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  • 11
    Digitale Medien
    Digitale Medien
    Venous malformation in the posterior fossa: Guidelines for treatment (1994)
    Springer
    Acta neurochirurgica 126 (1994), S. 107-112 
    Details
    ISSN: 0942-0940
    Schlagwort(e): Venous malformation ; posterior fossa ; management ; operative indication
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Venous malformations in the posterior fossa are relatively rare. Although the introduction of CT and MRI has made them easier to detect, their treatment is still controversial. Based on our experience with six patients and a review of the literature, we have tried to establish guidelines for their treatment. Since they have a benign natural course and may provide venous drainage in the posterior fossa, venous malformation found incidentally, unruptured venous malformation with nonhaemorrhagic complications, and those accompanied by small intracerebellar haematoma of less than 2 cm in diameter due to their rupture, should be treated conservatively unless they are associated with a coexistent malformation. Venous malformation with intracerebellar haematoma larger than 3 cm or reexpansion of the haematoma due to rebleeding should be treated surgically by evacuation of the haematoma. Resection of venous malformations in the posterior fossa should be restricted to cases in which the malformation is small and does not serve as a functional venous drainage route. Radiation therapy, including the “gammaknife”, may be a treatment of choice in the future.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01476418
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  • 12
    Digitale Medien
    Digitale Medien
    Role of cytokines in controlling connective tissue gene expression (1994)
    Springer
    Archives of dermatological research 287 (1994), S. 115-121 
    Details
    ISSN: 1432-069X
    Schlagwort(e): Cytokines ; Fibroblasts ; Connective tissue ; Gene expression ; Tumour necrosis factor-α (TNF-α)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Recently, the role of cytokines in controlling gene expression of connective tissue components has been increasingly emphasized. Many cytokines have been shown to have specific effects on gene expression of connective tissue components, and the roles of cytokines in controlling connective tissue metabolism during wound healing and in fibrosis have increasingly been discussed. In this article, the effects of cytokines on regulation of gene expression of connective tissue components, especially of type I collagen were described. We analysed transcriptional control of the α1(I) collagen gene by TNF-α by means of DNA mediated transfection experiments using recombinant plasmids in which the promoter region of the human α1(I) collagen had been fused to the chloramphenicol acetyl-transferase (CAT) gene, in human dermal fibroblasts. It was found that TNF-α reduced α1(I) collagen transcription through at least up to −107 bp upstream of the human α1(I) collagen promoter gene in dermal fibroblasts.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00370729
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  • 13
    Digitale Medien
    Digitale Medien
    Long-term monitoring of CSF lactate levels and lactate/pyruvate ratios following subarachnoid haemorrhage (1993)
    Springer
    Acta neurochirurgica 125 (1993), S. 20-26 
    Details
    ISSN: 0942-0940
    Schlagwort(e): Subarachnoid haemorrhage ; cerebrospinal fluid ; lactate ; pyruvate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Ventricular cerebrospinal fluid (CSF) lactate concentrations and lactate/pyruvate (L/P) ratios were measured daily in 20 patients from day 1 to day 12 after subarachnoid haemorrhage due to ruptured aneurysms. Patients without symptomatic vasospasm were classified in Group 1, patients with symptomatic vasospasm were classified in Group 2, and patients who were Hunt and Kosnik grade 4 on admission clinically were classified in Group 3. Patients in all three groups had high CSF lactate concentrations on day 1, and, especially in Group 3, the high lactate was accompanied by an increased L/P ratio and a decreased CSF bicarbonate. Lactate concentrations in Group 1 decreased throughout the observation period. Lactate concentrations in Group 2 also decreased but then began to increase again on days 5 to 7, correlating well with the onset of cerebral vasospasm. The delayed increase of CSF lactate in Group 2 was also accompanied by increases in the CSF pyruvate level and the CSF L/P ratio. Daily monitoring of CSF lactate may thus serve as a chemical marker for cerebral vasospasm.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01401823
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  • 14
    Digitale Medien
    Digitale Medien
    Purification and immunolocalization of a vitellin-like protein from the Pacific oyster Crassostrea gigas (1992)
    Springer
    Marine biology 113 (1992), S. 239-245 
    Details
    ISSN: 1432-1793
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract A female-specific protein from the hemolymph, and a related ovarian protein were identified in the Pacific oyster Crassostrea gigas using immunological procedures. The latter protein was isolated from ovarian extract by a combination of precipitation in distilled water, ammonium sulfate fractionation, hydroxylapatite chromatography and gel filtration on a Sepharose 6B column, and was identified as a macromolecular glycolipoprotein of ∼500 kD; sodium dodecylsulfate polyacrylamide gel electrophoresis, under reducing conditions, revealed seven heterogeneous polypeptides. Using a specific antiserum against purified protein, we also examined the immunohistochemical distribution of the protein at light- and electron-microscopic levels. Light microscopy revealed its presence in the oocytes, and electron microscopy identified it in yolk granules and the vitelline coat of the oocytes. These results indicate that the purified protein is a vitellin-like protein. Since no organ other than the ovary reacted with the antiserum, it is probable that the protein is produced inside the ovary, probably autosynthetically by oocytes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00347277
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  • 15
    Digitale Medien
    Digitale Medien
    Alteration of atrial natriuretic peptide receptors in the choroid plexus of rats with induced or congenital hydrocephalus (1990)
    Springer
    Child's nervous system 6 (1990), S. 190-193 
    Details
    ISSN: 1433-0350
    Schlagwort(e): Atrial natriuretic peptide ; Receptor ; Choroid plexus ; Hydrocephalus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Specific binding sites for atrial natriuretic peptide (ANP) in the choroid plexus of rats with induced or congenital hydrocephalus were examined using in vitro quantitative receptor autoradiographic methods. The number of125I-ANP binding sites in the choroid plexus of rats with kaolin-induced hydrocephalus was significantly higher as compared to findings in the control rats, whereas no differences in the binding affinity were observed 3 days and 3 weeks after the intracisternal injection of kaolin. Conversely, rats with congenital hydrocephalus (LEW-HYR and HTX rats) had a small number of binding sites for125I-ANP in the choroid plexus, as compared to findings in the control rats. These alterations may relate to the pathophysiology of hydrocephalus. The possibility that atrial natriuretic peptide may be involved in the regulation of cerebrospinal fluid production in the choroid plexus must be considered.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01850969
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  • 16
    Digitale Medien
    Digitale Medien
    Receiver operating characteristic (ROC) analysis of the ability of arterial ketone body ratio to predict graft outcome after liver transplantation — its sensitivity and specificity (1992)
    Springer
    Transplant international 5 (1992), S. 23-26 
    Details
    ISSN: 1432-2277
    Schlagwort(e): Liver transplantation ; graft prognosis test — Prognosis ; liver transplantation ; ketone body ratio — Arterial ketone body ratio ; prognosis liver graft
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract To evaluate the ability of arterial ketone body ratio (AKBR; acetoacetate/3-hydroxybutyrate) to predict graft prognosis after liver transplantation, the diagnostic value as a predictive index was compared between AKBR and conventional liver function tests using receiver operating characteristic (ROC) analysis. The ROC curves were determined for AKBR, GOT, GPT, total bilirubin, serum lactate level, and prothrombin time, all of which were measured on the 1st and 2nd postoperative days in 88 cases of liver transplantation. Comparisons of the areas under the ROC curves between AKBR and other tests revealed the significant superiority of AKBR to other tests in predicting graft death within 1 month after transplantation. The present study suggests that AKBR can be used as an accurate index to predict graft prognosis after liver transplantation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00337185
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  • 17
    Digitale Medien
    Digitale Medien
    Effect of prostaglandin E1 on preservation injury of canine liver grafts preserved in UW solution (1993)
    Springer
    Transplant international 6 (1993), S. 245-250 
    Details
    ISSN: 1432-2277
    Schlagwort(e): Preservation, liver, canine ; Liver transplantation, preservation, canine ; Prostaglandin E1, liver preservation ; UW solution, liver preservation, canine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This study investigated whether prostaglandin E1 (PGE1) could reduce hepatic injury to the liver graft caused by harvesting and 24-h preservation in University of Wisconsin (UW) solution in a canine model. The PGE1-treated group was intravenously administered 0.5 μg/kg per minute of PGE1 for 30 min before harvesting, as well as a concentration of 1 mg/l PGE1 in the washout and UW solutions. In both the PGE1-treated and the control group, all recipients survived for 1 week or more after transplantation. Arterial ketone body ratio (AKBR) remained over 1.0 in the early postoperative period. The PGE1 group showed significant reductions in guanase, GOT, and LDH during the early postoperative period compared to the untreated control group. Histological examination disclosed partial mitochondrial swelling, hepatocyte vacuolation, and necrosis in the control group, while such abnormalities were rarely seen in the PGE1 group. These results suggest that PGE1 can effectively reduce hepatic injury to liver grafts preserved in UW solution prior to transplantation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00336022
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  • 18
    Digitale Medien
    Digitale Medien
    A mitochondrial plasmid that promotes mitochondrial fusion inPhysarum polycephalum (1991)
    Springer
    Protoplasma 160 (1991), S. 167-169 
    Details
    ISSN: 1615-6102
    Schlagwort(e): Mitochondrial plasmid ; Mitochondrial fusion ; Mitochondrial nuclear fusion ; Physarum
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary We have identified a novel mitochondrial plasmid of about 16 kbp inPhysarum polycephalum. This plasmid was apparently responsible for promoting mitochondrial fusion. Only in strains carrying the plasmid, small spherical mitochondria fused with one another to form large knotted multinucleate mitochondria which subsequently nderwent fusion between the areas (mt-nuclear) that contained the mitochondrial DNA (mtDNA) derived from individual mitochondria. Several successive mitochondrial divisions followed, accompanied by mt-nuclear divisions. The resulting mitochondria contained recombinant mtDNAs, but the plasmid was transmitted to all mitochondria without any structural change.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01539968
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  • 19
    Digitale Medien
    Digitale Medien
    Field response of maritime pine scale,Matsucoccus feytaudi duc. (Homoptera: Margarodidae), to synthetic sex pheromone stereoisomers (1994)
    Springer
    Journal of chemical ecology 20 (1994), S. 2159-2170 
    Details
    ISSN: 1573-1561
    Schlagwort(e): Maritime pine scale ; Matsucoccus feytaudi ; Homoptera ; Margarodidae ; sex pheromone ; field trapping ; (8E,10E)-3,7,9-trimethyl-8,10-dodecadien-6-one ; absolute configuration
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract The absolute configuration of the primary component of the maritime pine scale (Matsucoccus feytaudi) pheromone (i.e., (8E, 10E)-3,7,9-trimethyl-8,10-dodecadien-6-one) was determined as 3S,7R by field-trapping experiments using synthetic stereoisomers and according to previous NMR considerations. The 3R,7R isomer showed similar activity to 3S,7R, whereasM. feytaudi males responded very weakly to the two other candidates (3R,7S and 3S,7S). Further studies were conducted to optimize scale trapping for monitoring scale populations. Results of these studies showed that the trapping efficiency was related to pheromone dose, trap area, and wind speed but not to trap height.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02033194
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  • 20
    Digitale Medien
    Digitale Medien
    Species discrimination in five species of winter-flying geometrids (Lepidoptera) based on chirality of semiochemicals and flight season (1993)
    Springer
    Journal of chemical ecology 19 (1993), S. 2721-2735 
    Details
    ISSN: 1573-1561
    Schlagwort(e): Chirality ; enantiomers ; sex pheromones ; (3Z,9Z)-(6R,7S)-epoxynonadecadiene ; (3Z,9Z)-(6S,7R)-epoxynonadecadiene ; (6Z,9Z)-(3S,4R)-epoxynonadecadiene ; Colotois pennaria ; Erannis defoliaria ; Agriopis aurantiaria ; A. marginaria ; A. leucophearia ; Lepidoptera ; Geometridae ; electroantennogram ; field trapping
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract Enantiomer separation of (6Z,9Z)-cis-3,4-epoxynonadecadiene and (3Z,9Z)-cis-6,7-epoxynonadecadiene could be achieved using chiral high-resolution gas chromatography and a cyclodextrin-bond column. (3Z,9Z)-(6R,7S)-Epoxynonadecadiene was identified from ovipositor extracts ofColotois pen-Naria, while inErannis defoliaria the 6S,7R-enantiomer was found. In field trapping tests pure synthetic enantiomers caught only conspecific males of these species. (3Z,6Z,9Z)-Nonadecatriene was found in both species, while the presence of (3Z,6Z,9Z)-heneicosatriene was indicated inC. Pennaria only. A 10∶10∶3 blend of (3Z,9Z)-(6R,7S)-epoxynonadecadiene, (3Z,6Z,9Z)-heneicosatriene, and (3Z,6Z,9Z)-nonadecatriene was found to be optimal for catchingC. Pennaria, whileE. Defoliaria males were optimally caught by a 1∶1 mixture of (3Z,9Z)-(6S,7R)-epoxynonadecadiene and (3Z,6Z,9Z)-nona-decatriene. (6Z,9Z)-(3S,4R)-Epoxynonadecadiene was identified from ovipositor extracts ofAgriopis (Erannis) aurantiaria. In field tests the pure enantiomer proved to be a highly specific sex attractant for both the late autumn/early winter flyingA. Aurantiaria and the late winter/early spring flyingA. Leucophearia. Males ofAgriopis marginaria, which fly in late winter/early spring, were attracted to (3Z,9Z)-(6S,7R)-epoxynonadecadiene. The addition of (3Z,6Z,9Z)-nonadecatriene to theS,R-enantiomer increased captures. Optimal catches were recorded with a 10∶3 epoxide-hydrocarbon blend. Enantiomer specificity in all species was confirmed in EAG measurements.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00980703
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