werden, daß der kurative Effekt von Aktivkohle, die 0,5, 1, 2 und 3 Stunden nach der Ingestion von 200 bzw. 300 mg Paraquat pro kg Körpergewicht verabfolgt wurde, ebenso gut oder sogar besser ist, als diejenige von ‘Fuller's Earth’ oder ‘Bentonit BP W.B.’. Aktivkohle ist ein gleichwertiger Ersatz der Mineralerden.
    Notes: Summary In vitro investigations have shown that the adsorption capacity of activated charcoal (‘Kohle-Compretten’, ‘Ultracarbon’, E. Merck, Darmstadt, FRG) is just as high as that of ‘Fuller's earth’ (Surrey powder, Laporte Industries Ltd., Luton, GB) or ‘Bentonite BP W.B.’ (Steetley Minerals Ltd., Milton Keynes, GB). Fuller's earth (‘Fullererde’) from another manufacturer has had very poor adsorption properties and is thus not suitable for the treatment of paraquat poisoning. Animal experiments have shown that the curative effect of activated charcoal given 0.5, 1, 2, and 3 h after ingestion of 200 and 300 mg paraquat/kg body weight is equally as good or even better than that of ‘Fuller's earth’ or ‘Bentonite BP W.B.’. Activated charcoal is a substitute of equal value to these mineral soils.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: Herbizide ; Paraquat ; Vergiftung ; Hämoperfusion ; Herbicides ; Paraquat ; Intoxication ; Hemoperfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary “Continuous hemoperfusion” (8 h/day for 2–3 weeks) was performed in two patients suffering from severe paraquat intoxication. On account of paraquat plasma concentrations a fatal outcome due to pulmonary fibrosis would have been expected in both cases. However, both patients survived following “continuous hemoperfusion” therapy. Coated activated charcoal seems to have a higher affinity for paraquat than lung tissue.
    Notes: Zusammenfassung „Kontinuierliche Hämoperfusion“ (ca. 8 h täglich während 2–3 Wochen) wurde wegen Paraquatvergiftung an zwei Patienten durchgeführt, bei denen aufgrund der Höhe der Paraquat-Plasma-Spiegel mit der Entwicklung einer letalen Lungenfibrose gerechnet werden mußte. Beide Patienten konnten durch diese Maßnahme der „Kontinuierlichen Hämoperfusion“ gerettet werden. Beschichtete Aktivkohle scheint eine größere Affinität für Paraquat zu haben als die Lungen.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 33 (1975), S. 251-257 
    ISSN: 1432-0738
    Keywords: Herbicides ; Intoxication ; Diquat ; Paraquat ; Hemodialysis ; Herbizide ; Intoxikation ; Diquat ; Paraquat ; Hämodialyse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei einer Patientin mit schwerer Diquat-Intoxikation wurden extrakorporale Hämodialysen durchgeführt. Die Diquat-Clearance betrug im Mittel 3,17 ml/min. Durch 11,5stündige Dialyse konnten nur 0,84 mg Diquat aus dem Blutserum eliminiert werden. Die Hämodialyse ist daher kein geeignetes Verfahren, um einen Tag nach der Ingestion toxikologisch relevante Mengen Diquat aus dem Organismus zu entfernen.
    Notes: Abstract Extracorporeal hemodialyses were carried out in a female patient with severe diquat intoxication. Diquat clearance was on average 3.17 ml/min. Only 0.84 mg diquat could be eliminated from the blood serum by 11.5 hrs of dialysis. Hemodialysis is therefore not an efficient technique for removing amounts of diquat from the organism that are toxicologically relevant one day after ingestion.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 35 (1976), S. 221-227 
    ISSN: 1432-0738
    Keywords: Anticholinesterase agents ; Clearance ; Demeton-S-methyl sulfoxide ; Dimethoate ; Hemodialysis ; Hemoperfusion ; Intoxication ; Nitrostigmine ; Organophosphate ; Therapy ; Anticholinesterasen ; Clearance ; Demeton-S-methylsulfoxid ; Dimethoat ; Hämodialyse ; Hämoperfusion ; Intoxikation ; Nitrostigmin ; Organophosphate ; Therapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde untersucht, ob extracorporale Hämodialyse oder Hämoperfusion mit beschichteter Aktivkohle bei Vergiftungen mit Nitrostigmin, Demeton-S-methylsulfoxid oder Dimethoat zur Elimination der Organophosphate eingesetzt werden können. Nitrostigmin war nicht hämodialysabel. Die beiden anderen Organophosphate dagegen ließen sich gut durch Hämodialyse aus dem Blut eliminieren. Bei einem Blutfluß von 100 ml/min betrug die Clearance für Demeton-S-methylsulfoxid 52,98 ml/min und für Dimethoat 59,07 ml/min. Die Clearancewerte durch Hämoperfusion mit beschichteter Aktivkohle waren unter gleichen Versuchsbedingungen höher. Sie betrugen für Demeton-S-methylsulfoxid 83,70 ml/min und für Dimethoat 87,84 ml/min. Auch Nitrostigmin konnte durch Hämoperfusion aus dem Blut entfernt werden; die Clearance betrug 59,20 ml/min. Bei einem Patienten mit Nitrostigmin-Intoxikation in suicidaler Absicht ließen sich die o. g. Ergebnisse der in vitro-Hämoperfusion bestätigen.
    Notes: Abstract Whether or not extracorporeal hemodialysis or hemoperfusion with coated activated charcoal might be used in eliminating organophosphates following poisoning with nitrostigmine, demeton-S-methyl sulfoxide, or dimethoate was here examined. Nitrostigmine could not be hemodialysed. The other two organophosphates, on the other hand could be well eliminated from the blood by hemodialysis. The clearance rates for demeton-S-methyl sulfoxide and dimethoate were 52.98 ml/min and 59.07 ml/min respectively, at a blood flow rate of 100 ml/min. The clearance values for hemoperfusion with coated activated charcoal were higher under the same trial conditions, the values being 83.70 ml/min for demeton-S-methyl sulfoxide and 87.84 ml/min for dimethoate. Nitrostigmine, too, could be eliminated from the blood by hemoperfusion, its clearance being 59.20 ml/min. These results from in vitro hemoperfusion were verified on a patient admitted with nitrostigmine intoxication following attempted suicide.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 36 (1976), S. 43-51 
    ISSN: 1432-0738
    Keywords: Intoxication ; Paraquat ; Diquat ; Gut lavage ; Hemodialysis ; Hemoperfusion ; Schlüsselwörter ; Intoxikation ; Paraquat ; Deiquat ; Darmspülung ; Hämodialyse ; Hämoperfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Klinische Untersuchungen und Laboratoriumsversuche wurden durchgeführt, um die Wirksamkeit von Darmspülung, Hämodialyse und Hämoperfusion bei Paraquat- und Deiquat-Vergiftungen zu prüfen. Bei einem Patienten wurde 30 Std nach Deiquat-Aufnahme durch Darmspülung 130mal mehr Deiquat entfernt als durch vollständige Aspiration des Mageninhaltes. In vitro-Versuche ergaben, daß bei Blutserumkonzentrationen von 1–2 ppm, die bei Vergiftungen oft gemessen werden, durch Hämodialyse keine toxikologisch relevanten Paraquat- oder Deiquat-Mengen entfernt werden können. Dagegen erwies sich die Hämodialyse bei 20 ppm und einer Blutumlaufgeschwindigkeit von 100 ml/min mit einer Clearance von 70 ml/min als wirksam. Die Hämoperfusion mit beschicheter Aktivkohle war in diesen Versuchen aber eindeutig überlegen, denn insbesondere bei Konzentrationen um 1–2 ppm waren die Clearance-Werte 5–7mal höher als bei der Hämodialyse. Die in vitro-Ergebnisse wurden bei einem Patienten mit einer Paraquat-Vergiftung bestätigt: Bei Konzentrationen unter 1 ppm war die Hämodialyse wirkungslos, während durch Hämoperfusion relativ hohe Clearance-Werte erreicht wurden, so daß der Serumspiegel rasch unter die Nachweisgrenze abfiel.
    Notes: Abstract Clinical and in vitro investigations were carried out to test the efficacy of gut lavage, hemodialysis, and hemoperfusion in the treatment of poisoning with paraquat or diquat. In a patient suffering from diquat intoxication 130 times more diquat was removed by gut lavage 30 h after ingestion than was removed by complete aspiration of the gastric contents. Determination of in vitro clearances for paraquat and diquat by hemodialysis showed that, at serum concentrations of 1–2 ppm, such as are frequently encountered in poisoning in man, toxicologically relevant quantities of herbicide cannot be removed from the body. At a concentration of 20 ppm, on the other hand, hemodialysis proved to be effective, the clearance being 70 ml/min at a blood flow rate of 100 ml/min. The efficacy of hemoperfusion with coated activated charcoal was on the whole better. Especially at concentrations around 1–2 ppm, the clearance values for hemoperfusion were some 5–7 times higher than those for hemodialysis. In a patient suffering from paraquat poisoning, both hemodialysis as well as hemoperfusion were carried out. The in vitro results could be confirmed: At serum concentrations of paraquat less than 1 ppm no clearance could be obtained by hemodialysis while by hemoperfusion with activated charcoal quite high clearance values were measured and the serum level dropped down to zero.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 2 (1976), S. 13-18 
    ISSN: 1432-1238
    Keywords: Anticholinesterase agents ; Blood exchange transfusion ; Demeton-S-methyl sulfoxide ; Dimethoate ; Haemodialysis ; Nitrostigmine ; Organophosphates ; Parathion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Human blood was contaminated with nitrostigmine, dimethoate and demeton-S-methyl sulfoxide. It was then dialysed, concentrations of organophosphates were determined and dialysance values calculated. The influence of blood exchange transfusion on poison elimination as well as on the cholinesterase activity of blood, brain and muscle was studied in rats poisoned with nitrostigmine. Haemodialysis was found to be quite an effective method for eliminating demeton-S-methyl sulfoxide and dimethoate, dialysance values of 52.98 ml/min and 59.07 ml/min being found for demeton-S-methyl sulfoxide and dimethoate respectively. Nitrostigmine could not be removed by haemodialysis. These findings suggest that haemodialysis could be of therapeutic value in the treatment of severe demeton-S-methyl sulfoxide and dimethoate poisoning in man. By blood exchange transfusion only 0.06% of the injected dose of nitrostigmine could be removed from the body of poisoned rats. Acetylcholinesterase activity increased only briefly in the period of blood exchange transfusion and decreased gradually afterwards. The enzymatic activity of brain and muscle was unaffected. Therefore, blood exchange transfusion has, if any at all, only poor therapeutic properties in nitrostigmine intoxication.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 61 (1983), S. 655-659 
    ISSN: 1432-1440
    Keywords: Dermal Toxicity ; Paraquat ; Percutaneous Absorption ; Poisoning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A fatal paraquat poisoning can occur when relatively large areas of skin are contaminated with a concentrated solution of paraquat (Gramoxone). A paraquat absorption takes place of the same magnitude as that with an equal dose per os. In the presence of mechanical or chemical lesion of the skin the percutaneous paraquat absorption is distinctly enhanced.
    Type of Medium: Electronic Resource
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