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  • 1
    Electronic Resource
    Electronic Resource
    Chemotherapy studies in autochthonous rat tumors: Carcinomas of the forestomach (1979)
    Springer
    Journal of cancer research and clinical oncology 95 (1979), S. 39-42 
    Details
    ISSN: 1432-1335
    Keywords: Tumors of the forestomach ; Acetoxymethyl-methyl nitrosamine ; Experimental chemotherapy ; Bleomycin, methotrexate, 5-fluorouracil, 1,2-bis-(2-chloroethyl)-1-nitrosourea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tumors of the forestomach were induced in male Sprague-Dawley rats by oral application of acetoxymethyl-methylnitrosamine (AMMN) in single weekly doses of 3.5 mg/kg body weight for 10 weeks. 100±5 days after the beginning of carcinogen treatment exploratory laparotomy was performed. One hundred animals in the same stage of tumor development were divided at random into one control group and four groups treated with cytostatics. Bleomycin (BLM), methotrexate (MTX), 5-fluorouracil (5FU), and 1,2-bis-(2-chloroethyl)-1-nitrosourea (BCNU) were tested in groups of 20 rats each. Only in animals receiving repeated doses of BLM a slight tumor response was observed but no increase in median survival times was seen. No therapeutic effects of the other drugs used were demonstrable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00411107
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  • 2
    Electronic Resource
    Electronic Resource
    Antitumor activity of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-(4-methyl-cyclohexyl)-1-nitrosourea (MeCCNU) on yoshida sarcoma ascites cells implanted into the colon wall of rats (1979)
    Springer
    Journal of cancer research and clinical oncology 94 (1979), S. 63-67 
    Details
    ISSN: 1432-1335
    Keywords: Sprague-Dawley-Ratten ; Verimpfen von Yoshida-Sarkom-Zellen ; Colon descendens ; Cyclophosphamid ; BCNU ; Methyl-CCNU ; Sprague-Dawley rats ; Inoculation of Yoshida sarcoma cells ; Descending colon ; Cyclophosphamide ; BCNU ; Methyl-CCNU
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Three thousand Yoshida sarcoma cells were inoculated into the wall of the descending colon of each of 120 male Sprague-Dawley rats. On day 8 after the tumor implantation, the animals were at random divided into four groups of 30 rats each. The effect of cyclophosphamide (70 mg/kg), BCNU (25 mg/kg), and methyl-CCNU (45 mg/kg) after single i.p. application was investigated. The Yoshida sarcoma transplanted into the colon is sensitive to all three chemotherapeutic drugs. At the doses given cyclophosphamide showed the best results. The two nitrosoureas had a comparable antitumor activity but methyl-CCNU showed a more distinct toxic effect. The introduction of this model for testing new cytostatics in animal experiments is discussed.
    Notes: Zusammenfassung Einhundertzwanzig männlichen Sprague-Dawley-Ratten wurden jeweils 3000 Zellen eines Yoshida-Sarkoms in die Wand des Colon descendens verimpft. Am 8. Tag nach der Tumorimplantation wurden die Tiere randomisiert in vier Versuchsgruppen von jeweils 30 Ratten aufgeteilt. Die Wirkung von Cyclophosphamid (70 mg/kg), BCNU (25 mg/kg) und Methyl-CCNU (45 mg/kg) bei einmaliger i.p. Gabe wurde untersucht. Das ins Colon transplantierte Yoshida-Sarkom ist gegeüber allen drei Chemotherapeutika sensibel. Bei den gewählten Dosierungen zeigte Cyclophosphamide die günstigsten Ergebnisse. Die beiden Nitrosoharnstoffe waren in ihrer Antitumoraktivität vergleichbar, während bei Methyl-CCNU die toxischen Wirkungen sich als ausgeprägter erwiesen. Der Einsatz des Modells im Rahmen der tierexperimentellen Prüfung neuer Cytostatika wird diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405350
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  • 3
    Electronic Resource
    Electronic Resource
    Zur carcinogenen Wirkung von N-Nitroso-Verbindungen (1978)
    Springer
    Journal of cancer research and clinical oncology 91 (1978), S. 317-322 
    Details
    ISSN: 1432-1335
    Keywords: Alkyl-Acetoxymethyl-Nitrosamines ; Carcinogenic action in SD rats ; Tumors of the forestomach ; Alkyl-Acetoxymethyl-Nitrosamine ; Carcinogene Wirkung bei SD-Ratten ; Tumoren des Vormagens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die homologe Reihe der Alkyl-Acetoxymethyl-Nitrosamine wurden auf ihre carcinogene Wirkung an SD Ratten getestet. Alle Verbindungen induzieren bei oraler Gabe innerhalb der gleichen Zeit Vormagentoumoren. Die benötigten Gesamtdosen sind dabei abhängig von der Länge der Alkyl-Kette und damit der Wasserlöslichkeit. Diese Ergebnisse werden diskutiert.
    Notes: Summary The homologons alkyl-acetoxymethyl-nitrosamines were tested for carcinogenicity in SD rats. All compounds were found to be carcinogenic and induced within the same time carcinomas of the forestomach. The total doses necessary for induction of tumors are related to the length of the alkyl chain and hence to the watersolubility. These results are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00312293
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  • 4
    Electronic Resource
    Electronic Resource
    Investigation of the tumorigenic response to benzo(a)pyrene in aqueous caffeine solution applied orally to Sprague-Dawley rats (1981)
    Springer
    Journal of cancer research and clinical oncology 102 (1981), S. 153-157 
    Details
    ISSN: 1432-1335
    Keywords: Benzo(a)pyrene ; Caffeine ; Oral administration ; Tumors of the forestomach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a lifetime experiment benzo(a)pyrene (B(a)P) was administered to Sprague-Dawley rats either as an admixture to the diet or by gavage in an aqueous 1.5% caffeine solution. Dissolved benzo(a)pyrene induced more tumors of the forestomach than undissolved benzo(a)pyrene. The 1.5% caffeine solution (annual dose 27 g/kg) did not exert any carcinogenic activity under the conditions of this bioassay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410666
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Wirkung der lokalen moderaten Hyperthermie in Kombination mit einer Chemotherapie durch Cyclophosphamid oder N-Nitroso-1,3-bis-(2-chlorethyl harnstoff (BCNU) auf das in das Colon descendens der Ratte transplantierte Yoshida-Sarkom (1983)
    Springer
    Langenbeck's archives of surgery 359 (1983), S. 205-213 
    Details
    ISSN: 1435-2451
    Keywords: Hyperthermia ; Yoshida sarcoma ; Chemotherapy ; Cyclophosphamide ; BCNU
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Anwendung der Hyperthermie zur Cytostase wird seit langem diskutiert. In der letzten Zeit stellte sich die Frage, ob durch eine Kombination der Chemotherapie mit der Hyperthermie die Erfolgsaussichten verbessert werden können. Zur experimentellen Überprüfung dieser Hypothese verwendeten wir einen gastrointestinalen Impftumor. Yoshida-Sarkom-Asci teszellen wurden in einer Konzentration von 2 x 106 in das Colon descendens von 101 Sprague-Dawley-Ratten implantiert. Gleichzeitig wurde ein doppel läufiger Anus praeter angelegt. Am 6. Tage nach Operation erfolgte die Chemotherapie, 24h danach eine lokale Hyperthermie, welche mittels einem in das stillgelegte Colon descendens eingeführten Silikonschlauch durchgeführt wurde. Die erreichte Temperatur betrug im Tumor 43 ± 0,5°C. Akute toxische Wirkungen der Hyperthermie wurden nicht beobachtet, ein Anstieg der Körpertemperatur konnte durch Kühlung im Normbereich gehalten werden. Anhand der Überlebenszeitkurven zeigten sich statistisch gesicherte Unterschiede zwischen den Gruppen mit Chemotherapie und der Kontrollgruppe, eine additive Wirkung der Hyperthermie konnte aber nicht aufgezeigt werden. Die alleinige Anwendung der Hyperthermie zeigte ebenso keinen Vorteil gegenüber der Kontrolle. Die Ergebnisse bestätigen die Skepsis über die therapeutische Wirksamkeit der Hyperthermie und unterstreichen die Notwendigkeit zur weiteren Überprüfung im klinisch orientierten Tierversuch.
    Notes: Summary. The application of hyperthermia in cytostatic therapy has been discussed for a long time. Recently the question arose whether the chances of therapy might be improved by combining chemotherapy with hyperthermia. We used an inoculated gastrointestinal tumor to verify this hypothesis experimentally. 2 x 106 Yoshida sarcoma ascites cells were implanted in the descending colon of 101 Sprague-Dawley rats. A preternatural anus with two lumina was established concomitantly. Chemotherapy started on day 6 after surgery. 24 h later local hyperthermia was applied by means of a silicone tube inserted in the immobilized descending colon. The temperature in the tumor was raised to 43 ± 0.5°C. No acute toxic effects of hyperthermia were noted. The body temperature was kept from rising above normal by cooling. The differences in survival time between the chemotherapeutically treated groups and the control group were statistically validated. Additional hyperthermia did not result in additive effects. No advantage of hyperthermia alone was noted over the control. The results support scepticism about the therapeutic efficacy of hyperthermia and underline the necessity of further investigations in clinically adapted animal experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01250983
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