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  • 1
    Electronic Resource
    Electronic Resource
    Indications for a more aggressive disease process in newly diagnosed insulin-dependent diabetic children in Northern than in Southern Europe (1994)
    Springer
    Acta diabetologica 31 (1994), S. 107-115 
    Details
    ISSN: 1432-5233
    Keywords: Insulin-dependent diabetes ; Islet cell antibodies ; Complement-fixing ICA ; C-peptide ; Geographical variation ; Seasonal variation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Finland and Sweden have the highest incidence of insulin-dependent diabetes in children in the world, about 3–4 times that of countries in the Mediterranean area, with the exception of Sardinia. We have collected information from several European clinics and from Pittsburgh, USA, in order to find out whether this difference in incidence is associated with corresponding differences of the disease pattern. Patients in Finland or Sweden (‘North’) and Pittsburgh were younger (〈10 years old) at diagnosis compared with those in the other clinics in Europe (P〈0.05 versusP〈0.02). In the North, boys were in excess (58%) in contrast to France (40%) and Pittsburgh (46%). Patients in the North had a shorter duration of symptoms (〈8 days;P〈0.001) and higher blood glucose (〉20 mmol/l;P〈0.05) than those attending the other European clinics. Irrespective of age, there were more ICA-positive patients in the North (94%) than in Berlin-Vienna (67%;P〈0.01) or in France (70%;P〈0.01). There was a tendency for non-diabetic parents and siblings in the North to have lower C-peptide values (〈0.26 pmol/ml) at the time of diagnosis of the proband and to be ICA-positive more often than relatives in the other European clinics. The seasonal variation of diagnosis, showed no obvious geographical differences, with recorded diagnosis always lowest during the summer. We conclude that certain factors seem to cause not only a high incidence of diabetes in children in Finland and Sweden but perhaps also a more aggressive early disease process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00570546
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  • 2
    Electronic Resource
    Electronic Resource
    Crohn's disease: current imaging approach (1998)
    Springer
    Der Radiologe 38 (1998), S. 15-22 
    Details
    ISSN: 1432-2102
    Keywords: Key words Crohn's disease • Ultrasound • Small bowel enema • Computed tomography ; Schlüsselwörter Morbus Crohn • Ultraschall • Enteroklysma • Irrigoskopie • Computertomographie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die vorliegende Übersichtsarbeit soll die Rolle bildgebender radiologischer Modalitäten bei der interdisziplinären Betreuung von Patienten mit Morbus Crohn (MC) diskutieren. Es wird ein Konzept vorgestellt, welches die unterschiedlichen Anforderungen an die bildgebende Diagnostik im Rahmen der Erstdiagnose, der Verlaufskontrolle sowie bei der Erfassung von Komplikationen eines MC definiert. Davon ausgehend wird versucht, für die einzelnen Fragestellungen die jeweils effektivste radiologische Abklärung vorzuschlagen. Mehrere Tabellen ermöglichen einen raschen und komprimierten Überblick der diagnostischen Problemstellungen im Rahmen einer schrittweisen Abklärung der Erkrankung. Im Rahmen der Erstdiagnostik soll die radiologische Dünndarmdarstellung bei der Differentialdiagnose (MC vs. Colitis ulcerosa) hilfreich sein und das genaue Ausmaß des Dünndarmbefalles eruieren. Im Rahmen der klinischen Verlaufskontrolle ist die Darmsonographie ideal zur Überwachung der Erkrankung sowie zur frühen Erfassung von Komplikationen geeignet. Bei geringstem Verdacht auf eine Komplikation sollte sofort eine CT durchgeführt werden.
    Notes: Purpose: This paper discusses the role of different imaging modalities in the diagnostic work-up of Crohn's disease (CD). Methods: We present a concept, which emphasizes different diagnostic aspects with regard to primary diagnosis, follow-up and assessment of complications of CD. The most effective imaging approach to various diagnostic problems of CD is discussed in detail. Discussion: With regard to the primary diagnosis barium studies should contribute to differentiate between CD and ulcerative colitis. Beyond that, these studies should evaluate location and extent of disease. During the follow-up bowel sonography provides staging of disease and enables the detection of complications at an early stage. CT is a valuable tool in the preoperative assessment of complications, such as fistulae and abscesses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050318
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  • 3
    Electronic Resource
    Electronic Resource
    Actinic elastosis in black skin (1978)
    Springer
    Archives of dermatological research 262 (1978), S. 7-14 
    Details
    ISSN: 1432-069X
    Keywords: Black skin ; Actinic elastosis ; Light- and electronmicroscopy ; Fibroblastic product ; Negerhaut ; Aktinische Elastose ; Licht- und Elektronenmikroskopie ; Fibroblastenprodukt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 9 hautgesunden südafrikanischen schwarzen Freiwilligen im Alter von 1–72 Jahren wurde sonnenlichtexponierte und nichtexponierte Haut licht- und elektronenmikroskopisch untersucht unter besonderer Berücksichtigung altersabhängiger und aktinisch bedingter Veränderungen dermaler Strukturen. Während bei einer 72jährigen Frau eine ausgeprägte aktinische Elastose im oberen Corium der sonnenexponierten Haut licht- und elektronenoptisch nachweisbar war, fand sich bei einem 72jährigen Mann eine nur elektronenoptisch darstellbare geringe Elastose. Im Gegensatz dazu waren bei diesen beiden Fällen im unteren Corium der sonnenexponierten und in allen Schichten der nichtexponierten Haut nur altersentsprechende elastische Fasern vorhanden. Diese Beobachtungen stehen in Gegensatz zu der noch gängigen Auffassung, daß eine aktinische Elastose bei der kongoiden Rasse nicht auftritt. Das elastotische Material ist offensichtlich ein de-novo-synthetisiertes und sezerniertes pathologisches Produkt von (durch chronische UV-Bestrahlung) alterierten Fibroblasten.
    Notes: Summary In 9 otherwise dermatologically normal South African Black volunteers (1–72 years old), sunlight-exposed and non-exposed skin has been examined by light- and electronmicroscopy with special references to age-dependent and actinic alteration of dermal structures. Two 72 year old Blacks exhibited typical dermal elastosis: in 1 case to a marked extent and already detectable by lightmicroscopy, in the other case only to a mild degree. In contrast, only age-related elastic fibers were revealed in the lower dermis of sunlight-exposed skin and in all dermal layers of unexposed skin. These observations are contradictory to the general view that actinic elastosis does not occur in Blacks. The elastotic material is obviously a de-novo synthesized and secreted pathological product of chronically UV-altered fibroblasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455568
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  • 4
    Electronic Resource
    Electronic Resource
    Glycosylation of glomerular basement membrane in type 1 (insulin-dependent) diabetic children (1982)
    Springer
    Diabetologia 23 (1982), S. 485-487 
    Details
    ISSN: 1432-0428
    Keywords: Non-enzymatic glycosylation ; glomerular basement membrane ; immunoelectrophoresis ; Type 1 diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunoelectrophoresis of glomerular basement membrane antigens in the urine of 20 Type 1 (insulin-dependent) diabetic and 10 healthy children was performed. In 10 of the diabetic children, there was altered α-1-mobility, while the other diabetic and normal children showed α-2-mobility. After incubation with glucose, glomerular basement membrane antigens in the urine of healthy children showed α-1-mobility. Isolated human kidney glomerular basement membrane split products obtained by proteolytic degradation (papain, trypsin, chymotrypsin) were also investigated by immunoelectrophoresis. A difference was observed in the immunoelectrophoretic pattern of native and glycosylated glomerular basement membrane split products. A distinct increase of thiobarbituric acid assay positive glomerular basement membrane structures after incubation with glucose provides suggestive evidence for the occurrence of non-enzymatic glycosylation of glomerular basement membrane proteins. Glycosylated glomerular basement membrane proteins may contribute to both functional and morphological changes in diabetic glomerulosclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254295
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  • 5
    Electronic Resource
    Electronic Resource
    HLA-DR 3 is associated with a more slowly progressive form of Type 1 (insulin-dependent) diabetes (1986)
    Springer
    Diabetologia 29 (1986), S. 207-210 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; children ; HLA-types ; heterogeneity symptoms at onset ; partial remission ; genetic susceptibility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The presence of HLA-DR 3 was analysed in 745 patients with Type 1 (insulin-dependent) diabetes with age at diagnosis between 1–19 years. HLA-DR 3 and/or 4 was found in 678/745 (91%) of the patients. Presence of DR 2 with neither DR 3 nor 4 was demonstrated in 15 patients. Patients with HLA-DR 3 without DR 4 presented with Type 1 diabetes more evenly over the year; they also presented without incidence peaks at 7 years or 10–11 years, as seen especially in DR 3/4 patients. The DR 3 patients more often had mild disease with less ketonuria at diagnosis, less often ketoacidotic symptoms and more often a subsequent partial remission. The apparently more severe disease among diabetic girls may, at least to some extent, be explained by their higher prevalence of HLA-DR4. The differences found were similar in North America and Europe. The results suggest that Type 1 diabetes is a genetically heterogenous disease and that HLA-typing may be a useful marker of this heterogeneity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00454876
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  • 6
    Electronic Resource
    Electronic Resource
    Painfulness of needle and jet injection in children with diabetes mellitus (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 409-410 
    Details
    ISSN: 1432-1076
    Keywords: Key words     Children ; Diabetes ; Insulin ; Jet injection ; Pain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract      The aim of this study was to investigate whether insulin application by jet injector is less painful than by needle. Pain was scored by 41 diabetic and seven healthy volunteers after injections with both methods. Injections by jet were no less painful than those by needle but produced several local side-effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983402
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  • 7
    Electronic Resource
    Electronic Resource
    Glycaemic responses to commonly ingested breakfasts in children with insulin-dependent diabetes mellitus (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 353-355 
    Details
    ISSN: 1432-1076
    Keywords: Insulin-dependent diabetes ; Children ; Glycaemic index ; Diet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The glycaemic response to commonly ingested breakfast with different glycaemic index (cornflakes, white bread, dark rye bread and muesli) was investigated in 14 children with insulin-dependent diabetes mellitus. The blood glucose response after cornflakes was significantly higher than after the other breakfasts, whereas the areas under the blood glucose curve were not statistically different. We observed no difference in blood glucose rise between the other breakfast types. Conclusion Postprandial blood glucose measurements after meals with high glycaemic index may be useful in order to minimize the postprandial rise in blood glucose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02072101
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  • 8
    Electronic Resource
    Electronic Resource
    Recurrent suppurative thyroiditis due to pyriform sinus fistula: a case report (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 640-642 
    Details
    ISSN: 1432-1076
    Keywords: Recurrent suppurative thyroiditis ; Pyriform sinus fistula ; Childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute suppurative thyroiditis is a rare disease, particularly in childhood. We present a case with recurrent acute suppurative thyroiditis due to a pyriform sinus fistula originating from the fourth branchial pouch. The typical symptoms of a piriform sinus fistula are recurrent left-sided pain and swelling of the neck with signs of acute bacterial inflammation. Diagnosis should be made by high resolution ultrasound, barium meal studies and endoscopic examination. During acute exacerbations treatment with antibiotics is indicated, but permanent cure can only be attained by complete fistulectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02079068
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  • 9
    Electronic Resource
    Electronic Resource
    Painfulness of needle and jet injection in children with diabetes mellitus (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 409-410 
    Details
    ISSN: 1432-1076
    Keywords: Children ; Diabetes Insulin ; Jet injection ; Pain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to investigate whether insulin application by jet injector is less painful than by needle. Pain was scored by 41 diabetic and seven healthy volunteers after injections with both methods. Injections by jet were no less painful than those by needle but produced several local side-effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983402
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Recurrent suppurative thyroiditis due to pyriform sinus fistula: a case report (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 640-642 
    Details
    ISSN: 1432-1076
    Keywords: Key words Recurrent suppurative ; thyroiditis ; Pyriform sinus fistula ; Childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute suppurative thyroiditis is a rare disease, particularly in childhood. We present a case with recurrent acute suppurative thyroiditis due to a pyriform sinus fistula originating from the fourth branchial pouch. The typical symptoms of a piriform sinus fistula are recurrent left-sided pain and swelling of the neck with signs of acute bacterial inflammation. Diagnosis should be made by high resolution ultrasound, barium meal studies and endoscopic examination. During acute exacerbations treatment with antibiotics is indicated, but permanent cure can only be attained by complete fistulectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02079068
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    Paper (German National Licenses)
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