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  • 1
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 75 (1994), S. 2189-2193 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We present the results of luminescence studies for free-standing CdZnS/ZnS strained layer superlattices (SLSs). The band discontinuity is estimated by an analysis of the luminescence results in terms of a finite-potential well model. CdZnS/ZnS SLSs are grown by metal-organic vapor phase epitaxy at 350 °C on (100) GaAs. Photoluminescence (PL) measurements of the CdZnS/ZnS SLS at 1.4 K show intense, sharp excitonic emission in the blue-ultraviolet spectral region. With decreasing CdZnS well width, the PL peaks shift to higher energy. The quantum transition energies are calculated, including the effect of exciton binding energy and elastic strain. A free-standing SLS is assumed. In a Cd0.3Zn0.7S/ZnS SLS, the analysis of the data yields a zero-stress band discontinuity of ΔEc=461 meV and ΔEv=88 meV, which is in extremely good agreement with the data calculated from Harrison's model (465 and 84 meV, respectively). The band discontinuity over the entire Cd composition range is also estimated.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The reflectivity of commercially available vacuum-evaporated platinum mirrors in photon energy was measured from 1.8–8 keV. The measured reflectivity was compared with that calculated using a graded refractive index model. For the two mirrors measured, assuming an rms surface roughness of 1.6 and 3.4 nm gave good fit of the measured to calculated reflectivity. These values are almost identical to the roughness measured by scanning tunneling microscopy. Using this model, the reflectivity of conventional vacuum-evaporated platinum mirrors in the few-keV range could be explained.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0568
    Keywords: Key words α-Smooth muscle actin ; Chronological changes ; Smooth musculature ; Chick ; Ileum ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The genesis of intestinal smooth muscle layers was immunohistochemically investigated by use of an antibody to α-smooth muscle actin (α-SMA) in the developing chick ileum. Myoblast cells positive for α-SMA were already found in the presumptive circular muscle layer on E 8.5. On E 11.5 radially oriented muscle fibers were protruded from the outermost layer of the developing circular musculature and then formed a tuft-like aggregates. These radial muscle bundles were bent into an L-shape. The long distal extension of muscle bundles run parallel to the long axis of the ileal loop and developed into the longitudinal muscle layer. The obliquely oriented muscle fibers, locating at the intermuscular space of the muscularis propria, probably are to be considered a remnant of the short extension of radial muscle bundles. The muscularis mucosae was formed by the processes equivalent to the genesis of longitudinal muscle layer. On E 14.5 centripetally oriented muscle fibers emerged from the innermost layer of circular musculature. The long distal extension of centripetal fibers lay along the inner surface of developing circular musculature. On E 19.5 the longitudinal muscle layer of the muscularis mucosae was newly formed by separating from the circular musculature. The villous myoblast cells initially developed from the innermost layer of the muscularis mucosae on E 18.5, and were widely distributed in the lamina propria mucosae on E 20.5. Temporal and chronological pattern in expression of α-SMA was observed during the development of the chick intestinal smooth muscle. By E 14.5 the entire layer of the muscularis propria was intensely immunostained for α-SMA, but from E 15.5 onward the staining intensity gradually began to decrease from the outer half of the circular musculature. Finally, the immunoreactivity was localized in the inner layer of circular muscle and the longitudinal muscle layer. A possible functional role of this inner layer of circular muscle is discussed.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0533
    Keywords: Neuropeptide Y ; Immunohistochemistry ; Hirschsprung's disease ; Aganglionosis ; Man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The localisation and distribution of neuropeptide Y (NPY)-like immunoreactivity were studied by use of immunohistochemical methods in gut tissues from 19 patients with Hirschsprung's disease, including 4 cases of long segment aganglionosis. In the normoganglionic segment, immunoreactive cell bodies and nonvaricose processes were seen within both myenteric and submucous plexuses. A scarce supply of varicose fibres was found in the lamina propria mucosae, muscularis mucosae and longitudinal muscle layer. NPY fibres were more frequently encountered in the circular muscle layer, although with a weakly immunostaining intensity. In addition, blood vessels in the submucosal connective tissue were surrounded by a typical plexus of varicose, NPY-positive fibres. Immunoreactive endocrine cells could be detected in the colonic epithelium. In the aganglionic segment, numerous nerve fasciculi comprising a small to moderate number of NPY fibres with varicosities were observed throughout the entire layer of the colonic wall. A few varicose, NPY-positive fibres were also contained in the relatively large, hypertrophic nerve fasciculi located in the intermuscular zone and submucosal connective tissue. NPY-immunoreactive fasciculi were more densely distributed in the distal aganglionic segment than in the proximal aganglionic one. On the other hand, the distribution of NPY-positive fibres in long segment aganglionosis was quite different from that in short segment type; in cases of long segment type, no immunoreactive nerve fibres were detected within the circular muscle layer of the proximal aganglionic segment near the oligoganglionic segment and only a few fibres were observed within the hypertrophic nerve bundle of the intermuscular zone. The present results suggest that NPY-like immunoreactive nerves in the human colon have a dual origin of intrinsic and extrinsic elements. The origin and nature of extrinsic NPY nerve fibres in the human colon are discussed.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1569-8041
    Keywords: advanced ovarian cancer ; chemotherapy ; docetaxel ; phase II trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:This phase II study was conducted to evaluate theefficacy and toxicity of docetaxel in Japanese patients with advanced ovariancancer. Patients and methods:Docetaxel was administered at a dose of 70mg/m2 intravenously to patients with platinum pre-treated advancedovarian cancer. Treatment was repeated every three weeks. No routinecorticosteroid premedication was given. Results:Ninety patients with advanced ovarian cancer were enteredand sixty were assessable for response. The overall response rate was28% in the assessable patients (95% confidence interval(95% CI): 17.5%–41.4%). CA125 responses were seenin 8 (24%) of 34 assessable patients for CA125 criteria. The 36platinum-refractory patients had a response rate of 25% compared with33% in the platinum-sensitive patients. The predominant toxicity wasneutropenia, with 86% of the patients experiencing grade 3 or 4.Hypersensitivity reactions occurred in 37% of the patients and were notlife threatening. Edema was mild and infrequent. Conclusion:Docetaxel at 70 mg/m2 demonstratedeffectiveness as a treatment of both platinum-sensitive andplatinum-refractory ovarian cancer patients, with a low incidence of severehypersensitivity reactions and edema.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International orthopaedics 24 (2000), S. 28-32 
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé  Les auteurs rapportent 4 cas de fracture ancienne du bassin pour lesquels les situations d’urgence mettant en jeu le pronostic vital n’avaient pas permis initialement un traitement correct. Il s’agit de quatre patients dont l’âge s’échelonne de 24 à 51 ans. La gêne fonctionnelle était représentée par une boiterie, des douleurs dans les fesses et les membres inférieurs. Le délais entre l’accident et l’intervention était de 2,5 à 3 ans. Les douleurs et la capacité de marche ont été améliorées chez tous les patients mais une paralysie n’a pas pu être améliorée.
    Notes: Abstract  We report on 4 patients, aged 24–51 years, with untreated pelvic ring fractures. The chief complaints were gait disturbances and pain in the buttocks and lower limb. The period between the initial injury and the surgical treatment ranged from 2.5 months to 3 years. Palsy was not improved, but pain and gait ability was improved in all patients.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 14 (1990), S. 648-652 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Pour évaluer l'efficacité du dépistage systématique du cancer colorectal, nous avons comparé les caractéristiques clinicopathologiques et le taux de survie des patients dont le cancer a été détecté par ce système (groupe du dépistage) avec celles des patients dont le cancer avait été détecté par la filière classique de consultation (groupe de consultation). Il y avait 53 patients dans le groupe dépistage. Leur cancer avait été détecté par la coloration élective des selles. Les caractéristiques étaient sensiblement les mêmes que celles des 120 patients dans le groupe de consultation en ce qui concerne l'âge, le sexe, le site, et le type histologique du cancer. Dans le groupe de dépistage, 90% des patients n'avaient aucun symptôme et c'est uniquement la découverte de sang occulte dans les selles qui a permis de détecter les cancers. Plus de 60% des patients avaient des cancers du stade Dukes A et B1. Dans le groupe de consultation, près de 90% des patients signalaient des symptômes et notamment des rectorragies. Il n'y avait que 20% de cancers précoces (stade A et B1). La survie à 5 ans dans le groupe de dépistage était de 91.5%, significativement plus élevée que le taux de 60% dans le groupe de consultation. On déduit que la détection systématique du cancer colorectal par la recherche de sang dans les selles avec la méthode guaïc aura une importance épidémiologique dans la réduction de la mortalité en rapport avec le cancer colique.
    Abstract: Resumen Como primer paso en el proceso de la evaluación epidemiológica de la efectividad del tamizaje masivo para la detección del cáncer colorrectal, hicimos la comparación entre las características clinicopatológicas y la tasa de supervivencia de los pacientes diagnosticados por el tamizaje (grupo de tamizaje) con los pacientes tratados en nuestra consulta externa (grupo de consulta externa) en el mismo intervalo de tiempo. El grupo de tamizaje estuvo constituído por 53 pacientes con cáncer colorrectal detectado mediante el exámen coprológico para sangre oculta por el método de guayaco en laminillas. Sus antecedentes eran comparables con los de los 120 pacientes del grupo de consulta externa, en relación a edad, sexo, ubicación, y tipo histológico del cáncer. En el grupo de tamizaje, 90% de los pacientes apareció asintomático y fue la prueba positiva para sangre oculta la que dió lugar a la detección del cáncer. Mas de 60% de los pacientes presentaron tumores tempranos Duke A y Duke B1 y sólo alrededor de 30% presentaron cánceres en estado avanzado. En el grupo de consulta externa cerca de 90% presentaron síntomas, incluso sangrado rectal. Los cánceres tempranos representaron sólo 20%, mientras los cánceres avanzados constituyeron 80%. La tasa de supervivencia a 5 años en el grupo de tamizaje fue de 91.5%, significativamente mayor que la de 60% para el grupo de consulta externa. Se puede plantear que el tamizaje masivo para cáncer colorrectal mediante la prueba de Guayaco para sangre oculta habrá de tener significación epidemiológica en cuanto a reducir la mortalidad por cáncer.
    Notes: Abstract As the first step in the epidemiological evaluation of the effectiveness of mass screening for colorectal cancer, we compared clinicopathological features and survival rates of patients with cancer detected by mass screening (screened group) with those for patients treated in our outpatient clinic in the same period (outpatient group). The screened group consisted of 53 patients with colorectal cancer detected by 2-day or 3-day screening for fecal occult blood by guaiac slides. Their background factors were comparable to those of 120 patients of the outpatient group in regard to age, sex ratio, location of cancer, and histological type of cancer. In the screened group, 90% of patients had no complaints, and positive occult blood tests led to the detection of cancers. More than 60% of the patients had Dukes' A and B1 early cancers while only about 30% had advanced cancers. In the outpatient group, nearly 90% of patients were symptomatic, most commonly from rectal bleeding. Early-stage cancers made up only 20%, and large, advanced-stage cancers accounted for 80%. The 5-year survival rate of the screened group was 91.5%, being significantly higher than the 60% survival rate for the outpatient group. It is anticipated that mass screening for colorectal cancer by guaiac fecal occult blood testing will significantly reduce the mortality due to this neoplasm.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 87 (1993), S. 75-80 
    ISSN: 1432-2242
    Keywords: Somatic hybrid ; Petunia hybrida ; Petunia variabilis ; Protoplast ; Electrofusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Somatic hybrid plants were regenerated following electrofusion between leaf mesophyll protoplasts of P. hybrida (2n = 14) and a wild sexually incompatible species, P. variabilis (2n = 18). The selection of hybrids was based on the hybrid vigour, expressed both in the growth of the callus and at the shoot formation stage, resulting from the combination of parental genomes. Calli exhibiting vigorous growth were selected, and upon transfer to regeneration medium gave rise to shoots. Four regenerated plants from three calli had morphological characteristics intermediate between those of the parents. The hybrid nature of these plants was confirmed by chromosome counts as well as isozyme and DNA analyses. They had amphidiploid chromosome numbers (2n = 32) and were fertile. Following self-pollination and backcrossing with P. variabilis, large numbers of F2 and BC1 seedlings were obtained.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 81 (1991), S. 509-513 
    ISSN: 1432-2242
    Keywords: Lycopersicon esculentum ; Solanum muricatum ; Intergeneric somatic hybrid ; Electrofusion ; Isozyme analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Mesophyll protoplasts of tomato (Lycopersicon esculentum) and pepino (Solanum muricatum) were fused by using an electrofusion method and cultured in modified MS medium supplemented with naphthaleneacetic acid and kinetin, in which only pepino and somatic hybrid protoplasts could divide. Somatic hybrid plants showing intermediate characteristics in morphology were regenerated from the calli exhibiting vigorous growth in contrast with those of pepino. The hybrid nature of these plants was confirmed by cytological observation and biochemical analyses of phosphoglucomutase isozymes and the fraction-1-protein. The regenerated somatic hybrids grew to flowering stage and set fruits.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-4986
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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