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  • Electronic Resource  (34)
  • 1995-1999  (15)
  • 1970-1974  (19)
  • 1
    Electronic Resource
    Electronic Resource
    Carbon-13 nuclear magnetic resonance spectroscopy of naturally occurring substances. XXV. Carbon-13 nuclear magnetic resonance spectral analysis of tobramycin and related antibiotics (1974)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 96 (1974), S. 3300-3305 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00817a045
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  • 2
    Electronic Resource
    Electronic Resource
    CARBOHYDRATE-MODULATED GENE EXPRESSION IN PLANTS (1996)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Plant Physiology and Plant Molecular Biology 47 (1996), S. 509-540 
    Details
    ISSN: 1040-2519
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Plant gene responses to changing carbohydrate status can vary markedly. Some genes are induced, some are repressed, and others are minimally affected. As in microorganisms, sugar-sensitive plant genes are part of an ancient system of cellular adjustment to critical nutrient availability. However, in multicellular plants, sugar-regulated expression also provides a mechanism for control of resource distribution among tissues and organs. Carbohydrate depletion upregulates genes for photosynthesis, remobilization, and export, while decreasing mRNAs for storage and utilization. Abundant sugar levels exert opposite effects through a combination of gene repression and induction. Long-term changes in metabolic activity, resource partitioning, and plant form result. Sensitivity of carbohydrate-responsive gene expression to environmental and developmental signals further enhances its potential to aid acclimation. The review addresses the above from molecular to whole-plant levels and considers emerging models for sensing and transducing carbohydrate signals to responsive genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.arplant.47.1.509
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The safety of ranitidine in over a decade of use (1997)
    Oxford BSL : Blackwell Science
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Ranitidine hydrochloride (Zantac) is one of the most extensively studied and widely used drugs of all time. This has provided an excellent opportunity to define its safety profile. Methods: Data from 189 controlled clinical trials in which more than 26000 patients received daily doses of ranitidine for 4 weeks or more were reviewed. More than 80% of patients were treated with up to 300 mg ranitidine daily; the remaining patients received doses of up to 1200 mg daily. Eighty-seven trials were placebo controlled. Analyses of post-marketing surveillance and a database of all spontaneously reported adverse events were also evaluated. Results: Overall in the clinical trial programme adverse events were reported by 20% of those receiving ranitidine compared with 27% of those receiving placebo. The pattern of events was similar in all treatment groups with no evidence of dose-related toxicity in regimens encompassing an eightfold range of therapeutic doses. Similarly in a programme of studies designed to evaluate a dose of ranitidine of 75  mg for non-prescription (over-the-counter) use in the treatment of heartburn, ranitidine was not associated with an adverse event profile distinct from that of placebo. Analysis of spontaneously reported adverse event data allowed identification of rare idiosyncratic events. Conclusions: Review of data from a large population of controlled clinical trials with analyses of postmarketing surveillance studies and spontaneously reported adverse events confirmed the excellent safety profile of ranitidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1997.136312000.x
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  • 4
    Electronic Resource
    Electronic Resource
    Extrarenal actions of aldosterone antagonists in guinea pigs (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 279 (1973), S. 9-18 
    Details
    ISSN: 1432-1912
    Keywords: Aldosterone Antagonists ; β-Methyl-Digoxin ; Guinea Pigs ; Potassium ; Cardiac Toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of aldosterone antagonists on the cardiotoxicity of β-methyl-digoxin in guinea pigs were investigated in vivo and in vitro. 1. Three days of pretreatment with spironolactone influenced neither plasma concentrations, urinary output and tissue distribution of radioactivity after intravenous injection of β-methyl-digoxin nor the pattern of lipid soluble metabolites in the urine. 2. Spironolactone injected intraduodenally 1 h before the infusion of β-methyl-digoxin decreased the cardiotoxicity of the latter if hypokalemia was reduced or prevented by giving 0.4–1.0 mEq/kg KCl 1 h before β-methyl-digoxin. 3. Three days of pretreatment with canrenoate-K decreased the cardiotoxicity of β-methyl-digoxin in vivo without the administration of KCl. 4. Isolated hearts from guinea pigs pretreated with canrenoate-K for 3 days tolerated the perfusion with toxic concentrations of β-methyl-digoxin better than those from controls although the rate of potassium extrusion from the heart was not decreased. 5. The addition of canrenone to the fluid perfusing isolated hearts decreased the potassium extrusion produced by and the toxicity of β-methyl-digoxin. The results suggest that the decreased glycoside toxicity is due to the stimulation of inward transport of potassium by aldosterone-antagonists described in the preceding paper.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00502063
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  • 5
    Electronic Resource
    Electronic Resource
    β-Methyl-digoxin (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 282 (1974), S. 9-14 
    Details
    ISSN: 1432-1912
    Keywords: Cardiac Glycosides ; Distribution ; Guinea Pigs ; Protein Binding ; Therapeutic Ratio
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In guinea pigs under urethane anaesthesia the concentrations of radioactivity in the plasma, the liver and the heart and the protein binding of radioactivity were measured 1 h after the intravenous injection of 0.2 μmoles/kg β-methyldigoxin or digoxin. The distribution coefficients were calculated between the concentrations in the plasma water and the tissues. Apart from a slightly higher distribution coefficient for β-methyl-digoxin than for digoxin between liver and plasma water there was no significant difference between the two glycosides. In guinea pigs under barbital anaesthesia, cardiac failure was produced by additional doses of barbital-Na. Bemegride was given to counteract the effects of barbital on the vasomotor centre. β-Methyl-digoxin and digoxin were infused until cardiac arrest. For each animal the doses were calculated which led to an increase in cardiac performance by 50 g · cm/sec, arrhythmia, ventricular fibrillation or cardiac arrest. The therapeutic range was calculated from the doses producing arrhythmias and those increasing cardiac performance by 50 g · cm/sec (“therapeutic” dose). There was no difference between the “therapeutic” and toxic doses and the therapeutic ratios of β-methyl-digoxin and digoxin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00647399
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  • 6
    Electronic Resource
    Electronic Resource
    CP-123,369: A potent, orally active immunosuppressive agent (1995)
    Springer
    Inflammation research 44 (1995), S. S183 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01778322
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  • 7
    Electronic Resource
    Electronic Resource
    Ion channel modulation as a drug discovery target in inflammatory diseases (1996)
    Springer
    Inflammation research 45 (1996), S. 435-437 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02252312
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  • 8
    Electronic Resource
    Electronic Resource
    Bedeutung nichtinvasiver Perfusions- und Funktionsuntersuchungen für Diagnose und Prognose der KHK (1998)
    Springer
    Der Internist 39 (1998), S. 684-696 
    Details
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Koronare Herzkrankheit ; Diagnostik ; Koronare Herzkrankheit ; Prognose ; Perfusionsszintigraphie ; Stress-Echokardiographie ; Belastungs-EKG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema In letzter Zeit spielen nichtinvasive Untersuchungen in der Diagnostik der koronaren Herzkrankheit wieder eine größere Rolle. Dies dürfte sicher nicht nur eine Folge weltweiter ökonomischer Zwänge im Gesundheitswesen sein sondern auch einem präzisierten medizinischen Denken entsprechen, das sich mehr um eine rationelle Stufendiagnostik bemüht. Allerdings ermöglichen auch verbesserte Methoden, besonders durch Perfusionsszinitigraphie und Stress-Echokardiographie, zunehmend höhere Sensivitäten und Spezifitäten nichtinvasiver Verfahren. Aus neuerer Zeit liegen auch zahlreiche Untersuchungen nicht nur zur diagnostischen sondern auch zur prognostischen Wertigkeit nichtinvasiver Methoden und somit zur Abschätzung koronarbedingter Risiken vor. Es ist geradezu ein generelles Anliegen der Zeitschrift DER INTERNIST, die gezielte Stufendiagnostik zu fördern; viele Hefte der letzten Jahre zeugen dafür. In dieses Konzept fügt sich auch die vorliegende Arbeit über nichtinvasive Methoden der Koronardiagnostik, die sich vorwiegend auf das Belastungs-EKG, die Perfusionsszintigraphie und die Stress-Echokardiographie fokussiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001080050231
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  • 9
    Electronic Resource
    Electronic Resource
    Langzeitbetreuung von Dialysepatienten I. Hochdruck und Anämie (1999)
    Springer
    Der Internist 40 (1999), S. 55-63 
    Details
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Dialyse ; Hypertonie ; Hypertonie ; Dialyse ; Dialyse ; Anämie ; Anämie ; Dialyse ; Nierenversagen ; Erythropoetin ; Dialyse ; Eisenstoffwechsel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema Die Urämie stellt ein außerordentlich komplexes Krankheitsbild dar und kann zu klinischen Manifestationen an nahezu allen Organsystemen führen. Entsprechend komplex gestaltet sich die chronische Betreuung von Dialysepatienten. Angesichts der Vielzahl von klinischen Problemen ist eine umfassende Diskussion der Langzeitbetreuung von Dialysepatienten (z.B. auch der psychologischen Betreuung) in der nachfolgenden Übersicht nur fragmentarisch möglich. Wir haben uns auf zentrale internistische Probleme von Dialysepatienten beschränkt und werden detailliert die Hypertonie, die renale Anämie und zwei bedeutsame Langzeitkomplikationen der Dialyse, die β2-Mikroglobulin assoziierte Amyloidose sowie die erworbene zystische Nierenkrankheit (siehe Teil II), besprechen. Zur Klinik und Therapie einer weiteren bedeutsamen Komplikation der chronischen Urämie, d.h. der renalen Osteopathie, sei auf den Beitrag von Schulz et al. in diesem Heft verwiesen. Zu den Themen „Ernährung bei chronischer Niereninsuffizienz” sowie der sekundären Hyperurikämie bzw. Gicht bei Niereninsuffizienz siehe den Beitrag von Hörl et al. in diesem Heft bzw. unsere kürzlich in Der Internist publizierte Übersicht [48].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001080050308
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  • 10
    Electronic Resource
    Electronic Resource
    Langzeitbetreuung von Dialysepatienten II. β2-Mikroglobulin Assoziierte Amyloidose und Erworbene Zystische Nierenerkrankung (1999)
    Springer
    Der Internist 40 (1999), S. 64-69 
    Details
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Amyloidose ; Dialyse ; Dialyse ; Amyloidose ; Dialyse ; Zystennieren ; Zystennieren ; Dialyse ; Dialyse ; Malignome ; Nierenversagen ; Beta2-Mikroglobulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema Mit dem routinemäßigen Einsatz der Dialyse und dem inzwischen bis zu 30jährigen Überleben einzelner Patienten nach Eintritt der terminalen Niereninsuffizienz haben sich verschiedene neue, Urämie-spezifische Krankheitsbilder manifestiert. Diese neuen Krankheitsbilder müssen als Folge metabolischer und adaptativer Veränderungen in der Urämie verstanden werden. Die beiden klinisch bedeutsamsten Erkrankungen aus dieser Gruppe stellen die β2-Mikroglobulin assoziierte Amyloidose sowie die erworbene zystische Nierenkrankheit dar. Beide Krankheitsbilder zeichnen sich durch einen chronischen Verlauf und asymptomatischen Beginn aus, können jedoch im Langzeitverlauf der Urämie zu erheblicher Morbidität und auch Mortalität führen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001080050309
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