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  • Articles: DFG German National Licenses  (10)
  • 2005-2009
  • 1990-1994  (6)
  • 1970-1974  (4)
  • 1955-1959
  • 1990  (6)
  • 1971  (4)
Source
  • Articles: DFG German National Licenses  (10)
Material
Years
  • 2005-2009
  • 1990-1994  (6)
  • 1970-1974  (4)
  • 1955-1959
Year
  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 94 (1990), S. 3040-3045 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 123 (1990), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on the growth and DNA synthesis of cultured human keratinocytes obtained from involved and uninvolved psoriatic epidermis and normal epidermis were studied. Treatment with 10-8m and 10-7m of 1,25(OH)2D3 inhibited cell growth as follows: 58.5±19.3% and 21.3±13.6% in normal keratinocytes (n=6); 43.8±22.8% and 17.8±12.3% in psoriatic uninvolved keratinocytes (n=4); 51.7±18.2% and 13.2±6.4% in psoriatic involved keratinocytes (n=6). Inhibition was virtually complete at 10-6m. DNA synthesis was also inhibited by 10-8m, 10-7m and 10-6m of 1,25(OH)2D3 as follows: 70.0±8.3%, 59.0±6.8% and 16.7±4.0%, respectively, in normal keratinocytes (n=3); 78.5±13.5%, 51.5±25.5% and 24.5±21.5%, respectively, in psoriatic uninvolved keratinocytes (n=2); and 69.3±14.5%, 41.3±19.1% and 14.8±11.2%, respectively, in psoriatic involved keratinocytes (n=4). These results indicate that 1,25(OH)2D3 functions as a growth inhibitor for cultured human keratinocytes derived from both normal and psoriatic skin.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Der Effekt von sechsβ-adrenergischen Blockierungsmitteln auf Akonitin-Arrhythmia bzw. Ouabain-Arrhythmia wurde mittels i.v. Verabreichung vergleichend untersucht. Reihenfolge der Wirksamkeit auf Akonitin-Arrhythmia: Propranolol〉MJ 1999〉LB 46〉H 56/28, ICI 50172 und DCI, und dieselbe auf Ouabain-Arrhythmia: Propranolol, LB 46 und H 56/28 gleichwertig, MJ 1999 und ICI 50172 wirkungslos.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 240 (1971), S. 349-364 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Kleine protoplasmatische Körnchen, welche in verschiedenen verhornenden Epithelien gefunden worden sind und als der Zellmembran aufliegende Körnchen oder Keratinosome bezeichnet wurden, konnten durch Phospholipase C gespalten werden. Körnchen, die in die intercellulären Zwischenräume abgestoßen waren, waren gleichfalls durch Phospholipase C spaltbar. Da angenommen wird, daß Phosphatide einen Teil der intercellularen Kittsubstanz bilden, nicht nur in der Haut, sondern auch in anderen eng zusammengefügten Epithelien, wird die Bezeichnung „Kittkörnchen“ oder „Kittkörper“ für diese Körnchen vorgeschlagen.
    Notes: Summary Small cytoplasmic granules, which have been found in various keratinizing epithelia and called the membrane-coating granules or keratinosomes, were found to be amenable to phospholipase C digestion. Granules discharged into the intercellular spaces could also be digested with phospholipase C. Since it is believed that phospholipids are part of the intercellular cement not only in the skin but in other tightly junctioned epithelia, the name “cement granule” or “cementsome” was proposed for these granules.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 240 (1971), S. 1-22 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Nagelzellen, die von den ventralen, apikalen und dorsalen Anteilen der proximalen Matrix gebildet wurden, rückten in axial-distaler Richtung vorwärts, bis sie amproximalen Verhornungspunkte zusammentrafen. Von diesem Punkte an wurden der proximalen Nagelplatte ununterbrochen Zellen von der ventralen und dorsalen Matrix und vom Nagelbett zugefügt. Bald hörte die dorsale Matrix auf, Nagelzellen zu entwickeln und wurde weiter distal in den hinteren Nagelfalz umgewandelt. Mit der differentialen Phasenkontrast-Apparatur von Zeiss-Nomarski konnte man die Teilung der proximalen Nagelplatte in eine ventrale und dorsale Hälfte erkennen. Nächst der Lunula entwickelte das Nagelbett noch eine weitere deutliche Schicht unter der proximalen ventralen Schicht. Elektronmikroskopisch zeigten alle Nagelzellen, ohne Rücksicht auf ihren Ursprung, Verhornung durch Anhäufung von Fibrillen ohne Bildung von Keratohyalinkörnern. Membrane-coating granules (MCG) entstanden in reichlicher Menge. Sie wurden abgestoßen und bildeten die intercellulßre Kittsubstanz. Das abgestoßene Material erweiterte einige der engen Membranspalten, während es gewöhnliche, klaffende (nicht-spezifische) Zellgrenzen verengte und dadurch 150–180 Å weite intercelluläre Zwischenräume bildete, nämlich dieengen Zellverkittungen. Die engen Zellverkittungen stellten den häufigsten Typ der intercellulären Anlagerung dar, wodurch die verhornten Nagelzellen zusammengehalten wurden. Die dicke Zellhülle der verhornten Zellen, nämlich dasGrenzband, wurde durch Niederschlag von dichtem Material an der protoplasmatischen Seite der Zellmembran gebildet und nicht durch die membrane-coating granules.
    Notes: Summary The nail cells produced in the ventral, apical and dorsal portions of the proximal matrix moved in axiodistal direction to meat together at theproximal point of keratinization. The proximal nail plate from this point on was added continuously by the cells from ventral matrix and nail bed. Dorsal matrix soon ceased to produce nail cells and further distally transformed into the posterior nail fold. With Zeiss-Nomarski differential interference contrast equipment, the proximal nail plate could be divided into the ventral and dorsal halves. Near the lunula the nail bed produced one more distinct layer beneath the proximal ventral layer. Electron miscroscopically all nail cells regardless of their origins were seen keratinizing by accretion of tonofibrils without formation of keratohyaline granules. Membrane-coating granules (MGG's) were produced in abundance. They were discharged and provided the intercellular cement. The discharged material widened some of the gap junctions while it tightened nonspeccific junctions to produce 150–180 Å intercellular spaces, i.e. thenarrow junctions. The narrow junctions were the most common type of intercellular junction connecting the keratinized nail cells. The thick cellular envelope of the keratinized cells, i.e. themarginal band, was formed by a precipitation of dense material on the cytoplasmic side of the plasma membranes and not by discharged MCG's.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 347 (1990), S. 658-660 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Two types of reversible processes, photochemical cis-trans isomerization (see, for example, ref. 3) and electrochemical oxidation-reduction4, are available in an azobenzene system.FIG. 1 Cyclic voltammograms of trans (dashed line) and cis (solid line) ABD monolayer films on a Sn02 glass electrode. ...
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 28 (1971), S. 1-11 
    ISSN: 1432-1246
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neurological and electrophysiological examination of 15 workers handling acrylamide in a factory revealed abnormal signs of peripheral nerve functions in all cases. Neurological abnormalities were: absent deep reflexes, decreased superficial sense and suppressed vibration sense. Action potentials in median nerve and tibial nerve were greatly reduced while conduction velocity was not greatly affected. Long-experienced workers had various complaints with ataxic gait and showed abnormal EEG.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1433-0350
    Keywords: Recurrence ; Low-grade glioma ; Children ; Malignant transformation ; Computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recurrent low-grade gliomas in children were studied with special reference to correlation between the computed tomography (CT) scan and pathological findings at recurrence. During the past 16 years (1970–1986) 105 cases of primary pediatric brain tumors were treated in our hospital. Seventeen of these had low-grade glioma, seven of which (five astrocytomas, one ependymoma, and one subependymoma) had recurrence of tumor by the end of 1987. The enhanced CT findings were classified into three types — cystic, false cystic, and solid, according to Lapras' classification. The pathological findings of recurrent tumors were reviewed with particular attention to malignant transformation. The results showed that in two out of three cases where CT findings had changed from initial cystic to solid type at recurrence malignant transformation was revealed. Enhanced CT scan was also useful for detecting small asymptomatic recurrent tumors in children. On the other hand, surgical procedures and adjuvant therapies demonstrated no significant relationship with recurrence. It is suggested that the recurrence of low-grade glioma in children is not rare, and that changes in findings on contrast enhanced CT might reflect malignant transformation in a recurrent tumor, necessitating a careful follow-up.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Colloid & polymer science 268 (1990), S. 460-468 
    ISSN: 1435-1536
    Keywords: Spinnability ; viscoelasticsurfactantsolution ; tetradecyltrimethylammoniumsalicylate ; hexadecyltrimethylammonium salicylate ; rodlikemicelle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The spinnability was measured for aqueous viscoelastic solutions of tetradecyl- and hexadecyltrimethylammonium salicylates (C14TASal, C16TASal) in the absence and presence of sodium salicylate (NaSal) and sodium bromide (NaBr). The spinnability is classified into two types, D and C. While the intrinsic drawing length in type D is proportional to the drawing velocity, the drawing intrinsic length in type C decreases with the drawing velocity or is independent of it. The spinnability changes from type D to C, as the drawing velocity and the surfactant concentration increase, and the temperature lowers. The effect of salt is different between NaSal and NaBr. It can be assumed that a pseudo-network structure composed of rod-like micelles is formed in viscoelastic and spinnable surfactant solutions. Then, the spinnability depends on the balance between the elasticity and the viscosity in which the structure results.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of comparative physiology 160 (1990), S. 233-239 
    ISSN: 1432-136X
    Keywords: Temperature ; Acclimation ; Myosin ; Myosin heavy chain ; ATPase activity ; Carp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Myosins were isolated from dorsal ordinary muscles of carp acclimated to 10°C and 30°C for a minimum of 5 weeks and examined for their ATPase activities. Ca2+-ATPase activity was different between myosins from cold-and warm-acclimated carp, especially at KCl concentrations ranging from 0.1 to 0.2 M, when measured at pH 7.0. The highest activity was 0.32 μmol Pi·min-1·mg-1 at 0.2 M KCl for cold-acclimated carp and 0.47 μmol Pi·min-1·mg-1 at 0.1 M KCl for warm-acclimated fish. The pH-dependency of Ca2+-ATPase activity at 0.5 M KCl for both carp was, however, similar exhibiting two maxima around 0.3 μmol Pi·min-1·mg-1 at pH 6 and 0.4 μmol Pi·min-1·mg-1 at pH 9. K+(EDTA)-ATPase activity at pH 7.0 neither exhibited differences between both myosins. It increased with increasing KCl concentration showing the highest value of about 0.4 μmol Pi·min-1·mg-1 at 0.6–0.7 M KCl. Actin-activated myosin Mg2+-ATPase activity was markedly different between cold-and warm-acclimated carp. The maximum initial velocity was 0.53 μmol Pi·min-1·mg-1 myosin at pH 7.0 and 0.05 M KCl for cold-acclimated carp, which was 1.6 times as high as that for warm-acclimated carp. These differences were in good agreement with those obtained with myofibrillar Mg2+-ATPase activity between both carp. No differences were, however, observed in myosin affinity to actin. Differences in myosin properties between cold- and warm-acclimated carp were further evidenced by its thermal stability. The inactivation rate constant of myosin Ca2+-ATPase was 25·10-4·s-1 at 30°C and pH 7.0 for cold-acclimated carp, which was about 4 times as high as that for warm-acclimated carp. Light chain composition did not differ between both carp myosins. The differences in a primary structure of the heavy chain subunit was, however, clearly demonstrated between both myosins by peptide mapping.
    Type of Medium: Electronic Resource
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