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  • 1
    Digitale Medien
    Digitale Medien
    Polychemotherapy of acute myelogenous leukemia in a patient with acute intermittent porphyria (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 338-340 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Porphyria ; Chemotherapy ; Acute myelogenous leukemia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The safety of drugs in hepatic porphyrias has largely been established by clinical experience, which is very limited in the case of antineoplastic agents. We administered three cycles of polychemotherapy consisting of daunorubicin, cytarabine and 6-thioguanine, and modified supportive care to a 33-year-old Turkish woman suffering from acute myelogenous leukemia. The urinary excretion of total porphyrins, porphobilinogen, and aminolevulinic acid was continuously monitored. Excreation of these metabolites was permanently elevated, but the values were comparatively low during cytotoxic therapy while peak values were recorded at the onset of fever during bone marrow aplasia; yet there were no clinical signs of porphyritic attacks at that time. A few potentially unsafe drugs were tolerated without an increase in porphyrin excretion. Although the susceptibility to drugs is highly variable in patients with hepatic porphyrias, the treatment of malignancy in these patients seems justified as long as porphyrin excretion under therapy is not grossly elevated over baseline values and appropriately modified supportive care is administered.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01745391
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  • 2
    Digitale Medien
    Digitale Medien
    Effect of rhGM-CSF on haematopoietic reconstitution after chemotherapy in small-cell lung cancer (1991)
    Springer
    Journal of cancer research and clinical oncology 117 (1991), S. S203 
    Details
    ISSN: 1432-1335
    Schlagwort(e): rhGM-CSF ; Small-cell lung cancer ; Chemotherapy ; Haemopoietic recovery
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In three consecutive pilot studies the effect of recombinant human granulocyte/macrophage-colony-stimulating factor (rhGM-CSF) on haematopoetic recovery after chemotherapy in patients with small-cell lung cancer was investigated. In study I, 20 patients received AIO chemotherapy (A, Adriamycin 25 mg/m2 on days 1+2; I, ifosfamide 2 g/m2 on days 1–5; O, vincristine 2 mg on day 1) at 4-week intervals either with or without rhGM-CSF (250 μg/m2 sc) from day 8 until recovery of leucocytes. Neither the degree nor the duration of myelosuppression was markedly influenced by rhGM-CSF. Suggesting that these disappointing results were caused by the late onset of GM-CSF application, in the following study we shortened chemotherapy to 3 days and started with GM-CSF on day 4. The main objective of this study was to test whether the earlier administration of GM-CSF allowed treatment intervals to be reduced or the dose to be escalated. After 10 patients had received a starting dose of AIO (A, 50 mg/m2 on day 1; I, 2 g/m2 on days 1–3; 0,2 mg on day 1) alternating with cisplatin (90 mg/m2 on day 1) and etoposide (150 mg/m2 on days 1–3), the dose of ifosfamide and etoposide was escalated to 2.5 g/m2 on days 1–3 and 200 mg/m2 on days 1–3 in the next 10 patients. Treatment was given at 2-week intervals when leucocytes were 〉 3500/mm3 and thrombocytes were 〉 100 000 mm3 on day 14. At each dose level patients were randomized to receive either rhGM-CSF 250 μg/m2 s.c. on days 4–12 or no GM-CSF. In this study, rhGM-CSF markedly shortened the duration of leukopenia. Reinstitution of chemotherapy on day 15 was possible at dose level 1 in 1/4 patients without and in 3/4 patients with GM-CSF, and at dose level 2 in 0/5 patients without and in 5/5 patients with GM-CSF. However, the degree of myelosuppression was not improved by GMCSF. In a third study we tried to apply rhGM-CSF simultaneously with chemotherapy. After 3 patients had received GM-CSF starting on day 1 concurrent to AIO chemotherapy, we noticed an increase of myelosuppression with prolonged neutropenia and thrombocytopenia and stopped this investigation. Considering all patients included in these three consecutive pilot studies, there is no difference in response rates and survival between patients with and without rhGM-CSF treatment. Optimal scheduled rhGM-CSF application shortens the period of myelosuppression and allows reinstitution of chemotherapy at 2-week intervals. Whether these modifications are able to improve the overall treatment results, has to be determined in future clinical trials.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01613228
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  • 3
    Digitale Medien
    Digitale Medien
    Poly[(4-N-ethylene-N-ethylamino)-α-cyanocinnamate]: A nonlinear optical polymer with a chromophoric mainchain. I. Synthesis and spectral characterization (1991)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 29 (1991), S. 1623-1631 
    Details
    ISSN: 0887-624X
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Poly[(4-N-ethylene-N-ethylamino)-α-cyanocinnamate] was prepared by solution esterification of (4-N-ethyl-N-(2-hydroxyethyl) amino)-α-Cyanocinnamic acid and by melt transesterification of ethyl (4-N-ethyl-N-(2-hydroxyethyl) amino)-α-cyanocinnamate. The melt transesterification generally yielded polymer with a number-average molecular weight of about 10,200 by gel permeation chromatography (GPC) versus polystyrene standards. The polymer was found to be amorphous with a glass transition temperature of about 103°C by differential scanning calorimetry (DSC). The solution esterification generally gave a polymer with a number-average molecular weight of about 2200 by GPC versus polystyrene standards. This polymer was found to have a glass transition temperature varying between 60 and 90°C by DSC. The infrared (IR) spectrum of the polymer made from both methods were analyzed in detail. The 1H- and 13C-NMR spectra of the meltsynthesized ethyl cinnamate derivative polymer are consistent with the reported structure.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/pola.1991.080291112
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  • 4
    Digitale Medien
    Digitale Medien
    Die galvanische Verchromung. Leitfaden für die moderne Glanz- und Hartverchromung von R. Weiner. DIN A 5. Bd. 6 der „Schriftenreihe Galvantechnik“ Eugen G. Leuze-Verlag, Saulgau/Württ. 1961. 182 S. mit 52 Abb. und 18 Tab. Halbleinen DM 16.50. Für Bezieher aller Bände dieser Reihe gilt der Vorzugspreis von DM 14,50 (1961)
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 12 (1961), S. 795-795 
    Details
    ISSN: 0947-5117
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/maco.19610121214
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  • 5
    Digitale Medien
    Digitale Medien
    Die Betriebsüberwachung und Untersuchung galvanischer Bäder und Niederschläge. Von H. Krause. Carl Hanser-Verlag, München 1959, 3. verbesserte Auflage, 281 S., 97 Abb., Leinen DM 19,80 (1960)
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 11 (1960), S. 75-75 
    Details
    ISSN: 0947-5117
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/maco.19600110116
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  • 6
    Digitale Medien
    Digitale Medien
    Vom Hand- und Automatenpolieren. W. Burkart (in der Schriftenreihe Galvanotechnik, Herausgeber: R. Weiner). E. G. Leuze Verlag, Saulgau/Wttbg. 1959, 109 S., 113 Abb., Geb. DM 8,50 (für Bezieher aller Bücher der Schriftenreihe DM 7,50) (1960)
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 11 (1960), S. 76-76 
    Details
    ISSN: 0947-5117
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/maco.19600110118
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  • 7
    Digitale Medien
    Digitale Medien
    Charge stripping C60+ (1991)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 5 (1991), S. 238-239 
    Details
    ISSN: 0951-4198
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Physik
    Notizen: Measurements of the translational energy loss accompanying the charge-stripping reactions M++N→M2++N+e- and M2++N→M3++N+e- have been performed for C60+, C70+ and C602+, C702+ respectively. The energy nesessary to remove the second electron from Buckminsterfullerene was determined, QminI=IE(C60+→C602+=12.25±0.5 eV.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/rcm.1290050506
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  • 8
    Digitale Medien
    Digitale Medien
    Spectra of Organic Molecules in Thin FilmsIn Memorial to Professor Heinrich Labhart (1978)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 61 (1978), S. 960-977 
    Details
    ISSN: 0018-019X
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: In order to investigate molecules and their interactions at interfaces we have developed a new spectroscopic technique based on integrated optics. A significant increase in sensitivity has been predicted and observed. We report here the details of the method and some preliminary spectra of organic dye molecules on thin films.
    Zusätzliches Material: 11 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/hlca.19780610304
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  • 9
    Digitale Medien
    Digitale Medien
    Beitrag zur Kenntnis der sauren Barium-diphosphateProfessor Paul Royen zum 60, Geburtstage am 17. Dezember 1964 gewidmet. (1964)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 334 (1964), S. 15-20 
    Details
    ISSN: 0044-2313
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: The precipitation of diphosphate from solutions of secondary alkali diphosphates by means of Ba2+ yields the acid salt Ba7H2P8O28·6H2O. With increasing alkalinity of the solutions, the hydrogen ion content of the Ba salt precipitate decreases. Precipitation from Na4-diphosphate solutions yields the neutral Ba2P2O7·1,5 H2O. From X-ray investigations (no structural differences between the two precipitates being found) it in concluded that the “neutral” Ba diphosphate has a phase range from Ba:H = 2:0 to 7:2.
    Notizen: Ba2+ bildet-im Unterschied zu vielen anderen zweiwertigen Metallen-bei der Fällung aus Lösungen sekundärer Diphosphate ein saures Diphosphat, Ba7H2P8O28·6H2O. Mit steigender Alkalität der Fällungslösung nimmt die Acidität der Ba-Verbindung ab. Das neutrale Na-Diphosphat entsteht nur bei der Fällung aus quaternären Diphosphat-Lösungen. Bemerkenswerterweise besteht kein struktureller Unterschied zwischen den sauren Verbindungen und dem quaternären Salz, was zu der Annahme führt, daß das quaternäre Ba-Diphosphat eine Phasenbreite zwischen Ba:H = 2:0 und 7:2 besitzt.
    Zusätzliches Material: 2 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/zaac.19643340104
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  • 10
    Digitale Medien
    Digitale Medien
    Pseudochalkogenverbindungen. XI. Über einen neuen Typ pseudochalkogen-modifizierter PhosphateProfessor Kurt Issleib zum 60. Geburtstage gewidmet (1979)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 458 (1979), S. 177-182 
    Details
    ISSN: 0044-2313
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Pseudochalcogeno Compounds. XI. On a New Type of Pseudochalcogeno-Modified PhosphatesThe preparation of pseudochalcogenophosphates of the general formulas [PO3Y]3- and [P2O7-nYn]4- (Y = C(CN)2, n = 1, 2) is described. Chromatography of sodium salts, the formation of silver and calcium salts, characteristic IR and 31P-NMR data are discussed.
    Notizen: Es wird über die Synthese von Pseudochalkogenophosphaten der allgemeinen Formeln [PO3Y]3-, [P2O7-nYn]4- (Y = C(CN)2, n = 1, 2) berichtet. Chromatographisches Verhalten der Natriumsalze, Silber- und Calciumsalzbildung, charakteristische IR- und 31P-NMR-Daten werden diskutiert.
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/zaac.19794580124
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