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  • Chromosome 14q11 anomaly  (1)
  • T-cell acute lymphoblastic leukemia  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Frequency and DNA sequence of tal-1 rearrangement in children with T-cell acute lymphoblastic leukemia (1992)
    Springer
    Annals of hematology 64 (1992), S. 305-308 
    Details
    ISSN: 1432-0584
    Keywords: T-cell acute lymphoblastic leukemia ; Gene rearrangement ; Minimal residual disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using nested polymerase chain reaction (PCR) a gene rearrangement named tal-1 deletion was found in five of 56 leukemic bone marrow samples from children with T-cell acute lymphoblastic leukemia (ALL). The DNA sequences of the PCR fragments consisted of the known conserved germline sequences in addition to short DNA insertions at the breakpoint region, which were different in each patient. Moreover, one patient was examined at diagnosis and at relapse 11 months later, revealing identical DNA sequences at the rearrangement site. The recombination site of the tal rearrangement therefore may be used as a genetic marker for detecting minimal residual disease in about 10% of T-cell ALL in childhood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695477
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    T-cell acute childhood lymphoblastic leukemia with chromosome 14q11 anomaly: a morphologic, immunologic, and cytogenetic analysis of 10 patients (1988)
    Springer
    Annals of hematology 56 (1988), S. 117-123 
    Details
    ISSN: 1432-0584
    Keywords: Acute childhood lymphoblastic leukemia ; T-cell immunophenotype ; Chromosome 14q11 anomaly
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ten patients with T-cell acute lymphoblastic leukemia (ALL) and a chromosome anomaly involving band 14q11 are described. Mitotic index of bone marrow blasts was high in all patients (average 3.0%). Lymphoid morphology of the leukemic blasts, however, varied somewhat among the patients. The leukemic cells of 5 patients showed an immunophenotypic profile corresponding to early or common thymic differentiation stages whereas 5 children showed strong expression of CD3 suggesting a more mature thymic phenotype. Leukemic karyotypes revealed a modal chromosome number of 46 in 9 cases, 92 in one case. A chromosome translocation t(11; 14) (p13; q11) was found in 5 cases, a t(1; 14) (p32; q11) in 2 cases, a t(10; 14) (q24; q11) in one case, a (hitherto undescribed) t(12; 14) (q22; q11) in one case, and an inv(14) (q11 q32) in one patient. Additional abnormalities were t(3; 10), t(7; 9), dup (7q), del (6q), del (10q), and del (1 q). Of 32 cases with T-cell ALL successfully karyotyped in our laboratory 15 (=47%) had structural aberrations involving chromosomes 1, 3, 6, 7, 9, 10, 12, 14. Ten of these 15 patients (=67%) had a chromosome 14q11 anomaly. It is concluded that chromosome band 14q11, the gene locus of the T-cell receptor α-chain, is the most common site for structural chromosome aberrations in T-cell ALL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320016
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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