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  • 1990-1994
  • 1985-1989  (179)
  • 1890-1899
  • 1860-1869
  • 1986  (179)
  • Biochemistry  (91)
  • Genetics
  • 1
    Electronic Resource
    Electronic Resource
    HLA-DR4 as a predictor of outcome three years after onset of rheumatoid arthritis (1986)
    Springer
    Rheumatology international 6 (1986), S. 233-235 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; Genetics ; Natural history ; HLA seropositivity ; Disability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Data from 59 patients with early rheumatoid arthritis were analysed to determine the predictive value of the possession of HLA-DR4 for disease severity and functional outcome at 3 years after disease onset. The previously reported association of that antigen with seropositive disease was confirmed. Conversely, however, there was no evidence that functional outcome was worse in the HLA-DR4 positive group as measured by the Stanford Health Assessment Questionnaire. The mean articular index was lower in the HLA-DR4 group which also had a smaller proportion with limited wrist extension. In addition, both patient and physicians' global assessment of disease status were better in the HLA-DR4 group. It is concluded that HLA-DR4 is not a useful predictor of poor outcome at 3 years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541373
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  • 2
    Electronic Resource
    Electronic Resource
    Myoadenylate deaminase deficiency (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 342-347 
    Details
    ISSN: 1432-1440
    Keywords: Myoadenylate deaminase deficiency ; Histochemistry ; Biochemistry ; Metabolic myopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This report concerns two unrelated males; one had sarcoidosis, sarcoid myopathy and muscle weakness, and the other had exercise-induced weakness and myalgia. Both patients had a lack of ammonia rise in their serum after an ischemic work test, minimal histochemical activity of myoadenylate deaminase in repeated muscle biopsies, and less than 5% of normal biochemical activity of myoadenylate deaminase in their skeletal muscles. These three criteria establish primary myoadenylate deaminase deficiency as a separate primary metabolic muscle disease which merits differential diagnostic consideration when patients complain of muscle weakness and cramps.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711958
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  • 3
    Electronic Resource
    Electronic Resource
    Pelizaeus-Merzbacher disease in a brother and sister (1986)
    Springer
    Acta neuropathologica 69 (1986), S. 343-346 
    Details
    ISSN: 1432-0533
    Keywords: Leukodystrophy ; Demyelination ; Pelizaeus-Merzbacher disease ; Genetics ; Neurochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A brother and sister developed a slowly progressive neurological disorder with cerebellar and pyramidal signs and mild dementia. The brother developed symptoms at 6 months and died aged 11 years; the sister developed symptoms at 3 years and died aged 18 years. At post-mortem both had severe widespread central nervous system demyelination with islands of preserved myelin, and small amounts of sudanophilic lipid products. Metachromatic material, globoid cells, and adrenal abnormalities were not seen. The features were those of Pelizaeus-Merzbacher disease (PMD). It has been proposed, on the basis of only a few family studies, that PMD is an X-linked recessive disorder. These cases suggest that autosomal recessive inheritance may occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688316
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  • 4
    Electronic Resource
    Electronic Resource
    Glucose tolerance in siblings of Type 1 diabetic patients relationship to HLA status (1986)
    Springer
    Diabetologia 29 (1986), S. 39-45 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; Genetics ; Aetiology ; Glucose tolerance ; HLA type ; Islet cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this report, we present an analysis of glucose and insulin responses during oral glucose tolerance tests in 369 siblings of Type 1 diabetic patients. All have been HLA typed at the A, B and C loci. Though most had normal glucose tolerance by National Diabetes Data Group criteria (92% of the males and 95% of the females), siblings who shared both HLA haplotypes with the diabetic patient in the family had higher mean 3-hour glucose areas than those who shared one or neither HLA haplotype (p 〈 0.01). This difference was more marked in males and older siblings. Insulin concentrations did not differ significantly between the two groups except that, for those aged 〈16 years, the group sharing both haplotypes had lower fasting insulin concentrations (p = 0.05); for 16–29 year olds, the corresponding group had marginally higher 3-hour insulin areas than the remainder of siblings (p = 0.17). Little association with specific haplotypes (A1B8 or A2B15) was seen. Multivariate analyses, adjusting for age and obesity, eliminated the 3-h glucose difference in females by HLA sharing status (p = 0.37) although in males it remained significant (p 〈 0.001). Failure to account for age, sex and obesity may explain some of the conflicts in the reported literature. The glucose tolerance differences seen by HLA haplotype sharing status did not correlate with the presence of anti-islet cell antibodies. These results are consistent with the hypothesis that the HLA identical siblings, particularly males, have different (i. e. worse) glucose tolerance than their haplo-identical and non-HLA identical siblings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02427279
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  • 5
    Electronic Resource
    Electronic Resource
    Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788 (1986)
    Springer
    Psychopharmacology 88 (1986), S. 1-11 
    Details
    ISSN: 1432-2072
    Keywords: Ro 15-1788 ; Benzodiazepine antagonist ; Behaviour ; Electrophysiology ; Biochemistry ; Neurology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The imidazodiazepine Ro 15-1788 is a benzodiazepine receptor antagonist that was initially reported to be lacking in intrinsic activity in a variety of test situations in which benzodiazepine-like effects can be identified. However, many recent studies have shown that this compound does indeed have intrinsic activity in a variety of behavioural, neurological, electrophysiological and biochemical preparations in both animals and man. The purpose of the present review is firstly to describe these intrinsic actions, and secondly to consider to what extent these intrinsic actions of Ro 15-1788 have implications for current concepts of the functioning of the benzodiazepine receptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310505
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  • 6
    Electronic Resource
    Electronic Resource
    The Dubowitz syndrome (1986)
    Springer
    European journal of pediatrics 144 (1986), S. 574-578 
    Details
    ISSN: 1432-1076
    Keywords: Dubowitz syndrome ; Genetics ; Growth retardation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Dubowitz syndrome is a rare, autosomal, recessively inherited disorder of intrauterine and postnatal growth retardation leading to microcephaly, moderate mental retardation and such characteristic facial anomalies as telecanthus, epicanthic folds, blepharophimosis, ptosis, broadening of the bridge and tip of the nose, abnormal ears and retrogenia. Further findings include hyperactivity, eczema, cryptorchidism in the affected males, and brachy-clinodactyly of the fifth fingers. Thirty-three cases with this syndrome have been reported in the literature. Five additional patients are presented. All five are sporadic cases. The diagnostic symptoms and the differential diagnosis are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496039
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  • 7
    Electronic Resource
    Electronic Resource
    The 4–5 Cycles per second rhythm — changes in time (1986)
    Springer
    European archives of psychiatry and clinical neuroscience 235 (1986), S. 299-300 
    Details
    ISSN: 1433-8491
    Keywords: 4–5 c/s rhythm ; Age ; Genetics ; EEG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The 4-5 cycles per second (c/s) rhythm is a relatively rare, individual EEG variant. Age distribution of subjects carrying this variant and longitudinal studies over many years have indicated that it may sometimes disappear during middle age. Observations on female monozygotic twins at 15, 23 and 45 years of age suggest that disappearance of this trait might also be under genetic control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00515917
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  • 8
    Electronic Resource
    Electronic Resource
    Environmental effects on zein chromatograms of maize inbred lines revealed by reversed-phase high-performance liquid chromatography (1986)
    Springer
    Theoretical and applied genetics 71 (1986), S. 607-612 
    Details
    ISSN: 1432-2242
    Keywords: Taxonomy ; Germplasm identification ; Varietal identity ; Environmental interaction ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Alcohol soluble seed storage proteins (zeins and alcohol soluble glutelins) of maize (Zea mays L.) were separated by reversed-phase high-performance liquid chromatography (RP-HPLC). The objectives were to assess the reproducibility of chromatographic profiles using seed of inbred lines that had been produced in different locations and years. Reproducible differences between sources were seen but these were restricted to proteins that contributed 2% or less to an inbred profile. The majority of variation (93% for peak percent area; 99.8% for elution time) was between inbreds. RP-HPLC can therefore provide distinctive phenotypic profiles that are largely characteristic of genotype. Such qualitative and quantitative data will be valuable for studies of taxonomy, evolution, genetics, and germplasm identification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00264264
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  • 9
    Electronic Resource
    Electronic Resource
    Genetic analysis of gliadin-encoding genes reveals gene clusters as well as single remote genes (1986)
    Springer
    Theoretical and applied genetics 73 (1986), S. 278-285 
    Details
    ISSN: 1432-2242
    Keywords: Genetics ; Gliadins ; Gene clusters ; Recombination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Analysis of F2 grains from two different crosses has revealed a complex organization of the family of gliadin-coding genes located on chromosomes of the first homoeological group in hexaploid wheat. Chromosome 1A of variety ‘Bezenchukskaya 98’ was found to carry at least five gliadin-coding genes of which three genes form a cluster controlling the synthesis of the GLD1A1 block. Two additional genes are located on the both sides of this cluster and recombine with it at frequencies of 5±1.3% and 13±2.9%. Gliadinencoding genes recombining with the main clusters were also found on chromosomes 1B and 1A in the ‘Bezenchukskaya 98’ and ‘Saratovskaya 210’ varieties, respectively. In ‘Chinese Spring’, widely used in genetic studies, we discovered a recombination between genes located on chromosome 1A and controlling the synthesis of ω- and γ-gliadins. Varieties and biotypes of one variety may differ by the presence or absence of such “selfish” (not included in clusters) gliadin components. The similarity of organization of prolamine-coding genes on chromosomes in different cereals is considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00289286
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  • 10
    Electronic Resource
    Electronic Resource
    Assessment of myocardial metabolism by PET —a sophisticated dream or clinical reality? (1986)
    Springer
    European journal of nuclear medicine 12 (1986), S. S70 
    Details
    ISSN: 1619-7089
    Keywords: Positron emission tomography ; Biochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00258111
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  • 11
    Electronic Resource
    Electronic Resource
    The pyridine nucleotide cycle of Salmonella typhimurium: Genetic characterization of the pncXA operon (1986)
    Springer
    Molecular genetics and genomics 205 (1986), S. 507-514 
    Details
    ISSN: 1617-4623
    Keywords: Pyridine nucleotide cycle ; NAD metabolism ; Salmonella typhimurium ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A series of Mud1 and Tn10 insertions were identified in the pncA chromosome region of Salmonella typhimurium which is responsible for the production of nicotinamide deamidase. Both pncA (resulting in no nicotinamide deamidase activity) and pncX (resulting in lowered nicotinamide deamidase activity) insertions were constructed. In addition, mutants which could utilize nicotinamide as a sole source of nitrogen were isolated. These mutants, designated pncH, hyperproduce nicotinamide deamidase. Genetic studies utilizing pncX-lacZ and pncA-lacZ operon fusions indicate that pncX::Tn10 insertions reduce transcription of pncA-lac while pncH mutations increase the expression of both pncA-lacZ and pncX-lacZ. The gene order was determined as purB-pncA-pncX-gdh with transcription of both pncA and pncX occurring in the counterclockwise direction. Merodiploid studies suggest a model whereby pncX and pncA form an operon with the major promoter occurring upstream from pncX. A second, weaker promoter for pncA must be situated between pncX and pncA. The pncH mutations appear to occur in the pncX promoter (pncXp) increasing promoter activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00338090
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  • 12
    Electronic Resource
    Electronic Resource
    The beta-adrenoceptor-adenylate cyclase complex (1986)
    Springer
    Pharmacy world & science 8 (1986), S. 209-222 
    Details
    ISSN: 1573-739X
    Keywords: Biochemistry ; Pharmacology ; Receptors, adrenergic, beta ; Review
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Developments in the receptor concept have greatly influenced our current knowledge of the beta-adrenoceptor. The triad of pharmacology, organic chemistry and studies in structure-activity relationships is discussed along historical lines, as it has been and still is an impetus for progress in the biochemistry of ligand-receptor interactions. With respect to the beta-adrenoceptor complex these advances which have led to a model in which three protein structures are functionally interacting within the frame of the cell wall: the beta-adrenoceptor, the regulatory guanine nucleotide binding protein, and the enzyme adenylate cyclase, are reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957781
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  • 13
    Electronic Resource
    Electronic Resource
    The genetics of actinorhizalFrankia: A review (1986)
    Springer
    Plant and soil 90 (1986), S. 429-453 
    Details
    ISSN: 1573-5036
    Keywords: Actinorhizae ; Frankia ; Genetics ; Nitrogen fixation ; Nodulation ; Symbiosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02277414
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  • 14
    Electronic Resource
    Electronic Resource
    Masthead (1986)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 7 (1986) 
    Details
    ISSN: 0192-253X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020070201
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  • 15
    Electronic Resource
    Electronic Resource
    Isocitrate dehydrogenase in D. melanogaster imaginal discs: Pattern development and alteration by homoeotic mutant genes (1986)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 7 (1986), S. 21-34 
    Details
    ISSN: 0192-253X
    Keywords: Drosophila ; pattern formation ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The distribution of the soluble form of NADP+ -dependent isocitrate dehydrogenase (ICDH) was examined in Drosophila melanogaster imaginal discs. Development of the enzyme patterns and the specific transformations of the patterns by homoeotic mutants were studied. ICDH pattern formation was followed in eye-antennal discs and wing discs from the late 2nd instar stage through 3rd instar and 8 hours into prepupal development. The patterns formed gradually in both disc types. The most interesting pattern developed in the eye portion of the eye-antennal disc complex. ICDH distribution as well as staining intensity correlated well with differentiation of the ommatidia. The spatial distribution of ICDH within the discs was under genetic control. The patterns reflected the state of determination of the disc. When the presumptive tissue type was transformed via mutant homoeotic genes to different determinative states, the ICDH pattern likewise transformed to the pattern characteristic of the newly acquired structure.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020070103
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  • 16
    Electronic Resource
    Electronic Resource
    Developmental profiles of three embryo-lethal maize mutants lacking leaf primordia: ptd*-1130, cp*-1418, and bno*-747B (1986)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 7 (1986), S. 35-49 
    Details
    ISSN: 0192-253X
    Keywords: zea mays ; embryogenesis ; defective kernel mutants ; genetic regulation ; maize ; leaf primordia ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The defective kernel (dek) mutants of maize are altered in both their embryo and endosperm development. Earlier studies have indicated that some of the dek mutants are unable to form shoot apical meristems or leaf primoirda. We have examined three embryo lethal dek mutants of this type, ptd*-1130, cp*-1418, and bno*-747B, to obtain a developmental profile for each. Allelism tests show that these three mutants are not allelic. Embryos were examined in early, mid-, and late kernel development as well as at kernel maturity by dissection and sectioning procedures and also at kernel maturity by scanning electron microscopy. All three mutants lag behind normal embryos in their rate of development. Embryos of ptd*-1130 reached the transition stage by early kernel development and progressed no further but underwent cell enlargement and necrosis during late kernel development. Embryos of cp*-1418 reached an early coleoptilar stage by midkernel development. They subsequently increased in size but did not form any leaf primordia. At kernel maturity, they no longer had a shoot apical meristem but often had a well formed root meristem. They appeared to remain healthy and did not become necrotic. Embryos of bno*747B reached the early coleoptilar stage by early kernel development but progressed no further. By kernel maturity, they had grown into masses of irregularly shaped embryonic tissue that no longer resembled any normal embryo stage but were not necrotic. None of these three mutants responded to attempts to support continued embryo development when cultured, but all three mutants formed callus on N6 and MS media supplemented with 2,4-D. These results indicate that these mutants are all uniformly blocked at specific stages early in embryonic development, have different subsequent developmental fates, and represent three different genes performing unique functions that are essential for embryogenesis.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020070104
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  • 17
    Electronic Resource
    Electronic Resource
    Noncoordinate synthesis of the vitellogenin proteins in tissues of Drosophila grimshawi (1986)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 7 (1986), S. 81-97 
    Details
    ISSN: 0192-253X
    Keywords: Hawaiian ; Drosophila grimshawi ; yolk proteins ; ovarian follicle development ; fat body ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: In analyzing the in vitro pattern of protein synthesis by the fat body and ovaries of the Hawaiian species Drosophila grimshawi, we have found that the ovaries synthesize much more protein than the female fat body and that the majority of the synthesized proteins are retained by the ovarian tissues. In contrast, the fat body secretes most of the proteins into the culture medium. Vitellogenins are the major class of proteins synthesized and released into the medium by both tissues. The synthesis of the three vitellogenin proteins (V1, V2, V3,) is noncoordinate in the two tissues. Ovaries synthesize much more of the V2 protein, less V1 and very little V3, whereas fat body synthesies more Vs1 protein with lesser qu antities of the other two. The follicle cells were identified as the site of ovarian vitellogenin synthesis in D. grimshawi, confirming the findings in D. melanogaster. In D. grimshawi, the three vitellogenins are synthesized by the follicle cells in a noncoordinate and developmentally regulated manner. V2 and V1 are the predominant proteins at the onset of vitellogenesis (S8-9); their production peaks together with that of V3 a few hours later (S10) and then decreases to quantitiesequalto that of V3 during early choriogenesis (S11). During active choriogenesis (S12), V2 and V1 cease to be synthesized, but V3 synthesis continues. The vitellogenins synthesized by the follicles in vitro are released into the medium and not incorporated into the oocyte.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020070204
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  • 18
    Electronic Resource
    Electronic Resource
    Masthead (1986)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 7 (1986) 
    Details
    ISSN: 0192-253X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020070401
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  • 19
    Electronic Resource
    Electronic Resource
    Sex ratio and testis size in mice carrying Sxr and T(X;16)16H (1986)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 7 (1986), S. 177-185 
    Details
    ISSN: 0192-253X
    Keywords: sex reversal ; X-chromosome inactivation ; testis formation ; sex determination ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Mice heterozygous for the T(X;16)16H translocation and carrying Sxr on their normal (inactive) X chromosome (ie, T16H/X Sxr individuals) may develop as males, females, or hermaphrodites. The proportion of males varied from 22% to 65% depending on the source of the normal X chromosome. A model is proposed, according to which relatively small variations in the spreading of inactivation from the X chromosome into the attached Sxr fragment produce large changes in the proportion of males. Testis weight in T16H/X Sxr males was found to be significantly smaller than in X/X Sxr males, irrespective of the source of the normal X chromosome.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020070403
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  • 20
    Electronic Resource
    Electronic Resource
    The relationship of relative gene dose to the complex phenotype of the daughterless locus in Drosophila (1986)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 7 (1986), S. 205-221 
    Details
    ISSN: 0192-253X
    Keywords: gene dosage effects ; Drosophila sex determination ; maternal-zygotic gene interactions ; tandem duplications ; maternal effects ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The daughterless (da) gene provides an essential maternally supplied component for Drosophila sex determination and dosage compensation. In this connection, it is required as a positive regulator of a female-specific master regulatory gene, Sex-lethal (Sxl). In addition, zygotic da gene function is required for male and female viability. Thus, the phenotype da is complex; it includes both maternal and zygotic aspects, as well as both sex-specific and nonsex-specific aspects. Assessment of wild-type da function has relied on the characterization of only a single leaky mutant da allele. In order to better understand the nature of this allele and the relationships between the various aspects of its complex phenotype, tandem duplications of both the mutant and wild-type da alleles were isolated and used in a dose study of this gene's function. Three conclusions were reached: (1) by the most stringent genetic criteria, the mutant da allele is a simple hypomorph, an allele with reduced but non-zero levels of wild-type functions; (2) since increased dose of da+ had no effect on viability or progeny sex ratio, this gene seems not to be a dose-sensitive element of the X/A ratio sex determination signal; and (3) expression of the maternal da+ allele does make a contribution to the nonsex-specific developmental processes that require zygotic da+ function; however, that contribution is clearly minor. In contrast, the zygotic genotype with respect to da appears to have no effect on the expression of Sxl+ in the zygote, the sex-specific process that requires maternal da+ function.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020070406
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  • 21
    Electronic Resource
    Electronic Resource
    Interaction energy studies of pyrrolopyrimidine nucleoside antibiotics-toyocamycin (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986), S. 13-19 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: The biological activity of toyocamycin has been examined on the basis of the model developed by Sanyal et al. for the incorporation of nucleoside analogs during transcription. Using the simplified formula of Claverie for intermolecular interactions, computations have been carried out on the pairing energy of toyocamycin base with the complimentary bases as well as on the interaction energy with nucleic acid base pairs. The results are compared with the results of similar computations with nucleic acids. On the basis of the model an attempt has been made to explain the mechanism of the biological action of toyocamycin.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcc.540070103
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  • 22
    Electronic Resource
    Electronic Resource
    Preliminary announcement: 6th International Congress on Quantum Chemistry (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986), S. 254-254 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcc.540070218
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  • 23
    Electronic Resource
    Electronic Resource
    Molecular associations: Values of the expansion parameters for new classes of atoms (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986), S. 55-57 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: Expansion parameters, for use in a 1/R expansion developed at this laboratory for the study of molecular interactions, have been determined for new classes of atoms. Test calculations with these new parameters have yielded very satisfactory results for the glycine zwitterion, in dimer form and solvated, confirming the goodness of the parameters and the appropriateness of the formulation.
    Additional Material: 4 Ill.
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    URL: http://dx.doi.org/10.1002/jcc.540070107
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    Symmetry properties of chemical graphs. IX. The valence tautomerism in the P73- skeletonThis contribution is dedicated to Professor F. A. Cotton for his prolonged support and appreciation of chemical graph theory. (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986), S. 35-54 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: We investigate the intramolecular rearrangement of the P73- ion in which P—P bonds are continuously broken and reestablished resulting in a dynamic structure with all seven phosphorus atoms being chemically equivalent. This leads to 7/3 = 1680 valence tautomers. The P73- ion is a typical fluctuating molecule, distantly related to C10H10 bullvalene. In order to determine the symmetry of the process we first consider the problem of the construction of the rearrangement graph. Initial steps toward this goal are illustrated, and additional characterizations of the graph are derived after its construction by computer. A number of properties of this rather complicated graph having 1680 vertices and 2520 edges are discussed: in particular the occurrence of various cycles, the maximal distance between vertices, the count of neighbors at different distance, and finally its symmetry.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcc.540070106
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    Symposium on Computational and Mathematical Chemistry. Satellite Symposium of the Canadian Institute of Chemistry Conference Saskatoon, Canada, June 1-4, 1986 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986), S. 89-89 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcc.540070110
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    Mindo/3 and mndo calculations of closed- and open-shell cations containing C, H, N, and O (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986), S. 93-104 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: Heats of formation of 119 closed- and open-shell carbocations calculated by the semiempirical quantum chemical methods MINDO/3 and MNDO are reported and compared with experimental data. With proper consideration of failures in specific areas, both methods can be used for the thermodynamics of carbocations containing C, H, N, and O. MINDO/3 predicts unrealistic values for nitrogen containing cations with nitrogen multiple bonds and is not suited for closed-shell cations containing oxygen. Saturated acyclic hydrocarbon radical cations often are computed with abnormally long CC bonds by MNDO. Otherwise, the standard deviation of the two methods is not very different, being in the range of ±13 kcal/mol. MINDO/3 tends to overestimate the cation stabilities, whereas MNDO calculates cations usually too high in energy. Some of the errors which were found in the calculations of the ions are related to the computed values for the parent neutral structures, but others are not.
    Additional Material: 3 Tab.
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    URL: http://dx.doi.org/10.1002/jcc.540070202
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    A force-field study of the conformational characteristics of the iduronate ring (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986), S. 105-112 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: Methods of molecular mechanics were applied to investigate the conformation of the (methyl 2-O-sulfate-4-methyl-α-L-idopyranose) uronic acid (DMIS), in order to correlate the peculiar vicinal proton coupling constants observed in polysaccharides containing the iduronate ring to the conformational characteristics of this sugar ring. We found three conformers with comparable energies, namely the two chair forms 1C4 and 4C1 and the skew-boat form 2S0(L); the latter is separated from each chair form by a barrier of about 9 kcal/mol. Along the pseudorotational path three additional minima (3S1, 1S3, and 1S5) were found, yet at least 4 kcal/mol higher than 2S0. The results obtained for the relative energies of the three conformers and the conformation of the side groups were affected by the inclusion of the electrostatic term and, in particular, by the charge assigned to the ionic groups of DMIS. However, the conformational properties of the idopyranosidic ring in DMIS (and in related compounds) should still be interpreted in terms of equilibrium among these three conformers only.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/jcc.540070203
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    An improved set of mndo parameters for sulfur (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986), S. 140-143 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: The MNDO parameters for sulfur have been reoptimized. Calculations for a number of sulfur compounds indicate a very significant improvement. Inclusion of d AOs failed to correct the errors for compounds of sulfur in its higher valence states. Since d AOs are not included, the calculations are still confined to compounds of divalent sulfur.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcc.540070206
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    The effect of including polarization functions on the geometrical parameters calculated for pyridine (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986), S. 153-157 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: Geometrical parameters for pyridine have been calculated using the 6-31G, 6-31G*(5D), 6-31G**(6D), and 6-31G(2 × 6D) basis sets. Comparisons are made with a microwave substitution structure and with results of other ab initio calculations reported in the literature. Particular attention is paid to the influence of polarization functions on the magnitude of the ring angle, 〈C6N1C2, which is analogous to the ipso angle in monosubstituted benzene derivatives.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcc.540070208
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    Spatially constrained minimization of macromoleculesSupported in part by grants from the national science foundation and the national institutes of health. (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986), S. 165-175 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: A structural minimization procedure which converges rapidly and restricts the atomic shifts is outlined. It is implemented by adding a harmonic penalty term for the displacements of atomic positions and resetting the reference coordinates with respect to which the constraints are computed during the minimization. The resetting serves to reduce the constraint energy of the minimized structure to negligible levels.
    Additional Material: 2 Ill.
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    URL: http://dx.doi.org/10.1002/jcc.540070210
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    Conformational study of the trinucleotide CpGpCp-pentapeptide Gly5 complex: The important role of bridging water in the complex formation (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986), S. 189-200 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: Conformational changes in the RNA-protein interaction were studied by calculating the intramolecular interaction energy of a model complex with the use of potential functions. The model complex has hydrogen-bonded water molecules bridging polypeptide NH groups to 2'-hydroxyl groups and sugar ring oxygen atoms. Since the sugar ring is constrained by the bridging water, preliminary calculations with the model compounds, the sugar ring, mononucleoside diphosphates, pCp and pGp, were carried out, and the flexibility and energetics of the sugar ring were compared with the previous results of DNA. The shift of the phase angle of the sugar ring occurred in the complex formation because of the hydrogen bond through the bridging water and the flexibility of the sugar ring. The free energy difference at 298 K is about -74.0 kcal/mol which was obtained from the intramolecular interaction energy difference of -67.5 kcal/mol by adding the conformational entropy change of 21.9 e.u., which in turn was calculated from the evaluation of the determinant of the matrix containing variances and covariances of the internal coordinates.
    Additional Material: 10 Ill.
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    URL: http://dx.doi.org/10.1002/jcc.540070212
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    Matrix elements for anharmonic potentials: Application to I2 morse oscillator (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986), S. 208-212 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: Many authors have contributed expressions for obtaining analytical matrix elements for Morse oscillators. In this work, we discuss the advantages of using these expressions. At the same time, we propose a full numerical method to calculate these matrix elements and we compare, for the I2 system, the different results given by Gallas, Vasan, and Cross, and the variational method.
    Additional Material: 3 Tab.
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    URL: http://dx.doi.org/10.1002/jcc.540070214
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    Masthead (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986) 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcc.540070401
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    MINDO/3 Study of the Rearrangement of 1-Methylcyclohexyl Cation to 1,2-Dimethylcyclopentyl Cation (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986), S. 417-427 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: The rearrangement of the 1-methylcyclohexyl cation to the 1,2-dimethylcyclopentyl cation has been studied by MINDO/3 calculations, as an application of the branching mechanism model for cycloalkanes. Possible intermediates and transition states have been characterized by diagonalization of their Hessian matrixes. Two nonequivalent pathways, α and β scissions, are relatively close in energy. The calculated transition states are almost equivalent in energy to those found for cyclohexyl cation. Hence, the energy barriers are higher for the rearrangement of the 1-methyl than for cyclohexyl cation, because the former is less stable than the latter.
    Additional Material: 11 Ill.
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    URL: http://dx.doi.org/10.1002/jcc.540070405
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    Transport Properties of Macromolecules by Brownian Dynamics Simulation: Vectorization of Brownian Dynamics on the Cyber-205 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986), S. 457-463 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: Time consuming portions in the computation of transport properties of rigid and flexible molecules are the evaluation of subunit hydrodynamic interaction tensors Q and σ, and the procedure for satisfying subunit-subunit distance constraints. Vector algorithms to speed up these parts of the computation are given. Using these algorithms, a vector version of the Ermak-McCammon Brownian dynamics code has been developed on a Cyber-205. To demonstrate the order of speedups that can be achieved, the code was tested on a rigid “trimer” system comprising 24 spherical subunits with a fixed geometry. A speedup of about 14 times for the whole program, and of 45, 6, and 18 times for the computation of Q, σ, and for the procedure to enforce the constraints, respectively, were obtained.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcc.540070408
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    On the Use of Constraints in Molecular Mechanics. Rigid Group Refinement (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986), S. 476-481 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: It is shown how the refinement of groups of atoms as rigid entities can be implemented in a molecular mechanics program. The method is worked out for the Newton-Raphson scheme and eventually combined with other constraints, including the Eckart conditions. An example is also given.
    Additional Material: 2 Ill.
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    URL: http://dx.doi.org/10.1002/jcc.540070410
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    Optimization of the Generalized Valence Bond Method for Vector ProcessorsWork performed under the auspices of the Office of Basic Energy Sciences, Division of Chemical Sciences, U. S. Department of Energy, under Contract W-31-109-Eng-38. (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986), S. 500-512 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: The Generalized Valence Bond [GVB(pp)] multiconfiguration self-consistent field wave function optimization program has undergone substantial revision in migration from serial scalar computers (like IBM and VAX) to the FPS-164, a minisupercomputer. Many of the code optimization strategies applied to the GVB program are portable and applicable to a wide range of scientific application codes. In benchmark calculations, the optimized FPS-164 program, GVB164, is 6.5 times faster than the initial FPS-164 implementation, both programs storing the two-electron integral list on disk. GVB164 runs 30 times faster in wall time (limited by the FPS-164 disk access speed) than a reference version of GVB2P5 on the VAX 11/780. The performance of GVB164 nearly doubles again when all of the two-electron integrals can be stored in main memory.
    Additional Material: 3 Tab.
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    URL: http://dx.doi.org/10.1002/jcc.540070413
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    Abstracts, S261-S280 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S261 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020516
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    Abstracts, S221-S240 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S221 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020514
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    Abstracts, S281-S300 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S281 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020517
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    Abstracts, S301-S320 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S301 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020518
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    Abstracts, S321-S340 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S321 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020519
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    Abstracts, S341-S360 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S341 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020520
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    Abstracts, S361-S380 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S361 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020521
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    Abstracts, S381-S400 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S381 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020522
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    The utilization of starch by yeasts (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 109-115 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020206
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    A comparative radiorespirometric study of glucose metabolism in yeasts (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 117-121 
    Details
    ISSN: 0749-503X
    Keywords: Hexose monophosphate pathway ; NADPH ; radiorespirometry ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: A comparative radiorespirometric study of glucos emetabolism in glucose-limited chemostat cultures of Saccharomyces cerevisiae, Candida utilis and Rhodosporidium toruloides was performed in an attempt to estimate the contribution of the hexose monophosphate (HMP) pathway to glucose metabolism. Radioactively labelled glucose was administered directly to the cultures in a constant substrate feed, without disturbance of the steady state. The 14CO2 yields from [1-14C]- and [6-14C]-glucose demonstrated that the HMP pathway activities for the three yeasts were very similar. Furthermore, a quantitative analysis of results indicated that the HMP pathway activities were close to the theoretical minimum needed to cover the NADPH requirement for biomass formation.
    Additional Material: 1 Tab.
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    URL: http://dx.doi.org/10.1002/yea.320020207
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    Yeast group formed in India (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 141-142 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020210
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    Cloning and sequencing of the PHO80 gene and CEN15 of Saccharomyces cerevisiae (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 129-139 
    Details
    ISSN: 0749-503X
    Keywords: Saccharomyces cerevisiae ; regulation ; pho ; pho80 ; CEN15 ; nucleotide sequence ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The PHO80 gene, which is one of the regulatory genes exerting negative control in the pho system of Saccharomyces cerevisiae, was cloned. The 1·8 kb DNA fragment carrying the PHO80 gene was sequenced and one open reading frame large enough to encode 293 amino acids was found in the sequence. Northern blot analysis of poly(A)+-RNA isolated from cells grown under repressed and derepressed conditions revealed that (i) the size of the PHO80 message was around 1·4 kb, (ii) the expression of the PHO80 gene was not affected by the presence or absence or absence of inorganic phosphate in the medium, and (iii) the expression of the PHO80 gene was not affected by pho2, pho4, pho81, or by pho80 itself. a centromere sequence was found downstream of the PHO80 coding region.
    Additional Material: 8 Ill.
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    URL: http://dx.doi.org/10.1002/yea.320020209
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    Third small meeting on yeast and energetics (SMYTE III) at Mook, the Netherlands, 21-23 August 1985 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 143-144 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020211
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    Linear DNA killer plasmids from the yeast Kluyveromyces (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 153-162 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020303
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  • 52
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    Ty, an endogenous retrovirus of yeast? (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 145-152 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020302
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    Mutations in ARS1 increase the rate of simple loss of plasmids in Saccharomyces cerevisiae (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 169-178 
    Details
    ISSN: 0749-503X
    Keywords: ARS1 ; plasmid maintenance ; replication ; segregation ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Autonomously replicating sequence (ARS) elements are DNA sequences that promote extrachromosomal maintenance of plasmids in yeast. Mutations generated in vitro in the ARS1 region were examined for their effect on plasmid maintenance in a yeast centromeric plasmid. Our data show that mutations in the regions surrounding the ARS1 consensus sequence cause increases in the frequency of simple loss (1:0) event without affecting the rate of non-disjunction (2:0). Removal of the consensus itself causes a drastic increase in the rate of simple loss. Sequences sensitive to mutagenesis were identified in each flanking region and differ with respect o their location and importance o ARS function. These results suggest that the role ARS1 plays in plasmid maintenance deals with the replication and/or localization of the plasmid in yeast.
    Additional Material: 2 Ill.
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    URL: http://dx.doi.org/10.1002/yea.320020305
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    Abstracts, S181-S200 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S181 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020512
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    Abstracts, S201-S220 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S201 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020513
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  • 56
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    Abstracts, S241-S260 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S241 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020515
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  • 57
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    Masthead (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986) 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020101
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  • 58
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    Degradation of organic nitrogen compounds by yeasts (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 1-34 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020102
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  • 59
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    mRNA-dependent yeast cell-free translation systems: Theory and practice (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 35-52 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020103
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  • 60
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    Inter- and intra-species crosses between Candida albicans and Candida guilliermondii (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 53-58 
    Details
    ISSN: 0749-503X
    Keywords: Candida albicans ; Candida guilliermondii ; hybrid ; recombination ; segregants ; DNA ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Hybridization was shown to occur both between strains of the imperfect diploid yeast Candida albicans and between C. albicans and the distantly related hapoid yeast Candida (Pichia)guilliermondii Protorophic hybrids were selected from croses of multiply marked auxotropic mutants two species. In most cases, mild ultraviolet irradiation of the C. albicans partmer was reqiured.Examination of auxotropic markers in segregants from the hybrid indicated that recombination, rather than the heterokaryon, formation, had occured in these croses. The DNA content of the hybrids varied from diploid or aneuploid (for crosses between C. albicans and C. guilliermodii) to triploid (for C. albicabs × C. albicans). It seems possible that genetic exchange analogous to this may occur in nature.
    Additional Material: 2 Ill.
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    URL: http://dx.doi.org/10.1002/yea.320020104
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  • 61
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    Xth international specialized symposium on yeasts (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 69-73 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020106
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  • 62
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    Calendar (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 74-74 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020107
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  • 63
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    Identification of the RNA2 protein of Saccharomyces cerevisiae (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 59-67 
    Details
    ISSN: 0749-503X
    Keywords: Splicing ; S. cerevisiae ; RNA2 ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The rna2-1 mutant Saccharomyces cerevisiae. has a consitional lethal phenotype, accumulating high molecular weight RNAs of intron-conataining nuclear genes at 36°C. The cloned RNA2 gene suppresses this phenotype and the RNA2 gene product has been implicated in RNA splicing. Rabbit antisera have been raised againts an N-terminal synthetic peptide taken from the RNA2 gene DNA sequence data, and against a β-galactosidase/RNA2 gene fusion protein. Both antisera identify that same 97-105 kd protein from S. cerevisiae cell extracts which is consistent with the predicted size of the RNA2 protein (from the 2800 nucleotide transcript size and DNA sequence data).
    Additional Material: 6 Ill.
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    URL: http://dx.doi.org/10.1002/yea.320020105
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  • 64
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    Alcoholic fermentation by ‘non-fermentative’ yeastsCentraalbureau voor Schimmelcultures, Yeast Division, Delft, The NetherlandsDedicated to Dr Nelly J. W. Kreger-van Rij. (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 123-127 
    Details
    ISSN: 0749-503X
    Keywords: Yeasts ; fermentation ; ethanol ; Durham tube test ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: All type strains of ‘non-fermentative’ yeasts, available in the culture collection of the Centraalbureau voor Schimmelcultures, were reinvestigated for their capacity to ferment glucose in the classical Durham tube test. Although visible gas production was absent, nearly all strains produced significant amounts of ethanol under the test conditions. Under conditions of oxygen-limited growth, even strong alcoholic fermentation may occur in a number of yeasts hitherto considered as non-fermentative. Thus, shake-flask cultures of Hansenula nonfermentans and Candida silvae fermented more than half of the available sugar to ethanol. It is concluded that the taxonomic test for fermentation capacity, which relies on detection of gas formation in Durham tubes, is not reliable for a physiological classification of yeasts as fermentative and non-fermentative species.
    Additional Material: 4 Ill.
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    URL: http://dx.doi.org/10.1002/yea.320020208
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  • 65
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    Masthead (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986) 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020301
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  • 66
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    Abstracts, S401-S420 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S401 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020523
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  • 67
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    Abstracts, S421-S440 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S421 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020524
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    Abstracts, S441-S442 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S441 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020525
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  • 69
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    Announcement (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 75-75 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020108
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  • 70
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    Masthead (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986) 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020201
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  • 71
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    A new type of methylamine oxidase: The sole oxidase produced during growth of Sporobolomyces albo-rubescens on primary alkylamines (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 87-92 
    Details
    ISSN: 0749-503X
    Keywords: Amine oxidase ; yeast ; methylamine ; n-butylamine ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Under conditions known to separate methylamine oxidase from benzylamine oxidase in other yeast strains, only a single oxidase could be detected in Sporobolomyces albo-rubescens. This occurred irrespective of whether methylamine or n-butylamine was the nitrogen source for growth. The oxidase did not attack benzylamine. It was concluded that this organism can only produce a methylamine oxidase. The enzyme was purified to 90% homogeneity and found to have properties significantly a methylamine oxidases previously characterised. It lost only 40% of its activity in 30 min at 45°C, whereas methylamine oxidase previously described had half-lives of from 2 to 9 min at 45°C. It showed also a lower activity with short chain 1-aminoalkanes and a higher activity with longer chain 1-aminoalkanes than other methylamine oxidases, and had a significantly smaller subunit molecular weight (57 000 compared with 80 000).
    Additional Material: 4 Ill.
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    URL: http://dx.doi.org/10.1002/yea.320020203
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  • 72
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    Vanadium metabolism in wild type and respiratory-deficient strains of S. cerevisiae (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 77-85 
    Details
    ISSN: 0749-503X
    Keywords: Vanadium metabolism ; magnetic resonance spectroscopy ; respiratory-deficient strains ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Vanadium metabolism was studied in a wild type and respiratory-deficient strains of S. cerevisiae. Inhibition of growth by vanadate [V(+5)], vanadate accumulation, and conversion of medium vanadate [V(+5)] to both cell-associated and medium vanadyl [V(+4)] and vanadate [V(+5)] were compared. The growth of both the parental and respiratory-deficient strains was inhibited by vanadate at concentrations greater than or equal to 1 mM. Both parental and respiratory-deficient strains accumulated vanadate and converted medium vanadate to cellular vanadyl as detected using electron spin resonance (ESR). The accumulation of cell-associated vanadyl was correlated with the loss of medium vanadate in both strains using a chemical assay. In contrast, the respiratory-deficient strain showed a greater amount of a cell-associated vanadate compound, as detected with vanadium-51 nuclear magnetic resonance (51V-NMR), than the wild strain or a representative respiratory-competent vanadate-resistant mutant. These data imply that mitochondrial function may be directly involved in vanadium metabolism.
    Additional Material: 3 Ill.
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    URL: http://dx.doi.org/10.1002/yea.320020202
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  • 73
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    Synergistic effects of weak-acid preservatives and pH on the growth of Zygosaccharomyces bailii (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 93-100 
    Details
    ISSN: 0749-503X
    Keywords: pH ; weak acid ; synergism ; growth ; Zygosaccharomyces ; yeast ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: In completely randomised factorial experiments, individual and synergistic effects of pH, benzoic acid and sorbic acid on the growth rate of the yeast Zygosaccharomyes bailii were determined, and expressed in polynomial equations. Synergism between benzoic and sorbic acid was pH dependent. A distinct effect of the anionic form of benzoic acid on doubling time was demonstrated by experiments in which concentrations of benzoic acid and benzoate were varied. The resultant polynomial equation showed that both species act synergistically.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/yea.320020204
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  • 74
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    Mechanism of inactivation of UDP-glucose 4-epimerase from Saccharomyces cerevisiac by D-xylose and L-arabinose (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 101-108 
    Details
    ISSN: 0749-503X
    Keywords: L-Arabinose ; D-xylose ; UDP-glucose 4-epimerase ; inactivation ; Saccharomyces ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: In a previous paper (Cármenes et al., 1984) we reported that UDP-glucose 4-epimerase from Saccharomyces was inactivated both in vitro (Crude extracts) by L-arabinose or D-xylose. In this paper, we reported that pure epimerase requires the presence of UMP or UDP to be inactivated by sugars and that the inactivation is due to the reduction of the epimerase NAD+, which is essential for epimerase activity. The inactivation rate is directly proportional to epimerase and sugar concentrations and hyperbolically proportional to UMP concentration. In situ experiments made with permeabilized cells showed that epimerase is inactivated in the same way when it is inside the cell. In vivo studies showed that epimerase is inactivated to a smaller extent when 1% Dgalactose is present in the culture medium than when 1% ethanol is the main carbon source.
    Additional Material: 5 Ill.
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    URL: http://dx.doi.org/10.1002/yea.320020205
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  • 75
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    Yeast/E. coli shuttle vectors with multiple unique restriction sites (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 163-167 
    Details
    ISSN: 0749-503X
    Keywords: Shuttle vectors ; gene cloning ; Saccharomyces ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Two yeast/E. coli shuttle vectors have been constructed. The two vectors, YEp351 and YEp352, have the following properties: (1) they can replicate autonomuosly in Saccharomyces cerevisiae and in E. coli; (2) they contain the β-lactamase gene and confer ampicillin resistance to E. coli; (3) they contain the entire sequence of pUC18; (4) all ten restriction sites of the multiple cloning region of pUC18 including EcoRI, SacI, KpnI, SmaI, BamH1, XbaI, SbaI, SalI, PstI, SphI and HindIII are unique in YEp352; these sites are also unique in YEp351 except for EcoRI and KpnI, which occur twice; (5) recombinant plasmids with DNA inserts in the multiple cloning region of YEp351 and YEp352 can be recognised by loss of β-galactosidase function in appropriate E. coli hosts; (6) YEp351 and YEp352 contain the yeast LEU2 and URA3 genes, respectively, allowing for selection of these grown under non-selective conditions indicative of high plasmid copy number. The above properties make the shuttle vectors suitable for constructions of yeast genomic libraries and for cloning of DNA fragments defined by a large number of different restriction sites.The two vectors have been further modified by deletion of the sequences necessary for antunomous replication in yeast. The derivative plasmids YIp651 and YIp352 can therefore be used ti integrate specific sequences into yeast chromosomal DNA.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/yea.320020304
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    Physical separation and functional interaction of Kluyveromyces lactis and Saccharomyces cerevisiae ARS elements derived from killer plasmid DNA (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 179-191 
    Details
    ISSN: 0749-503X
    Keywords: ARS elements ; bifunctional vectors ; plasmids ; DNA replication ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Teo DNA fragments which have autonomously replicating sequence (ARS) activity in both Saccharomyces cerevisiae and Kluyveromyces lactis have been isolated from the K. lactis kl killer plasmid. One fragment (Kla1) is 700 base pairs (bp) in length plasmids carrying it are mitotically unstable in both hosts. In K. lactis, this instability leads to colonies having a ‘nibbled’ phenotype when grown on selective media and appears to be the results of inefficient plasmid segregation. The other fragment of 1100 bp which was produced during the cloning procedure. Kla2 has been divided into the sub-fragments Kla2A and Kla2B which have, respectively, ARS activity in K. lactis and S. Cerevisiar but not the other species. This indicates that these two closely elated yeasts have different sequence requrements for ARS activity. Kla2B contains a perfect match to the S. cerevisiae ARS consensus but Kla2A does not. Both Kla2A and Kla1 share a 10 bp sequence as the sole region of homology between them. This sequence, 5‘TCATAATATA3’, is tentatively offered as defining the ARS consensus sequence for K. lactis.
    Additional Material: 6 Ill.
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    URL: http://dx.doi.org/10.1002/yea.320020306
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  • 77
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    Masthead (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986) 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020401
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  • 78
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    Orthogonal-field-alternation gel electrophoresis banding patterns of DNA from yeasts (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 193-204 
    Details
    ISSN: 0749-503X
    Keywords: Orthgonal-field-alternation gel electrophoresis ; karyotyping ; ascomycetous yeasts ; basidiomycetous yeasts ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Chromosomal DNAs from various yeast species were separated by orthogonal-field-alternation gel electrophoresis (OFAGE). To this end we developed a spheroplasting and lysis method to obtain intact DNA from both ascomycetous and basidiomycetous yeasts. The OFAGE banding patterns of 22 ascomycetous and four basidiomycetous yeast strains were compared. The strains represented species from the genera: Brettanomyces, Candida, Croococcus, Filobasidiella, Geotrichum, Hansenula, Kluyveromyces, Pachysolen, Pichia, Rhodosporidium, Rhodotorula, Saccharomyces, Saccharomycodes, Saccharomycopis, Schizosaccharomyces and Zygosaccharomyces. Variations occurred in the number of bands and their positions in the gel, not only among strains of different genera but also among species from the same genus and even between varieties of the same species. The ascomycetous yeasts, with the exeption of Saccharomyces cerevisiae, only showed one to five bands of DNA larger than 1000 kilobase pairs (kb) in general none smaller. The paterns of the four basidiomycetous yeasts revealed also a few large DNA bands but in addition one to six bands ranging in size from 500 to 1000 kb, with the exception of a single smaller chromosome in Rhodotorula mucilaginosa. From the OFAGE banding patterns of strains studied here it appears that in Saach. cerevisiae the partitioning of DNA over chromosomes in unique. But rather than the large number of chromosomes, the presence of four chromosomes with less than 500 kb of DNA is characteristic for Sacch. cerevisiae.
    Additional Material: 3 Ill.
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    URL: http://dx.doi.org/10.1002/yea.320020307
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    Involvement of lipids in solute transport in yeasts (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 205-220 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020402
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    Misconceptions about the energy metabolism of Saccharomyces cerevisiae (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 221-228 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020403
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    Calendar (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 237-237 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020405
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    Masthead (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986) 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020501
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  • 83
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    Sequences important for gene expression in filamentous fungi (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. 229-236 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020404
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  • 84
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    Scientific program (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. i 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020502
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  • 85
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    Abstracts, S1-S20 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S1 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020503
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  • 86
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    Abstracts, S21-S40 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S21 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020504
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  • 87
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    Abstracts, S41-S60 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S41 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020505
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  • 88
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    Abstracts, S61-S80 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S61 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020506
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  • 89
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    Abstracts, S81-S100 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S81 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020507
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  • 90
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    Abstracts, S101-S120 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S101 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020508
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  • 91
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    Abstracts, S121-S140 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S121 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020509
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  • 92
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    Abstracts, S141-S160 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S141 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020510
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  • 93
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    Abstracts, S161-S180 (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 2 (1986), S. S161 
    Details
    ISSN: 0749-503X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320020511
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  • 94
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    Complementation between alleles at the ovarian tumor locus of Drosophila melanogaster (1986)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 7 (1986), S. 1-20 
    Details
    ISSN: 0192-253X
    Keywords: ethyl methane sulfonate ; female sterile mutations ; gene dosage effects ; gene mapping ; germ line-expressed mutation ; heteroallelic interactions ; heterodimer ; hypomorphic mutation series ; one gene one band issue ; oogenesis ; ovarian tumor genes ; polytene nurse cell chromosomes ; pseudonurse cells ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The (ovarian tumor) otu gene resides at 23.2 on the genetic map of the X chromosome and near 7F1 on the cytological map. This germ line-expressed locus behaves as if it encodes a gene product which is required during certain steps in the transformation of oogonia into functional oocytes. On the basis of their ovarian morphologies 17 ethyl methane sulfonate (EMS)-induced mutants have been distributed among three developmental classes as follows: quiescent (eight), oncogenic (four), and differentiated (five). The otu13 and otu14 alleles interact to yield fertile females, and many other heteroallelic combinations show partial complementation. Since many mutant alleles interact beneficially, the functional product of the otu gene may be a multimer. We conclude, from an analysis of heteroallelic interactions and dosage effects, that the abnormal phenotypes observed are graded consequences of reduced levels of functional gene product and that the minimum concentration required for development increases as oogenesis proceeds.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020070102
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  • 95
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    Decreased methylation of the major mouse long interspersed repeated DNA during aging and in myeloma cells (1986)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 7 (1986), S. 65-73 
    Details
    ISSN: 0192-253X
    Keywords: long interspersed repeated DNA ; demethylation ; myeloma cells ; aging ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Sequences of DNA that hybridize on Southern blots with cloned EcoR1 1.3 kb (ER1) of long interspersed repeated sequence (L1Md) of mouse have been examined in genomic DNA of neonatal mice, livers and brains of adult mice (3, 10, 27, and 30 mo old), and the solid myeloma tumor MOPC-315. The isoschizomers Hpa II (CCGG or mCCGG) and Msp I (CCGG or CmCGG) were used to assess methylation. We found that the L1Md sequence is fully methylated in young animals but demethylated in myeloma. Demethylation of L1Md sequence also occurred in aged animals. By scanning the autoradiogram, we found that approximately 8% of the 104-105 copies have been demethylated in 27-mo-old liver.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020070202
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  • 96
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    Announcement (1986)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 7 (1986), S. 117-117 
    Details
    ISSN: 0192-253X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020070207
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  • 97
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    Intron-delay and the precision of expression of homoeotic gene products in Drosophila (1986)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 7 (1986), S. 119-131 
    Details
    ISSN: 0192-253X
    Keywords: determination of regional fate ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: It is suggested that the time taken in transcribing the large introns within homoeotic transcription units will reduce the quantity of mature transcript synthesised per nuclear division cycle. This could provide an additional level of control that would affect the ratios of fate-determining gene products to each other. Determination of regional fate depends on both the large domains of homoeotic genes and the small, serially repeated domains of segmentation genes. As a consequence, each row of cells along the anteroposterior axis of the embryo could be assigned a precise, and unique, fate. This precision is apparently not dependent on cell lineage discontinuities.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020070302
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  • 98
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    DNA methylation in vegetative and conjugating cells of a protozoan ciliate: Blepharisma japonicum (1986)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 7 (1986), S. 149-158 
    Details
    ISSN: 0192-253X
    Keywords: macronucleus ; gene expression ; cell union ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: We report here the presence of N6-methyladenine (MeAde) in the macronuclear DNA (maDNA) of Blepharisma japonicum vegetative cells. We have further investigated the relationship between DNA methylation and cell union in cells activated for conjugation. Such activation was induced by treating cells of mating type I with complementary gamone 2. We found a reduction of about 24% of MeAde content in gamone-treated cells ready for cell union. First indications of the presence and reduction of MeAde content came from electrophoresis of maDNA digested by appropriate restriction endonucleases. Chromatographic determination of the amount of methylated base by HPLC substantiated these observations. In vegetative cells, 1.576 ± 0.02% of total adenine was found to be methylated as opposed to 1.193 ± 0.04% in activated cells. The HPLC analysis of maDNA also revealed a peak with a retention time corresponding to that of 5-hydroxymethyluracil, already found in some species of dinoflagellates. In that gamone treatment is correlated with a differential gene expression (indicated by a differential RNA and protein synthesis), our results suggest that there is a relationship between macronuclear genome activation and demethylation of maDNA. This is the first report of a correlation between gene activation and adenine demethylation in a eukaryotic organism.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020070304
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  • 99
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    Analysis of mating type determination by transplantation of O macronuclear karyoplasm in Paramecium tetraurelia (1986)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 7 (1986), S. 187-195 
    Details
    ISSN: 0192-253X
    Keywords: nuclear factor ; microinjection ; transfer of macronuclear karyoplasm ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The odd (O) or even (E) mating type in Paramecium tetraurelia is determined during the first cell cycle after new macronuclear development. The present paper demonstrates that mating type E is irreversibly determined at the end of the first cell cycle. Direct evidence comes from transplanting O macronuclear karyoplasm containing O-determining factor into E autogamous cells during a new postzygotic macronuclear development. Transplantation of O macronuclear karyoplasm into E autogamous cells at 7-8 hr after the origin of the macronucleus from a product of the synkaryon produces nearly 100% O mating type among the exautogamous cell lines but almost none 10-11 hr after the origin of the macronucleus (around the end of the first cell cycle). The macronuclear anlagen at the stage at which mating type E seems to be fixed contains about 20 times as much DNA as the vegetative G1 micronucleus. The O-determining factor shifting E cells toward O mating type by transplanting O macronuclear karyoplasm is also produced by the newly developed macronucleus in an effective concentration at 10-11 hr after the sensitive period and produced at full levels by the third cell cycle. The level of O factor in the macronucleus then gradually declines with subsequent repeated rounds of DNA synthesis and is finally lost by the eighth cell cycle.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020070404
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  • 100
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    Masthead (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 7 (1986) 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcc.540070101
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