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  • Articles: DFG German National Licenses  (8)
  • dog  (4)
  • crystal  (2)
  • enterohormones  (2)
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  • Articles: DFG German National Licenses  (8)
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Keywords
  • 1
    Electronic Resource
    Electronic Resource
    The mechanism of insulin secretion after oral glucose administration (1977)
    Springer
    Diabetologia 13 (1977), S. 269-272 
    Details
    ISSN: 1432-0428
    Keywords: Insulin secretion ; oral glucose ; reflex insulin secretion ; portal vein ; dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Concentrations of immunoreactive insulin activity and of blood glucose were measured in portal and peripheral venous blood in six conscious dogs after oral administration of 1.0 g/kg glucose. Portal venous samples were obtained either by chronic catheterization or by direct puncture of the portal vein through a London-cannula. Portal venous IRI was already significantly increased 5 min after the onset of the stimulus. Peripheral venous IRI pattern reflected this early increase, but the peripheral venous blood glucose level was unchanged. The results indicate that the early peripheral venous IRI increase reflects a pancreatic insulin secretory reflex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01219711
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The Mechanism of Insulin Secretion after Oral Glucose Administration (1972)
    Springer
    Diabetologia 8 (1972), S. 111-116 
    Details
    ISSN: 1432-0428
    Keywords: Oral glucose tolerance ; insulin secretion ; reflex ; sham-feeding ; enterohormones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Des chiens éveillés et entraînés portant des fistules de l'oesophage ou de l'estomac ne présentent aucune élévation du sucre sanguin après alimentation simulée de glucose, néanmoins une augmentation considérablede la concentration insulinique dans le sang veineux périphérique apparaît. Celle-ci consiste en deux pics bref s entre la 5 e et la 10 e min et aussi entre la 15 e et la 25 e min. Ces deux pics apparaissent aussi après alimentation simulée d'eau potable, mais à un moindre degré. Leur ordre chronologique correspond aux pics précoces d'IRI que nous avons observés antérieurement, après administration orale de glucose chez des animaux intacts, avant l'élévation glycémique réelle. Après application de glucose dans l'ouverture aborale de la fistule chez des animaux portant une fistule de l'oesophage, il manque le premier pic d'IRI, le deuxième et le troisième pic (provoqués par résorption) apparaissent invariablement. Une insulino-sécrétion intensifiée, couplée à la prise de nourriture et induite par l'ingestion orale est suggérée et discutée dans le cadre de l'«entero-insular axis» du mécanisme de l'insulino-sécrétion.
    Abstract: Zusammenfassung Wache trainierte Hunde mit doppelläufigen Fisteln des Oesophagus oder des Magens zeigen nach Scheinfütterung mit Glucose keinen Blutzucker -anstieg, aber eine sichere Erhöhung des immunchemisch gemessenen Seruminsulins im peripheren Venenblut. Es wurden zwei kurzzeitige Peaks zwischen der 5. und 10. sowie der 15. und 25. min beobachtet. In geringerem Ausmaß fanden sich diese beiden Peaks auch nach Scheinfütterung mit Leitungswasser. Sie entsprechen in ihrer zeitlichen Anordnung den von uns früher beobachteten frühen Insulingipfeln nach oraler Glucosegabe an intakte Tiere vor dem eigentlichen Blutzuckeranstieg. Bei Glucoseverabfolgung in die aborale Fistelöffnung von Oesophagusfistelträgern fehlt der erste IRI-Gipfel, der zweite und der dritte (resorptionsbedingte) sind unverändert ausgeprägt. Es wird eine von Rezeptoren der Mundhöhle ausgelöste Vorwärtskopplung der Insulinsekretion bei oraler Verabfolgung stimulierender Substanzen angenommen und im Rahmen der „enteroinsulinären Achse“ des Insulininkretionsmechanismus diskutiert.
    Notes: Summary After sham-feeding of glucose, conscious trained dogs bearing double-barrelled fistulas of the oesophagus or of the stomach do not show any blood sugar increase. Nevertheless their IRI-levels in the peripheral venous blood increased considerably. This increase consists of two peaks of short duration between the 5th and the 10th as well as the 15th and the 25th min. Such IRI-peaks oceured also after sham-feeding of tap water, but to a smaller extent. Their temporal order corresponds to the early IRI-peaks after oral glucose administration in intact animals, but before the blood glucose increase which was observed by us previously. After the application of glucose into the oral opening of the oesophageal fistula the first IRI-peak does not occur, the second and the third peaks appeared to the same extent. A feed-forward of insulin secretion induced by oral ingestion is suggested. It may be interpreted within the scope of the “entero-insular axis” of the mechanism of insulin secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01235635
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The Mechanism of insulin secretion after oral glucose administration (1972)
    Springer
    Diabetologia 8 (1972), S. 104-110 
    Details
    ISSN: 1432-0428
    Keywords: Oral glucose tolerance test ; insulin secretion ; feed-forward ; enterohormones ; N.vagus ; reflex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Chez des chiens-bergers éveillés et entraînés, après administration orale de glucose, la concentration d'IRI dans le sang veineux périphérique augmente déjà alors que la glycémie n'a pas encore changé. Après un ou deux pics durant les vingt premières minutes, l'IRI augmente parallèlement au glucose sanguin. Comparativement à l'injection intra-veineuse de glucose, le maximum d'IRI, après administration orale, se produit plus tôt. De plus, le quotient des surfaces d'IRI et de glycémie est élevé. Sans aucun changement du glucose sanguin, la concentration d'IRI augmente avec un ou deux pics après administration orale d'eau potable. Ces pics correspondent aux deux premiers pics après administration orale de glucose. Ces résultats sont discutés dans le sens d'une sécrétion d'insuline précédant la digestion via N.vague et via entérohormones. Il faut accorder plus d'attention à l'évolution d'IRI durant la première phase du test de tolérance au glucose par voie orale.
    Abstract: Zusammenfassung Bei wachen trainierten Schäferhunden steigt die Insulinkonzentration im peripheren Venenblut nach oraler Glucosegabe schon zu einem Zeitpunkt an, da die Glykämie noch nicht verändert ist. Nach Durchlaufen von 1 oder 2 Gipfeln in den ersten 20 min tritt der Anstieg ein, der parallel dem Blutzuckergipfel verläuft. Im Verhältnis zur intravenösen Glucosegabe liegt das erste IRI-Maximum nach oraler Verabfolgung zeitlich früher. Auch ist der Quotient aus IRIÜberschreitungsfläche und Blutzuckerüberschreitungsfläche erhöht. Ohne daß es zu einer Blutzucker Veränderung kommt, steigt auch nach oraler Gabe von Leitungswasser die IRI-Konzentration 1-oder 2gipflig an. Diese Gipfel entsprechen den beiden ersten Erhöhungen nach oraler Glucosegabe. Die beobachteten Phänomene werden im Sinne einer Vorwärtskopplung der Insulinsekretion nach Nahrungsaufnahme via N.vagus und Enterohormone diskutiert. Der Beurteilung des IRI-Verlaufs in der frühen Phase des oralen Glucosetoleranztests sollte größere Beachtung geschenkt werden.
    Notes: Summary In conscious trained dogs (Alsatians) the IRI-concentration in the peripheral venous blood after oral administration of glucose increases when the blood glucose is still unchanged. After one or two peaks during the first 20 min IRI increases parallel to the blood sugar increase. In relation to the intravenous injection of glucose the IRI maximum after oral administration occurs earlier. Furthermore the ratio of the IRI to blood sugar areas is raised. Without any blood sugar change the IRI concentration after oral application of tap water increases with one or two peaks. These peaks correspond to the first peaks after oral administration of glucose. These findings are discussed in the sense of a “feed-forward” of insulin secretion after feeding via N.vagus as well as via enterohormones. More attention should be payed to the IRI course during the early phase of the oral glucose tolerance test.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01235634
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A physiological solvent for crystalline insulin (1981)
    Springer
    Diabetologia 20 (1981), S. 51-53 
    Details
    ISSN: 1432-0428
    Keywords: Insulin ; crystal ; dissolution ; bicarbonate ; pH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Insulin is insoluble in water at physiological pH, but dissolves relatively rapidly in plasma. To quantify the ability of various solutions to dissolve crystalline insulin, a simple assay measuring dissolution time was developed. At pH 7.5 and room temperature, distilled water, 0.154 mol/1 NaCl, Ringer's lactate solution, and 5% albumin in 0.154 mol/1 NaCl did not dissolve insulin crystals within 30 min. Normal postprandial human plasma and a proteinfree cell culture medium dissolved insulin crystals within 3 to 8 min. This ability was inhibited by acid titration of the fluids to a stable pH of 6.30, at which point bicarbonate depletion could be implied. Repletion of bicarbonate did restore the ability of these solutions to dissolve insulin crystals, but back-titration to the initial pH with NaOH did not. The effect of sodium bicarbonate alone was strongly concentration dependent above 23 mmol/1. We suggest that the ability of physiological fluids to dissolve insulin crystals at normal pH depends on their bicarbonate content. The ability to dissolve insulin with a physiological solvent which prevents its reaggregation promises to facilitate its use in portable pumping systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253817
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    A physiological solvent for crystalline insulin (1981)
    Springer
    Diabetologia 21 (1981), S. 51-53 
    Details
    ISSN: 1432-0428
    Keywords: Insulin ; crystal ; dissolution ; bicarbonate ; pH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Insulin is insoluble in water at physiological pH, but dissolves relatively rapidly in plasma. To quantify the ability of various solutions to dissolve crystalline insulin, a simple assay measuring dissolution time was developed. At pH 7.5 and room temperature, distilled water, 0.154 mol/l NaCl, Ringer's lactate solution, and 5% albumin in 0.154 mol/l NaCl did not dissolve insulin crystals within 30 min. Normal postprandial human plasma and a protein-free cell culture medium dissolved insulin crystals within 3 to 8 min. This ability was inhibited by acid titration of the fluids to a stable pH of 6.30, at which point bicarbonate depletion could be implied. Repletion of bicarbonate did restore the ability of these solutions to dissolve insulin crystals, but back-titration to the initial pH with NaOH did not. The effect of sodium bicarbonate alone was strongly concentration dependent above 23 mmol/l. We suggest that the ability of physiological fluids to dissolve insulin crystals at normal pH depends on their bicarbonate content. The ability to dissolve insulin with a physiological solvent which prevents its raggregation promises to facilitate its use in portable pumping systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01789114
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    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    The effect of prehepatic insulin administration on alanine flux rates in diabetic dogs (1987)
    Springer
    Diabetologia 30 (1987), S. 402-408 
    Details
    ISSN: 1432-0428
    Keywords: Alanine metabolism ; insulin-dependent diabetes ; dog ; isotopic study ; portal insulin infusion ; artificial B cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The in vivo flux rates of glucose (6-3H-glucose) and of alanine (U-14C-alanine) were measured in insulin-dependent chronically diabetic dogs which were infused with insulin employing a bedside-type artificial B cell and either the peripheral or the portal venous route. In comparison with non-diabetic control animals the diabetic dogs had near-normal patterns of glucose metabolism and pancreatic glucagon regardless of the route of insulin administration. They also showed reduced basal portal but moderately elevated peripheral insulin levels on peripheral and near-normal peripheral values on portal insulin infusion. Both concentration and production rates of alanine were reduced on peripheral (0.142±0.016mmol/l, 4.73±0.49 μmol·kg−1·min−1, p〈 0.05) but normal on portal insulin (0.206±0.030 mmol/l, 6.33±0.63 μmol·kg−1 ·min−1). The alanine clearance was slightly elevated or normal in the diabetic dogs, and the glucose production from alanine showed a strongly delayed response to an exogenous glucose load on either route of insulin administration. It is concluded that the peripheral hyperinsulinism during posthepatic insulin administration stimulates glucose utilisation to a normal extent, but inhibits the provision of amino groups in resting muscle. Alanine synthesis is thereby reduced, and the carbon moieties are shunted from glucose into circulating lactate. Long-term studies are needed to elucidate the role of the liver under these conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00292542
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Alterations in alanine metabolism in diabetic dogs during short-term treatment with an artificial B cell (1985)
    Springer
    Diabetologia 28 (1985), S. 763-768 
    Details
    ISSN: 1432-0428
    Keywords: Artificial B cell ; dog ; experimental diabetes ; alanine metabolism ; gluconeogenesis ; tracer study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The flux rates of plasma glucose and alanine were studied isotopically (6-3H-glucose and U-14C-alanine simultaneously) in resting chronically diabetic dogs during short-term treatment with an artificial B cell where the insulin was infused into a peripheral vein. Despite perfect blood glucose control and normal glucose flux rates, the concentration and rates of appearance and disappearance of alanine were significantly elevated in the diabetic animals before, during and after an exogenous glucose load. The incorporation of the carbon moiety of alanine into circulating glucose was also increased, but diminished to a near-normal extent when exogenous glucose was given. The plasma clearance rates for alanine in the diabetic dogs were normal throughout the study. It is concluded that normal blood glucose control in diabetes does not necessarily mean normalization of the entire metabolic network. On the basis of peripheral hyperinsulinaemia alanine formation from glucose and branched chain amino acids is elevated in muscle. This may explain increased flux of alanine despite normal blood glucose control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265025
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Estimation of pancreatic IRI output rate and its relation to glucose tolerance in normal anaesthetized dogs (1975)
    Springer
    Diabetologia 11 (1975), S. 291-299 
    Details
    ISSN: 1432-0428
    Keywords: Insulin secretion rate ; pancreatic blood flow ; mathematic model ; IRI concentration ; blood glucose ; glucose assimilation ; dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pancreaticoduodenal and portal venous blood flows were recorded electromagnetically in anaesthetized dogs. Blood glucose and IRI were measured in the arterial, portal, and peripheral venous as well as in the intestinal venous blood. By a mathematical model the actual net IRI output of the whole pancreas was estimated. Under basal conditions it is 10.2±2.4 mU/min (n = 30; 26 kg mean body wt). After i.v. glucose injection, IRI output is rapidly enhanced. The biphasic nature of this reaction was unequivocally demonstrated by consideration of the ratio IRI output: blood glucose. Pancreaticoduodenal blood flow increases transiently in relation to the increased blood glucose concentration. The IRI secretion rate is well correlated with the blood glucose concentration and to the amounts of glucose or of blood reaching the whole pancreas. It is also correlated with the portal IRI concentration. The overall peripheral venous or arterial IRI concentrations are correlated with the IRI secretion rate, but not in all individual experiments. The different phases of IRI output (basal rate, stimulated output 1–10 min and 10–60 min) show no influence on each other, nor are they correlated with the peripheral IRI concentration area. Basal IRI output is negatively correlated with the glucose assimilation constants. These constants or the peripheral B G areas, however, are independent of the stimulated IRI output rate. However, both the assimilation constants and the peripheral BG areas are related to the peripheral IRI concentration areas. Hepatic uptake of insulin and dynamics of pancreatic blood flow seem to contribute considerably to the estimated correlation pattern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422394
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    Paper (German National Licenses)
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