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  • 1
    Electronic Resource
    Electronic Resource
    Phenytoin as a liquid material for embolisation of tumours (1999)
    Springer
    Neuroradiology 41 (1999), S. 320-323 
    Details
    ISSN: 1432-1920
    Keywords: Key words Meningioma ; embolisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We carried out embolisation with phenytoin in seven patients with meningiomas; in three by cannulation of the middle meningeal artery during surgery and in four by microcatheter introduced into the middle meningeal artery. Phenytoin (125–500 mg) diluted with saline (25 mg/ml) was injected slowly as a bolus. There was no evidence of devascularisation in two meningiomas treated with 125 mg and 150 mg of phenytoin. Large areas of ischaemic and haemorrhagic necrosis were found in five meningiomas treated with 250–500 mg. After embolisation, the tumour blush disappeared, with preservation of the feeding arteries. Total resection of the tumour was performed with minimum blood loss. Caution and proper use are emphasised to avoid increase in tumour volume and reflux. Phenytoin could be a suitable material for superselective embolisation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050756
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  • 2
    Electronic Resource
    Electronic Resource
    Lectin-binding sites of the human pituitary adenoma cells by means of the ferritin-labeling technique (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 67-74 
    Details
    ISSN: 1432-0533
    Keywords: Ferritin labeled lectin ; Human pituitary adenoma ; Functioning adenoma ; Non-functioning adenoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lectin-binding sites of the human pituitary adenoma cells were examined by electron microscopy in correlation with their functional states. In this study used were 37 cases of the human pituitary adenomas which had been operated in our clinics from 1977 to 1979. They were divided into four groups: 13 cases of PRL-producing adenomas, nine of hGH-producing adenomas, three of ACTH-producing adenomas, and 12 of hormonal non-functioning adenomas. In parallel with the detection of the lectinbinding sites by means of the ferritin-labeling method, the basal levels of their secreting hormones were determined by the radioimmunoassay technique, and their producing hormones were characterized light microscopically by the immunocytochemical HRP-labeling technique. The present study clearly shows that the ferritinlabeled, lectin-binding sites of the human pituitary adenoma cells prefixed with aldehyde are different in number between PRL- or hGH-producing adenoma cells and non-functioning ones. Morphologically resemblin, non-functioning adenoma cells and mixed somatotrophic and lactotrophic adenoma cells are definitely distinguished from each other by the findings of the ferritin-labeled RCA-binding sites' distribution pattern. Lectins have been proved very useful to evaluate the membrane characteristics of the human pituitary adenoma cells in association with their functional states.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691184
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  • 3
    Electronic Resource
    Electronic Resource
    Current Treatment Strategies and Factors influencing Outcome in Patients with Bacterial Brain Abscess (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 1263-1270 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Brain abscess; infection; mortality; outcome; intraventricular rupture of brain abscess.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  We clearly determined the key to managing patients with brain abscess by retrospectively evaluating the factors affecting poor outcome in these patients. This study included 113 patients with brain abscess diagnosed in the CT era. Basic characteristics and therapeutic parameters were estimated as independent predictors of poor outcome by using univariate and multivariate logistic regression analysis. Patients with poor outcomes more frequently had deeply-located abscesses (p〈0.02), IVROBA (intraventricular rupture of brain abscess) (p〈0.001) and were in a severely deteriorated neurological state (p〈0.001) than those with good outcomes. Multiple logistic regression analysis predicted that IVROBA (ORs, 24.5; 95% CI, 3.04 to 197.9) and severely deteriorated cases (ORs, 13.7; 95% CI, 2.34 to 80.8) resulting from IVROBA increased the relative risk of poor outcome. Patients with IVROBA more frequently had also deeply-located abscesses (p〈0.005), positively immunocompromised states (p〈0.05) an (p〈0.003) than those without IVROBA. Patients with metastatic abscess had also IVROBA (p〈0.006). Multiple logistic regression analysis anticipated that deeply-located abscess (ORs, 3.90; 95% CI, 1.38 to 11.04), and metastatic abscess (ORs, 12.26; 95% CI, 1.35 to 111.2) increased the relative risk of IVROBA. Patients in an obtunded state and with marked neurological deficit had IVROBA more often than patients in an alert state and/or mild neurological deficit (ORs, 3.23; 95% CI, 1.17 to 8.86, (p〈0.03) before treatment. Our findings suggest that IVROBA strongly influences poor outcome in patients with brain abscess. The key to decreasing poor outcomes may be the prevention and management of IVROBA, by evaluating intracranial pressure pathophysiology. IVROBA should be aggressively treated by aspiration methods for the abscess coupled with appropriate intravenous and intrathecial administration of antibiotics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050248
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  • 4
    Electronic Resource
    Electronic Resource
    Thrombin Activity in CSF after SAH is Correlated with the Degree of SAH, the Persistence of Subarachnoid Clot and the Development of Vasospasm (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 579-584 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Fibrinopeptide; subarachnoid haemorrhage; thrombin; vasospasm.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  We previously reported that the coagulation system in cerebrospinal fluid (CSF) is strongly activated in the early stage of a subarachnoid haemorrhage (SAH). We evaluated the relationship among thrombin activity, degree of SAH, amount of clearance of SAH, and vasospasm. The CSF levels of fibrinopeptide A (FPA) were measured by radio-immunoassay in 36 SAH patients, who were diagnosed by computerized tomography (CT) within 12 hours and on whom surgery was performed within 48 hours. Clearance of SAH (%) was evaluated as the size of the clot in the basal cistern visualized between the initial and postoperative CT. The mean level of FPA in the patients of Group 3 (Fisher's CT classification) (182.2 ng/ml) was significantly higher than those in the patients of Group 2 (36.2 ng/ml). There was a significant difference in the mean level of FPA between patients with (47.6 ng/ml) and without infarction (408.3 ng/ml). In 18 of the 27 patients of Group 3 for whom the clearance of the SAH was determined, the patients showing a lower clearance rate (〈50%) of SAH demonstrated a significantly higher rate of infarction and a significantly higher level of FPA (466.6 ng/ml) than did the patients with a higher clearance rate (〉50%) of SAH (79.2 ng/ml). These results suggest that, the thrombin activity in CSF is correlated with the degree of SAH, the persistence of subarachnoid clot and the development of vasospasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050143
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  • 5
    Electronic Resource
    Electronic Resource
    Anterior sacral meningocele discovered by whole body computerized tomography (1981)
    Springer
    Acta neurochirurgica 59 (1981), S. 267-272 
    Details
    ISSN: 0942-0940
    Keywords: Anterior sacral meningocele ; whole body computerized tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of anterior sacral meningocele which was clearly visualized on whole body computerized tomography is presented. Posterior surgical approach with ligation of the narrow communication between the sacral dural sac and the meningocele alleviated the subjective complaints of a feeling of abdominal distention and of dysuria. For the purpose of postoperative follow-up study, examination by whole body computerized tomography proved to be the best method of evaluating the size of the meningocele and also the state of neighbouring structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01406358
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  • 6
    Electronic Resource
    Electronic Resource
    Roles of subarachnoid blood clots and norepinephrine in cerebral vasospasm (1982)
    Springer
    Acta neurochirurgica 63 (1982), S. 277-280 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The content of norepinephrine (NE) in the ventricular, basal cisternal and lumbar cerebrospinal fluid (CSF) was determined in 19 patients with ruptured cerebral aneurysms. The cisternal CSF in patients with vasospasm contained a significantly higher level of NE (0.246 ± 0.049 ng/ml) compared with those without vasospasm (0.075 ± 0.001 ng/ml) (p 〈 0.001). However, this increase is not considered to be high enough to constrict cerebral arteries, unless there is an increased NE-sensitivity in subarachnoid haemorrhage. Vascular responses to NE in vivo were then studied after reversing blood-induced prolonged vasospasm of the rabbit's basilar artery through a transclival approach as well as a newly developed basal cisternal irrigation model. However, NE in molar concentrations between 1 × 10−10 and 10−2 failed to produce further contraction of the artery. In conclusion, the increase in NE with vasospasm might be only a secondary phenomenon, and not a causative factor of vasospasm. Early removal of subarachnoid blood clots seemed to prevent the development of vasospasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728882
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  • 7
    Electronic Resource
    Electronic Resource
    Superior sagittal sinus thrombosis treated with combined local thrombolytic and systemic anticoagulation therapy (1997)
    Springer
    Acta neurochirurgica 139 (1997), S. 332-335 
    Details
    ISSN: 0942-0940
    Keywords: Superior sagittal sinus thrombosis ; local thrombolytic therapy ; anticoagulation therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We recently encountered a patient with thrombosis of the superior sagittal sinus of an idiopathic cause. The patient was treated initially with combined local thrombolytic therapy through the burr hole over the superior sagittal sinus and systemic anticoagulant therapy. Continuous ventricular drainage and hyperbaric oxygenation therapy were used to control the increased intracranial pressure. The superior sagittal sinus was successfully recanalized. Whereas the patient suffered a complication with subacute subdural haematoma, he was successfully treated with the combination of these therapies. The rationale and approach are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01808829
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  • 8
    Electronic Resource
    Electronic Resource
    Chronic expanding epidural haematoma (1995)
    Springer
    Acta neurochirurgica 132 (1995), S. 150-153 
    Details
    ISSN: 0942-0940
    Keywords: Epidural haematoma ; chronic epidural haematoma ; chronic expanding haematoma ; haematoma membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An encapsulated fluid epidural haematoma in a 9-year-old boy was successfully evacuated by a simple burr hole procedure 5 months after a minor head injury. Clinicopathological findings suggested that chronic expansion of an initially unsuspected epidural haematoma occurred as a result of repeated haemorrhages from the haematoma membrane, resulting in an unusually long delayed appearance of clinical evidence. This case demonstrates that a chronic expanding process similar to that seen in chronic subdural haematoma needs to be considered as a possible complication of epidural haematoma and indicates an important role for the haematoma membrane in the chronic expansion of epidural haematoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01404865
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  • 9
    Electronic Resource
    Electronic Resource
    Localization of concanavalin A binding sites in human pituitary adenoma cells as revealed by HRP-labelling method (1983)
    Springer
    Acta neuropathologica 62 (1983), S. 59-66 
    Details
    ISSN: 1432-0533
    Keywords: Horseradish peroxidase ; Concanavalin A ; Human pituitary adenoma ; Functioning adenoma ; Non-functioning adenoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intracellular lectin (Con A)-binding sites of human pituitary adenoma were examined by electron microscopy using the horseradish-peroxidase (HRP)-labelling technique. In this study were used 16 cases of human pituitary adenomas operated on in our clinics between 1977 and 1981: they concluded 4 each of PRL-, GH-, ACTH-producing and hormonal non-functioning adenomas. In parallel with the detection of lectin-binding sites, basal levels of their secreting hormones were determined by the radioimmunoassay technique, and their producing hormones were characterized light microscopically by the immunocytochemical HRP-labelling technique. In the present study, for hormonal functioning adenoma cells, mature or large granules of each specific type of adenoma cells had no definite Con A-binding sites. On the other hand, immature or small secretory granules of RPL- or GH-producing adenoma cells showed a positive reaction with Con A. ACTH-producing adenomas so far examined revealed no definite binding sites. Some variable results were obtained concerning non-functioning adenomas. Lectins have been and will be very useful in the detection of different subtypes of adenomas in each specific group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684921
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  • 10
    Electronic Resource
    Electronic Resource
    Selective destruction of the outer leaflet of the capillary endothelial membrane after intracerebral injection of arachidonic acid in the rat (1982)
    Springer
    Acta neuropathologica 58 (1982), S. 303-306 
    Details
    ISSN: 1432-0533
    Keywords: Capillary endothelium ; Outer leaflet ; Mitochondria ; Arachidonic acid ; Vasogenic edema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A peculiar ultrastructural change of the cytoplasmic membrane is described. It concerns selective destruction of the outer leaflet of the luminal side of the capillary endothelium in the white matter of the rat brain. 30 min and 3h after intracerebral injection of arachidonic acid (AA). The cristae of the mitochondria disappeared in the endothelium of many capillaries. These changes were observed mainly in the central part of brain edema, where the extracellular space was markedly widened. The possible mechanism whereby these changes developed is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688614
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