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  • 2020-2023  (7)
  • 2000-2004  (20)
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  • 1
    Digitale Medien
    Digitale Medien
    Is Routine Intraoperative Frozen-Section Examination of Sentinel Lymph Nodes in Breast Cancer Worthwhile? (2000)
    Springer
    Annals of surgical oncology 7 (2000), S. 651-655 
    Details
    ISSN: 1534-4681
    Schlagwort(e): Sentinel lymph nodes ; Frozen section ; Macrometastases ; Micrometastases
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Background: Routine intraoperative frozen section (FS) of sentinel lymph nodes (SLN) can detect metastatic disease, allowing immediate axillary dissection and avoiding the need for reoperation. Routine FS is also costly, increases operative time, and is subject to false-negative results. We examined the benefit of routine intraoperative FS among the first 1000 patients at Memorial Sloan Kettering Cancer Center who had SLN biopsy for breast cancer. Methods: We performed SLN biopsy with intraoperative FS in 890 consecutive breast cancer patients, none of whom had a back-up axillary dissection planned in advance. Serial sections and immunohistochemical staining for cytokeratins were performed on all SLN that proved negative on FS. The sensitivity of FS was determined as a function of (1) tumor size and (2) volume of metastatic disease in the SLN, and the benefit of FS was defined as the avoidance of a reoperative axillary dissection. Results: The sensitivity of FS ranged from 40% for patients with T1a to 76% for patients with T2 cancers. The volume of SLN metastasis was highly correlated with tumor size, and FS was far more effective in detecting macrometastatic disease (sensitivity 92%) than micrometastases (sensitivity 17%). The benefit of FS in avoiding reoperative axillary dissection ranged from 4% for T1a (6 of 143) to 38% for T2 (45 of 119) cancers. Conclusions: In breast cancer patients having SLN biopsy, the failure of routine intraoperative FS is largely the failure to detect micrometastatic disease. The benefit of routine intraoperative FS increases with tumor size. Routine FS may not be indicated in patients with the smallest invasive cancers.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s10434-000-0651-3
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  • 2
    Digitale Medien
    Digitale Medien
    A new nonlinear elliptic multilevel FEM in clinical cancer therapy planning (2000)
    Springer
    Computing and visualization in science 3 (2000), S. 115-120 
    Details
    ISSN: 1433-0369
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract. In the clinical cancer therapy regional hyperthermia certain nonlinear perfusion effects inside and outside the tumor seem to play a significant role. A stationary model of such effects leads to a nonlinear Helmholtz term within an elliptic boundary value problem. The present paper reports about the application of a recently designed adaptive multilevel FEM (code NEWTON-KASKADE) to this problem. For two 3D virtual patients, nonlinear and linear models are compared. Moreover, the numerical efficiency of the new algorithm is compared with a former application of an adaptive FEM to the corresponding non stationary model PDE.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/PL00013546
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  • 3
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    Unbekannt
    Asymptotic Mesh Independence of Newton's Method Revisited (2003)
    Details
    Publikationsdatum: 2019-01-29
    Beschreibung: The paper presents a new affine invariant theory on asymptotic mesh independence of Newton's method in nonlinear PDEs. Compared to earlier attempts, the new approach is both much simpler and more natural from the algorithmic point of view. The theory is exemplified at collocation methods for ODE boundary value problems and at finite element methods for elliptic PDE problems.
    Schlagwort(e): ddc:000
    Sprache: Englisch
    Materialart: reportzib , doc-type:preprint
    Format: application/postscript
    Format: application/pdf
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  • 4
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    A new nonlinear elliptic multilevel FEM in clinical cancer therapy planning (2000)
    Details
    Publikationsdatum: 2020-04-30
    Sprache: Englisch
    Materialart: article , doc-type:article
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  • 5
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    Affine Invariant Convergence Analysis for Inexact Augmented Lagrangian SQP Methods (2002)
    Details
    Publikationsdatum: 2019-01-29
    Sprache: Englisch
    Materialart: article , doc-type:article
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  • 6
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    Optimality Conditions for a Constrained Parameter Identification Problem in Hyperthermia (2004)
    Details
    Publikationsdatum: 2019-01-29
    Sprache: Englisch
    Materialart: report , doc-type:report
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  • 7
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    Function space interior point methods for PDE constrained optimization (2004)
    Details
    Publikationsdatum: 2019-01-29
    Sprache: Englisch
    Materialart: article , doc-type:article
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  • 8
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    Interior Point Methods in Function Space (2003)
    Details
    Publikationsdatum: 2019-01-29
    Beschreibung: A primal-dual interior point method for optimal control problems is considered. The algorithm is directly applied to the infinite dimensional problem. Existence and convergence of the central path are analyzed, and linear convergence of a short step pathfollowing method is established.
    Schlagwort(e): ddc:000
    Sprache: Englisch
    Materialart: reportzib , doc-type:preprint
    Format: application/postscript
    Format: application/pdf
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  • 9
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    Function space interior point methods for PDE constrained optimization (2004)
    Details
    Publikationsdatum: 2019-01-29
    Beschreibung: A primal-dual interior point method for optimal control problems with PDE constraints is considered. The algorithm is directly applied to the infinite dimensional problem. Existence and convergence of the central path are analyzed. Numerical results from an inexact continuation method applied to a model problem are shown.
    Schlagwort(e): ddc:000
    Sprache: Englisch
    Materialart: reportzib , doc-type:preprint
    Format: application/postscript
    Format: application/pdf
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  • 10
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    The Central Path towards the Numerical Solution of Optimal Control Problems (2001)
    Details
    Publikationsdatum: 2019-01-29
    Beschreibung: A new approach to the numerical solution of optimal control problems including control and state constraints is presented. Like hybrid methods, the approach aims at combining the advantages of direct and indirect methods. Unlike hybrid methods, however, our method is directly based on interior-point concepts in function space --- realized via an adaptive multilevel scheme applied to the complementarity formulation and numerical continuation along the central path. Existence of the central path and its continuation towards the solution point is analyzed in some theoretical detail. An adaptive stepsize control with respect to the duality gap parameter is worked out in the framework of affine invariant inexact Newton methods. Finally, the performance of a first version of our new type of algorithm is documented by the successful treatment of the well-known intricate windshear problem.
    Schlagwort(e): ddc:000
    Sprache: Englisch
    Materialart: reportzib , doc-type:preprint
    Format: application/postscript
    Format: application/pdf
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