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  • 1985-1989  (853)
  • 1987  (853)
  • Chemical Engineering  (726)
  • pharmacokinetics  (127)
  • 101
    ISSN: 1573-0646
    Keywords: ICRF-187 ; phase I ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract ICRF-187 was given to 62 evaluable patients with advanced solid tumors in a Phase I clinical trial. Weekly infusions were given in dosages ranging from 0,85 g/m2 to 7.42 g/m2 for a total of four weeks with a two week rest period between courses. Dose-limiting hematological toxicity was seen in heavily pretreated patients at a dose of 3.8 g/m2/week. All patients also developed reversible SGOT elevations. In patients with less prior therapy hematologic toxicity was not dose-limiting but hepatotoxicity, manifest by transient SGOT levels greater than 5 times baseline was seen at 7.42 g/m2/week even though only 3/6 patients could receive 4 consecutive weekly doses. At virtually all dose levels tested some patients developed anemia. Other toxicities, including alopecia, nausea, vomiting and reversible serum amylase elevations, were mild. Cumulative monthly doses achieved on this weekly schedule are significantly higher than a 48-hour infusion or daily times 3 or 5 schedule in adults and a daily times 3 schedule in children. Pharmacokinetic studies in eight patients indicate that the drug disappears from the plasma biphasically with a terminal t1/2 of 3.2 +0.9 hr. The total clearance was 288.7 + 85.0 ml/hr/kg and the volume of distribution (Vda) was 1.3 ± 0.4 1/kg. Pharmacokinetics were not dose-dependent from 3.8–7.4 g/m2 and no difference in pharmacokinetics was found in patients studied during the first and second treatments of a course. If Phase II trials of ICRF-187 are to be pursued on this schedule, appropriate doses would be 3.8 g/m2/week × 4 for heavily pretreated and 7.42 g/m2/week for “good risk” patients. Because of erratic hematologic toxicity in heavily pretreated patients, some might only tolerate three weekly doses. In good risk patients transaminitis was significant but reversible, thus, Phase II protocols should include dose escalation schemata.
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  • 102
    Electronic Resource
    Electronic Resource
    Springer
    Investigational new drugs 5 (1987), S. 365-371 
    ISSN: 1573-0646
    Keywords: caracemide ; phase I ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A Phase I study of caracemide evaluating a short intravenous infusion repeated every 21 days is presented. Patients were entered at 85 mg/m2 with subsequent escalation levels of 170, 425, 595, and 795 mg/m2. Mild to moderate nausea and vomiting occurred at all dose levels. An apparent allergic reaction was observed at the 425 mg/m2 level. A “burning pain” originating in the mucosal areas of the head and neck, progressing to the chest and abdomen, was noted at the 425 mg/m2 level. Because of this observation, the infusion time was extended to 4 h. At the 795 mg/m2, this toxicity precluded completion of the 4 h infusion. Pharmacokinetic evaluation disclosed blood levels of 0.74–2.31 μg/ml at the 425 mg/m2 during the 0.5 h infusion. At the same dose for a 4 h infusion time, blood levels were 0.15–0.18 μg/ml. At 595 mg/m2 administered as a 4 h infusion, blood levels increased to 0.33 ± 0.14 μg/ml. The drug was cleared rapidly from the blood compartment with a half-life of 2.5 min and a total body clearance of 11.5 1/min/m2. No partial or complete response was observed. However, an advanced colon carcinoma patient experienced subjective pain relief with a decrease in carcinoembryonic antigen. The dose-limiting toxicity of caracemide using the 4 h infusion was an intolerable “burning pain” with a maximum tolerated dose of 795 mg/m2. Further characterization of this dose-limiting toxicity is required prior to further clinical evaluation of caracemide.
    Type of Medium: Electronic Resource
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  • 103
    ISSN: 1573-8221
    Keywords: prazosin ; prazosin metabolite ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 104
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of experimental biology and medicine 103 (1987), S. 658-660 
    ISSN: 1573-8221
    Keywords: ethanol ; rats ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 105
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of experimental biology and medicine 104 (1987), S. 941-944 
    ISSN: 1573-8221
    Keywords: ethanol ; predisposition ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 106
    Electronic Resource
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    Springer
    Journal of pharmacokinetics and pharmacodynamics 15 (1987), S. 145-177 
    ISSN: 1573-8744
    Keywords: Chemotherapy ; mutation ; resistance ; compartmental analysis ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The pharmacokinetics of antineoplastic drugs based on compartmental models are combined with deterministic exponential growth models of tumors containing drug-resistant and sensitive cells. Model predictions for single-drug therapy are compared with in vivodata obtained by other investigators for L1210 t-cell leukemia in mice treated with BCNU and AraC and for in vitrotreatment of L1210 with Ara-C. The model and data compare favorably in terms of rate of tumor growth and duration of drug action for both constant infusion and bolus delivery of the drugs.
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  • 107
    ISSN: 1573-8744
    Keywords: Structure-activity relationships ; pharmacokinetics ; protein binding ; glycopeptide antibiotics ; charge ; lipophilicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In previous studies of the pharmacokinetics and urinary excretion of nine glycopeptides with diverse isoelectric points (pI),as pIdecreases, the total systemic and renal clearance, urinary recovery, and volume of distribution decrease, whereas the half-life increases. With glycopeptides of similar pI,clearance decreases and half-life increases with increasing lipophilicity. The present study examines the serum protein binding of these glycopeptide antibiotics in mouse, rat, and human serum and calculates the previously reported pharmacokinetic parameters for these drugs based on unbound concentration. Increased negative charge and lipophilicity increase serum protein binding (90-fold, fu 83% to 0.96%), which decreases the renal clearance and total systemic clearance (90-fold, 16.4 to 0.18 ml/min/kg) of these drugs. Increased serum protein binding also decreases the volume of distribution of these compounds, but this change is relatively small (sixfold, 755 to 131 ml/kg) compared with the change in total systemic clearance causing an increase in elimination half-life (25-fold, 20 to 492 min). The results demonstrate that the large differences in the total systemic clearance and half-life of these glycopeptide antibiotics are primarily due to dramatic differences in serum protein binding and notto differences in the intrinsic elimination processes (enzymes or transport proteins). It appears that the same physical-chemical properties that govern the protein binding and pharmacokinetics of small organic molecules govern the disposition of these high-molecular weight glycopeptide antibiotics.
    Type of Medium: Electronic Resource
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  • 108
    Electronic Resource
    Electronic Resource
    Springer
    Journal of pharmacokinetics and pharmacodynamics 15 (1987), S. 255-269 
    ISSN: 1573-8744
    Keywords: pharmacokinetics ; singie-point dose prediction ; dosage ; minimax estimation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The single-point dose prediction method is based on the observation that for drugs obeying single compartment elimination kinetics there is a nearly constant reciprocal relation between the plasma level at a fixed time following a single loading dose and the dose that is required to maintain the desired steady state plasma level of the drug. This paper describes an improved method for choosing a plasma sampling time and a proportionality constant. It applies to either drugs administered intravenously or to drugs whose rates of absorption from the site of administration are very rapid compared to their rates of elimination from the body. The sampling time and proportionality constant chosen are those that minimize the maximum relative deviation of the maintenance dose estimated by the single-point method from the dose that would be estimated if the individual's true elimination rate constant were known. The paper also supplies a method to determine the maximum error that may be introduced into the estimation of the maintenance dose by using the single-point method.
    Type of Medium: Electronic Resource
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  • 109
    ISSN: 1573-8744
    Keywords: cotinine ; nicotine ; rat ; tissue distribution ; pharmacokinetics ; constant-rate infusion ; physiological model ; iv bolus ; osmotic minipump
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The tissue partition of cotinine was measured by a GC-MS method following a 6-day constant-rate input of nicotine and cotinine to male rats by means of an osmotic minipump. The tissue-to-blood partition coefficients of cotinine were calculated for adipose (0.08), brain (0.48), heart muscle (0.55), intestinal (0.53), hepatic (0.64), pulmonary (0.50), renal (0.99), and skeletal muscle tissue (0.51), following the cotinine infusion. When nicotine was infused the tissue partitioning of cotinine increased by a factor of 2.3–4.9, depending on the tissue sampled. Another group of animals were killed at timed intervals from 10 min to 30 hr, after having received a single intravenous bolus dose of 0.5 mg cotinine, and the washout of cotinine was traced in blood and tissues. A physiological model was used to simulate the disposition of cotinine. Generally, the model-predicted concentrations were consistent with those found experimentally. The fractional uptake of cotinine into various tissues was simulated. Blood, intestinal, and skeletal muscle tissues embodied more than 70% of the total body load of the drug. Clearance (Cl),volume of distribution (Vd),and the biological half-life (t1/2)were calculated both from the infusion study and by fitting a monoexponential model to the iv blood data of the rat. Significant differences were found in the apparent clearance calculated from the single iv bolus dose compared to the constant rate infusion. The volume of distribution was, however, consistent from both studies. The impact of a change in clearance was also simulated.
    Type of Medium: Electronic Resource
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  • 110
    ISSN: 1573-8744
    Keywords: veralipride ; pharmacokinetics ; enterohepatic recycling ; double site of drug absorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Equal doses of veralipride have been given to 12 healthy volunteers by three different administrations-intravenous infusion, oral solution, and oral capsule-in a randomized cross-over design. After the intake of the solution, but not after infusion or capsules, two maximum plasma concentrations have been observed and interpreted, according to a double-site model for drug absorption.
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  • 111
    Electronic Resource
    Electronic Resource
    Springer
    Journal of pharmacokinetics and pharmacodynamics 15 (1987), S. 39-55 
    ISSN: 1573-8744
    Keywords: Ajmaline ; antiarrhythmic drug ; pharmacokinetics ; pharmacodynamics ; plasma protein binding ; combined pharmacokinetic-pharmacodynamic model ; ECG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Pharmacokinetics and pharmacodynamics of ajmaline were studied in four healthy dogs after intravenous administration of the drug at the infusion rate of 1.0 mg/min for 45 min. Ajmaline exhibited a saturable binding to plasma protein. One kind of binding site was found in the range of observed drug concentrations and its binding capacity showed nearly threefold interindividual difference. The time course of ajmaline concentration in whole blood Cbcould be described by the two-compartment open model and the unbound concentration of ajmaline in plasma Pf wasestimated from Cbby using the hematocrit value and the parameters of plasma protein binding and erythrocyte partitioning. The pharmacologic responses to ajmaline were assessed by recording ECG, and the changes in PQ and QRS interval were studied in relation to ajmaline disposition. When ECG changes were related to the ajmaline concentration, a significant degree of hysteresis was observed. The relationship between the unbound drug concentration and the pharmacologic effect was analyzed by a combined pharmacokinetic-pharmacodynamic model, where the hypothetical effect compartment is connected to the Pfin the central compartment by a first-order process. This model allows estimation of the changes in PQ and QRS intervals after intravenous administration of ajmaline. By comparing the drug effect on PQ and QRS intervals, it was suggested that ajmaline distributes to the atrial and the ventricular tissue in a similar degree and causes a reduction in the conduction rate in both sites with similar activity.
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  • 112
    Electronic Resource
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    Springer
    Journal of pharmacokinetics and pharmacodynamics 15 (1987), S. 101-115 
    ISSN: 1573-8744
    Keywords: Lignocaine ; MEGX ; pharmacokinetics ; pharmacodynamics ; active metabolite
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Lignocaine clearance declines during continuous intravenous infustion in man and in vitrostudies suggest that this may partly be due to inhibition by MEGX, a metabolite of lignocaine, MEGX is pharmacologically active in animals, but this is not yet proven in man. This study examined the pharmacokinetics and pharmacodynamics of lignocaine and MEGX in eight healthy male volunteers given lignocaine HCl 120mg, MEGX HCl 120 mg, lignocaine HCl 120 mg+MEGX HCl 120 mg, and placebo, administered according to a randomized double-blind protocol. One-, two-, or three-compartment models were fitted to drug and metabolite blood concentration-time profiles and clearance, volume (V ss ), andhalf-life values were calculated and compared by paired t-test. Systolic time intervals and QTinterval were recorded and compared by repeated measures ANOVA. When administered in combination with MEGX, lignocaine clearance was significantly reduced from 58±18 to 48±13 L hr(su−1) (p 〈0.02). The V(inss) was unchanged and there was a trend toward an increase in terminal half-life. Lignocaine, MEGX, and the combination significantly reduced QTinterval up to 30 min after injection and this was maintained to 2 hr with the lignocaine and the combination. Transient side effects were experienced with all active treatments, but were most pronounced with the combination. Thus, lignocaine clearance was inhibited by MEGX, which was pharmacologically active in man.
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  • 113
    Electronic Resource
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    Springer
    Journal of pharmacokinetics and pharmacodynamics 15 (1987), S. 557-568 
    ISSN: 1573-8744
    Keywords: etintidine ; propranolol ; 4-hydroxypropranolol ; interaction ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Etintidine HCl is a potent H2 -blocker. The effect of clinical doses of etintidine on the disposition of a single oral dose of propranolol was investigated in 12 normal subjects. This was a double-blind, two-way crossover study. Each subject received etintidine (400 mg) or placebo twice a day with meals for 4 days on two occasions (separated by 4 days). On each occasion, the subjects were fasted overnight on Day 3 and were given an oral dose of Inderal® (40 mg propranolol hydrochloride) 30 min following the administration of the morning dose of etintidine or placebo on Day 4. Blood samples were collected prior to and up to 24 hr following the administration of propranolol. The plasma samples were analyzed for propranolol and 4-hydroxypropranolol by HPLC. Comparison of the pharmacokinetic parameters of propranolol between etintidine and the placebo groups indicates that etintidine significantly increased the AUC0−∞,values (573.5 vs. 146.4 ng·hr/ml, p=0.0001)and prolonged the elimination half-life (4.61 vs. 2.33 hr) of propranolol. Statistical evaluation of the pharmacokinetic parameters of 4-hydroxypropanolol indicates that etintidine also increased the AUC0−24 values (43.8 vs. 16.4 ng·hr/ml, p=0.0028) and prolonged the elimination half-life (4.87 vs. 1.97 hr) of 4-hydroxypropranolol. The data suggest that etintidine, like cimetidine, impaired the elimination of propranolol. Etintidine also protracted the elimination of 4-hydroxypropranolol, an active metabolite of propranolol.
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  • 114
    ISSN: 1573-904X
    Keywords: etretinate ; pharmacokinetics ; dose proportionality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Twelve healthy male subjects received single oral doses of etretinate, ranging from 25 to 100 mg (1 to 4 × 25-mg capsules) in an open-label, four-way randomized crossover design. Plasma concentrations of etretinate and two active metabolites were determined by a specific high-performance liquid chromatographic (HPLC) method. Analysis of variance and orthogonal contrasts were used to assess dose proportionality. Mean (± %CV) maximum concentrations after 25- to 100-mg doses were 133 (50), 195 (33), 261 (53), and 446 (65) ng/ml, whereas AUC0−12 values were 581 (46), 1090 (39), 1500 (52), and 2440 (63) ng · hr/ml, respectively. The test for proportionality indicated that C max and AUC0−12 increased proportionally with an increase in dose (P 〉 0.05).
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  • 115
    ISSN: 1573-904X
    Keywords: oral cephalosporin ; cefixime ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Cefixime (CL 284,635; FK 027) is a new third-generation oral cephalosporin. To study dose-dependent pharmacokinetics of cefixime in dogs, two balanced four-way crossover studies were conducted. In the first study, oral doses of 50, 100, and 200 mg/kg and an intravenous dose of 50 mg/kg cefixime were administered. In the second study, oral doses of 6.25, 12.5, and 25 mg/kg and an intravenous dose of 12.5 mg/kg cefixime were administered to the same dogs. A period of 1 month separated the two studies. When the two intravenous doses were compared (i.e., 12.5 and 50 mg/kg), a twofold increase in clearance and volume of distribution was observed after the higher dose. The oral systemic bioavailability in the dose range 6.25–50 mg/kg was 55%. It decreased to 44% at 100 mg/kg and 27% at 200 mg/kg. The average peak serum concentrations ranged from 15.8 µg/ml at 6.25 mg/kg to 119 µg/ml at 200 mg/kg. Within this concentration range, the fraction of free drug in serum (unbound to proteins) increased from 7 to 25%. This concentration-dependent protein binding was primarily responsible for changes in total clearance, volume of distribution, and bioavailability of the drug in dogs.
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  • 116
    ISSN: 1573-904X
    Keywords: enterohepatic recirculation ; pharmacokinetics ; bioavailability ; area under the curve ; bile ; hepatic extraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A relationship between systemic availability and its determinants has been derived for a physiologically realistic model of drug disposition that includes enterohepatic cycling (EHC), gallbladder emptying (with an arbitrary time course), first-pass metabolism to noncycling metabolites, and fecal excretion. Systemic availability (F) has been shown to be determined by the fraction of the dose initially absorbed (f a*), the fraction of the drug excreted into the GI tract that is reabsorbed with each cycle (f a), the hepatic extraction ratio (E), and the fraction of extracted drug that is transported to the gallbladder for EHC (f g) according to the relationship F = f a*(1 −E/(1 − f a f g E) The implications of the above relationship are that (1) systemic availability is dependent on EHC, (2) values of F calculated to be greater than unity cannot be explained simply by the presence of EHC, (3) calculations of E based on the usual expression F = f a* (1 − E) are erroneous for drugs subject to EHC, and (4) a compound that has a high systemic availability and is subject to EHC is not necessarily inefficiently metabolized. The quantitative interrelationship of systemic availability and its determinants is illustrated using a contour plot. Slices through the surface are used to demonstrate that the presence of EHC changes the sensitivity of F to changes in E.
    Type of Medium: Electronic Resource
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  • 117
    Electronic Resource
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    Springer
    Pharmaceutical research 4 (1987), S. 59-61 
    ISSN: 1573-904X
    Keywords: mean residence time ; pharmacokinetics ; Michaelis–Menten elimination ; one-compartment model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract An equation for the mean residence time (MRT) of drug in the body is derived for the system where drug is injected intravenously into a one-compartment model and eliminated by a single, capacity-limited process. This MRT is a complex function of dose, volume, V m, and K m but degenerates into the classical volume/clearance expression under limiting low-dose conditions (K m ≫ C 0). The equation was validated by comparison of the MRT obtained by direct calculation versus numerical area estimation for simulated data. The equation may be useful analytically in the estimation of the fundamental Michaelis–Menten parameters, V m and K m, from experimental data.
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  • 118
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    Springer
    Pharmaceutical research 4 (1987), S. 251-254 
    ISSN: 1573-904X
    Keywords: amiodarone ; antipyrine ; desethylamiodarone ; drug metabolism ; drug interactions ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The effect of amiodarone on hepatic drug metabolism in vivo was examined in the rat using antipyrine as a model substrate. Pretreatment with oral amiodarone hydrochloride, 100 mg/kg/day, for 5 days resulted in a 19% reduction in antipyrine clearance and a 22% increase in half-life. The administration of single oral doses of amiodarone hydrochloride, 100 mg/kg, 1 or 5 hr prior to antipyrine administration had no significant effect on antipyrine pharmacokinetics. The administration of a single intravenous dose of amiodarone hydrochloride, 50 mg/kg, reduced antipyrine clearance by 32% and increased the half-life by 46%. The desethyl metabolite of amiodarone was also found to reduce antipyrine clearance (21%) after a single oral dose of 100 mg/kg.
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  • 119
    ISSN: 1573-904X
    Keywords: computer-designed formulation ; prolonged-action dosage forms ; drug delivery systems ; long-acting formulations ; theophylline delivery systems ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The method provides an a priori assessment of the maximum allowable flexibility in the rate of release from a prolonged-release formulation. The clinical pharmacokinetic parameters describing the drug candidate are employed to calculate the ranges of rate constants and doses required for the formulation to provide a selected therapeutic duration. For a given patient, there may be an infinite number of combinations of release rate constants and dose sizes which will maintain steady-state plasma drug concentrations within a desired range when the formulation is administered at the selected dosing interval. Computer simulations of steady-state plasma concentrations are employed to establish the ranges for all of the acceptable rate constants and doses for each member of a group. The entire group is then examined to define the range of release rate constants and doses which would provide a useful formulation for every member in the group. Literature values for theophylline clinical pharmacokinetics in children and adults have been employed to illustrate the application of this method. The method is unique in that it provides an entire range of release rates on which to gauge the feasibility for success.
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  • 120
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    Springer
    Pharmaceutical research 4 (1987), S. 332-336 
    ISSN: 1573-904X
    Keywords: pharmacokinetics ; gold ; rabbits ; intramuscular ; intravenous ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Male, New Zealand white rabbits (3.5–4.3 kg) received a single 2-mg/kg dose of gold sodium thiomalate (Myochrysine) via intramuscular (N = 4) and intravenous (N = 3) routes. Blood samples were drawn from the marginal ear vein for a period of 5–10 days. The concentration of gold in whole blood was determined using graphite furnace atomic absorption spectrophotometry. The blood concentration–time profiles obtained following both routes of administration were best described by a two-compartment open model with first-order absorption for the intramuscular route. Gold was absorbed rapidly with a mean (harmonic) absorption half-life of 9.0 min, with a peak concentration of 6.0 ± 1.0 µg/ml (N = 4). Blood concentrations declined in a biphasic manner; the mean α half-lives were 0.738 and 1.78 hr for the iv and im routes, respectively. The corresponding terminal (β) half-lives were 54.1 and 63.0 hr. The estimated volume of the central compartment (70 to 93 ml/kg) agreed closely with the rabbit blood volume. The mean ( ±SD) extent of the dose absorbed following intramuscular injection was 68.9 ± 12.4%.
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  • 121
    ISSN: 1573-904X
    Keywords: zero-order delivery ; drug delivery system ; sustained release ; computer simulation ; dosage form design ; theophylline ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Classical methods employing pharmacokinetic data to calculate zero-order release rates for sustained release products require that a constant-rate drug delivery system must have a duration which is exactly equal to the desired dosage interval. This traditional approach fails to establish the minimum acceptable duration and also fails to provide any flexibility in the formulation goal. While it does calculate one pair of duration and dose values, there are infinite pairs of values capable of maintaining the desired plasma concentrations using the selected dosing interval. In the current method, computer simulations are used to establish the boundary conditions within which any pair of duration and dose values will maintain the desired levels when administered on the chosen dosing interval. By comparing the boundary conditions for every subject in a group, a single set of conditions which would work for the entire group can be selected. These final limits represent the broadest specifications for zero-order drug delivery system design for that particular drug combined with the plasma concentration goals and the desired dosing interval. The method is illustrated using theophylline pharmacokinetics.
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  • 122
    ISSN: 1573-7241
    Keywords: drug interactions ; digoxin ; pharmacokinetics ; antiarrhythmic drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary While preliminary screening for interactions between new cardiovascular pharmacotherapeutic agents and digoxin can be efficiently and safely conducted in normal healthy volunteers, it is particularly important to detect and quantify drug interactions in patients with varying degrees of cardiac, hepatic and/or renal dysfunction. Much of the previously published literature provides only minimal data to guide clinical practice because of limitations of study design including sample size and measurement techniques. Important factors that determine the ability of a particular study design to detect a drug interaction with digoxin include the accuracy and precision of the assay method for serum digoxin concentrations, intrasubject and intersubject variability in serum digoxin concentration, and sample size. The format of the trial (chronic versus single digoxin dosing in cardiac patients; chronic verus single digoxin dosing in normal subjects) and the method of assessment of alterations in digoxin handling (formal determination of digoxin clearance, comparison of multiple or single digoxin measurements during various phases of trial) also impact greatly on the clinical relevance of such investigations. Guidelines for future studies of drug interactions with digoxin in cardiac patients are proposed with particular emphasis on laboratory methods; measurement techniques during baseline, placebo, and active drug phases; calculation of the statistical power of the study; time course of the trial; and assessment of the clinical significance of the findings.
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  • 123
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    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 27 (1987), S. 1021-1034 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Equations are derived that relate the orientation of “pseudo-affine” reoriented structural units after a biaxial deformation to the degrees and the directions of the effective drawings. The connection between these drawing parameters and those externally applied is analyzed in detail. It is shown how a comparison of these two sets of drawing parameters allows conclusions regarding the distribution throughout the material of the stresses that cause the deformation, the inhomogeneity of the deformation, and the role of non-orienting flow during deformation. In particular, the orientation of biaxially drawn poly(ethylene terephthalate) films is investigated, and it is shown what general information can be obtained on the deformation behavior of this material on the basis of these considerations.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 124
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    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 27 (1987), S. 1059-1068 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Scale-up from small laboratory size extruders to large production size extruders is a procedure of great practical importance. Many scale-up rules and theories have been proposed in the past, however it is not always clear how the different scale-up methods will affect extruder performance. A basic analysis of scale-up in plasticating single screw extruders is developed from which the effect of a certain scale-up strategy on extrusion performance can be evaluated in terms of solids conveying, melting, melt conveying, mixing, residence time, heat transfer, power consumption, and specific energy consumption. Various existing scale-up theories are evaluated and compared using the basic analysis. A number of existing scale-up theories have some significant drawbacks, in particular with non-constant specific energy consumption and imbalance between melting rate and pumping rate. Conditions that are desirable to achieve in scale-up are enumerated and ranked in terms of importance. This leads to two new scale-up methods that result in constant mechanical specific energy consumption and high throughput rates. The first scale-up method keeps the specific surface area constant. This scale-up should work well for high values of the Brinkman number. However, at low values of the Brinkman number, the melting rate may be insufficient. The second scale-up method keeps the melting rate at low Brinkman number equal to the pumping rate and, thus, should be useful in cases where the first scale-up method cannot be used.
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  • 125
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    Polymer Engineering and Science 27 (1987) 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
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  • 126
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    Polymer Engineering and Science 27 (1987), S. 1128-1136 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The plane strain fracture toughness and fracture mechanisms of several tough engineering plastics have been studied and compared with poly(methyl methacrylate) (PMMA), a relatively brittle polymer. The tough polymers all are observed to form a multiple craze zone at the crack tip, which is shown to be the primary source of plane strain fracture toughness in these materials. The multiple craze zone is retained during slow crack growth but is metastable, and at a critical stress intensity and associated crack velocity, the system passes through a transition to a greatly accelerated single craze mode of unstable propagation.
    Additional Material: 14 Ill.
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  • 127
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    Polymer Engineering and Science 27 (1987), S. 1148-1155 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The optical properties of bisphenol-A polycarbonate resin as described by the complex index of refraction, N = n - ik, are derived by Kramers-Kronig analysis of experimental absorption and reflectance data obtained in the range 40μm ≥ λ ≥ 105 nm. Electronic absorption processes in polycarbonate are characterized by two broad absorption peaks centered at ∼200 and ∼100 nm.
    Additional Material: 10 Ill.
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  • 128
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    Polymer Engineering and Science 27 (1987), S. 1182-1186 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Three-layer coextruded blown (either blend or composite) films, made of low-density polyethylene and linear lowdensity polyethylene (1:1 ratio) of identical density, were compared. The tensile properties of both systems are nearly as high as those of the linear polyethylene while high strain rate properties including impact strength and tear resistance of the composite film are superior. Some structural insight was obtained by thermal analysis and thermoelastic measurements. Structure property relationships are discussed in light of the unique behavior, structure, and morphology of linear low-density polyethylene. The two polyethylenes are only compatible to a rather limited extent mainly affecting their blend behavior. However, a strong mutual reinforcement effect was observed.
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  • 129
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    Polymer Engineering and Science 27 (1987), S. 1203-1208 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A Viton copolymer containing vinylidene fluoride (VF2) and hexafluoropropylene (HFP), and a terpolymer containing VF2, HFP, and tetrafluoroethylene (TFE) were cross linked using varying amounts of Bisphenol AF to yield two series of fluoroelastomer networks, Stress-strain isotherms in elongation were determined for these samples at several temperatures and at two degrees of swelling with phenyl acetate. Strain-induced crystallization was observed, as evidenced by upturns in the isotherms at high elongations. It appears to be more pronounced in the terpolymer samples, presumably because the TFE units not only can crystallize themselves, but can co-crystallize with the VF2 units. The crystallization was found to persist upon moderate increase in temperature, but was suppressed when the networks were swollen, Thermoelastic (force-temperature) measurements were used to obtain values of the fraction fe/f of the elastic force that is due to energetic effects. Negative values were obtained for both types of samples and, in the case of two samples studied in detail, their magnitudes increased with increase in elongation. The magnitudes were larger and the increases more pronounced in the case of the terpolymer networks, as would be expected from a greater tendency for straininduced crystallization.
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  • 130
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    Polymer Engineering and Science 27 (1987), S. 1221-1228 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The transesterification reaction of molten ethylene and vinyl alcohol copolymers (EVA), in presence of paraffinic alcohols and basic catalysts, leads to high conversion of the ester groups to secondary alcohol in both discontinuous and continuous processing equipment. Various kinds of alcohols and two different catalysts were used. Sodium methoxide is a powerful catalyst for the equilibrated transesterification reaction, but we also observed side reactions, such as cross-linking with low-molecular-weight alcohols and hydrolysis of the catalyst followed by partial saponification of the EVA. Kinetic studies were performed in the presence of dibutyltin dilaurate, an efficient catalyst without any side reactions. The solubility of the main alcohol reagents was verified by diffusion measurements. The general reaction scheme and the related kinetics, corresponding to a homogeneous system, lead to a fair evaluation of the rate constants.
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  • 131
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    Polymer Engineering and Science 27 (1987), S. 1252-1257 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The mechanical properties of polyurethane-unsaturated polyester interpenetrating polymer networks (IPNs) that were prepared by reaction injection molding (RIM) process were measured with variations In composition, cross-link density, and relative reaction rate. From dynamic mechanical analysis (DMA), it was found that the two component polymers had a good compatibility over the whole composition range. The tensile strengths of the blends were greater than those of the pure components and had a maximum value at 50/50 composition. The modulus of elasticity and surface hardness decreased and the impact strength increased as the polyurethane content was increased, but the changes were not high at low polyurethane content, below 50%. For higher cross-link density, the compatibility was enhanced and the mechanical properties were improved. When the reaction rates of the components were different, some extent of phase separation was found in DMA and the properties were affected adversely.
    Additional Material: 7 Ill.
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  • 132
    ISSN: 1573-904X
    Keywords: clozapine ; pharmacokinetics ; multiple-dose regimen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract After a 2-day buildup, patients were dosed continuously with clozapine solution at three ascending dose levels (37.5, 75, and 150 mg bid for 7 days at each dose level). Following the morning administration on the twenty-third day of dosing a drug holiday was instituted which lasted for a minimum of 48 hr. Serial plasma samples were obtained during each of the periods and during the drug holiday for the calculation of the steady-state parameters AUCSS, CSS max, and CSS min at each dose level as well as for the assessment of the terminal elimination rate. Mean parameter values for AUGSS, CSS max, and CSS min showed a linearly increasing response with the dose, well described by a straight line passing through the origin. The terminal elimination appeared to follow linear kinetics and had a mean half-life of 15.8 hr (range, 5.8–33 hr).
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  • 133
    ISSN: 1573-904X
    Keywords: potassium chloride ; sustained-release tablet ; bioavailability ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The bioavailability of a new sustained-release potassium chloride (KC1) tablet, designed for once-a-day dosing, was compared to a KC1 elixir using urinary excretion data. The study utilized 25 male volunteers dosed in a crossover design in a dietary/activity-controlled environment. The regimens consisted of a total of 80 mEq of potassium in three equally divided doses of elixir every 6 hr and a single 80-mEq dose using four 20-mEq sustained-release (SR) tablets. The mean time to maximum rate of potassium urinary excretion was 2.2 hr for the first elixir dose and 5.5 hr after the SR tablet (P 〈 0.01), thereby supporting the prolonged-release properties of this formulation. After correction for baseline urinary potassium excretion, the mean total 24-hr urinary potassium excretion was 42.18 mEq for the elixir and 40.41 mEq for the SR tablet. The results indicate that the absorption pattern from the SR tablet is equal to three doses of KC1 elixir dosed 6 hr apart.
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  • 134
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    Pharmaceutical research 4 (1987), S. 433-435 
    ISSN: 1573-904X
    Keywords: pentoxifylline ; theophylline ; xanthine ; pharmacokinetics ; drug metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
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  • 135
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    Pharmaceutical research 4 (1987), S. 515-518 
    ISSN: 1573-904X
    Keywords: antipyrine ; drug metabolism ; hydralazine ; hypothermia ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The concomitant administration of hydralazine with metoprolol or propranolol substantially increases the oral bioavailability of these beta-blockers, presumably via reduction of the first-pass effect. It has been suggested that this effect may be secondary to a decrease in the intrinsic clearance of propranolol, possibly by inhibition of oxidative metabolism. To examine the possibility that hydralazine alters oxidative metabolism in vivo, the effect of hydralazine on the pharmacokinetics of antipyrine was examined in the rat. The oral administration of hydralazine hydrochloride, 7.5 mg/kg, 15 min prior to antipyrine administration reduced antipyrine clearance from 9.66 ± 1.18 to 8.19 ± 0.76 ml/min/kg (P 〈 0.05). Hydralazine was observed to cause substantial hypothermia. The study was repeated in temperature-regulated animals and no alteration in antipyrine clearance was found. Two doses of hydralazine in temperature-regulated rats also failed to alter antipyrine clearance. Thus, it appears that the effect of hydralazine on antipyrine clearance is secondary to the hypothermic effect of hydralazine and not due to a direct inhibition of cytochrome P-450-mediated enzyme activity.
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  • 136
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Forced Rayleigh scattering, a relatively recently developed optical technique, is used to measure tracer diffusion coefficients in polymer-solvent mixtures near the system glass transition temperature, Tg. The technique has a wider range of potential application than has yet been realized, and so is presented in some detail. The objectives were to obtain data necessary to scrutinize free volume theory, and to understand so-called anomalous, non-Fickian diffusion effects observed by others in polymer-solvent mixtures near Tg. Data on dye tracer diffusion coefficients in the systems polyvinyl acetate-toluene, polystyrene-toluene, and polystyrene-tri-m-tolyl phosphate were obtained over a polymer concentration range from infinite dilution to 96 wt. %. Small molecule diffusion coefficients are seen to vary by as much as nine orders of magnitude (10-14 to 10-5 cm2/s) over this concentration range. The data are in reasonable accord with expectations based on the Duda-Vrentas version of free-volume theory.
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  • 137
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    AIChE Journal 33 (1987), S. 604-618 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Microflow calorimeter design for heats of mixing is surveyed. Precise temperature equilibration of the fluids before mixing, the elimination of frictional energy effects from the instrument response, and the absence of flow-rate and physical-property-dependent heat leaks are particularly important. A design using a differential mode of operation is based on a careful analysis of entropy generation in flows with mixing and friction. The compensation for frictional heating and the lack of dependence of measurements on flow rate and mixture physical properties other than hE represents a major advance. Measured data for the welltested cyclohexane-hexane system had an average deviation of only 0.41%. For the more viscous cyclohexane-1-hexanol system, measured data of similar precision are considered the best available.
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  • 138
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    AIChE Journal 33 (1987), S. 643-653 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Energy requirements of four different thermally coupled distillation systems were minimized for an assumed ideal ternary solution being separated. Minimum vapor flows and values of decision variables have been found in the form of analytical expressions. This enables making a quick and simple comparison of these systems. The solution method can be used for synthesis of separation systems or for screening calculations.
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  • 139
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    AIChE Journal 33 (1987), S. 628-642 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A mathematical model is presented for the codeposition of cadmium and tellurium onto a rotating-disk electrode. The treatment incorporates the equation of convective diffusion for liquid phase mass transport, Butler-Volmer expressions for charge-transfer reactions, and a thermodynamic model for individual component activities in the solid state. Because of the formation of CdTe, a compound that has a large negative free energy of formation, the cadmium deposition reaction occurs at potentials substantially positive to its standard electrode potential (Uθ = -0.40 V). This reaction, along with the deposition of tellurium (Uθ = + 0.55 V), produces an electrodeposit that contains cadmium, tellurium, and cadmium telluride. The model can be used to calculate transient current-potential relationships, ionic concentration profiles, and deposit compositions. Transport and kinetic parameters for cadmium and tellurium deposition are reported; a multidimensional optimization routine is used to evaluate physiochemical parameters from experimental data for the codeposition process.
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  • 140
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    AIChE Journal 33 (1987), S. 668-671 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 3 Ill.
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  • 141
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    AIChE Journal 33 (1987), S. 677-680 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 3 Ill.
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  • 142
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    AIChE Journal 33 (1987), S. 686-689 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
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  • 143
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    AIChE Journal 33 (1987), S. 694-696 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 2 Tab.
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  • 144
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    AIChE Journal 33 (1987), S. 701-702 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
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  • 145
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    AIChE Journal 33 (1987), S. 705-710 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Studies of the attack of gel-stabilized suspensions of hydroxyapatite show dissolution at the boundary of the solid region and reprecipitation within this region. The results are apparently consistent with a theory which assumes that porous solid dissolution is diffusion-controlled but constrained by nonlinear solubility products.
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  • 146
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    AIChE Journal 33 (1987), S. 1829-1834 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A test has been designed and used to compare flow hydrodynamics in different thermogravimetric analysis (TGA) systems used as pulse microreactors. The test involves passing a pulse of injectant over the sample pan containing an adsorbent. Water and zeolite are used in the present case. The technique is easily performed and is insensitive to variations in temperature. A model is developed by which the fraction of gas pulse bypassing the sample pan within the TGA can be obtained. In gas/solid reactions, either catalytic or noncatalytic, the test should prove useful for comparing TGA extent-of-conversion data to similar measurements taken from other reactor configurations, carrier flow rates, and flow geometries.
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  • 147
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    AIChE Journal 33 (1987), S. 1835-1843 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Published models for gas-solid reactions have been used with certain modifications to interpret sulfation data for CaO, MgO, and ZnO with SO2 and SO3. None of the models evaluated gave an adequate interpretation for high solid conversions, which were found to exceed 90% in some cases. Such high conversions are inconsistent with the current models, and a new mechanism must be postulated to explain the reaction after the solid product theoretically fills the initial pores of the particle. An important factor in successfully interpreting the experimental data is the distributed nature of the pore sizes within the solid particle.
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  • 148
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    AIChE Journal 33 (1987), S. 1844-1849 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Contact nucleation studies were performed with the dextrose-water system. Under some conditions two crystallographic phases were formed, which were identified in situ using a laser Raman microprobe. In addition, the growth of the contact nuclei was monitored in situ using photomicroscopy. The results are discussed in the context of contact nucleation and growth models.
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  • 149
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    AIChE Journal 33 (1987), S. 1873-1881 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: An efficient frequency domain methodology for the design of set point regulators for high-order process models involving relatively large pure time delay is presented. The unique advantage of the methodology is that it enables the designer to rapidly visualize the structure of the required controller as soon as the time and frequency domain specifications are stipulated for the closed-loop system. Optimizing the parameters of an appropriate structure improves the robustness of the controller. The method does not require order reduction of the original model, and time delay is handled directly. Also, only output feedback is utilized.
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  • 150
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    AIChE Journal 33 (1987), S. 1865-1872 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A new bubble diameter correlation is derived to predict bubbling characteristics of fluidized beds of varieties of powders. The present model is founded on the postulate that the steady bubble size, which is often called the maximum stable diameter, observed in a bed of Geldart group A powder is formed as a result of an equilibrium of successive coalescence and splitting. For the cases of group B powders the present correlation automatically converges to the conventional correlation of Mori and Wen (1975), whose predictions are close to those of Rowe (1976) and Darton et al. (1977). For group A powders the present correlation is validated by comparison with experimental data in the literature. Based on this correlation a theoretical explanation is presented for the fact that the maximum bubble diameters observed were up to 50 to 100 times as large as those from the stable bubble theory of Harrison et al. (1961).
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  • 151
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    AIChE Journal 33 (1987), S. 1850-1864 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Global bifurcations are frequently encountered in the dynamic behavior of chemically reacting systems and their models. They cause dramatic qualitative changes in the system response, such as the birth and death of oscillations and even the onset of chaos. They involve entire regions of the system phase space, and due to their nature they are in general not predictable by standard local bifurcation methods, analytical or numerical. Special methods and algorithms must therefore be developed to locate and analyze them in parameter space. This paper presents such methods and algorithms and illustrates them through standard chemical engineering examples. Test cases include lumped chemical reactor models (homogeneous and heterogeneous, autonomous and periodically forced), a problem of compressible gas flow in porous media, and a case of two coupled oscillators. The phenomena discussed include infinite-period bifurcations, saddle connections, frequency locking, and the creation and extinction of multifrequency responses through global manifold interactions (homoclinic tangles).
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  • 152
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    AIChE Journal 33 (1987), S. 1882-1887 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The general collinearity conditions at phase boundaries for mixtures are proved by thermodynamic identities for density and for entropy as functions of temperature, pressure, and composition. In the case of density/temperature/pressure/composition collinearity is always found at the cricondentherm or any temperature extremum, whereas for entropy/temperature/pressure/composition collinearity is always found at the cricondenbar or any pressure extremum. Qualitative phase diagrams for a typical binary system are presented in accordance with the derived inequalities. Whether a particular slope, involving the above variables, from the homogeneous side of the phase boundary is greater or less than that from the heterogeneous side depends on location on the phase boundary with respect to cricondentherm, critical point, and cricondenbar.
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  • 153
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    AIChE Journal 33 (1987), S. 1899-1902 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 6 Ill.
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  • 154
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    AIChE Journal 33 (1987), S. 1895-1898 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 10 Ill.
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  • 155
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    AIChE Journal 33 (1987), S. 1888-1893 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Average and local heat transfer coefficients were measured for transfer from circulating fluidized beds of sand particles (mean size 188 and 356 μm) to two water-cooled membrane wall surfaces located on one face of a 152 mm square by 7.3 m tall column. The measurements cover a range of superficial gas velocities from about 4 to 7 m/s, suspension densities from about 8 to 130 kg/m3, suspension temperatures from 150 to 400°C, and secondary-to-primary air ratios of 0 to 1.5. Heat transfer coefficients, averaged over a 1.53 m length of the membrane waterwall surfaces, depend strongly on suspension density, but show almost no separate dependence on gas velocity, bed temperature, or secondary-to-primary air ratio for the conditions studied. For the surface nearest the top of the unit, the coefficient decreases with distance measured downward from the top, suggesting that particles travel downward along the surface. As a result, averaged coefficients are lower and the influence of particle size is less than for previously reported circulating fluidized bed heat transfer measurements where miniature heat transfer surfaces were employed.
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    AIChE Journal 33 (1987), S. 1903-1907 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
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  • 157
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    AIChE Journal 33 (1987), S. 1908-1911 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
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  • 158
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    AIChE Journal 33 (1987), S. 1912-1915 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
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  • 159
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    AIChE Journal 33 (1987), S. 1916-1920 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
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  • 160
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    AIChE Journal 33 (1987), S. 1921-1925 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
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  • 161
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    AIChE Journal 33 (1987), S. 1926-1929 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 3 Ill.
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    AIChE Journal 33 (1987), S. 1932-1932 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
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  • 163
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    AIChE Journal 33 (1987), S. 1933-1933 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
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  • 164
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    AIChE Journal 33 (1987) 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
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  • 165
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    AIChE Journal 33 (1987), S. 1930-1932 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
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  • 166
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    AIChE Journal 33 (1987), S. 1949-1958 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The role of inter- and intraparticle transport resistances in the sensitivity behavior of a fixed-bed catalytic reactor is fully elucidated. The parametric sensitivity regions obtained using a heterogeneous one-dimensional plug flow model are reported for various values of the involved dimensionless parameters. Comparisons with previous sensitivity criteria and with experimental data are also presented.
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  • 167
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    AIChE Journal 33 (1987), S. 1937-1948 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A flash-evaporation technique is used to obtain vapor deposition characteristics for the binary alkali sulfates K2SO4 + Na2SO4 at 1 atm above 1, 100 K. This technique gives results of immediate engineering interest, such as dewpoint temperatures, condensate composition and rates of vapor deposition as well as useful data on the system's thermodynamic characteristics. It is concluded that alkali sulfate deposition and vaporization in combustion environments are inevitably influenced by chemical reactions such as hydroxide formation. It is also concluded that solution nonideality is important even for homologous alkali-salt mixtures.Predictions are made using convective-diffusion mass transfer theory, accounting for chemical reactions by means of effective volatilities, and assuming regular, nonideal condensate solutions. The predicted dewpoints, condensate compositions and deposition rates are quantitatively consistent with experimental observations. This approach, validated here, can be extended to more extreme conditions of engineering interest, including turbulent, high-temperature/pressure systems.
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  • 168
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    AIChE Journal 33 (1987), S. 1959-1970 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: New data and analyses are presented for describing gas and solids behavior in a slurry bubble column. Axial solids concentration and bubble size distributions were measured in a 0.108 m ID slurry bubble column apparatus operated at steady state conditions. The column was operated with and without internal baffles. The slurry and gas superficial velocities ranged from 0.0077 to 0.009 m/s and from 0.031 to 0.24 m/s, respectively. The solid phase consisted of glass spheres in a narrow size range with a mean diameter of 96.5 μm; the liquid phase consisted of tap water.With a one-dimensional sedimentation-dispersion model, the data have been used to predict average solids loadings and axial distributions of the solids for specified operating conditions. Local bubble size and concentration measurements indicate that the slurry bubble column was operated in the churn-turbulent flow regime throughout the entire range of operating conditions used in this study. The impact of internal baffles and solids concentration on the gas and solids behavior is discussed.
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  • 169
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    AIChE Journal 33 (1987), S. 1977-1985 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A finite-element method is given for efficient simulation of multiphase distillation systems. Breakpoints are adaptively located to coincide with phase discontinuities. Thermodynamic criteria for the states at these discontinuities are included in the equation system. The adjustable breakpoint locations are calculated simultaneously with the other system variables by global Newton iteration. Worked examples demonstrate the accuracy and efficiency of the method.
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    AIChE Journal 33 (1987), S. 1986-1992 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Fuzzy set theory is used to describe similarity of chemical engineering systems. The development of system similarity is given, and methods of determining a similarity relation are discussed. The system similarity relation is applied to the problems of measuring correlation confidence and quantifying modeling error. Sample problems are examined.
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  • 171
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    AIChE Journal 33 (1987), S. 1971-1976 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The oxidation of CO over aluminum-supported Ag was studied at 147°C using transient experiments. Long-time-scale dynamics were observed that could not be explained by previously postulated kinetic mechanisms for this reaction system. A model is presented with kinetic parameters estimated from steady state and transient data that is able to reproduce a variety of cycled feed stream experiments. The model incorporates a slow reversible step which forms an adsorbed oxygen species that blocks reaction sites.
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  • 172
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    AIChE Journal 33 (1987), S. 1993-1997 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Diffusion and chemical reaction in a catalyst pore is simulated as a Monte Carlo process. In this analysis the average diffusion distance, calculated for a large number of wall collisions, and the reaction probability are computed as two independent statistical events. This formulation yields results that compare very well with the theoretical values, yet uses minimal computer time. Results reported include typical concentration profiles and effectiveness factors for first- and second-order isothermal reactions using the method described. These results show promise of extension to more complex systems where analytical solutions are not available.
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  • 173
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    AIChE Journal 33 (1987), S. 1998-2002 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: In turbulent flow the equations governing the development of conversion vs. distance are not closed because of the contribution of the concentration fluctuations to the average reaction rate. Toor's hypothesis permits closure from data obtained for mixing without reaction. This paper presents a critical review of the derivation of the hypothesis and discusses its validity.
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  • 174
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    AIChE Journal 33 (1987), S. 2003-2007 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A new, unobtrusive method for liquid-liquid two-phase flow data collection was proved to be reliable in this research. Drop size distributions and concentration profiles were determined for a dilute water-inkerosene system under horizontal straight pipe flow using this technique, and the Segev model for predicting concentration profiles was tested with the data collected here.The drop size distributions were found to follow a Rosin-Rammler function for a limited droplet diameter range, and the average value of the exponent in the Rosin-Rammler equation was determined to be 2.0. The velocity where the flow regime makes a transition from stratified to adequately dispersed flow was found to be between 2.0 and 2.2 m/s. Concentration profiles predicted by the Segev model were in general agreement with the profiles determined in this work, and using the proper choice of model parameters noticeably improves the model predictions.
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  • 175
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    AIChE Journal 33 (1987), S. 2017-2026 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The reaction rate constant was adjusted continuously over two orders of magnitude for the unimolecular decomposition of α-chlorobenzyl methyl ether using the supercritical fluid solvent 1, 1 diffluoroethane. Activation volumes were observed as low as -6,000 cm3/mol, which is about an order of magnitude more negative than those reported previously in the literature for a homogeneous reaction. Spectral shift (solvatochromic) data were measured for phenol blue in the same fluid in order to interpret the rate data. A method is presented to predict solvent effects on rate constants at supercritical fluid conditions.
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  • 176
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    AIChE Journal 33 (1987), S. 2027-2036 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Pressure-drop in cocurrent gas-liquid downflow through packed beds was experimentally measured for nonfoaming, foaming Newtonian, and non-Newtonian liquids. The variables include the column diameter, packing size and shape, flow rates of the phases, and their physical properties. Unified correlations are presented for the data of the present study as well as data available in literature in terms of Lockhart-Martinelli parameters and flow variables and packing characteristics. The data were modeled using a dynamic interaction model.
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  • 177
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    AIChE Journal 33 (1987), S. 2037-2046 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: To understand better the impact of gas phase reactions on chemical vapor deposition, a new experimental method has been developed to isolate and study homogeneous reactions separately from heterogeneous reactions. This new system heats reactant gases by rapidly compressing them to temperatures greater than 1,000 K; the walls of the reactor remain constant at 500 K or less. Pressure and volume measurements determine the mean temperature of the gas. Results from a series of test reactions and simple models show that this apparatus and measurement method work well. The apparatus is inexpensive and simple to use, and has advantages over shock tubes and static systems.
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  • 178
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    AIChE Journal 33 (1987), S. 2008-2016 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Mass transfer rates in laminar and turbulent nonseparated boundary layers are asymptotically expanded for small values of the diffusivity DAB, with a uniform state on the mass transfer surface. Results for heat transfer follow by analogy. The thermal or binary Nusselt number at small net mass transfer rates is given asymptotically by a generalized penetration expression \documentclass{article}\pagestyle{empty}\begin{document}$$ \langle Nu\rangle \, = \,a_{00} Pe^{1/2} \, + \,a_{01} Pe^0 \, + \,.\,.\,.\,{\rm (A)} $$\end{document} for short times, or for boundary layers that duplicate the surface tangential motion. For flows past rigid interfaces, the long-time average of 〈Nu〉 is given asymptotically by a generalized Chilton-Colburn relation \documentclass{article}\pagestyle{empty}\begin{document}$$ \langle \overline {Nu} \rangle \, = \,b_{00} Pe^{1/3} \, + \,b_{01} Pe^0 \, + \,.\,.\,.\,{\rm (B)} $$\end{document} in regions of nonrecirculating motion. The measurable functions aij and bij depend only on the system shape and laminar or turbulent velocity field. Formal expressions for a00 are given, and an expression for b00 in steady flows. These results agree well with data on mass transfer operations in tubes, packed beds, and fluid-fluid contactors.
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  • 179
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    AIChE Journal 33 (1987), S. 2057-2066 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A two-parameter, corresponding-states form for direct correlation function integrals in liquids is applied to many types of systems with one substance being supercritical. This gives a quantitative correlation for volumetric behavior, pure and mixed solvent Henry's constants, and Henry's Law deviations over wide ranges of conditions using only pure-component information and a single binary parameter. Details of the method and results are given for H2, N2, CO, CH4, and other gases in pure and mixed simple, polar, and aqueous solvents and coal oils. Because of its reliable predictive capability, the present approach can serve as a generator of data for parameter estimation by other models such as equations of state.
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  • 180
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    AIChE Journal 33 (1987), S. 2047-2056 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Data and finite-element simulations are presented for the blade coating of a series of Newtonian and non-Newtonian fluids. Numerical simulations for purely viscous fluids show good agreement with coating thickness data for Newtonian and relatively inelastic non-Newtonian liquids, including geometries for which lubrication theory is inaccurate. These simulations account for the shape of the free surface, with surface tension included, and incorporate realistic inflow and outflow boundary conditions. By comparing pressure distributions generated with the finite-element technique to those calculated using lubrication theory, it is shown that the simple lubrication theory analysis suffers from inadequate inflow and outflow boundary conditions. Comparison of these simulations with new experimental results for three well-characterized viscoelastic liquids, having nearly identical steady shear viscosities but different normal stress behavior, confirms speculations of earlier work with respect to the effect fluid rheology has on coating thickness.
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    AIChE Journal 33 (1987), S. 2067-2076 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A detailed kinetic model for the bulk styrene polymerization initiated by symmetrical diperoxyester bifunctional initiators is presented. When chain termination occurs via a combination termination mechanism, six distinct polymeric species are identified in accordance with the nature of the polymer end units. It is shown that the unequal thermal decomposition characteristics of the peroxides of the bifunctional initiator system lead to the formation of polymers having considerably higher molecular weight than those obtained by the monofunctional intiator systems. It has also been found that high monomer conversion, high molecular weight, and narrow molecular weight distribution can be obtained simultaneously by using the bifunctional initiators at high reaction temperatures. This is due to the reinitiation and propagation of inactive polymers carrying undecomposed peroxides. The molecular-weight-increasing effect of the bifunctional initiator is more pronounced at high reaction temperatures. The new possibilities of increasing the monomer conversion and controlling the polymer molecular weight properties more effectively through the use of bifunctional initiators are discussed.
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    AIChE Journal 33 (1987), S. 2080-2083 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 5 Ill.
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    AIChE Journal 33 (1987), S. 2077-2079 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 3 Ill.
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    AIChE Journal 33 (1987), S. 2084-2086 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 2 Ill.
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    AIChE Journal 33 (1987), S. 2087-2090 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
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    AIChE Journal 33 (1987), S. 2091-2092 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
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    AIChE Journal 33 (1987), S. 2092-2093 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
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    AIChE Journal 33 (1987), S. 2092-2092 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
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    AIChE Journal 33 (1987), S. 2093-2093 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
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  • 190
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    AIChE Journal 33 (1987), S. 2094-2094 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
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    AIChE Journal 33 (1987), S. 2095-2096 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
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  • 193
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    AIChE Journal 33 (1987), S. 2096-2096 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
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    AIChE Journal 33 (1987), S. 2094-2095 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
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    AIChE Journal 33 (1987), S. 2096-2097 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
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  • 197
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 33 (1987), S. 2097-2097 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 198
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 33 (1987), S. 2098-2100 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 199
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 33 (1987), S. 1187-1196 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A model including the effects of diffusion and convection can be used to predict the etch rate of crystalline silicon in a plasma discharge of nitrogen trifluoride. The case of a radial flow reactor with crystalline silicon wafers located at discrete positions can be solved using a finite-element solution to a boundary value problem. Such a model is useful to predict the effects of pressure, flow rate of etchant gas, percent silicon exposed, and wafer position on both inter-and intrawafer etch rates. It was found from modeling that greater uniformity in etch rate is achieved by lowering the pressure and percent exposure of silicon, and to a lesser degree the volumetric flow rate.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
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  • 200
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 33 (1987), S. 1207-1211 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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