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  • Tumors of the forestomach  (3)
  • Metastatic breast cancer  (2)
  • 1
    Electronic Resource
    Electronic Resource
    On the role of additive hormone monotherapy with tamoxifen, medroxyprogesterone acetate and aminoglutethimide, in advanced breast cancer (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 959-966 
    Details
    ISSN: 1432-1440
    Keywords: Metastatic breast cancer ; Hormone monotherapy ; Tamoxifen ; Medroxyprogesterone acetate ; Aminoglutethimide ; Remission rates and duration ; Survival times
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We analyzed the results of clinical studies on the therapeutic efficacy of hormone monotherapy with tamoxifen, medroxyprogesterone acetate, and aminoglutethimide in metastatic breast cancer, which were published between 1971 and 1986 and involved altogether 7000 patients. The overall response rates in patients treated with these hormonal single agents at various dose levels ranged from 31%–42%. When only estrogen receptor-positive patients were considered, the response rates lay between 41% and 54% in groups which were treated with the antiestrogenic agents tamoxifen or aminoglutethimide. The duration of remission was 12 months for tamoxifen- and aminoglutethimide-treated women, whereas medroxy-progesterone acetate effected remissions lasting from 6–16 months. The overall mean survival from start of therapy in tamoxifen- and aminoglutethimide-treated groups was 20 months, whereas information concerning this therapeutic parameter was available only in a minority of medroxyprogesterone acetate-treated groups. With respect to the response by site of metastatic lesions, all three agents caused a significantly higher degree of remissions in the soft tissue as compared to visceral disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01717830
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Chemotherapy studies in autochthonous rat tumors: Carcinomas of the forestomach (1979)
    Springer
    Journal of cancer research and clinical oncology 95 (1979), S. 39-42 
    Details
    ISSN: 1432-1335
    Keywords: Tumors of the forestomach ; Acetoxymethyl-methyl nitrosamine ; Experimental chemotherapy ; Bleomycin, methotrexate, 5-fluorouracil, 1,2-bis-(2-chloroethyl)-1-nitrosourea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tumors of the forestomach were induced in male Sprague-Dawley rats by oral application of acetoxymethyl-methylnitrosamine (AMMN) in single weekly doses of 3.5 mg/kg body weight for 10 weeks. 100±5 days after the beginning of carcinogen treatment exploratory laparotomy was performed. One hundred animals in the same stage of tumor development were divided at random into one control group and four groups treated with cytostatics. Bleomycin (BLM), methotrexate (MTX), 5-fluorouracil (5FU), and 1,2-bis-(2-chloroethyl)-1-nitrosourea (BCNU) were tested in groups of 20 rats each. Only in animals receiving repeated doses of BLM a slight tumor response was observed but no increase in median survival times was seen. No therapeutic effects of the other drugs used were demonstrable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00411107
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Zur carcinogenen Wirkung von N-Nitroso-Verbindungen (1978)
    Springer
    Journal of cancer research and clinical oncology 91 (1978), S. 317-322 
    Details
    ISSN: 1432-1335
    Keywords: Alkyl-Acetoxymethyl-Nitrosamines ; Carcinogenic action in SD rats ; Tumors of the forestomach ; Alkyl-Acetoxymethyl-Nitrosamine ; Carcinogene Wirkung bei SD-Ratten ; Tumoren des Vormagens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die homologe Reihe der Alkyl-Acetoxymethyl-Nitrosamine wurden auf ihre carcinogene Wirkung an SD Ratten getestet. Alle Verbindungen induzieren bei oraler Gabe innerhalb der gleichen Zeit Vormagentoumoren. Die benötigten Gesamtdosen sind dabei abhängig von der Länge der Alkyl-Kette und damit der Wasserlöslichkeit. Diese Ergebnisse werden diskutiert.
    Notes: Summary The homologons alkyl-acetoxymethyl-nitrosamines were tested for carcinogenicity in SD rats. All compounds were found to be carcinogenic and induced within the same time carcinomas of the forestomach. The total doses necessary for induction of tumors are related to the length of the alkyl chain and hence to the watersolubility. These results are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00312293
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Investigation of the tumorigenic response to benzo(a)pyrene in aqueous caffeine solution applied orally to Sprague-Dawley rats (1981)
    Springer
    Journal of cancer research and clinical oncology 102 (1981), S. 153-157 
    Details
    ISSN: 1432-1335
    Keywords: Benzo(a)pyrene ; Caffeine ; Oral administration ; Tumors of the forestomach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a lifetime experiment benzo(a)pyrene (B(a)P) was administered to Sprague-Dawley rats either as an admixture to the diet or by gavage in an aqueous 1.5% caffeine solution. Dissolved benzo(a)pyrene induced more tumors of the forestomach than undissolved benzo(a)pyrene. The 1.5% caffeine solution (annual dose 27 g/kg) did not exert any carcinogenic activity under the conditions of this bioassay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410666
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    No relevant influence on overall survival time in patients with metastatic breast cancer undergoing combination chemotherapy (1988)
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 183-185 
    Details
    ISSN: 1432-1335
    Keywords: Cytotoxic chemotherapy ; First line ; Second line ; Metastatic breast cancer ; Overall survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The results of clinical studies dealing with first and second line chemotherapy of metastatic breast cancer published between 1975 and early 1986 which involved 9350 women were reviewed. Our special aim was to evaluate combination chemotherapy and its influence on overall survival in late stage breast cancer patients. No significant improvement in overall survival times was found in this selected group of patients who were treated with intense palliative chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417834
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    Paper (German National Licenses)
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