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  • aldosterone  (1)
  • androgens  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Interrelation between plasma testosterone and plasma insulin in healthy adult men: the Telecom Study (1992)
    Springer
    Diabetologia 35 (1992), S. 173-177 
    Details
    ISSN: 1432-0428
    Keywords: Insulin ; insulin resistance ; testosterone ; androgens ; healthy men ; cardiovascular risk factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma insulin is a risk factor for diabetes mellitus and cardiovascular disease in men. We investigated the association between plasma testosterone and plasma insulin in an occupational sample of 1292 healthy adult men. Total plasma testosterone decreased with each decade of age and insulin increased with each decade of age. In these cross-sectional data, this significant graded inverse association between testosterone and insulin was independent of age. The association was reduced but not explained by the addition of obesity and subscapular skinfold to the model. Adjustment for alcohol consumption, cigarette smoking and plasma glucose did not materially alter the association. These results are the reverse of the positive association of androgens with insulin in women and suggest alternative possible explanations for the effect of hyperinsulinaemia on cardiovascular disease risk. Prospective studies will be necessary to determine the direction and causal nature of this association.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402551
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Lack of effect in vivo of clofibrate on adrenal steroid secretion (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 87-89 
    Details
    ISSN: 1432-1041
    Keywords: clofibrate ; hyperlipidaemia ; glucocorticoids ; mineralocorticoids ; progesterone ; aldosterone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Clofibrate inhibits the synthesis of adrenal steroids when administered in vitro. In the present study the effect in vivo of clofibrate on adrenal steroid secretion has been investigated. Basal levels of plasma progesterone, corticosterone, aldosterone, 17-hydroxyprogesterone, 11-deoxycortisol, cortisol, dehydroepiandrosterone sulphate and dehydroepiandrosterone, and their response to ACTH 1 mg im, were not reduced by chronic administration of clofibrate 2 g per day p.o. for 8 to 34 days to 6 hyperlipidaemic men.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561031
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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