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  • 1
    Electronic Resource
    Electronic Resource
    Synchrotron radiation lithography system in an atmospheric environment (invited) : INTERNATIONAL CONFERENCE ON SYNCHROTRON RADIATION INSTRUMENTATION (1989)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 60 (1989), S. 1643-1648 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The atmospheric environmental exposure system for synchrotron radiation (SR) lithography has been integrated using the Photon Factory storage ring (2.5 GeV). The system, composed of a highly reliable beamline, an SR extracting chamber and a prototype SR stepper, aims at attaining higher accuracy and throughput. Based on a fail-safe mechanism notion, a double-vacuum protection system, in which two sets of a fast closing valve and acoustic delay line are installed in the main beamline and branch beamline, respectively, has been organized. Vacuum breakdown tests indicated that any vacuum breakdown, a beryllium (Be) window rupture in the worst case, exerts little influence on the storage ring ultrahigh vacuum. The SR extracting chamber, equipped with a Be window and an extraction window, is filled with helium at atmospheric pressure. Particularly, the 50-μm-thick, 35-mm-diam Be window, vacuum-sealed by a Viton O-ring, was preliminarily employed and, so far, has operated successfully, giving a 25-mm square exposure area. In terms of practical availability and simplicity, the SR stepper in an atmospheric environment has been constructed. A novel differential mode linear Fresnel zone plate alignment method, which can detect an alignment error between a mask and a wafer during exposure, was developed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1141050
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  • 2
    Electronic Resource
    Electronic Resource
    Real-space computation of dynamic hyperpolarizabilities (2001)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 115 (2001), S. 8773-8783 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A real-space method is developed to calculate molecular hyperpolarizabilities in the time-dependent density functional theory. The method is based on the response function formalism which was developed by Senatore and Subbaswamy for the third harmonic generation of rare-gas atoms [Phys. Rev. A 35, 2440 (1987)]. The response equations are discretized in real space employing a uniform grid representation in the three-dimensional Cartesian coordinate, and are solved with iterative methods such as conjugate-gradient and conjugate-residual methods. The method works efficiently for both small and large molecules, and for any nonlinear optical processes up to third order. The spatial convergence of the calculation can be examined with two intuitive parameters, the grid spacing and the spatial box size. Applications of our method are presented for rare-gas atoms and molecules, N2, H2O, C2H4, C6H6, and C60. Our results agree well with other calculations employing basis functions except for a slight deviation in a large molecule, C60. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1411996
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  • 3
    Electronic Resource
    Electronic Resource
    Purification and characterization of an alkaline protease from Oerskovia xanthineolytica TK-1
    Amsterdam : Elsevier
    Journal of Fermentation and Bioengineering 77 (1994), S. 554-556 
    Details
    ISSN: 0922-338X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0922-338X(94)90128-7
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  • 4
    Electronic Resource
    Electronic Resource
    Purification and characterization of a yeast lytic β-1,3-glucanase from Oerskovia xanthineolytica TK-1
    Amsterdam : Elsevier
    Journal of Fermentation and Bioengineering 78 (1994), S. 407-412 
    Details
    ISSN: 0922-338X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0922-338X(94)90038-8
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  • 5
    Electronic Resource
    Electronic Resource
    Determination of 17-oxosteroid sulphates in serum by ion-pair extraction, prelabelling with dansylhydrazine and high-performance liquid chromatography with fluorescence detection
    Amsterdam : Elsevier
    Journal of Chromatography A 474 (1989), S. 363-371 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0021-9673(01)93929-9
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  • 6
    Electronic Resource
    Electronic Resource
    Biphasic caffeine contracture of frog cardiac muscle exposed to excess calcium
    Amsterdam : Elsevier
    Journal of Molecular and Cellular Cardiology 9 (1977), S. 49 
    Details
    ISSN: 0022-2828
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0022-2828(77)80123-5
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  • 7
    Electronic Resource
    Electronic Resource
    An alignment system for X-ray lithography
    Amsterdam : Elsevier
    Microelectronic Engineering 11 (1990), S. 263-266 
    Details
    ISSN: 0167-9317
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-9317(90)90111-6
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  • 8
    Electronic Resource
    Electronic Resource
    Ultrastructure of Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus-8 (HHV-8) in a primary effusion lymphoma cell line treated with tetradecanoyl phorbol acetate (TPA) (1999)
    Springer
    Medical electron microscopy 32 (1999), S. 94-99 
    Details
    ISSN: 1437-773X
    Keywords: Key words KSHV ; HHV-8 ; TPA ; Ultrastructure ; Primary effusion lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The ultrastructure of Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus-8 (HHV-8) has not yet been fully elucidated, although some findings have been reported using primary effusion lymphoma (PEL) cell lines, KS-1, harboring no Epstein–Barr virus (EBV) coinfection. In the present study, detailed fine structural examination of KSHV/HHV-8 was performed after stimulation of the PEL-derived cell line KS-1 with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in vitro. While unstimulated KS-1 cells contained a small number of intranuclear virus particles associated with no extracellular mature particles, KS-1 cells stimulated with TPA produced many extracellular mature particles as well as intranuclear particles, in addition to interesting tubulo-reticular structures and aggregated tubular structures in vesicles. The induced intranuclear particles were empty, doughnut shaped, and dense cored, with outer and inner diameters of 100–110 nm and 60–70 nm, respectively. Dense-cored extracellular mature particles were 150–160 nm in diameter, and some contained doughnut-shaped cores, together with a few megaloviruses, 260 nm in outer diameter. These findings indicate that KS-1 cells treated with TPA can produce extracellular mature particles as well as intranuclear particles, which were proven to be KSHV/HHV-8.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007950050014
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  • 9
    Electronic Resource
    Electronic Resource
    Overexpression of cyclin D1 in nonmelanocytic skin cancer (2000)
    Springer
    Virchows Archiv 436 (2000), S. 370-376 
    Details
    ISSN: 1432-2307
    Keywords: Key words Cyclin D1 ; Skin cancer ; Differentiation ; Sun exposure ; Aging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Although the overexpression of cyclin D1 has been believed to play important roles in neoplastic transformation of some tumors, little is known about the function of cyclin D1 protein in carcinogenesis in human skin. A total of 307 patients with nonmelanocytic skin cancer, being 46 with Bowen’s disease (BOD), 134 with squamous cell carcinoma (SCC) and 127 with basal cell carcinoma (BCC), were investigated immunohistochemically using monoclonal antibody to cyclin D1 by the LSAB method, to assess the expression of cyclin D1 in skin cancer including its precursors. The positive rates of cyclin D1 immunostaining in BOD, SCC and BCC were 63.0%, 69.4% and 54.3%, respectively. The positive rates in dysplasia adjoining BOD, SCC and BCC were 43.6%, 67.9% and 59.8%, respectively. In morphologically normal skin, however, only 2 cases, 1 of SCC and 1 of BCC, exhibited positive staining. These findings suggested that overexpression of cyclin D1 is an early event in dysplastic lesions of skin. Overexpression of cyclin D1 was related to sun exposure, especially in dysplasia of SCC. The score for cyclin D1 expression in dysplasia of BCC was correlated with age. Expression of cyclin D1 markedly increased from normal skin through dysplasia to BOD, but was not significantly related to the degree of SCC differentiation. These findings demonstrate that the effect of cyclin D1 overexpression is restricted to proliferation of cells, so that they gain a growth advantage, but their differentiation is not increased. Comparison with the results for p53 protein expression in these tumors, a significant correlation with cyclin D1 expression was found in dysplasia in BOD and SCC, and in patients with BCC who were less than 74 years old. These findings suggested the hypothesis that prior aberrant p53 expression may affect or regulate the overexpression of cyclin D1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050461
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  • 10
    Electronic Resource
    Electronic Resource
    Ameloblastoma of the mandible metastasizing to the orbit with malignant transformation (1997)
    Springer
    Virchows Archiv 430 (1997), S. 501-507 
    Details
    ISSN: 1432-2307
    Keywords: Key words Ameloblastoma ; Metastasis ; Orbit ; Malignant transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report here a case of ameloblastoma of the mandible with multiple local recurrences and metastasis to the orbit. The patient was a 63-year-old Japanese woman with visual disturbance of her right eye. Diagnostic imaging revealed a mass occupying the right orbital apex with partial intracranial involvement. She had been surgically treated for mandibular ameloblastoma 27 years previously, and the tumour had recurred three times in the past 5 years. The orbital tumour and recurrent ameloblastomas were investigated histopathologically and immunohistochemically. The tumour changed in morphology as it recurred, from follicular ameloblastoma without atypia to apparent malignant tumours disclosing undifferentiated or squamoid features. On immunohistochemical analysis, staining for cytokeratin was positive in the squamoid cells but not in the undifferentiated cells. Both histopathologically and immunohistochemically, the orbital tumour was almost identical to the undifferentiated recurrent tumour. The orbital tumour was distinct from the primary site or sites of recurrence of ameloblastoma, and we concluded that the mandibular ameloblastoma underwent malignant transformation with multiple recurrences and finally metastasized to the orbit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050061
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