Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 11
    Electronic Resource
    Electronic Resource
    Reactions with aziridines - 39 - Ring opening of activated 2,2-dimethylaziridines by grignard reagents. A mechanistic study
    Amsterdam : Elsevier
    Tetrahedron 43 (1987), S. 565-576 
    Details
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4020(01)89990-7
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 12
    Electronic Resource
    Electronic Resource
    Nucleophilic cleavage of 2,2-dimethylaziridines: competition between S"N"2 and postulated ''SET'' mechanism.
    Amsterdam : Elsevier
    Tetrahedron Letters 23 (1982), S. 5021-5024 
    Details
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4039(00)85562-8
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 13
    Electronic Resource
    Electronic Resource
    Analysis and characterization of resorbable dl-lactide-trimethylene carbonate copolyesters (1993)
    Springer
    Journal of materials science 4 (1993), S. 381-388 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Randomized copolyesters of dl-lactide (DLLA) and trimethylene carbonate (TMC) in a wide range of composition were synthesized, analysed and characterized with the aim of assessing their potential benefit in biomedical applications. The chemical composition was analysed using 1H-nuclear magnetic resonance (NMR) spectroscopy. Sequence information was obtained by means of 13C-NMR spectroscopy. From the occurrence of TMC-lactate-TMC triads it is concluded that synthesis by melt copolymerization at 190°C is accompanied by transesterification. The copolymers were characterized by means of differential scanning calorimetry (DSC), tensile testing and accelerated hydrolysis tests at 80°C. Their properties were compared with those of the parent polymers. It was found that all properties under investigation are strongly affected by the molar composition: with increasing TMC moieties the glass transition temperature (T g) is depressed, the tensile strength reduced, the elasticity increased and the in vitro hydrolysis rate decelerated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00122196
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 14
    Electronic Resource
    Electronic Resource
    Mechanisms of resistance to methotrexate in childhood acute lymphoblastic leukemia: circumvention of thymidylate synthase inhibition (1999)
    Springer
    Journal of cancer research and clinical oncology 125 (1999), S. 513-519 
    Details
    ISSN: 1432-1335
    Keywords: Key words Acute lymphoblastic leukemia ; Methotrexate polyglutamates ; Thymidylate synthase ; Salvage pathway ; Relapse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: In about 25% of patients suffering from acute lymphoblastic leukemia (ALL) treatment failures occur that are most likely due to development of resistance to methotrexate (MTX). Blasts from patients with ALL were evaluated for MTX uptake, formation of long-chain MTX polyglutamates (MTX-Glu5+6), cytotoxicity and thymidylate synthase inhibition by MTX and compared to blasts from patients with acute myelogenous leukemia (AML). Methods: Radioactively labeled MTX-Glu n were analyzed by means of HPLC. Thymidylate synthase activity was measured by a tritium-release assay. Cytotoxicity was determined by trypan blue exclusion. Results: In most ALL blasts (n = 9) large amounts of MTX-Glu5+6 (1.06–7.03 pmol/107cells) and high cytotoxicity (43.5%–92.7%) were found, while in others small amounts of MTX-Glu5+6 (0.0–0.39 pmol/107cells) caused only weak cytotoxicity (6.0%–27.9%) (n = 5, 2 relapsed patients). Resistance to MTX in blasts from AML patients (n = 5) was also caused by reduced synthesis of MTX-Glu5+6 (0.0–0.42 pmol/107cells). In contrast, some ALL blasts (n = 7, 4 relapsed patients) were able to survive MTX treatment despite large amounts of MTX-Glu5+6 (1.5–5.05 pmol/107cells) and extensive thymidylate synthase inhibition. Conclusions: Since the majority of ALL patients were examined at first diagnosis, an inherent mechanism of resistance seems most likely. We propose a mechanism based on the switch of thymidylate synthesis to the salvage pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004320050310
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 15
    Electronic Resource
    Electronic Resource
    HLA-DP antibodies in patients awaiting renal transplantation (1995)
    Springer
    Transplant international 8 (1995), S. 180-184 
    Details
    ISSN: 1432-2277
    Keywords: HLA-DP antibodies ; kidney transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sera from 505 patients awaiting renal transplantation with known panel-reactive cytotoxic antibody (PRA) status were tested for HLA-DP antibodies of the IgG class by means of the monoclonal antibody immobilization of leukocyte antigens (MAILA) technique. The overall incidence of HLA-DP antibodies was 7.3%. A positive HLA-DP antibody status correlated only weakly (r=0.23) with a positive cytotoxic antibody status. After retrospective analysis, patients with HLA-DP antibodies prior to retransplantation revealed a significantly (P〈0.025) higher graft function rate than HLA-DP-negative patients. One patient was found to possess IgG HLA-DP autoantibodies prior to transplantation; thus far, his graft has been functioning for more than 2 years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336534
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 16
    Electronic Resource
    Electronic Resource
    Tacrolimus and cyclosporine efficacy in high-risk kidney transplantation (1998)
    Springer
    Transplant international 11 (1998), S. S73 
    Details
    ISSN: 1432-2277
    Keywords: Key words Tacrolimus ; Cyclosporine ; Kidney transplantation ; High risk
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The efficacy and safety of tacrolimus- and cyclosporine-based immunosuppressive regimens were compared in a prospectively defined subgroup of kidney transplant recipients from the European, open, multicentre, 2 : 1 randomised, parallel group study. Patients were stratified as high risk for immunological events if they had a panel-reactive antibodies grade greater than 80 % and/or a previous transplant functional for less than 1 year. The primary efficacy variables evaluated were the incidence of acute rejection, steroid usage and patient and graft survival. Safety was assessed based on adverse events and laboratory evaluations. At 1 year, the tacrolimus group (n = 22) had a lower incidence of biopsy-proven acute rejection (31.8 %) and a higher graft survival (86.0 %) than the 11 patients in the cyclosporine group (54.5 % and 72.0 %, respectively). The frequencies of adverse events were similar between the two groups. The tacrolimus regimen appears more beneficial for high risk patients than cyclosporine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00014036
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 17
    Electronic Resource
    Electronic Resource
    Magnetresonanztomographie ohne und mit Gadolinium-DTPA zur Beurteilung von Nierentransplantaten (1997)
    Springer
    Der Radiologe 37 (1997), S. 225-232 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Magnetresonanztomographie ; Nierentransplantate ; Kontrastmittel ; Key words MR imaging ; Renal allografts ; Contrast medium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Purpose: To determine the value of MR imaging in differentiating the various causes of human renal allograft dysfunction. Methods: A total of 123 human renal allografts (normal n = 20, acute rejection n = 57, acute tubular necrosis n = 14, interstitial fibrosis n = 11, chronic allograft glomerulopathy n = 11, cyclosporine nephrotoxicity n = 3, cortical necrosis n = 7) were investigated by means of MR imaging. Axial T1-weighted spin-echo images and coronal T1-weighted gradient-echo images were obtained before and after Gd-DTPA injection. Diagnostic parameters included corticomedullary contrast and allograft size and shape on the pre-contrast sequences. Results: None of the diagnostic parameters used could differentiate among the various diagnostic groups. Diagnosis of cortical necrosis could be made only on post-contrast scans. Contrast-enhanced scans were superior to pre-contrast images in detection of focal allograft lesions. Otherwise, contrast-enhanced scans did not provide any more information than pre-contrast studies. Spin-echo and gradient-echo sequences displayed the same diagnostic value. Conclusions: MR imaging has a limited value in differentiating the various causes of renal allograft dysfunction.
    Notes: Zusammenfassung Um den Stellenwert der MRT bei der Klärung der Fehlfunktion von Nierentransplantaten zu untersuchen, wurden 123 menschliche Nierentransplantate (unauffällig: n = 20, akute Rejektion: n = 57, akute tubuläre Nekrose: n = 14, interstitielle Fibrose: n = 11, Transplantatglomerulopathie: n = 11, Cyclosporinschaden: n = 3, kortikale Nekrose: n = 7) MR-tomographiert. An einem 1,5-T-Gerät wurden axiale T1-gewichtete Spinecho- und koronare T1-gewichtete Gradientenechoaufnahmen vor und nach Gabe von Gd-DTPA akquiriert. Als Beurteilungskriterien wurden der kortikomedulläre Kontrast sowie die Größe und Form des Transplantatorganes in der Nativuntersuchung herangezogen. Keines der Kriterien ermöglichte die Differenzierung der verschiedenen Diagnosegruppen. Abgesehen von der kortikalen Nekrose, die nur anhand der kontrastmittelunterstützten Sequenzen erkennbar war, lieferte die Gd-DTPA-Applikationen für die Differenzierung der verschiedenen parenchymalen Komplikationen keine Zusatzinformationen. Beim Nachweis fokaler Parenchymläsionen war die Kontrastmittelserie der Nativuntersuchungen überlegen. Die Spinecho- und Gradientenechoaufnahmen führten zu ähnlichen Resultaten. Schlußfolgernd kann davon ausgegangen werden, daß die statische MRT bei der Klärung der Fehlfunktion einer Transplantatniere eine untergeordnete Rolle spielt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050203
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 18
    Electronic Resource
    Electronic Resource
    Reproduktionsmedizinische Aspekte chronischer Infektionen mit Hepatitisviren (2000)
    Springer
    Reproduktionsmedizin 16 (2000), S. 319-325 
    Details
    ISSN: 1434-808X
    Keywords: Schlüsselwörter Hepatitis • HBV • HCV • Spermien • Assistierte Reproduktion ; Keywords Hepatitis • HBV • HCV • Sperm • ART
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract In Germany about 1 million people are chronically infected with the hepatitis B or C virus and most of them are in the reproductive age. If a child is desired, liver function and moreover sexual and materno-fetal risk of transmission should be taken into consideration. Active vaccination can prevent sexual transmission of HBV and simultaneous passive vaccination strategies are able to inhibit consecutive infection of the newborn. Perinatal aquired chronic hepatitis B is typically asymptomatic and shows good short term prognosis. In men with chronic HBV infection transmission of the virus to the fetus by the infected sperm cannot fully be excluded. In HCV infection no successful vaccination strategies are available yet and preventing sexual transmission is based on condom use. Assisted reproduction techniques can reduce the risk of male to female transmission. HCV transmission to the newborn depends on maternal viral load. Perinatal aquired chronic hepatitis C shows a good prognosis. Prior to assisted reproduction antiviral treatment should be considered.
    Notes: Zusammenfassung In Deutschland sind etwa 1 Mio. Menschen chronisch mit Hepatitisviren der Gruppen B und C infiziert, die Mehrzahl davon im reproduktionsfähigen Alter. Bei Kinderwunsch ist neben der hepatologischen Situation insbesondere das sexuelle und das maternofetale Übertragungsrisiko zu berücksichtigen. Bei Hepatitis B kann durch Vakzinierung die sexuelle Transmission vermieden und durch neonatale Simultanimpfung die maternofetale Übertragungsrate drastisch gesenkt werden, die Langzeitprognose konnatal infizierter Kinder ist eher günstig. Bei chronischer Infektion kann derzeit aber die Möglichkeit einer paternofetalen Virustransmission durch infizierte Spermien nicht ausgeschlossen werden. Da für Hepatitis C weder eine Vakzinierung noch eine Immunprophylaxe verfügbar ist, erfordert die Prävention der sexuellen Übertragung den Gebrauch von Kondomen. Bei Infektion des (Ehe-)Mannes kann zur Risikoreduktion eine ART mit aufbereiteten Spermien angeboten werden. Bei Infektion der (Ehe-)Frau lassen das geringe maternofetale Übertragungsrisiko und die jahrzehntelang günstige Prognose konnatal infizierter Kinder keine Kontraindikation gegen ART erkennen. Vor jeder reproduktionsmedizinischen Intervention sollte aber die Option einer viruseliminierenden Therapie geprüft werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004440000212
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 19
    Electronic Resource
    Electronic Resource
    Electric and magnetic hyperfinestructure investigations in the 5s 25p 3 and 5s 25p 26s Configurations of121, 123Sb (1978)
    Springer
    The European physical journal 288 (1978), S. 247-256 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Optical hyperfinestructure investigations in several spectral lines were carried out in the Sb-I spectrum from which for the first time accurate values of the hfs-splitting constantsA andB of the ground configuration 5p 3 and also for five of the eight levels of the first excited configuration 5p 26s were obtained. With these parameters the influence of core polarization effects is calculated to bea c= −6.6(4) mK, (equivalent to a magnetic field of −283(20) kG perp-electron spin). The quadrupole momentQ 121= −0.36(4) b (including Sternheimer correction) was obtained with the experimental valuesb 3/2= −14.3(1.0) mK and 〈r −3〉 =11.2(3) a.u. andQ 123= −0.49(5) b withb 3/2= −19.9(1.0) mK resp. This evaluation also yields the relativistic correction factor η= −(C″/C′) · S r/R′ r=1.13(2). —For the first time, too, isotope shift investigations in Sb-I lines were possible which permit to determine the isotope shift constant βC exp= 40(10) mK, and a value δ〈r 2〉121, 123=0.12(4) fm2 for the change in the mean square nuclear charge radius between121Sb and123Sb which is about 50 percent of the prediction of the unified nuclear model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01415192
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 20
    Electronic Resource
    Electronic Resource
    139. Verbesserung der Organqualität bei der Nierenspende (1981)
    Springer
    Langenbeck's archives of surgery 355 (1981), S. 530-530 
    Details
    ISSN: 1435-2451
    Keywords: Kidney donation ; Donor procurement ; En-bloc perfusion ; Nierenspende ; organerhaltende Therapie ; En-bloc Perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Neben immunologischen Faktoren nimmt die Organqualität bei der Nierenspende eine Schlüsselposition für den Transplantationserfolg ein. Anhand von 110 Organentnahmen werden die wesentlichen organisatorischen und intensivmedizinischen Maßnahmen sowie die in Münster weiterentwickelte extracorporale transaortale Nierenperfusion dargestellt.
    Notes: Summary Besides immunological problems the anatomical and functional integrity of the transplanted kidney has a decisive influence on the outcome of kidney grafting. Using the data obtained from 110 kidneys explanted in Münster, we outline the essential regimen of donor procurement in an intensive care unit. A sophisticated technique in terms of extracorporeal transaortic en bloc graft perfusion is offered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01286969
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...