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  • 1
    Digitale Medien
    Digitale Medien
    Improved imaging of the spinal cord in multiple sclerosis using three-dimensional fast spin echo (1998)
    Springer
    Neuroradiology 40 (1998), S. 416-419 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Key words Multiple sclerosis ; Spinal cord ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We report assessment of a new three-dimensional fast spin echo (3D FSE) sequence in ten patients with clinically definite multiple sclerosis, comparing it with standard 2D FSE, and in ten normal controls. We saw 29 focal lesions on the 2D images and 53 on the 3D FSE imgages (P = 0.05); none were seen in controls. Lesion length was significantly smaller on the 3D FSE than on to the 2D FSE images (3D: 1.36; 2D 2,0; P = 0.03). This may relate in part to separation into several lesions on the 3D images of confluent abnormal signal seen on 2D and in part to detection of small lesions missed by the thicker 2D FSE slices (3 mm compared to 1.5 mm). The 3D FSE sequence looks promising in improving spinal cord imaging.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002340050614
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  • 2
    Digitale Medien
    Digitale Medien
    Dynamic gadolinium-enhanced MRI in the detection of spinal arteriovenous malformations (1994)
    Springer
    Neuroradiology 36 (1994), S. 522-529 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Magnetic resonance imaging ; Arteriovenous malformations ; Spinal cord ; Contrast media
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Arteriovenous fistulae and malformations (AVFs and AVMs) of the spinal cord are rare, potentially treatable causes of progressive disability. Although a variety of MRI abnormalities has been described, the diagnosis rests on the findings on selective spinal angiography.Collecting T2*-weighted MR images during the passage of a gadolinium bolus gives information about perfusion and blood volume. We carried out dynamic MRI in seven patients with vascular abnormalities (5 dural AVFs, 1 intramedullary AVM, 1 cryptic angioma) and in two patients without an AVM. High resolution T1- and T2-weighted sagittal images of the whole spinal cord were first obtained using a multiarray receiver coil. Sagittal radiofrequency spoilt gradient echo images (GE34/25, flip angle 100) were then obtained during bolus injection of gadolinium-DTPA. Abnormalities were seen in all seven patients with AVFs or AVMs. In the patient with an intramedullary AVM and four of the five with dural AVFs transient signal reduction was seen within the perimedullary venous plexus during passage of the bolus. The findings correlated well with those from selective spinal angiography. We conclude that dynamic MRI offers a useful adjunct to angiography and may localise an arteriovenous shunt when conventional MRI fails to do so. In combination with high-resolution imaging of the entire spinal cord the technique may make myelography redundant; it is simple, well tolerated and can be carried out without significant time penalty.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00593515
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  • 3
    Digitale Medien
    Digitale Medien
    In vivo 1H-magnetic resonance spectroscopy of the spinal cord in humans (2000)
    Springer
    Neuroradiology 42 (2000), S. 515-517 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Key words Magnetic resonance spectroscopy ; Spinal cord ; Multiple sclerosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Magnetic resonance spectroscopy (MRS) has been used in a variety of conditions affecting the central nervous system. Until now, only the brain has been studied, and spectroscopy of the spinal cord has not been previously reported. During the past 12 months, we have been experimenting with MRS of the cervical spinal cord of healthy volunteers. We present this technique, its current limitations, and possible future technological improvements and potential applications.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002340000323
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  • 4
    Digitale Medien
    Digitale Medien
    Imaging of the spinal cord and brain in multiple sclerosis: a comparative study between fast flair and fast spin echo (1997)
    Springer
    Journal of neurology 244 (1997), S. 119-124 
    Details
    ISSN: 1432-1459
    Schlagwort(e): Key words Multiple sclerosis ; Brain ; Spinal cord ; Magnetic ; resonance imaging ; FLAIR
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Recent reports have suggested that fluid attenuated inversion recovery (FLAIR) is a technique superior to conventional (CSE) or fast spin echo (FSE) T2-weighted sequences in detecting intrinsic lesions both in the brain and spinal cord. We report our experience of an inversion recovery prepared FSE, which we refer to as fast FLAIR, in a comparative study of ten patients with clinically definite multiple sclerosis (MS) who underwent cervical cord and brain imaging with both FSE and fast FLAIR. The results showed that in the cerebral hemispheres fast FLAIR detected more lesions than FSE (P 〈 0.001). However, FSE detected more lesions than fast FLAIR in the posterior fossa (P = 0.02) and in the cord fast FLAIR was much inferior detecting only 2 of 33 lesions seen on FSE. Estimating the T2 relaxation times of lesions in each of three areas (periventricular, posterior fossa, cervical cord) showed that the T2 value of posterior fossa and cervical cord lesions was significantly lower than that of periventricular lesions, suggesting that the lesion composition is different and consequently their imaging appearances are different. In conclusion, although fast FLAIR improves the detection of MS lesions in the cerebral hemispheres, its substantially lower sensitivity in the posterior fossa and spinal cord is a potentially important limitation to its use as a tool for the diagnosis of MS and for monitoring therapies. Further studies are needed to elucidate the mechanisms underlying the loss of sensitivity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004150050060
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